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Evaluating the safety of forsythin from Forsythia suspensa leaves by acute and sub-chronic oral administration in rodent models

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Asian Pacific Journal of Tropical Medicine 2017年第1期10卷 47-51页

作者： Zhong Han Xia-Ling Lei Hong Zhang Lu Liu Zhi-Sen Chen Wei Yang zhao-rong lun School of Life Sciences Sun Yat-sen UniversityGuangzhou 510275China Guangdong Key Laboratory of Animal Conservation and Resource Utilization Guangdong Public Laboratory of Wild Animal Conservation and UtilizationGuangdong Institute of Applied Biological Resources Guangdong Lewwin Pharmaceutical Research Institute Co. Ltd.Guangzhou 510990China

Objective: To access the toxicity of forsythin from Forsythia suspensa leaves and evaluate its safety,Methods: Acute toxicity was determined by oral administration of a single dose of 18 100 mg/kg forsythin in NIH mice,Sub-chronic toxicity was evaluated by oral administration of several doses of forsythin for 30 days at does of 0,540,1 620,and 6 480 mg/kg in SD ***: In the acute toxicity study,mortality was not observed after 14 days,In addition,clinically relevant adverse effects,or variations in body weight or food consumption were not observed,Similarly,after 30 days in the sub-chronic toxicity study,no mortality or significant toxicological effects such as decreased food consumption,body weight,biochemical parameters and vital organs etc,were noticed,Conclusion: The results revealed that the forsythin from Forsythia suspensa leaves has low or no toxicity via oral administration,and therefore is suitable for further development and applications.

关键词： Forsythin Acute toxicity Sub-chronic toxicity Safety

Rat Trypanosoma lewisi, a novel human pathogen?

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Rat Trypanosoma lewisi, a novel human pathogen?

中国动物学会寄生虫学专业委员会第十三次全国学术会议暨第四次国际寄生虫学学术研讨会

作者： zhao-rong lun Center for Parasitic Organisms School of Life Sciences Sun Yat-Sen University

Trypanosoma lewisi is a rat(Rattus spp)trypanosome which is distributed *** parasite has long been considered a rat specific and non-pathogenic ***,more and more cases infected with this parasite reported have caused the attention by the related health organization such as WHO and *** on the reports of the cases infected with ***,results from the experimental infection and from our current work on this parasite,we will discuss why this parasite should be considered as new human pathogen.

关键词： Rattus spp Trypanosoma lewisi Apo L1 in vitro in vivo

SARS-CoV-2 nucleocapsid protein triggers hyperinflammation via protein-protein interaction-mediated intracellular Cl^(−) accumulation in respiratory epithelium

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Signal Transduction and Targeted Therapy 2022年第8期7卷 3080-3092页

作者： Lei Chen Wei-Jie Guan Zhuo-Er Qiu Jian-Bang Xu Xu Bai Xiao-Chun Hou Jing Sun Su Qu Ze-Xin Huang Tian-lun Lei Zi-Yang Huang Jincun zhao Yun-Xin Zhu Ke-Nan Ye zhao-rong lun Wen-Liang Zhou Nan-Shan Zhong Yi-Lin Zhang School of Life Sciences Sun Yat-sen UniversityGuangzhouChina State Key Laboratory of Respiratory Disease National Clinical Research Center for Respiratory DiseaseGuangzhou Institute of Respiratory HealthThe First Affiliated Hospital of Guangzhou Medical UniversityGuangzhou Medical UniversityGuangzhouChina Department of Thoracic Surgery Guangzhou Institute for Respiratory HealthThe First Affiliated Hospital of Guangzhou Medical UniversityGuangzhou Medical UniversityGuangzhouChina Guangzhou Laboratory GuangzhouChina

SARS-CoV-2,the culprit pathogen of COVID-19,elicits prominent immune responses and cytokine *** Cl^(−)is a crucial regulator of host defense,whereas the role of Cl^(−)signaling pathway in modulating pulmonary inflammation associated with SARS-CoV-2 infection remains *** using human respiratory epithelial cell lines,primary cultured human airway epithelial cells,and murine models of viral structural protein stimulation and SARS-CoV-2 direct challenge,we demonstrated that SARS-CoV-2 nucleocapsid(N)protein could interact with Smad3,which downregulated cystic fibrosis transmembrane conductance regulator(CFTR)expression via *** intracellular Cl^(−)concentration([Cl^(−)]i)was raised,resulting in phosphorylation of serum glucocorticoid regulated kinase 1(SGK1)and robust inflammatory *** or knockout of SGK1 abrogated the N protein-elicited airway ***,N protein promoted a sustained elevation of[Cl^(−)]i by depleting intracellular cAMP via upregulation of phosphodiesterase 4(PDE4).Rolipram,a selective PDE4 inhibitor,countered airway inflammation by reducing[Cl^(−)]*** findings suggested that Cl^(−)acted as the crucial pathological second messenger mediating the inflammatory responses after SARS-CoV-2 *** the Cl^(−)signaling pathway might be a novel therapeutic strategy for COVID-19.

