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Mechanisms of ＂kidney governing bones＂ theory in traditional Chinese medicine

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Frontiers of Medicine 2014年第3期8卷 389-393页

作者： Dahong Ju Meijie Liu Hongyan zhao jun wang Institute of Basic Theory China Academy of Traditional Chinese Medicine Beijing 100700 China

Studies conducted by our group on the mechanism of ＂kidney governing bones＂ theory in traditional Chinese medicine （TCM） are reviewed in this paper. Conclusions can be summarized as follows. （1） Neuroendocrine-immune network （NIN）-osteoclast regulatory pathway OPG-RANKL-RANK is one of the mechanisms of ＂kidney governing bones.＂ Although kidney-reinforcing therapy is regarded as one of the holistic regulatory mechanisms of the body, characteristic holistic regulation in TCM can be reflected through nonselective regulation of the NIN during kidney reinforcement therapy, which can be used to treat osteoporosis through microadjustments in the microenvironment of the bone marrow. （2） Marrow exhaustion in TCM, which is the state wherein lipocytes in the bone marrow increase whereas other cells decrease, serves as the pathogenesis of osteoporosis brought about by failure of the ＂kidney governing bones.＂（3） The kidney in TCM can be regarded as a complex system comprising multiple functional units in the body, including the unit ＂governing bones.＂ Kidney deficiency refers to a deficiency in only one or more units of the kidney system and not the whole system itself, which explains the kidney-reinforcing effect of many herbs; some herbs can treat osteoporosis, but some cannot. Although both classified as kidney-reinforcing agents, the former can resolve failure of the ＂kidney governing bones＂ unit while the latter regulates the failure of other units in the kidney system. Despite the current understanding on ＂kidney governing bones＂ theory, the mechanism of ＂kidney governing bones＂ remains complicated and unresolved. Thus, further studies in this area are warranted.

关键词： kidney governing bones kidney deficiency marrow osteoporosis neuroendocrine-immune network osteoclastregulatory pathway

Contribution of dust produced by binary merger ejecta

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Research in Astronomy and Astrophysics 2015年第1期15卷 55-63页

作者： zhao-jun wang Chun-Hua Zhu Guo-Liang Lü School of Physical Science and Technology Xinjiang University

By means of a population synthesis code and by constructing a simple toy model of dust produced by asymptotic giant branch（AGB） stars, common envelope（CE） ejecta and binary merger ejecta, we estimate the dust product rates（DPRs） of these processes in the Milky Way. The total DPR from AGB stars is～ 6.7 × 10-4M yr-1, in which about 73% of dust grains are carbon, 24% are silicates and 3% are iron. The total DPR from CE ejecta is ～ 4.2 × 10-4M yr-1, in which about 83% of dust grains are silicates, about 12% are carbon and 5% are *** DPR from binary merger ejecta is less than 1/3 that from AGB stars or CE ejecta,and it could even be negligible under certain circumstances. Therefore, compared with AGB stars and CE ejecta, the contribution of dust produced by binary merger ejecta to total dust grains in the Milky Way is smaller or can be negligible.

关键词： binaries: close stars: evolution circumstellar matter dust

Population synthesis of high mass X-ray binaries

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Research in Astronomy and Astrophysics 2011年第3期11卷 327-334页

作者： Guo-Liang Lu Chun-Hua Zhu zhao-jun wang School of Physics Xinjiang University .Urumqi 830046 China Xinjiang University-National Astronomical ObserVatories Joint＇Center for Astrophysics Urumqi830046 China National Astronomical Observatories / Urumqi Observatory Chinese Academy of Sciences Urumqi 830011 China

By simulating the evolution of spin periods of magnetized neutron stars which interact with their environment in binary systems,we investigate the Galactic population of high mass X-ray binaries（HMXBs） .The number of HMXBs in the Galaxy is between 190 and 240,and their birthrate is from 5.9×10-5 yr-1 to 6.3× 10-5 *** the Corbet diagram（the positions of the spin periods *** orbital periods of HMXBs） in our model with the associated observations,we find that the stellar wind structure and the process of matter transfer are very important for understanding HMXBs.

