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Journal of Oceanology and Limnology 2023年第6期41卷 2060-2076页

作者： zhaohua WANG Dongliang zhao Kejian WU Lian XIE Ocean University of China Qingdao 266100China Department of Marine Earth and Atmospheric SciencesNorth Carolina State UniversityBox 8208RaleighNC 27695USA

Track density function(TDF)was computed for all Western North Pacific tropical cyclones(WNP TCs)tracks from 1950 to 2018,and the TDFs were further investigated using principal component analysis(PCA)to analyze their inter-annual spatial and temporal ***,the relationships between each empirical orthogonal function(EOF)mode and the typhoon count,typhoon landfall count,track pattern,and the Qinghai-Xizang Plateau snow cover(QXPSC)were examined,and the possible physical mechanisms implied by the statistical relationship were *** results show the QXPSC significantly affected the surface-atmosphere heat exchange through snow cover(SC)level,then changed the East Asian summer monsoon regional circulation pattern,influenced the subtropical high-pressure system strength and location,and ultimately affected the WNP TCs track patterns and thus changed their landfall locations.

关键词： tropical cyclone Qinghai-Xizang Plateau snow cover track pattern landfall location

血浆外泌体miR-548k在食管鳞癌中的表达及诊断价值

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山东大学学报（医学版） 2024年第5期62卷 79-88页

作者：冯绪梅宋相庆季冠虹赵小刚肖兆华山东大学第二医院健康管理科山东济南250033 山东大学第二医院胸外科山东济南250033

目的探讨血浆外泌体中与食管鳞癌(esophageal squamous cell carcinoma,ESCC)发生相关的microRNAs(miRNAs),并评估其在ESCC诊断中的应用价值。方法选取2020年3月至2021年6月山东大学第二医院胸外科收治的55例ESCC患者为ESCC组,另选取55... 详细信息

目的探讨血浆外泌体中与食管鳞癌(esophageal squamous cell carcinoma,ESCC)发生相关的microRNAs(miRNAs),并评估其在ESCC诊断中的应用价值。方法选取2020年3月至2021年6月山东大学第二医院胸外科收治的55例ESCC患者为ESCC组,另选取55例健康体检者为对照组,提取受试者血浆外泌体,并通过透射电镜、NanoSight粒径分析及Western blotting进行鉴定。筛选阶段,送检对照组、ESCC组术前血浆外泌体RNA各5例进行测序。采用qRT-PCR法对训练集、验证集中差异性miRNAs分子表达进行检测,并通过受试者工作特征(receiver operating characteristic,ROC)曲线评估差异性miRNAs分子的诊断价值。结果测序结果显示,与对照组相比,5个miRNAs(miR-548k、miR-6516-5p、let-7b-3p、miR-3934-5p、miR-196a-5p)在ESCC组血浆外泌体中表达显著上调,8个miRNAs(miR-34c-5p、novel_167、miR-548u、miR-548ah-3p、miR-548p、miR-200a-5p、miR-200b-3p、miR-1228-5p)明显下调。通过训练队列证实,miR-548k在ESCC组血浆外泌体中明显上调(P<0.001),血浆外泌体miR-548k用于ESCC诊断时ROC曲线下面积(area under curve,AUC)为0.918,明显优于miR-34c-5p、miR-548u、miR-6516-5p。通过验证队列进一步证实,miR-548k在ESCC组血浆外泌体中高表达(P<0.001),血浆外泌体miR-548k可用于ESCC患者诊断(AUC值为0.889)。结论miR-548k在ESCC组血浆外泌体中表达显著增高,血浆外泌体miR-548k对ESCC诊断有一定的临床应用价值。

关键词：食管鳞癌血浆外泌体诊断生物标志物 miR-548k

HETEROGENEITY OF THE LITHOSPHERE IN TIBETAN PLATEAU ON THE CONSTRAINTS OF MAGMATISM

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地学前缘 2000年第S1期7卷 322-322页

作者： Mo Xuanxue,Guo Tieying, zhao Zhidan, Luo zhaohua [WT5,5”BX](China University of Geosciences, Beijing 100083, China)

