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Impact of psychological stress on irritable bowel syndrome

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World Journal of Gastroenterology 2014年第39期20卷 14126-14131页

作者： Hong-Yan Qin Chung-Wah Cheng Xu-Dong Tang zhao-xiang bian Department of Pharmacy First Hospital of Lanzhou University Lab of Brain and Gut Research School of Chinese Medicine Hong Kong Baptist University China Academy of Chinese Medical Sciences

Psychological stress is an important factor for the development of irritable bowel syndrome(IBS). More and more clinical and experimental evidence showed that IBS is a combination of irritable bowel and irritable brain. In the present review we discuss the potential role of psychological stress in the pathogenesis of IBS and provide comprehensive approaches in clinical treatment. Evidence from clinical and experimental studies showed that psychological stresses have marked impact on intestinal sensitivity, motility, secretion and permeability, and the underlying mechanism has a close correlation with mucosal immune activation, alterations in central nervous system, peripheral neurons and gastrointestinal microbiota. Stress-induced alterations in neuro-endocrine-immune pathways acts on the gut-brain axis and microbiota-gut-brain axis, and cause symptom flare-ups or exaggeration in IBS. IBS is a stresssensitive disorder, therefore, the treatment of IBS should focus on managing stress and stress-induced responses. Now, non-pharmacological approaches and pharmacological strategies that target on stress-related alterations, such as antidepressants, antipsychotics, miscellaneous agents, 5-HT synthesis inhibitors, selective 5-HT reuptake inhibitors, and specific 5-HT receptor antagonists or agonists have shown a critical role in IBS management. A integrative approach for IBS management is a necessary.

关键词： Psychological stress Irritable bowel syndrome Microbiota-gut-brain axis Immune activation

A clinical pathway for integrative medicine in the treatment of functional constipation in Hong Kong,China

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Journal of Integrative Medicine 2023年第6期21卷 550-560页

作者： Dong-jue Wei Hui-juan Li Zi-pan Lyu Ai-ping Lyu zhao-xiang bian Linda LD Zhong School of Chinese Medicine Hong Kong Baptist UniversityHong KongChina School of Biological Sciences Nanyang Technological University637551Singapore

Objective:Functional constipation(FC)is a common intestinal disease *** the presence of criteria such as Roman IV,there is no standardized diagnosis and treatment algorithm in Hong Kong that combines both Western and Chinese medicine *** study integrates current effective and safe diagnosis and treatment methods for FC and provides a clear and scientific pathway for clinical professionals and ***:A systematic search of the PubMed,Cochrane Library,and China National Knowledge Infrastructure databases was performed from their inception to June 30th,2022,collecting the current evidence about the efficacious integrative management for *** organized a meeting of professionals in fields relevant to treatment and management of FC to develop a consensus agreement on clinical pathway ***:We developed a clinical pathway for the treatment of FC based on the most recent published guidelines and consultation with *** pathway includes a hierarchy of recommendations for every step of the clinical process,including clinical intake,diagnostic examination,recommended labs,diagnostic flowchart,and guidance for selection of therapeutic ***:This pathway establishes clinical standards for the diagnosis and treatment of FC using Chinese medicine and Western medicine;it will help to provide high-quality medical services in Hong Kong for patients with FC.

关键词： Functional constipation Clinical pathway Hong Kong Integrative medicine

Systematic review of Chinese herbal medicine for functional constipation

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World Journal of Gastroenterology 2009年第39期15卷 4886-4895页

作者： Chung-Wah Cheng zhao-xiang bian Tai-xiang Wu School of Chinese Medicine Hong Kong Baptist University Hong Kong China Department of ClinicalEpidemiology Chinese Evidence-Based Medicine Centre West China Hospital Sichuan University Chengdu 610041 Sichuan Province China

Constipation is a common gastrointestinal complaint in clinical practice, affecting an estimated 27% of the population. Many patients are disappointed by current conventional treatments and, therefore, seek help from complementary and alternative medicine （CAM）. Traditional Chinese medicine, is the most important part of CAM and has been practiced for treating diseases and promoting the health of humans for thousands of years, and has become a popular alternative choice. Although there are many Chinese herbal medicine （CHM interventions available, and some have been verified b＇ clinical trials, their efficacy and safety are still questioned by both patients and health care providers worldwide. The purposes of this review are, first, to appraise the qualities of individual study designs in the new Cochrane approach. Second, the benefits of individual CHM interventions or individual types of CHM intervention for the treatment of functional constipation are analyzed. Finally, valid and comprehensive conclusions are drawn, if applicable, in order to make clinical recommendations.