关键词： stars:evolution—X-rays:binaries—Galaxy:stellar content

Population synthesis of ultra-compact X-ray binaries

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Research in Astronomy and Astrophysics 2012年第11期12卷 1526-1534页

作者： Chun-Hua Zhu Guo-Liang Lu zhao-jun wang School of Physical Science and Technology Xinjiang University Urumqi 830046 China

Ultra-compact X-ray binaries （UCXBs） are very interesting and impor- tant objects. By taking the population synthesis approach to the evolution of binaries, we carry out a detailed study of UCXBs. We estimate that there are - 5000-10000 UCXBs in the Galaxy, and their birthrates are - 2.6-7.5×10-4 yr-1. Most UCXBs are transient X-ray sources, but their X-ray luminosities are much lower than those of persistent sources. Therefore, the majority of observed UCXBs should be persistent sources. About 40% - 70% of neutron stars （NSs） in UCXBs form via an accretion- induced collapse from an accreting ONe white dwarf （WD）, 1%-10% of NSs in UCXBs form via core-collapse supernovae and others form via the evolution-induced collapse of a naked helium star. About 50% - 80% of UCXBs have naked helium star donors, 5% - 10% of UCXBs have HeWD donors, 15% - 40% of UCXBs have COWD donors and UCXBs with ONeWD indicates that the uncertainty mainly comes which develops in these systems. donors are negligible. Our investigation from evolution of the common-envelope

关键词： binaries: close -- stars: neutron -- X-rays: binaries

Optimization of Holding Temperature and Holding Thickness for Controlled Rolling on Plate Mill

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Journal of Iron and Steel Research International 2006年第3期13卷 21-25页

作者： HU Xian-lei zhao Zhong wang jun wang zhao-dong LIU Xiang-hua wang Guo-dong State Key Laboratory of Rolling and Automation Northeastern University Shenyang 110004 Liaoning China

Holding temperature and holding thickness are main parameters for two-phase controlled rolling on plate mill. The optimization of holding temperature and holding thickness for pass schedule calculation of two-phase controlled rolling on plate mill was presented and its feature is as follows：（1） Determination of holding thickness can be automatically obtained based on the influence of mill safety limits, tracking zone length and holding time on holding thickness; （2） Determination of holding temperature can be automatically obtained and the holding time can be reduced as much as possible; （3） Algorithm can modify the holding temperature and thickness depending on slab size and product size.

关键词： plate two-phase controlled rolling pass schedule holding temperature holding thickness

CUSUM control charts based on likelihood ratio for preliminary analysis

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Science China Mathematics 2007年第1期50卷 47-62页

作者： Yi DAI zhao-jun wang Chang-liang ZOU LPMC and Department of Statistics School of Mathematical SciencesNankai UniversityTianjin 300071China

To detect and estimate a shift in either the mean and the deviation or both for the preliminary analysis, the statistical process control (SPC) tool, the control chart based on the likelihood ratio test (LRT), is the most popular method. Sullivan and woodall pointed out the test statistic lrt(n1, n2) is approximately distributed as x2(2) as the sample size n,n1 and n2 are very large, and the value of n1 = 2,3,..., n - 2 and that of n2 = n - n1. So it is inevitable that n1 or n2 is not large. In this paper the limit distribution of lrt(n1, n2) for fixed n1 or n2 is figured out, and the exactly analytic formulae for evaluating the expectation and the variance of the limit distribution are also obtained. In addition, the properties of the standardized likelihood ratio statistic slr(n1, n) are discussed in this paper. Although slr(n1, n) contains the most important information, slr(i, n)(i≠n1) also contains lots of information. The cumulative sum (CUSUM) control chart can obtain more information in this condition. So we propose two CUSUM control charts based on the likelihood ratio statistics for the preliminary analysis on the individual observations. One focuses on detecting the shifts in location in the historical data and the other is more general in detecting a shift in either the location and the scale or both. Moreover, the simulated results show that the proposed two control charts are, respectively, superior to their competitors not only in the detection of the sustained shifts but also in the detection of some other out-of-control situations considered in this paper.

