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Role of epithelial-to-mesenchymal transition in the pulmonary fi brosis induced by paraquat in rats

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World Journal of Emergency Medicine 2021年第3期12卷 214-220页

作者： Jian-hua Yi zhao-cai zhang Mei-bian zhang Xin He Hao-ran Lin Hai-wen Huang Hai-bin Dai Yu-wen Huang Emergency Department the Second Affi liated Hospital of Zhejiang University School of MedicineHangzhou 310009China Scientifi c Research Department the Second Affi liated Hospital of Zhejiang University School of MedicineHangzhou 310009China Zhejiang Provincial Center for Disease Control and Prevention Hangzhou 301051China Shangyu People’s Hospital Shaoxing 312300China Pharmacy Department the Second Affi liated Hospital of Zhejiang University School of MedicineHangzhou 310009China

BACKGROUND:This study aims to explore the characteristics of the epithelial-to-mesenchymal transition(EMT)process and its underlying molecular mechanisms in the period of paraquat(PQ)-induced pulmonary fi brosis(PF).METHODS:Picrosirius red staining and collagen volume fraction were utilized to evaluate the pathological changes of PQ-induced PF in rats.Immunohistochemistry,Western blot,and real-time reverse transcriptase-polymerase chain reaction(RT-PCR)were used to measure the protein and gene expression of EMT markers,EMT-associated transcription factors,and regulators of EMT-related pathways,respectively.RESULTS:The collagen deposition in the alveolar septum and increased PF markers were characteristics of pathological changes in PQ-induced PF,reached a peak on day 14 after PQ poisoning,and then decreased on day 21.The protein and gene expression of the fibrosis marker,EMT markers,transcription factors,and regulators of EMT-related signaling pathways signifi cantly increased at diff erent time points after PQ poisoning compared with corresponding controls(P0.05).CONCLUSIONS:EMT process plays a role in the PQ-induced PF,in which most PF and EMT markers have a peak phenomenon,and its underlying molecular mechanisms might be determined by further studies.

关键词： Pulmonary fibrosis Paraquat Epithelial-to-mesenchymal transition Rats

预测脓毒症患者心脏功能障碍和死亡率的多生物标记物策略

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2020年第7期21卷 537-548页

作者： Fa-chao CHEN Yin-chuan XU zhao-cai zhang Department of Cardiology the Second Affiliated HospitalZhejiang University School of MedicineHangzhou 310009China Intensive Care Unit the Second Affiliated HospitalZhejiang University School of MedicineHangzhou 310009China

目的:评估联合应用多种生物标记物以预测脓毒症患者早期心脏功能障碍及28天死亡率的可行性。创新点:(1)通过净重分类改善(NRI)和综合辨别改善(IDI)指标,评估多种生物标志物策略相比单一生物标志物策略对脓毒症患者心脏功能障碍及28天死... 详细信息

目的:评估联合应用多种生物标记物以预测脓毒症患者早期心脏功能障碍及28天死亡率的可行性。创新点:(1)通过净重分类改善(NRI)和综合辨别改善(IDI)指标,评估多种生物标志物策略相比单一生物标志物策略对脓毒症患者心脏功能障碍及28天死亡率的预测价值。(2)评估心脏型脂肪酸结合蛋白(h-FABP)、髓过氧化物酶(MPO)以及妊娠相关血浆蛋白A(PAPP-A)等新型生物标记物在脓毒症中的临床预测价值。方法:检测147例脓毒症患者在入院后6小时内血浆中脑钠肽(BNP)、心肌肌钙蛋白I(cTnI)、h-FABP、MPO及PAPP-A的水平。使用受试者工作特征(ROC)曲线来评估各种单一生物标志物在脓毒症患者心脏功能障碍诊断和28天死亡率预测中的最佳截止值。采用ROC曲线、NRI和IDI指标评估多种生物标志物策略相比单一生物标志物策略在预测脓毒症相关心脏功能障碍及28天死亡率中的价值。结论:MPO、cTnI和h-FABP联合应用显著提高了对脓毒症患者心脏功能障碍的预测能力,同时PAPP-A、MPO和h-FABP联合应用显著提高了预测脓毒症患者28天死亡率的能力。

关键词：多种生物标志物心脏功能障碍脓毒症死亡率

Community-Level Practice Checklists for Health Protection During Cold Spells in China

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China CDC weekly 2024年第5期6卷 83-87页