关键词： Chinese herbal medicine Functional constipation Systematic review

Proteome profiling of spinal cord and dorsal root ganglia in rats with trinitrobenzene sulfonic acid-induced colitis

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World Journal of Gastroenterology 2012年第23期18卷 2914-2928页

作者： Xiao-Jun Zhang Feung Ping Leung Wendy WL Hsiao Shun Tan Shao Li Hong-Xi Xu Joseph JY Sung zhao-xiang bian School of Chinese Medicine HongKong Baptist University Hong Kong China Ministry of Education Key Laboratory of Bioinformat- ics and Bioinformatics Division TNLIST/Department of Auto- mation Tsinghua University Beijing 100084 China Shanghai University of Traditional Chinese Medi- cine Shanghai 200032 China Faculty of Medicine The Chinese University of Hong Kong Hong Kong China

AIM: To investigate proteomic changes in spinal cord and dorsal root ganglia (DRG) of rats with trinitrobenzene sulfonic acid (TNBS)-induced colitis. METHODS: The colonic myeloperoxidase (MPO) activity and tumor necrosis factor-(TNF- ) level were determined. A two-dimensional electrophoresis (2-DE)-based proteomic technique was used to profile the global protein expression changes in the DRG and spinal cord of the rats with acute colitis induced by intracolonic injection of TNBS. RESULTS: TNBS group showed significantly elevated colonic MPO activity and increased TNF-level. The proteins derived from lumbosacral enlargement of the spinal cord and DRG were resolved by 2-DE; and 26 and 19 proteins that displayed significantly different expression levels in the DRG and spinal cord were identified respectively. Altered proteins were found to be involved in a number of biological functions, such as inflammation/immunity, cell signaling, redox regulation, sulfate transport and cellular metabolism. The over-expression of the protein similar to potassium channel tetramerisation domain containing protein 12 (Kctd 12) and low expression of proteasome subunit type-1 (psma) were validated by Western blotting analysis. CONCLUSION: TNBS-induced colitis has a profound impact on protein profiling in the nervous system. This result helps understand the neurological pathogenesis of inflammatory bowel disease.

关键词： Inflammatory bowel disease Trinitrobenzenesulfonic acid Two-dimensional electrophoresis-basedproteomic technique Dorsal root ganglia Spinal cord

Evaluation of the Pharmacokinetics and Renal Excretion of Ma-Zi-Ren-Wan in Health Subjects

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World Journal of Traditional Chinese Medicine 2017年第2期3卷 8-15页

作者： Dong-Dong Hu Linda Li-Dan Zhong Kun Wai Huai-Xue Mu Cheng-Yuan Lin Ling zhao Liang Dai Tao Huang zhao-xiang bian Hong Kong Chinese Medicine Study Centre Hong Kong Baptist University School of Chinese Medicine Hong Kong Baptist University Hong Kong Baptist University Shenzhen Research Institute and Continuing Education

Background: Ma-Zi-Ren-Wan(MZRW) is a classic Chinese formula for treating human constipation. It is comprised of six *** previous studies have shown its great therapeutic effect. The absorbed compounds had been studied in rat, while there was no study about its components in human ***: To observe the components of MZRW absorbed in health subjects and study the pharmacokinetics of major compounds. At the same time, to observe the renal excretion of MZRW in health subjects based on the quantification of major ***: Health adults were randomly assigned to three dose groups(5 g, 7.5 g and 10 g q.d.) of MZRW. Blood samples were collected from the medial cubital vein just before and at 0.25, 0.5, 1, 2, 4, 8 and 12 h after administration. Urine samples were collected at 0 to 3 h, 3 to 6 h, 6 to 9 h and 9 to 12 h after MZRW administration, with the urine volume recorded for each time segment. Plasma and urine samples were analyzed by optimized LC-MSMS(Liquid chromatography-tandem mass spectrometry) method for pharmacokinetics and renal excretion study of ***: Ten compounds of MZRW were observed in 23 health subjects. Due to the low concentration in plasma at the current dose, only four compounds(Albiflorin, paeoniflorin, magnolol and rhein) were quantified in the plasma sample. Honokiol, aloe emodin and emodin could only meet the LLOQ at some time points of the high dose group. Hesperidin, naringin and amygdalin could not be detected in plasma sample. While seven compounds(Amygdalin, albiflorin, paeoniflorin, magnolol, honokiol, rhein and aloe emodin) could be quantified in urine, the renal excretion was well ***: MZRW was safe and well tolerated in this clinical study. Albiflorin, paeoniflorin, magnolol and rhein was well quantified in plasma. The renal excretion of paeoniflorin, albiflorin and rhein were dose dependent for doses ranging between 5 and 10 g.

