Application of nonlinear chemical fingerprinting to identification,evaluation and clinical use of Glycyrrhiza

作     者：FANG XuanQi ZHANG TaiMing ZHAO Zhe XIANG FengQin LIANG YiZeng WANG Mei ZHU Rong CHEN Su QIAO JunXi 

作者机构：College of Chemistry and Chemical Engineering Central South University Changsha 410083 China Institute oflnformation Science and Engineering Central South University Changsha 410083 China 

出 版 物：《Chinese Science Bulletin》 (科学通报(英文版))

年 卷 期：2010年第55卷第26期

页      面：2937-2944页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 070304[理学-物理化学(含∶化学物理)] 08[工学] 0817[工学-化学工程与技术] 09[农学] 0901[农学-作物学] 0703[理学-化学] 

基　　金：supported by the National Key Technologies R&D Program of China (2009GJD20033) 

主　　题：指纹图谱分析 非线性化学 甘草 临床使用 相似系统理论 中药成分 识别 评估 

摘      要：Nonlinear chemical fingerprinting is a new technique for analyzing traditional Chinese medicines (TCMs). We developed such a method and applied it to Glycyrrhiza, a significant TCM. Nonlinear chemical fingerprints were obtained for Glycyrrhiza from four different production areas, and for 14 other TCMs with similar induction time. The calculation of their similarities was based on similarity system theory. Using intuitive visual comparison of the data and the similarity calculation results, Glycyrrhiza was discriminated from the 14 other TCMs. There was a linear relationship between the content of active TCM components and the induction time. This was used to compare the content of active components in Glycyrrhiza from the four different production areas, and establish an equivalent-dose relationship for these four samples. This method provides a new tool for discrimination and evaluation of Glycyrrhiza, and a dosage reference for clinical application of Glycyrrhiza from the four regions studied.