作者： Jing Shang Mengzhen zhao zhao Liu Xiya zhang Shiguang Miao Ishaq D.Sulaymon Wenjia cai Institute of Urban Meteorology CMABeijingChina School of Management and Economics Beijing Institute of TechnologyBeijingChina School of Airport Economics and Management Beijing Institute of Economics and ManagementBeijingChina Department of Earth System Science Tsinghua UniversityBeijingChina Sand and Dust Storm Warning Regional Center National Center for MeteorologyJeddahSaudi Arabia Jiangsu Key Laboratory of Atmospheric Environment Monitoring and Pollution Control Collaborative Innovation Center of Atmospheric Environment and Equipment TechnologySchool of Environmental Science and EngineeringNanjing University of Information Science and TechnologyNanjing CityJiangsu ProvinceChina

Communities play a crucial role in protecting the health of vulnerable populations such as the elderly,low-income groups,and high-risk individuals during cold spells.However,current strategies for responding to cold spells primarily consist of programmatic policies that lack practicality,specificity,and detailed implementation guidelines for community workers.Therefore,this study aims to identify and analyze the challenges faced by communities in responding to cold spells,review international experiences,and develop a set of practical checklists for community-level health protection.These checklists will assist community workers and volunteers in effectively preparing for,responding to,and recovering from cold spells.

关键词： preparing income primarily

Heavier Group 14 Congeners of Metalla-isobenzenes:Access to Metalla-isosilabenzene and Metalla-isogermabenzene by One-Pot Reactions

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Chinese Journal of Chemistry 2024年第10期42卷 1121-1127页

作者： Jinyu zhao Yapeng cai Xin Yang Hong zhang Department of Chemistry Xiamen UniversityXiamenFujian 361005China

Metalla-isosilabenzenes and metalla-isogermabenzenes have been successfully synthesized by the formal[5+1]-cycloaddition of diethynylsilane or diethynylgermane with simple metal complexes.This is the first example of a heavier Group 14 metalla-isobenzene isomer bearing a cumulative double bond motif within a metallacycle.These novel complexes were fully characterized by NMR spectroscopy and single-crystal X-ray diffraction analysis.The stabilization of the cyclic metal-vinylidene complexes has been analyzed using density functional theory(DFT)calculations.When the metalla-isosilabenzenes bearing Si—H bond were treated with the trityl salt as a hydride scavenger,the formation of silylium cation was observed spectroscopically.Both of metalla-isosilabenzenes and metalla-isogermabenzenes can readily undergo migratory insertion reactions to furnish siloles or germoles.

关键词： Metalla-isosilabenzene Metalla-isogermabenzene Density functional calculations Cycloaddition Metallacycles

Communication efficiency optimization of federated learning for computing and network convergence of 6G networks

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Frontiers of Information Technology & Electronic Engineering 2024年第5期25卷 713-727页

作者： Yizhuo cai Bo LEI Qianying zhao Jing PENG Min WEI Yushun zhang Xing zhang Wireless Signal Processing and Network Laboratory Beijing University of Posts and TelecommunicationsBeijing 100876China Research Institute of China Telecom Co. Ltd.Beijing 102209China Beijing Telecom Beijing 100011China

Federated learning effectively addresses issues such as data privacy by collaborating across participating devices to train global models.However,factors such as network topology and computing power of devices can affect its training or communication process in complex network environments.Computing and network convergence(CNC)of sixth-generation(6G)networks,a new network architecture and paradigm with computing-measurable,perceptible,distributable,dispatchable,and manageable capabilities,can effectively support federated learning training and improve its communication efficiency.By guiding the participating devices'training in federated learning based on business requirements,resource load,network conditions,and computing power of devices,CNC can reach this goal.In this paper,to improve the communication eficiency of federated learning in complex networks,we study the communication eficiency optimization methods of federated learning for CNC of 6G networks that give decisions on the training process for different network conditions and computing power of participating devices.The simulations address two architectures that exist for devices in federated learning and arrange devices to participate in training based on arithmetic power while achieving optimization of communication efficiency in the process of transferring model parameters.The results show that the methods we proposed can cope well with complex network situations,effectively balance the delay distribution of participating devices for local training,improve the communication eficiency during the transfer of model parameters,and improve the resource utilization in the network.

