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Comparative study of the clinical efficacy of all-inside and traditional techniques in anterior cruciate ligament reconstruction

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World Journal of Clinical Cases 2023年第14期11卷 3195-3203页

作者： Bai-Jing An Yao-Ting Wang zhe zhao Ming-Xin Wang Geng-Yan Xing Department of Sports Medicine The Fourth Medical Center of PLA General HospitalBeijing 100000China

BACKGROUND Many studies have focused on the femoral tunnel technique and fixation method,but few studies have involved the tibial tunnel technique and fixation *** all-inside technique is one of the new techniques that has been described in recent ***-inside anterior cruciate ligament(ACL)reconstruction is based on a tibial socket instead of a full *** method has many potential *** To compare clinical outcomes of knee ACL autograft reconstruction using allinside quadrupled semitendinosus(AIST)and traditional hamstring tendon(TBT)*** From January 2017 to October 2019,the clinical data of 80 patients with ACL reconstruction were retrospectively analyzed,including 67 males and 13 *** patients had an average age of 24.3±3.1 years(age range:18-33 years).The AIST technique was used in 42 patients and the TBT technique was used in 38 *** time between operation and injury,operative duration,postoperative visual analogue scale(VAS)score and knee functional recovery were recorded and compared between the two *** International Knee Documentation Committee(IKDC)and Lysholm scoring system were used to comprehensively evaluate clinical *** Eighty patients were followed for 24-36 mo,with an average follow-up duration of 27.5±1.8 *** were no significant differences in the time between surgery and injury,operative duration,IKDC and Lysholm scores of the affected knee at the last follow-up evaluation between the two *** were significant differences in VAS scores 1 d,3 d,7 d,2 wk and 1 mo after surgery(P<0.05).There was no significant difference in VAS score at 3 mo,6 mo and 1 year after *** The efficacy of the AIST ACL reconstruction technique was comparable to the TBT technique,but the postoperative pain was less with the AIST ***,the AIST technique is an ideal treatment choice for ACL reconstruction.

关键词： Anterior cruciate ligament reconstruction All-inside quadrupled semitendinosus Clinical curative effect Traditional hamstring tendon Visual analogue scale

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Novel compound FLZ alleviates rotenoneinduced PD mouse model by suppressing TLR4/MyD88/NF-kB pathway through microbiotaegutebrain axis

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Acta Pharmaceutica Sinica B 2021年第9期11卷 2859-2879页

作者： zhe zhao Fangyuan Li Jingwen Ning Ran Peng Junmei Shang Hui Liu Meiyu Shang Xiu-Qi Bao Dan Zhang State Key Laboratory of Bioactive Substrate and Function of Natural Medicine Institute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100050China

Parkinson’s disease(PD)is the second most common neurodegenerative disease,but none of the current treatments for PD can halt the progress of the disease due to the limited understanding of the *** PD development,the communication between the brain and the gastrointestinal system influenced by gut microbiota is known as microbiota-gut-brain ***,the explicit mechanisms of microbiota dysbiosis in PD development have not been well elucidated ***,a novel squamosamide derivative,has been proved to be effective in many PD models and is undergoing the phase I clinical trial to treat PD in ***,our previous pharmacokinetic study revealed that gut microbiota could regulate the absorption of FLZ in *** aims of our study were to assess the protective effects of FLZ treatment on PD and to further explore the underlying microbiota-related mechanisms of PD by using FLZ as a *** the current study,chronic oral administration of rotenone was utilized to induce a mouse model to mimic the pathological process of *** we revealed that FLZ treatment alleviated gastrointestinal dysfunctions,motor symptoms,and dopaminergic neuron death in rotenone-challenged mice.16 S rRNA sequencing found that PD-related microbiota alterations induced by rotenone were reversed by FLZ ***,FLZ administration attenuated intestinal inflammation and gut barrier destruction,which subsequently inhibited systemic ***,FLZ treatment restored blood-brain barrier structure and suppressed neuroinflammation by inhibiting the activation of astrocytes and microglia in the substantia nigra(SN).Further mechanistic research demonstrated that FLZ treatment suppressed the TLR4/MyD88/NF-κB pathway both in the SN and ***,FLZ treatment ameliorates microbiota dysbiosis to protect the PD model via inhibiting TLR4 pathway,which contributes to one of the underlying mechanisms beneath its neuroprotective *** research also suppo