Many evidences including those from magmatism and igneous rocks strongly support the heterogeneity of lithosphere in Tibetan *** estimation, volcanic and plutonic rocks occupy an area of 300000km\+2, equaling to 10% of total area of the Tibetan Plateau. Temporal and spatial distribution of igneous rocks in the Tibetan Plateau is very inhomogeneous (Mo et al., 1998). Temporarily, most of plutonic and volcanic rocks, which occurred in 60% of total area of igneous rocks in the plateau, formed in the period of 65～45Ma. Spatially, 80% of igneous rocks in the plateau concentrated in the Gangdise—Nyainqentanglha region formed a huge complex granite\|volcanic belt. Petrotectonic assemblage and type of igneous rocks also vary from district to district. While Himalayas (especially High\|Himalayan region) were characterized by well development of muscovite\|bearing granites with no high\|potassium volcanic rocks and other volcanic contemporaries, North Tibet (Qiangtang region) by highly potassic volcanic rock series without muscovite\|bearing granites. Besides wide\|spreading calc\|alkaline igneous rocks, however, both highly potassic volcanic rocks and muscovite\|bearing granites developed in the central portion of Gangdise\|Nyainqentanglha region. It was lack of igneous activities in the Pamirs. Mantle\|derived nodules and their hosted rocks have been found only on northern and eastern margins of the plateau so far. All mentioned above, combined with other evidences from geophysics, geochemistry and structural geology, give us a hint to understand the heterogeneity of the lithosphere in its structure, thermal state and evolution processes underneath Tibetan plateau.

关键词： heterogeneity lithosphere Tibet plateau

The Novel Variable Stiffness Composite Systems with Characteristics of Repeatable High Load Bearing and Response Rate

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Journal of Bionic Engineering 2023年第2期20卷 495-505页

作者： Zhiwei Tuo zhaohua Lin Qian zhao Yunhong Liang Han Wu Chang Liu ZhiWu Han The Key Laboratory of Bionic Engineering Ministry of EducationJilin UniversityChangchun130025China School of Mechanical and Aerospace Engineering Jilin UniversityChangchun130022China

On the base of controllable variable stiffness property,variable stiffness composites were the main components of functional materials in ***,the relatively low mechanical strength,stiffness range,and response rate restricted the application of variable stiffness *** this work,the novel variable stiffness composite system with characteristics of repeatable high load bearing and response rate was successfully prepared via the double-layer anisotropic structure to solve the bottlenecks of variable stiffness *** novel variable stiffness composite systems were composed of variable stiffness layer of polycaprolactone(PCL)and the driven layer of silicone elastomer with alcohol,which continuously changed Young’s modulus from 0.1 to 7.263 MPa(72.63 times variation)in 200 s and maintained maximum weight of 11.52 times its own weight(8.5 g).Attributed to the relatively high variable stiffness range and load bearing value of variable stiffness composite system,the repeatable response process led to the efficient high load driven as“muscle”and diversified precise grab of objects with different shapes as“gripper”,owning widespread application prospects in the field of bionics.

关键词： Variable stiffness composite High strength Repeatable High load bearing Bionic

维普期刊数据库评论

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微小卫星星载处理器CAN接口设计与实现

数据采集与处理 2009年第B10期24卷 233-236页

作者：赵小辉杨照华全伟北京航空航天大学仪器科学与光电工程学院北京100191

针对现今两款流行的高性能ARM9芯片没有CAN资源,研制出基于AT91RM9200处理器的CAN接口。本文利用ARM芯片串行同步外设接口(SPI),选择带有标准SPI接口的CAN控制器,设计实现了CAN接口硬件电路,并完成CAN总线报文收发的软件设计与实现,最... 详细信息

针对现今两款流行的高性能ARM9芯片没有CAN资源,研制出基于AT91RM9200处理器的CAN接口。本文利用ARM芯片串行同步外设接口(SPI),选择带有标准SPI接口的CAN控制器,设计实现了CAN接口硬件电路,并完成CAN总线报文收发的软件设计与实现,最后在三种波特率下进行了测试,结果表明利用SPI接口扩展的CAN接口功耗低,工作稳定可靠,可满足微小卫星工作需求。