关键词： Computing and network convergence Communication efficiency Federated learning Two architectures

Co_(3)O_(4)as an efficient passive NO_(x) adsorber for emission control during cold-start of diesel engines

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Chinese Journal of Chemical Engineering 2024年第2期66卷 1-7页

作者： Jinhuang cai Shijie Hao Yun zhang Xiaomin Wu Zhenguo Li Huawang zhao Department of Environmental Science&Engineering College of Chemical EngineeringHuaqiao UniversityXiamen 361021China Wuxi Weifu Environmental Catalysts Co. LtdWuxi 214000China National Engineering Laboratory for Mobile Source Emission Control Technology China Automotive Technology&Research Center Co.Ltd.Tianjin 300300China

The Co_(3)O_(4)nanoparticles,dominated by a catalytically active(110)lattice plane,were synthesized as a low-temperature NO_(x) adsorbent to control the cold start emissions from vehicles.These nanoparticles boast a substantial quantity of active chemisorbed oxygen and lattice oxygen,which exhibited a NO_(x) uptake capacity commensurate with Pd/SSZ-13 at 100℃.The primary NO_(x) release temperature falls within a temperature range of 200-350℃,making it perfectly suitable for diesel engines.The characterization results demonstrate that chemisorbed oxygen facilitate nitro/nitrites intermediates formation,contributing to the NO_(x) storage at 100℃,while the nitrites begin to decompose within the 150-200℃range.Fortunately,lattice oxygen likely becomes involved in the activation of nitrites into more stable nitrate within this particular temperature range.The concurrent processes of nitrites decomposition and its conversion to nitrates results in a minimal NO_(x) release between the temperatures of 150-200℃.The nitrate formed via lattice oxygen mainly induces the NO_(x) to be released as NO_(2) within a temperature range of 200-350℃,which is advantageous in enhancing the NO_(x) activity of downstream NH_(3)-SCR catalysts,by boosting the fast SCR reaction pathway.Thanks to its low cost,considerable NO_(x) absorption capacity,and optimal release temperature,Co_(3)O_(4)demonstrates potential as an effective material for passive NO_(x) adsorber applications.

关键词： Emission control Cold-start Low-temperature adsorption Co_(3)O_(4) Nitrate formation

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Dual‑Atom Nanozyme Eye Drops Attenuate Inflammation and Break the Vicious Cycle in Dry Eye Disease

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Nano-Micro Letters 2024年第6期16卷 439-457页

作者： Dandan Chu Mengyang zhao Shisong Rong Wonho Jhe Xiaolu cai Yi Xiao Wei zhang Xingchen Geng Zhanrong Li Xingcai zhang Jingguo Li Henan Eye Hospital Henan Provincial People’s HospitalPeople’s Hospital of Zhengzhou UniversityZhengzhou 450003People’s Republic of China Department of Ophthalmology Mass Eye and EarMass General BrighamHarvard Medical SchoolBostonMA 02114USA School of Engineering and Applied Sciences Harvard UniversityCambridgeMA 02138USA College of Chemistry Zhengzhou UniversityZhengzhou 450001People’s Republic of China

Dry eye disease(DED)is a major ocular pathology worldwide,causing serious ocular discomfort and even visual impairment.The incidence of DED is gradually increasing with the highfrequency use of electronic products.Although inflammation is core cause of the DED vicious cycle,reactive oxygen species(ROS)play a pivotal role in the vicious cycle by regulating inflammation from upstream.Therefore,current therapies merely targeting inflammation show the failure of DED treatment.Here,a novel dual-atom nanozymes(DAN)-based eye drops are developed.The antioxidative DAN is successfully prepared by embedding Fe and Mn bimetallic single-atoms in N-doped carbon material and modifying it with a hydrophilic polymer.The in vitro and in vivo results demonstrate the DAN is endowed with superior biological activity in scavenging excessive ROS,inhibiting NLRP3 inflammasome activation,decreasing proinflammatory cytokines expression,and suppressing cell apoptosis.Consequently,the DAN effectively alleviate ocular inflammation,promote corneal epithelial repair,recover goblet cell density and tear secretion,thus breaking the DED vicious cycle.Our findings open an avenue to make the DAN as an intervention form to DED and ROSmediated inflammatory diseases.

关键词： Dry eye disease DAN Dual-atom nanozyme Vicious cycle NLRP3 inflammasome Nanomedicine

A combination of straw incorporation and polymer-coated urea offsets soil ammonia and nitrous oxide emissions in winter wheat fields

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Journal of Integrative Agriculture 2024年第5期23卷 1718-1736页

作者： Xiaoyun Wang Yajie Tian Qianhui zhang Zhengxin zhao Rui Wang Huanjie cai Key Laboratory of Agricultural Soil and Water Engineering in Arid and Semiarid Areas of Ministry of Education Northwest A&F UniversityYangling712100China College of Water Resources and Architectural Engineering Northwest A&F UniversityYangling 712100China