关键词： FLZ Microbiota-gut-brain axis Parkinson’s disease Rotenone mouse model TLR4/MyD88/NF-kB pathway Gastrointestinal dysfunction Systemic inflammation Neuroinflammation

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Mathematical Statistics Method of Residual Static Torque Controlling

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International Journal of Plant Engineering and Management 2018年第3期23卷 168-171页

作者： zhao zhe Automotive Engineering Institute Guangzhou Automobile Group Co.Ltd

This paper analyzes the problems existing in the detection and determination on the traditional residual torque. It is pointed out that the detection value is mistakenly used as the truth value and the lower limit of design torque is mistakenly used as the residual torque criterion. The calculation formula of the determination （limit） value of the test value of RM and DFM is proposed. By defining related parameters,the torque limitvalue corresponding to the tightening level, the ratio of the measured value to the truth value, μ and σ related tothe ratio of A and C, and the confidence coefficient related to the confidence probability, a mathematical statistical method of residual static torque controlling is established, which improves the control precision on the residual torque.

关键词： residual torque mathematical statistics determination

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Arthroscopy with subscapularis upper one-third tenodesis for treatment of recurrent anterior shoulder instability independent of glenoid bone loss

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World Journal of Clinical Cases 2022年第25期10卷 8854-8862页

作者： Bai-Jing An Feng-Lin Wang Yao-Ting Wang zhe zhao Ming-Xin Wang Geng-Yan Xing Department of Sports Medicine The Fourth Medical CenterPLA General HospitalBeijing 100048China Department of Clinical Laboratory The Third Medical CenterPLA General HospitalBeijing 100039China Department of Orthopedics The Third Medical CenterPLA General HospitalBeijing 100039China

BACKGROUND Recurrent anterior shoulder instability is a common traumatic injury,the main clinical manifestation of which is recurrent anteroinferior dislocation of the humeral *** current follow-up study showed that the effect of arthroscopic Bankart repair is *** To evaluate the clinical efficacy of arthroscopy with subscapularis upper one-third tenodesis for treatment of anterior shoulder instability,and to develop a method to further improve anterior stability and reduce the recurrence *** Between January 2015 and December 2018,male patients with recurrent anterior shoulder instability were *** hundred and twenty patients had a glenoid defect20%.The average age was 25 years(range,18–45 years).Patients with a glenoid defect20%underwent an arthroscopic iliac crest bone autograft with a subscapularis upper one-third *** patients were assessed with Rowe and Constant *** The average shoulder forward flexion angle was 163.6°±8.3°and 171.8°±3.6°preoperatively and at the last follow-up evaluation,*** average external rotation angle when abduction was 90°was 68.4°±13.6°and 88.5°±6.2°preoperatively and at the last follow-up evaluation,*** mean Rowe scores preoperatively and at the last follow-up evaluation were 32.6±3.2 and 95.2±2.2,respectively(P<0.05).The mean Constant scores preoperatively and at the last follow-up evaluation were 75.4±3.5 and 95.8±3.3,respectively(P<0.05).No postoperative dislocations were recorded by the end of the follow-up *** Arthroscopy with subscapularis upper one-third tenodesis was effective for treatment of recurrent anterior shoulder instability independent of the size of the glenoid bone defect,enhanced anterior stability of the shoulder,and did not affect postoperative range of motion

关键词： Arthroscopy Subscapularis Iliac crest bone autograft Recurrent anterior shoulder instability Glenoid bone loss

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Atomic layer deposition-induced integration of N-doped carbon particles on carbon foam for flexible supercapacitor

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Journal of Materiomics 2020年第1期6卷 209-215页

作者： zhe zhao Ye Kong Chang Liu Jinrun Liu Zhijie Wang Gengfeng zheng Gaoshan Huang Yongfeng Mei Department of Materials Science Fudan UniversityShanghai200433China Laboratory of Advanced Materials Fudan UniversityShanghai200438China

Flexible devices have attracted abundant attention in energy storage *** this paper,we presented a novel approach for fabricating flexible supercapacitor based on metal organic frameworks-derived *** this approach,a uniform zeolitic imidazolate frameworks-8 layer with a high mass loading was deposited on a flexible carbon foam(CF)skeleton efficiently by the induction of a uniform ZnO nanomembrane prepared via an atomic layer deposition technique.A flexible N-doped carbon particle-carbon foam(N-CP-CF)composite with a hierarchically porous structure and a large specific surface area(i.e.,538 m^(2) g^(-1))was obtained in a subsequent pyrolysis *** resultant materials have the excellent electrochemical performance(i.e.,a high specific capacitance of 300 F g^(-1) and a high energy density of 20.8 W h kg^(-1)).The N-CP-CF composite can provide a stable capacitance(i.e.,250 F g^(-1))and an energy density(i.e.,17.36 W h kg^(-1))under large deformation(25% of original thickness).This work could propose a promising strategy in fabrication of flexible electrode with a large potential towards energy storage applications in the future.