关键词： preliminary analysis false alarm probability CUSUM chart likelihood ratio test 62P30

(D-Ser2) oxyntomodulin recovers hippocampal synaptic structure and theta rhythm in Alzheimer’s disease transgenic mice

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Neural Regeneration Research 2022年第9期17卷 2072-2078页

作者： Guang-zhao Yang Qi-Chao Gao Wei-Ran Li Hong-Yan Cai Hui-Min zhao Jian-Ji wang Xin-Rui zhao Jia-Xin wang Mei-Na Wu jun Zhang Christian Hölscher Jin-Shun Qi zhao-jun wang Department of Cardiovascular Medicine the First Hospital of Shanxi Medical UniversityTaiyuanShanxi ProvinceChina Department of Physiology Shanxi Medical UniversityKey Laboratory of Cellular PhysiologyMinistry of EducationKey Laboratory of Cellular Physiology in Shanxi ProvinceTaiyuanShanxi ProvinceChina Department of Microbiology and Immunology Shanxi Medical UniversityTaiyuanShanxi ProvinceChina Functional Laboratory Center Shanxi Medical UniversityTaiyuanShanxi ProvinceChina Research and Experimental Center Henan University of Chinese MedicineZhengzhouHenan ProvinceChina

In our previous studies,we have shown that(D-Ser2)oxyntomodulin(Oxm),a glucagon-like peptide 1(GLP-1)receptor(GLP1R)/glucagon receptor(GCGR)dual agonist peptide,protects hippocampal neurons against Aβ1-42-induced cytotoxicity,and stabilizes the calcium homeostasis and mitochondrial membrane potential of hippocampal ***,we have demonstrated that(D-Ser2)Oxm improves cognitive decline and reduces the deposition of amyloid-beta in Alzheimer’s disease model ***,the protective mechanism remains *** this study,we showed that 2 weeks of intraperitoneal administration of(D-Ser2)Oxm ameliorated the working memory and fear memory impairments of 9-month-old 3×Tg Alzheimer’s disease model *** addition,electrophysiological data recorded by a wireless multichannel neural recording system implanted in the hippocampal CA1 region showed that(D-Ser2)Oxm increased the power of the theta *** addition,(D-Ser2)Oxm treatment greatly increased the expression level of synaptic-associated proteins SYP and PSD-95 and increased the number of dendritic spines in 3×Tg Alzheimer’s disease model *** findings suggest that(D-Ser2)Oxm improves the cognitive function of Alzheimer’s disease transgenic mice by recovering hippocampal synaptic function and theta rhythm.

关键词： (D-ser2)oxyntomodulin Alzheimer’s disease cognitive decline glucagon-like peptide-1 hippocampus local field potential synapse theta rhythm

A novel small-signal equivalent circuit model for GaN HEMTs incorporating a dual-field-plate

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Journal of Semiconductors 2024年第5期45卷 61-68页

作者： Jinye wang jun Liu Zhenxin zhao School of Integrated Circuit Science and Engineering Hangzhou Dianzi UniversityHangzhou 310018China

An accurate and novel small-signal equivalent circuit model for GaN high-electron-mobility transistors(HEMTs)is proposed,which considers a dual-field-plate(FP)made up of a gate-FP and a *** equivalent circuit of the overall model is composed of parasitic elements,intrinsic transistors,gate-FP,and source-FP *** equivalent circuit of the gate-FP is identical to that of the intrinsic *** order to simplify the complexity of the model,a series combination of a resistor and a capacitor is employed to represent the *** analytical extraction procedure of the model parameters is presented based on the proposed equivalent *** verification is carried out on a 4×250μm GaN HEMT device with a gate-FP and a source-FP in a 0.45μm *** with the classic model,the proposed novel small-signal model shows closer agreement with measured S-parameters in the range of 1.0 to 18.0 GHz.

关键词： small-signal model dual field-plate(FP) GaN high-electron-mobility transistors(HEMT) parameter extraction

The effects of convective overshooting on naked helium stars

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Research in Astronomy and Astrophysics 2016年第9期16卷 75-82页

作者： Jing-Zhi Yan Chun-Hua Zhu zhao-jun wang Guo-Liang Lü School of Physical Science and Technology Xinjiang University

Using stellar evolutionary models, we investigate the effects of convective overshooting on naked helium stars. We find that a larger value of overshooting parameter δov results in a larger convective core, which prolongs the lifetimes of naked helium stars on the helium main sequence and leads to higher effective temperatures and luminosities. For naked helium stars with masses lower than about 0.8 Mo, they hardly become giant stars as a result of a weak burning shell. However, naked helium stars with masses between about 0.8 M⊙ and 1.1 M⊙ can evolve into giant branch phases, and finally become carbon oxygen white dwarfs.

关键词： stars evolution- stars interiors- stars fundamental parameters