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Use of tunnel endoscopy for diagnosis of obscure submucosal esophageal adenocarcinoma:A case report and review of the literature with emphasis on causes of esophageal stenosis

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World Journal of Clinical Cases 2019年第5期7卷 668-675页

作者： Song Liu Nian Wang Jian Yang Jia-Yao Yang zhao-hong shi Department of Gastroenterology The First Hospital of Wuhan

BACKGROUND The tunnel endoscopic technique is the treatment of choice for submucosal tumors. However, the use of tunnel endoscopy to diagnose adenocarcinoma of the esophagus originating from the submucosa has not been well *** SUMMARY A 74-year-old man who presented with dysphagia for half a year underwent a series of checks, such as gastroendoscopy, X-ray contrast examination of the upper digestive tract, endoscopic ultrasonography, high-resolution esophageal manometry, and positron emission computed tomography. It should be noted that the stenosis of the esophagus was too narrow for endoscopic ultrasoundguided fine needle aspiration. The cause remained undiagnosed. Eventually, the tunnel endoscopic technique was perform for the pathological examination in the submucosa and the final diagnosis was adenocarcinoma of the esophagus. The patient and family members chose expectant treatment due to the patient's age and the high costs of surgical *** Tunnel endoscopy could be used to diagnose tumors. Moreover, we review the literature to provide guidance regarding the causes of esophagostenosis.

关键词： Esophageal stenosis Adenocarcinoma of the esophagus Tunnel endoscopic technique Case report

Effect of the regimen of Gaoshan hongjingtian on the mechanism of poly（ADP-ribose） polymerase regulation of nuclear factor kappa B in the experimental diabetic retinopathy

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Chinese Medical Journal 2013年第9期126卷 1693-1699页

作者： zhao hong-shu shi Xiang-yu WEI Wen-bin WANG Ning-li Beijing Tongren Eye Center Beijing Tongren Hospital Capital Medical University Beijing Ophthalmology & Visual Sciences Key Laboratory Beijing 100730 China

Background Poly（ADP-ribose） polymerase （PARP） plays an important role in the death of retinal capillary cells in diabetic retinopathy （DR） partly via its regulation of nuclear factor kappa B （NF-κB）. The current study investigated the effect of the regimen of Gaoshan hongjingtian （RG） on the mechanism of PARP regulation of NF-κB, and demonstrated the possible impact of the RG and Gaoshan hongjingtian （Rhodiola sachalinensis, RS） on diabetic retinopathy. Methods Wistar rats were made diabetic by administering streptozotocin. They were then assigned to three groups at random. After 2 months, the three groups of these diabetic rats were treated with RS or RG, or untreated. Analyses of expression levels of PARP, NF-κB, and intercellular adhesion molecule-1 （ICAM-1） in the retinas of rats in different groups were performed by Western blotting and immunohistochemical assays, and mRNA levels of NF-κB and ICAM-1 were determined by real-time polymerase chain reaction （PCR）. In addition, the basement membranes of capillaries in the rats＇ retinas were observed using electron microscopy, and diabetes-induced capillary degeneration （ghost pericytes and acellular capillaries） were quantitated. Results From the third month after the injection of streptozotocin, the diabetic rats were given daily RG, RS or tap water separately. The diabetic rats failed to gain weight compared with normal age-matched rats, whereas their glycated hemoglobin levels were significantly increased. After 5 months, the mRNA levels of NF-KB and ICAM-1 and the protein expression of PARP, NF-κB, and ICAM-1 were significantly increased in the retinas of diabetic rats in the untreated group compared with the nondiabetic controls. After 8 months, the number of degenerated retinal capillaries （ghost pericytes and acellular capillaries） was significantly increased in the diabetic rats in the untreated group compared with normal age-matched rats. RG and RS inhibited diabetes-induced over-expression of PARP, NF-KB,

关键词： Rhodiola sachalinensis Gaoshan hongjingtian diabetic retinopathy poly(ADP-ribose) polymerase nuclear factor kappa B

Influence of Input Pulse Durations on Properties of Er^(3+)/Yb^(3+) Co-doped DCFA

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Semiconductor Photonics and Technology 2006年第3期12卷 205-210页

作者： ZHAN Sheng-bao zhao Shang-hong shi Lei XU Jie zhao Xiao-ming Institute of Telecommunication Engineering Air Force Engineering University Xi＇an 710077 CHN

Based on propagation-rate equations, the influence of different input pulse durations on the properties of Er^3＋/Yb^3＋ co-doped double-clad fiber amplifier at dynamic equilibrium was analyzed. The change characteristic of output power sag with pulse duration and repetition rate was shown. Whether single or multichannel input pulses are amplified, the shorter the input pulse duration is, the smaller the power sags of output pulse will be. At low repetition rate, upper gain values（Gupper） of gain swing are almost the same for different input pulse durations, which tend to the small signal gain, but lower gain value（Glower） of short input pulse is larger than that of long input pulse. At highrepetition rate, lower gain value（Glower） approaches to upper gain value（Glower）.