关键词： inflammation respiratory epithelium

Trypanosome mitochondrial genome:the mechanism of inheritance

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Trypanosome mitochondrial genome:the mechanism of inheritanc...

2021中国畜牧兽医学会兽医寄生虫学分会第二届青年科学家学术论坛

作者：赖德华 zhao-rong lun Guangdong Provincial Key Laboratory of Aquatic Economic Animals State Key Laboratory of BiocontrolSchool of Life SciencesSun Yat-Sen University

Trypanosomes are haemoflagellates parasiting various *** represent a group of early branched eukaryotic,with numbers of diverged characteristics from mammalian *** most obvious one is that they contain a specialized mitochondrial genome,termed a *** kinetoplast forms a disc shape of interlocking DNA circles of two types,maxicircle and *** is generally over 20 kb,and encoding some typical and more encrypted mitochondrial genes,which are decrypted only using hundreds of keys from *** this structure,there are some very interesting questions to be answered.1)How do they maintain this complex mitochondrial genome?2) How does this complex mitochondrial genome work?3) How does this complex mitochondrial genome evolve from and to?To address these questions,the authors investigate the model organisms of Trypanosome brucei,Trypanosome evansi,Trypanosome equiperdum and Trypanosome *** authors confirmed the maintenance of kinetoplast via basal body,and identified novel protein of *** authors revealed the transcriptome patterns of kinetoplast,and identified new structure of *** authors revealed the distinct feathers of various kinetoplasts,and proposed evolutionary scenery of ***,kinetoplast is a distinct and complex structural mitochondrial genome,which is also an excellent examples to show the diversity of eukaryotic cells and stupidity of designer if presents.

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Cancer in the parasitic protozoans Trypanosoma brucei and Toxoplasma gondii

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Cancer in the parasitic protozoans Trypanosoma brucei and To...

中国畜牧兽医学会兽医寄生虫学分会第十三次学术研讨会

作者： zhao-rong lun De-Hua Lai Yan-Zi Wen Ling-Ling Zheng Ji-Long Shen Ting-Bo Yang Wen-Liang Zhou Liang-Hu Qu Geoff Hide Francisco J.Ayala Center for Parasitic Organisms State Key Laboratory of BiocontrolSchool of Life SciencesSun Yat-Sen University Ecosystems and Environment and Biomedical Research Centres School of Environment and Life SciencesUniversity of Salford The Key Laboratories of Pathogen Biology and Zoonoses Anhui Province and Department of ParasitologyAnhui Medical University Department of Ecology and Evolutionary Biology University of California

Cancer is a general name for more than 100 malignant *** is postulated that all cancers start from a single abnormal cell that grows out of *** cancers can cause serious consequences and deaths.A great progress has been made in cancer research which significantly improved our knowledge to understand the nature and mechanisms of the disease,but the origins of cancer are far from being well understood due to limitations of suitable model systems and to the complexities of the *** view of the fact that the cancers are found in various species of vertebrates and other metazoa,here,we suggest that cancer also occurs in parasitic protozoans such as Trypanosoma brucei,a blood parasite,and Toxoplasma gondii,an obligate intracellular *** treatment,these protozoan cancers may cause severe disease and death in mammals including *** simpler genomes of these single cell organisms,in combination with their complex life cycles and fascinating life cycle differentiation processes,may help us to better understand the origins of cancers,in particular,leukemias.

关键词： Malignancy single cell organisms mammals evolution transmissible

The Effective Degree of Freedom of Low Energy QCD

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Communications in Theoretical Physics 2002年第2期37卷 193-208页

作者： PANGHou－rong PINJia－lun 等 DepartmentofPhysics NanjingUniversityNanjing210093China DepartmentofPhysics NanjingNormalUniversityNanjing210097China

The adiabatic effective baryon-baryon interactions and dibaryon candidates are studied syst ematicallywith three constituent quark models based on different effective degrees of freedom: Glozman-Riska-Brown Goldstoneboson exchange model based on constituent quark and Goldstone boson coupling; Fujiwara model based on constituentquark gluon coupling and Nijmegen one-boson exchange; QDCSM based on constituent quark and gluon coupling withquark delocalization and color screening. We find that the three models predicted the similar effective baryon-baryoninteractions for roughly two thirds among the 64 states consisted of octet and decuplet baryons. The differences amongthree models and their separate characteristics are also studied.