关键词：微小卫星 CAN总线 ARM SPI

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电影《功夫熊猫3》的中西文化融合

湖北工业大学学报 2017年第3期32卷 65-69页

作者：梁钊华赵丽玲湖北工业大学外国语学院湖北武汉430068

在经济全球化的时代,各国家各民族的文化也突破壁垒,走向全世界,开始了世界文化多元化发展的格局。作为文化传播重要媒介的电影行业,中外合拍电影也渐成趋势。《功夫熊猫3》是第一部中美合拍动画片,影片不仅展现了各类中国文化符号,融... 详细信息

在经济全球化的时代,各国家各民族的文化也突破壁垒,走向全世界,开始了世界文化多元化发展的格局。作为文化传播重要媒介的电影行业,中外合拍电影也渐成趋势。《功夫熊猫3》是第一部中美合拍动画片,影片不仅展现了各类中国文化符号,融合了中国传统价值观,同时也彰显着美国文化的元素和个人英雄主义精神价值观。影片巧妙地把中国传统文化和美国价值观结合起来,在全球化的背景下呈现出中西文化的融合,其成功经验必将对我国传统文化的传播起到深刻的启示作用。

关键词：《功夫熊猫3》中国文化文化融合

血管活性肠肽对暂时性脑缺血大鼠梗死体积的影响

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西安交通大学学报（医学版） 2007年第5期28卷 494-497页

作者：赵朝华胡晓丹杨杰钱亦华邱芬刘勇西安交通大学医学院人体解剖与组织胚胎系陕西西安710061

目的通过活体实验研究血管活性肠肽(VIP)对脑缺血损伤的神经保护作用。方法大鼠侧脑室内注射VIP后,采用大脑中动脉线栓(MCAO)法诱导建立暂时性局部脑缺血模型。通过神经学的评价对MCAO大鼠进行判定和筛选;TTC染色测定大鼠脑梗死体积;双... 详细信息

目的通过活体实验研究血管活性肠肽(VIP)对脑缺血损伤的神经保护作用。方法大鼠侧脑室内注射VIP后,采用大脑中动脉线栓(MCAO)法诱导建立暂时性局部脑缺血模型。通过神经学的评价对MCAO大鼠进行判定和筛选;TTC染色测定大鼠脑梗死体积;双抗夹心ELISA检测血清S100β的含量。结果MCAO后2 h大鼠呈现不同程度的神经功能损伤症状。评定为1-2级的仅有2例出现明显脑梗死区,3级的为全部。VIP注射后大鼠脑梗死体积明显缩小,较对照组减少约25%(P<0.05);血清S100β浓度也明显降低(P<0.05)。结论以神经学评分3级作为MCAO模型成功的判定标准是较为可靠的。VIP脑内注射可明显减小脑缺血后梗死体积,具有神经保护作用。VIP可以降低S100β的含量,这可能涉及到VIP的另一神经保护机制。

关键词：血管活性肠肽脑缺血梗死体积 S100β

Photosynthetic and water-related physiological characteristics of Periploca sepium in response to changing soil water conditions in a shell sand habitat

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Journal of Forestry Research 2023年第2期34卷 453-467页

作者： Xiao Wang Jiangbao Xia Ximei zhao Mingming Dong Xianshuang Xing Ying Fang Qinqin Fu zhaohua Lu Institute of Restoration Ecology School of Chemical and Environmental EngineeringChina University of Mining and Technology(Beijing)Beijing 100083People’s Republic of China Shandong Provincial Key Laboratory of Eco-Environmental Science for Yellow River Delta Binzhou UniversityBinzhou 256603People’s Republic of China Shandong Hydrology Center Jinan 250013People’s Republic of China

This study was performed to observe the effects of water on photosynthesis and water-related physiology in dominant shrubs in shell sand ***-year-old Periploca sepium seedlings were used as model species.A gradient of 12 water levels was established by artificially supplying the shell sand with water up to saturation and then allowing natural evapotranspiration to *** photo synthetic,chlorophyll fluorescence and stem sap flow parameters of *** were measured under a range of water *** different soil water conditions were classified according to the responses of these parameters.(1)With the increase in the relative water content(RWC)of the shell sand,the parameters of leaf photosynthesis,chlorophyll fluorescence and water-related physiology in *** showed significant critical *** net photo synthetic rate(Pn),transpiration rate(Tr),instantaneous water use efficiency(WUE),potential water use efficiency(WUEi),maximum photochemical efficiency(Fv/Fm),actual photochemical efficiency(ΦPSII)and daily accumulation of stem sap flow all increased first and then decreased with increasing RWC,but the corresponding water conditions associated with their maximum values were not the *** RWC of 69.40%was determined to be the optimal water condition for photosynthesis and water-related physiological activity in *** an RWC of 36.61%,the mechanism of photosynthetic inhibition in *** changed from stomatal limitation to nonstomatal limitation;this was also the minimum water requirement for maintaining normal photo synthetic *** RWC of 50.27%resulted in the highest WUE in ***,indicating that moderate drought stress increased WUE.(2)Based on the quantitative relationship between the photo synthetic parameters of *** and the shell sand water gradient,the soil water availability was classified into 6 water *** RWC range for maintaining strong photosynthesis and high WUE in *** was 63.22-69.98%.(3)Gas