关键词： Er^3+/Yb^3+ co-doped Double-clad fiber amplifier Pulse duration Pulse repetition rate

Regulation and function of endoplasmic reticulum autophagy in neurodegenerative diseases

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Neural Regeneration Research 2025年第1期20卷 6-20页

作者： Xiu-Yun zhao De-En Xu Ming-Lei Wu Ji-Chuan Liu Zi-Ling shi Quan-hong Ma Department of Neurology and Clinical Research Center of Neurological Disease the Second Affiliated Hospital of Soochow UniversitySuzhouJiangsu ProvinceChina Institute of Neuroscience&Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases Soochow UniversitySuzhouJiangsu ProvinceChina Department of Neurology Jiangnan University Medical CenterWuxiJiangsu ProvinceChina

The endoplasmic reticulum,a key cellular organelle,regulates a wide variety of cellular *** reticulum autophagy,one of the quality control systems of the endoplasmic reticulum,plays a pivotal role in maintaining endoplasmic reticulum homeostasis by controlling endoplasmic reticulum turnover,remodeling,and *** this review,we briefly describe the endoplasmic reticulum quality control system,and subsequently focus on the role of endoplasmic reticulum autophagy,emphasizing the spatial and temporal mechanisms underlying the regulation of endoplasmic reticulum autophagy according to cellular *** also summarize the evidence relating to how defective or abnormal endoplasmic reticulum autophagy contributes to the pathogenesis of neurodegenerative *** summary,this review highlights the mechanisms associated with the regulation of endoplasmic reticulum autophagy and how they influence the pathophysiology of degenerative nerve *** review would help researchers to understand the roles and regulatory mechanisms of endoplasmic reticulum-phagy in neurodegenerative disorders.

关键词： autophagy endoplasmic reticulum endoplasmic reticulum autophagy endoplasmic reticulum quality control system endoplasmic reticulum receptors endoplasmic reticulum-associated degradation neurodegeneration neurodegenerative disease selective autophagy unfolded protein response

Aberrant expression and function of TCF4 in the proliferation of hepatocellular carcinoma cell line BEL-7402

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Cell Research 2004年第1期14卷 74-80页

作者： Dong hong zhao, Jian Jun hong, shi Ying GUO, Run Lin YANG, Jun YUAN, Chuan Jun WEN, Kai Ya ZHOU, Chao Jun LI~* The Jiangsu Key Laboratory of Molecular Medical Biotechnology, College of Life Science, Nanjing Normal University, Nanjing 210097, Jiangsu, China. The Jiangsu Key Laboratory of Molecular Medical Biotechnology College of Life Science Nanjing Normal University Nanjing China

Wnt signaling pathway is essential for development and tumorigenesis, however, this signaling pathway in the progress of hepatocellular carcinoma (HCC) remains unclear. In this paper, we studied the function of human T-cell transcription factor-4 (TCF4), a key factor of Wnt signaling pathway, on the proliferation of HCC cell line. We showed that the expression of TCF4 mRNA in HCC cell line BEL-7402 was higher than that in immortalized normal liver cell line L02. Blockage of Wnt pathway by △NTCF4, a dominant negative TCF4, could suppress BEL-7402 cells growth and decrease the expression of cyclin D1 and c-myc, two of target genes of Wnt pathway. On the other hand, stimulating Wnt pathway by introducing a degradation-resistant β-catenin S37A could increase BEL-7402 cells proliferation. But all the treatments had no effect on L02 cells. Our data indicated that TCF4 might be another key factor in Wnt pathway involved in HCC cells proliferation and TCF4 could be an effective therapeutic target for suppress

关键词： Wnt signaling pathway β-catenin dominant negative TCF4.

Annexin A2 promotes choroidal neovascularization by increasing vascular endothelial growth factor expression in a rat model of argon laser coagulation-induced choroidal neovascularization

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Chinese Medical Journal 2010年第6期123卷 713-721页

作者： zhao shi-hong PAN Dong-yan ZHANG Yuan WU Jin-hui LIU Xin XU Yu Department of Ophthalmology Changhai HospitalSecond Military Medical UniversityShanghai 200433China