关键词： Atomic layer deposition Zeolitic imidazolate framework-8 Flexible device Supercapacitor

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STI PCR: An efficient method for amplification and de novo synthesis of long DNA sequences

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Molecular Plant 2022年第4期15卷 620-629页

作者： zhe zhao Xianrong Xie Weizhi Liu Jingjing Huang Jiantao Tan Haixin Yu Wubei Zong Jintao Tang Yanchang zhao Yang Xue Zhizhan Chu Letian Chen Yao-Guang Liu State Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources College of Life SciencesSouth China Agricultural UniversityGuangzhou 510642China Guangdong Laboratory for Lingnan Modern Agriculture Guangzhou 510642China

Despite continuous improvements,it is difficult to efficiently amplify large sequences from complex templates using current PCR ***,we developed a suppression thermo-interlaced(STI)PCR method for the efficient and specific amplification of long DNA sequences from genomes and synthetic DNA *** method uses site-specific primers containing a common 50 tag to generate a stem-loop structure,thereby repressing the amplification of smaller non-specific products through PCR suppression(PS).However,large target products are less affected by PS and show enhanced amplification when the competitive amplification of non-specific products is ***,this method uses nested thermointerlaced cycling with varied temperatures to optimize strand extension of long sequences with an uneven GC *** combination of these two factors in STI PCR produces a multiplier effect,markedly increasing specificity and amplification *** also developed a webtool,calGC,for analyzing the GC distribution of target DNA sequences and selecting suitable thermo-cycling programs for STI *** this method,we stably amplified very long genomic fragments(up to 38 kb)from plants and human and greatly increased the length of de novo DNA synthesis,which has many applications such as cloning,expression,and targeted genomic *** method greatly extends PCR capacity and has great potential for use in biological fields.

关键词： STI PCR PCR suppression thermo-interlaced cycling long genomic fragments de novo DNA synthesis

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Loss of O-GlcNAcylation on MeCP2 at Threonine 203 Leads to Neurodevelopmental Disorders

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Neuroscience Bulletin 2022年第2期38卷 113-134页

作者： Juanxian Cheng zhe zhao Liping Chen Ying Li Ruijing Du Yan Wu Qian Zhu Ming Fan Xiaotao Duan Haitao Wu Department of Neurobiology Beijing Institute of Basic Medical SciencesBeijing 100850China Chinese Institute for Brain Research Beijing 102206China Key Laboratory of Neuroregeneration Co-innovation Center of NeuroregenerationNantong UniversityNantong 226019China State Key Laboratory of Toxicology and Medical Countermeasures Beijing Institute of Pharmacology and ToxicologyBeijing 100850China

Mutations of the X-linked methyl-CpG-binding protein 2(MECP2)gene in humans are responsible for most cases of Rett syndrome(RTT),an X-linked progressive neurological *** genome-wide screens in clinical trials have revealed several putative RTT-associ-ated mutations in MECP2,their causal relevance regarding the functional regulation of MeCP2 at the etiologic sites at the protein level requires more *** this study,we demonstrated that MeCP2 was dynamically modified by O-linked-P-N-acetylglucosamine(O-GlcNAc)at threonine 203(T203),an etiologic site in RTT *** of the O-GlcNAcylation of MeCP2 specifically at T203 impaired dendrite development and spine maturation in cultured hippocampal neurons,and disrupted neuronal migration,dendritic spine morphogenesis,and caused dysfunction of synaptic transmission in the developing and juvenile mouse cerebral ***,genetic disruption of O-GlcNAcylation at T203 on MeCP2 decreased the neuronal activity-induced induction of Bdnf *** study highlights the critical role of MeCP2 T203 O-GlcNAcylation in neural development and synaptic transmission potentially via brain-derived neurotrophic factor.