关键词： Water gradient range Periploca sepium Photosynthesis Water physiology Water availability classifi cation Shell sand

小檗碱对冈田酸拟AD大鼠空间学习记忆的改善作用及其机制

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神经解剖学杂志 2012年第2期28卷 136-140页

作者：杨吉平徐曦王爽赵朝华魏明西安医学院解剖学教研室西安710021 西安医学院病理生理学教研室西安710021 西安医学院药理学教研室西安710021

目的:探讨小檗碱(berberine,Ber)对冈田酸拟阿尔茨海默病(Alzheimer’s disease,AD)大鼠学习记忆的改善作用及其可能机制。方法:36只雄性SD大鼠随机分为对照组、模型组和Ber组,用侧脑室微量注射冈田酸(okadaic acid,OA,0.4 mmol/L,1.5... 详细信息

目的:探讨小檗碱(berberine,Ber)对冈田酸拟阿尔茨海默病(Alzheimer’s disease,AD)大鼠学习记忆的改善作用及其可能机制。方法:36只雄性SD大鼠随机分为对照组、模型组和Ber组,用侧脑室微量注射冈田酸(okadaic acid,OA,0.4 mmol/L,1.5μl/次,共3次)建立AD模型,Ber组是在模型制作前后灌胃(100mg/kg/d,共4周);采用Morris水迷宫测试大鼠的空间学习记忆能力,用Bieischowsky镀银改良法观察脑内神经原纤维缠结(neurofibrillary tangle,NFTs)的变化;用免疫组织化学方法检测pTau-Ser396和pTau-Ser404蛋白的表达。结果:与对照组相比,模型组大鼠各时间段的逃避潜伏期均延长,脑内出现较多NFTs,皮层和海马神经元pTau-Ser396/404的表达明显增高(P<0.01);Ber组大鼠潜伏期较模型组明显缩短,脑内NFTs的数量减少,pTau-Ser396/404的表达明显下调(P<0.01,P<0.05)。结论:小檗碱可明显改善AD模型大鼠空间学习记忆障碍,其机制可能与降低Tau磷酸化水平,减少NFTs有关。

关键词：阿尔茨海默病小檗碱神经原纤维缠结(NFTs) tau 磷酸化大鼠

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WK12型矿用挖掘机提升机构优化设计

矿山机械 2024年第1期52卷 72-74页

作者：朱宴南赵炎龙靳润王朝华国家电投扎哈淖尔煤业有限公司内蒙古通辽029199 太原科技大学机械工程学院山西太原030024

矿用挖掘机广泛应用于露天矿的开采作业^([1]),据统计,全世界2/3的固体矿物资源采用露天开采,而露天采场中80%以上的剥离量和采掘量是用挖掘机械完成的。因此,矿用挖掘机是大型露天矿山开采的关键设备。矿用挖掘机工作过程分为铲斗插入... 详细信息

矿用挖掘机广泛应用于露天矿的开采作业^([1]),据统计,全世界2/3的固体矿物资源采用露天开采,而露天采场中80%以上的剥离量和采掘量是用挖掘机械完成的。因此,矿用挖掘机是大型露天矿山开采的关键设备。矿用挖掘机工作过程分为铲斗插入堆料、离开堆料、卸料、复位及行走5个动作,依靠推压、提升、回转、开斗、行走机构和其他辅助机构配合完成^([2])。其中,提升与推压机构配合完成铲斗插入堆料、离开堆料及卸料等动作^([3-4])。

关键词：挖掘机械行走机构辅助机构推压机构机构优化设计堆料露天采场剥离量