关键词： Ma-Zi-Ren-Wan LC-MS/MS Pharmacokinetics Human plasma Renal Excretion

Chinese Herbal Medicine for Ulcerative Colitis:A Systematic Review Protocol

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World Journal of Traditional Chinese Medicine 2017年第2期3卷 16-19页

作者： Hong Mi Linda Zhong Tao Huang Cheng-yuan Lin Ling zhao Dong-dong Hu Hai-tao Xiao zhao-xiang bian Feng-bin Liu Department of Gastroenterology the First Affiliated Hospital of Guangzhou University of Chinese Medicine School of Chinese medicine Hong Kong Baptist University

Introduction: This manuscript aims to provide a protocol of systematic review to assess the safety and effectiveness of Chinese herbal medicine(CHM) for the treatment of ulcerative colitis(UC). Although CHM has been widely used for UC, its effectiveness and safety has not yet been well defined and *** and analysis: Seven electronic databases were searched, including China National Knowledge Infrastructure(CNKI), Chinese Biomedical literature(CBL), VIP database, Cochrane Library, MEDLINE, PubMed and China Journals Full-text Database. Related Chinese literature will be searched in other Chinese databases. All relevant randomized controlled literature of publication type will be *** of risk of bias, data synthesis and subgroup analysis will be carried out using Review Manager *** and dissemination: The results of the systematic review will be disseminated via publication in a peer-reviewed journal and presented at a relevant conference.

关键词： Chinese herbal medicine Ulcerative colitis Systematic review Protocol

Novel N-heteroaromatic dyes for textile substrates

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Chinese Chemical Letters 2014年第8期25卷 1165-1168页

作者： Kim-Hung Lam Sarah Sze-Wah Ho Pik-Ling Lam Johnny Cheuk-On Tang zhao-xiang bian Albert Sun-Chi Chan Hua Li Wai-Yeung Wong Chung-Hin Chui Department of Applied Biology and Chemical Technology Institute of Textile and Clothing The Hong Kong Polytechnic University Clinical Division School of Chinese Medicine Hong Kong Baptist University Institute of Molecular Functional Materials Department of Chemistry and Institute of Advanced Materials Hong Kong Baptist University College of Life and Environmental Sciences Minzu University of China HKBU Institute of Research and Continuing Education Shenzhen Virtual University Park

This study reports the synthesis and characterization of quinoline derivatives. The synthesized quinoline compounds were applied to the dyeing treatment of acrylic fabrics. The color fastness to washing and light of quinoline compound-dyed fabrics was examined. Human skin HaCaT cell line was also used for the skin cytotoxicity evaluation of the quinoline compound-dyed acrylic fabrics.

关键词： Acrylic fabrics Fluorescent Quinoline dyes Skin cytotoxicity

Chinese Herbal Medicine for Chemotherapy Induced Gastrointestinal Side Effects: A Systematic Review of Randomized Controlled Trials

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World Journal of Traditional Chinese Medicine 2017年第2期3卷 31-50页

作者： Chung-Wah Cheng zhao-xiang bian Li-Dan Zhong Justin CY Wu Zhi-Xiu Lin Eric TC Ziea Vivian CW Wong Hong Kong Chinese Medicine Clinical Study Centre Hong Kong Baptist University School of Chinese Medicine Hong Kong Baptist University Faculty of Medicine The Chinese University of Hong Kong School of Chinese Medicine The Chinese University of Hong Kong Chinese Medicine Department Hospital Authority

Objective: To determine how safe and effective Chinese Herbal Medicine(CHM) is in alleviating the nausea, vomiting, oral ulceration,diarrhea and constipation for cancer patients with ***: Data sources: A systematic review of Chinese and English articles using Ovid SP, CNKI, VIP Database and Traditional Chinese Medicine Database System. Study selection: Only randomized controlled trials(RCTs) for the prevention or treatment of any one of gastrointestinal side effects, namely nausea, vomiting, oral ulceration, diarrhea and constipation, of CHM with or without western medicine(WM) vs WM, placebo or no treatment were included. Data Extraction: Independent extraction of articles was first performed by four medical students using predefined data fields. Then, all data, including study quality indicators, was checked by two ***: Eighty-six RCTs involving 7076 cancer patients were found and analyzed in this review. Because of the heterogeneity of study design and low overall methodological quality, only descriptive summaries were performed. Beneficial effects were found in some CHM interventions,regardless of being taken alone or taken with WM. Moreover, none of serious adverse effect was reported. However, same intervention had not been repeatedly investigated by different research ***: Implications of the analysis support the efficacy and safety of CHM for the management of gastrointestinal side ***, definite clinical recommendation for particular CHM intervention still cannot be made due to low methodological quality of included studies and lack of duplicated verification. Further large scale and high quality RCTs on the same CHM interventions are suggested.

关键词： Chinese herbal medicine Systematic review Chemotherapy induced side effects Gastrointestinal diseases

A Systematic Review of Chinese Herbal Medicine for Constipation:From Zheng-based Prescription to Selections of Herbs and Formula

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A Systematic Review of Chinese Herbal Medicine for Constipat...