关键词： MeCP2 O-GlcNAcylation-Dendrite development Synaptic transmission Braiderived neurotrophic factor

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Stainless steel anisotropic superhydrophobic surfaces fabrication with inclined cone array via laser ablation and post annealing treatment

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Journal of Central South University 2022年第10期29卷 3261-3269页

作者： zhao Yi-zhe HONG Ming-hui Department of Electrical and Computer Engineering National University of Singapore4 Engineering Drive 3117576Singapore

Metal superhydrophobic surfaces with anisotropic wettability and adhesion have become more and more important due to their promising applications. Herein, we report a new fabrication strategy through a combination of pulsed laser ablation and low-temperature annealing post-processing. An inclined cone structure array is made on stainless steel surfaces, and then 120 °C low-temperature annealing is applied. Such surface displays excellent mechanical durability and anisotropic superhydrophobicity. It is demonstrated experimentally that the contact angle of water droplets on the surface is different along the parallel(167° ±2°) and perpendicular directions(157° ±2°) of the inclined cone structure. The sliding behaviors of water droplets and mechanical durability of the inclined cone structures are studied. These surfaces obtained in a short time with environmentally friendly fabrication can be applied in industries for water harvesting, droplet manipulation, and pipeline transportation.

关键词： superhydrophobic anisotropy laser precision engineering micro/nano-structure bio-inspired surface

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Overview of the plague in the late Ming Dynasty and its prevention and control measures

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Traditional Medicine Research 2020年第3期5卷 136-144页

作者： Qiu-Hua Li Yue-Hai Ma Ning Wang Ying Hu zhao-zhe Liu The Second Hospital of Liaoning University of Chinese Medicine Shenyang 110034China Shengjing Hospital of China Medicine University Shenyang 110004China Northern Theater Command General Hospital Shenyang 110016China

The plague of the late Ming Dynasty(15511644 C.E.)was long lasting,affected a wide range of the population,and had serious *** purpose of this study is to review the medical system in place at the time and the measures instituted to prevent and control the plague during the late Ming *** on the history of the Ming Dynasty(13681644 C.E.),local chronicles,and related research literature were consulted and analyzed in terms of duration,geographical area,and other dimensions of the *** of the abnormal climate,wide range of natural disasters,and the impact of war,the epidemic spread over a wide area during the late Ming *** government’s epidemic prevention measures were affected by war and other factors,resulting in poor control of the ***,in terms of the medical system in place during the Ming Dynasty,some of the thinking and methods of prevention and control of the plague were historical and *** outstanding physicians such as Wu Youke(15821652 C.E.)appeared during this *** theory of plague prevention and control had a profound influence on the formation and development of pestilence deterrence in later *** the late Ming Dynasty,rich experiences and measures of prevention and control were accumulated in the struggle against the *** methods and experiences also have a significant,positive guiding influence on the prevention and control of plague in the present day.

关键词： Late Ming dynasty Plague Infectious diseases Traditional Chinese medicine Prevention and control

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Application of nonlinear chemical fingerprinting to identification,evaluation and clinical use of Glycyrrhiza

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Chinese Science Bulletin 2010年第26期55卷 2937-2944页

作者： FANG XuanQi ZHANG TaiMing zhao zhe XIANG FengQin LIANG YiZeng WANG Mei ZHU Rong CHEN Su QIAO JunXi College of Chemistry and Chemical Engineering Central South University Changsha 410083 China Institute oflnformation Science and Engineering Central South University Changsha 410083 China

Nonlinear chemical fingerprinting is a new technique for analyzing traditional Chinese medicines (TCMs). We developed such a method and applied it to Glycyrrhiza, a significant TCM. Nonlinear chemical fingerprints were obtained for Glycyrrhiza from four different production areas, and for 14 other TCMs with similar induction time. The calculation of their similarities was based on similarity system theory. Using intuitive visual comparison of the data and the similarity calculation results, Glycyrrhiza was discriminated from the 14 other TCMs. There was a linear relationship between the content of active TCM components and the induction time. This was used to compare the content of active components in Glycyrrhiza from the four different production areas, and establish an equivalent-dose relationship for these four samples. This method provides a new tool for discrimination and evaluation of Glycyrrhiza, and a dosage reference for clinical application of Glycyrrhiza from the four regions studied.

关键词：指纹图谱分析非线性化学甘草临床使用相似系统理论中药成分识别评估

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