关键词： effective degree of freedom baryon-baryon interaction

Tensor Interaction Effect in Dibaryon

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Communications in Theoretical Physics 2005年第1期43卷 127-132页

作者： CHENLing-Zhi PANGHou-rong PINGJia-lun WANGFan DepartmentofPhysics NanjingUniversityNanjing210093China DepartmentofPhysics NanjingUniversityNanjing210093China／／InstituteofTheoreticalPhysicstheChineseAcademyofSciencesBeijing100080China DepartmentofPhysics NanjingNormalUniversityNanjing210097China／／CenterforTheoreticalPhysicsNanjingUniversityNanjing210093China DepartmentofPhysics NanjingUniversityNanjing210093China／／CenterforTheoreticalPhysicsNanjingUniversityNanjing210093China

The gluon and Goldstone boson induced tensor interaction effect on thedibaryon mass and the D-wave decay width has been studied in the quark delocalization, colorscreening model. The effective S-D wave transition interactions induced by gluon and Goldstone bosonexchanges decrease quickly as the increasing of the channel strangeness. The K and η meson tensorcontribution is negligible in this model. No six-quark state in the light Savor world can become abound one by the help of these tensor interactions except the deuteron. The partial D-wave decaywidth of I J~p = (1/2) 2~+ NΩ state to spin 0, 1 ΛΞ final state is 20.7 keV and 63.1 keVrespectively. It is a very narrow dibaryon resonance and might be detected in the relativistic heavyion reaction by the existing RHIC detectors through the reconstruction of the ΛΞ vertex mass andthe future COMPAS detector at CERN and FAIR project in Germany.

关键词： dibaryon tensor interaction extended quark delocalization color screeningmodel

Exploring High Strangeness Dibaryons with the Extended Quark Delocalization andColor Screening Model

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Communications in Theoretical Physics 2004年第1期41卷 67-72页

作者： PANGHou-rong PINGJia-lun WANGFan zhaoEn-Guang DepartmentofPhysics NanjingUniversityNanjing210093ChinaInstituteofTheoreticalPhysicstheChineseAcademyofSciencesBeijing100080China DepartmentofPhysics NanjingNormalUniversityNanjing210097ChinaCenterforTheoreticalPhysicsNanjingUniversityNanjing210093China DepartmentofPhysics NanjingUniversityNanjing210093ChinaCenterforTheoreticalPhysicsNanjingUniversityNanjing210093China InstituteofTheoreticalPhysics theChineseAcademyofSciencesBeijing100080China

Promising high strangeness dibaryons are studied by the extended quark delocalization and color screeningmodel. It is shown that besides H particle and di-Ω, there might be other dibaryon candidates worth to be searc... 详细信息

关键词： dibaryon meson exchange

PCR-SSCP as a molecular tool for the identification of Benedeniinae (Monogenea:Capsalidae) from marine fish

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PCR-SSCP as a molecular tool for the identification of Bened...

中国畜牧兽医学会家畜寄生虫学分会第五次代表大会暨第八次学术研讨会

作者： An-Xing Li~a Xiang-Yun Wu~a Xue-Juan Ding~a Rui-Qing Lin~b Ming-Quan Xie~a zhao-rong lun~a Xing-Quan Zhu~(b*) ~aCenter for Parasitic Organisms,School of Life Sciences,Zhongshan (Sun Yat-Sen) University,135 West Xingang Street,Haizhu District,Guangzhou 510275,The People’s Republic of China ~bLaboratory of Parasitology,College of Veterinary Medicine,South China Agricultural University,483 Wushan Street,Tianhe District,Guangzhou 510642,Guangdong Province,The People’s Republic of China

PCR-based single strand conformation polymorphism(SSCP)analysis was used tocharacterize monogenean specimens of the subfamily Benedeniinae of morphologically uncertainspecific status from different marine fish species,using Neobenedenia melleni,*** andEntobdella corona for *** first internal transcribed spacer(ITS-1)and the 5’terminalvariable region(D1-D3 domains)of the large subunit ribosomal DNA(lsrDNA).were amplifiedseparately from individual monogeneans,and the amplicons were subjected to PCR-SSCP analyses,followed by direct *** SSCP patterns and the ITS-1 sequences data allowed specimensrepresenting Entobdella *** the host Taeniura melanospilos to be unequivocally distinguishedfrom those representing Neobenedenia *** those representing Benedenia ***,a morphologically controversial species,had identical SSCP banding pattern and ITS-1sequence to that of ***,supporting the proposal that *** is a synonym of *** *** Benedenia *** identical SSCP patterns and ITS-1 *** and the PCR-SSCP approach taken should have implications for the accurate identification andassessment of taxonomic validity of other important monogenean groups of the marine fish.

关键词： Single strand conf ormation polymorphism(SSCP) Polymerase chain reaction Large subunit ribosomal DNA(lsrDNA) First internal transcribed spacer(ITS-1) Benedeniinae