The combined effects of straw incorporation(SI)and polymer-coated urea(PCU)application on soil ammonia(NH_(3))and nitrous oxide(N_(2)O)emissions from agricultural fields have not been comprehensively evaluated in Northwest China.We conducted a two-year field experiment to assess the effects of combining SI with either uncoated urea(U)or PCU on soil NH_(3)emissions,N_(2)O emissions,winter wheat yields,yield-scaled NH_(3)(/NH_(3)),and yield-scaled N_(2)O(/N_(2)O).Five treatments were investigated,no nitrogen(N)fertilizer(N_(0)),U application at 150 kg N ha-1 with and without SI(SI+U and S_(0)+U),and PCU application at 150 kg N ha^(-1) with and without SI(SI+PCU and S_(0)+PCU).The results showed that the NH_(3);emissions increased by 20.98-34.35%following Sl compared to straw removal,mainly due to increases in soil ammonium(NH_(4)^(+)-N)content and water-flled pore space(WFPS).SI resulted in higher N_(2)O emissions than under the So scenario by 13.31-49.23%due to increases in soil inorganic N(SIN)contents,WFPS,and soil microbial biomass.In contrast,the PCU application reduced the SIN contents compared to the U application,reducing the NH_(3)and N_(2)O emissions by 45.99-58.07 and 18.08-53.04%,respectively.Moreover,no significant positive effects of the SI or PCU applications on the winter wheat yield were observed.The lowest /NH_(3) and /N_(2)O values were observed under the S_(0)+PCU and SI+PCU treatments.Our results suggest that single PCU applications and their combination with straw are the optimal agricultural strategies for mitigating gaseous N emissions and maintaining optimal winter wheat yields in Northwest China.

关键词： straw incorporation polymer-coated urea NH_(3)and N_(2)O emissions winter wheat yields

The virulence regulator AbsR in avian pathogenic Escherichia coli has pleiotropic effects on bacterial physiology

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Journal of Integrative Agriculture 2024年第2期23卷 649-668页

作者： Dongfang zhao Haobo zhang Xinyang zhang Fengwei Jiang Yijing Li Wentong cai Ganwu Li State Key Laboratory for Animal Disease Control and Prevention Harbin Veterinary Research InstituteChinese Academy of Agricultural SciencesHarbin 150069China College of Veterinary Medicine Northeast Agricultural UniversityHarbin 150038China National Animal Tuberculosis Reference Laboratory Division of Zoonoses SurveillanceChina Animal Health and Epidemiology CenterQingdao 266032China Department of Veterinary Diagnostic and Production Animal Medicine College of Veterinary MedicineIowa State UniversityAmesIowa 50011-1134the United States

Avian pathogenic Escherichia coli(APEC)belonging to extraintestinal pathogenic E.coli(ExPEC)can cause severe infections in extraintestinal tissues in birds and humans,such as the lungs and blood.MprA(microcin production regulation,locus A,herein renamed AbsR,a blood survival regulator),a member of the MarR(multiple antibiotic resistance regulator)transcriptional regulator family,governs the expression of capsule biosynthetic genes in human ExPEC and represents a promising druggable target for antimicrobials.However,a deep understanding of the AbsR regulatory mechanism as well as its regulon is lacking.In this study,we present a systems-level analysis of the APEC AbsR regulon using ChIP-Seq(chromatin immunoprecipitation sequencing)and RNA-Seq(RNA sequencing)methods.We found that AbsR directly regulates 99 genes and indirectly regulates 667 genes.Furthermore,we showed that:1)AbsR contributes to antiphagocytotic effects by macrophages and virulence in a mouse model for systemic infection by directly activating the capsular gene cluster;2)AbsR positively impacts biofilm formation via direct regulation of the T2SS(type II secretion system)but plays a marginal role in virulence;and 3)AbsR directly upregulates the acid tolerance signaling system EvgAS to withstand acid stress but is dispensable in ExPEC virulence.Finally,our data indicate that the role of AbsR in virulence gene regulation is relatively conserved in ExPEC strains.Altogether,this study provides a comprehensive analysis of the AbsR regulon and regulatory mechanism,and our data suggest that AbsR likely influences virulence primarily through the control of capsule production.Interestingly,we found that AbsR severely represses the expression of the type I-F CRISPR(clustered regularly interspaced short palindromic repeats)-Cas(CRISPR associated)systems,which could have implications in CRISPR biology and application.

关键词： avian pathogenic Escherichia coli(APEC) extraintestinal pathogenic Escherichia coli(ExPEC) AbsR RNA-Seq ChIP-Seq gene regulation