Background Choroidal neovascularization （CNV） is a common cause of visual loss in the elderly patients with age-related macular degeneration and represents the growth of subretinal new vessels in the macular region. This study aimed to investigate the relationship between annexin A2 （ANXA2） and vascular endothelial growth factor （VEGF） in *** In a rat model of argon laser coagulation-induced CNV, the mRNA expressions of the annexins and VEGF protein expression in the retina were detected using fluorescent real-time polymerase chain reaction （PCR） and immunohistochemistry, respectively. The interactions between ANXA2 and VEGF in both a retinal pigment epithelial cell line RPE-J and the rat model of CNV were examined by means of RNA interference, real-time PCR, Western blotting, enzyme-linked immunosorbent assay （ELISA） and histopathological examinations. Results Fundus fluorescein angiography （FFA） showed that argon laser coagulation of the retina induced stable CNV models in the rats. Two to three weeks after the coagulation, ANXA2. and VEGF expressions in the coagulated area in the retina and choroid increased to the peak level, while the other annexin members （ANXA4, ANXA5, ANXA7 and ANXA11） showed no obvious changes. In RPE-J cells and the CNV model, RNA interference of ANXA2 gene significantly lowered the VEGF protein and mRNA expressions, and application of an adenoviral vector containing ANXA2 gene markedly increased VEGF expressions in the rat model of CNV, but produced no significant effects on the expressions of the kinase insert domain-containing receptor （KDR） or the fms-like tyrosine kinase （Fit-l）. The expression of KDR inhibited the increment in ANXA2 expression, but VEGF and Rt-1 did not directly affect ANXA2 expression. Conclusion Besides the role as a plasminogen and the receptor of tissue plasminogen activator, ANXA2, which is under regulation of KDR via a negative feedback mechanism, also participates in neovascularization by regulating VE

关键词： annexin A2 vascular endothelial growth factor choroid neovascularization

视网膜黄斑区神经节细胞复合体厚度检测的研究进展

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第二军医大学学报 2018年第4期39卷 417-421页

作者：张红军赵世红海军军医大学(第二军医大学)长海医院眼科上海200433

视网膜神经节细胞与视功能密切相关。大多致盲性眼病如原发性青光眼、视神经炎、糖尿病性视网膜病变、萎缩型年龄相关性黄斑变性等均存在视网膜神经节细胞凋亡及其轴突的损害。神经节细胞主要存在于黄斑区的视网膜神经纤维层、神经节细... 详细信息

视网膜神经节细胞与视功能密切相关。大多致盲性眼病如原发性青光眼、视神经炎、糖尿病性视网膜病变、萎缩型年龄相关性黄斑变性等均存在视网膜神经节细胞凋亡及其轴突的损害。神经节细胞主要存在于黄斑区的视网膜神经纤维层、神经节细胞层、内丛状层结构中,此3层结构统称为视网膜神经节细胞复合体,其厚度变化可用于反映视网膜神经节细胞状况。研究发现视网膜神经节细胞受损会出现神经节细胞复合体厚度变薄,因此观察视网膜神经节细胞复合体厚度变化对诊断相关眼病、了解病情严重程度及判断预后有重要意义。本文就视网膜黄斑区神经节细胞复合体厚度检测在多种眼病中的研究进展进行综述,为相关眼病的早期诊断、防治及判断预后提供帮助。

关键词：视网膜神经节细胞黄斑原发性青光眼视神经炎糖尿病性视网膜病变年龄相关性黄斑变性

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动眼神经麻痹的常见病因及相应临床特征

第二军医大学学报 2017年第1期38卷 91-96页

作者：崔元玥赵世红第二军医大学长海医院眼科上海200433

动眼神经对眼球功能的调节具有重要作用,主要支配提上睑肌、上直肌、下直肌、内直肌、下斜肌、瞳孔括约肌、睫状肌等。动眼神经麻痹作为临床常见症状之一,常出现复视、上睑下垂、眼肌麻痹、瞳孔功能障碍等一项或多项表现;其病因复杂,常... 详细信息

动眼神经对眼球功能的调节具有重要作用,主要支配提上睑肌、上直肌、下直肌、内直肌、下斜肌、瞳孔括约肌、睫状肌等。动眼神经麻痹作为临床常见症状之一,常出现复视、上睑下垂、眼肌麻痹、瞳孔功能障碍等一项或多项表现;其病因复杂,常见有颅内动脉瘤、脑血管梗死或出血性疾病、糖尿病、颅内炎症、颅脑外伤、先天性等。每种病因所致的动眼神经麻痹均有其相应的临床特征。本文综述了动眼神经麻痹的常见病因和相应的发病机制、临床表现、体征、治疗方法以及预后等,为临床上快速、准确地寻找病因并进行有效治疗提供帮助。

关键词：动眼神经麻痹颅内动脉瘤脑血管障碍颅内炎症颅脑损伤

Quantum public-key crypto via EPR pairs

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 58-63页

作者： Xiang-Qun Fu hong-Wei Li Jian-hong shi Tan Li Wan-Su Bao Henan Key Laboratory of Quantum Information and Cryptography Information Engineering University Synergetic Innovation Center of Quantum Information and Quantum Physics University of Science and Technology of China

With the development of quantum computing technology, quantum public-key cryptography is gradually becoming an alternative to the existing classical public-key cryptography. This paper designs a quantum trapdoor one-way function via EPR pairs and quantum measurements. Based on this, a new quantum public-key cryptosystem is presented, which offers forward security,and can resist the chosen-plaintext attack and chosen-ciphertext attack. Compared with the existing quantum public-key cryptos,eavesdropping can be automatically detected in this new quantum public-key cryptosystem under a necessary condition, which is also detailed in the paper.

关键词： quantum public-key crypto trapdoor one-way function EPR pairs