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Quick photofabrication of functional nanospheres from de novo designed peptides for NIR fluorescence and MR imaging

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Nano Research 2023年第3期16卷 4029-4038页

作者： jingyi zhao Chen Li Xue-Wang Gao Ke Feng Hao Liu Sijie He Wenhua zhao Shumin Yang Jianqun Shao Ling Ye Bin Chen Nan Xie Chen-Ho Tung Li-Zhu Wu School of Pharmaceutical Sciences Capital Medical UniversityBeijing 100069China Key Laboratory of Photochemical Conversion and Optoelectronic Materials Technical Institute of Physics and ChemistryChinese Academy of SciencesBeijing 100190China

Combining the noncovalent and covalent interactions,a series of peptide amphiphiles were designed de novo and synthesized to architect functional assemblies by means of *** strand of peptide sequence was structurally capped with photoactive tyrosine-tyrosine(YY)motifs at both termini,and the spacing was filled by alternating of hydrophilic D(L-aspartate)and hydrophobic X(ε-aminocaproic acid)*** visible-light irradiation,these de novo designed peptides underwent rapid photocrosslinking within merely 10 ***,the modulation of alternating D-X pairs in occupying spacer would adjust molecular amphiphilicity,regulate charge distribution,and control particle size and loading capacity of peptide nanospheres(PNS)in aqueous *** entirely peptide-based matrix,this PNS system could host cationic indicators of fluorescent rhodamine and magnetic GdIII for exemplar near infrared(NIR)fluorescence and magnetic resonance(MR)imaging,which paves a pathway to biomaterial and biomedical applications using de novo designed peptides.

关键词： synthetic peptide photocrosslinking de novo design encapsulable nanosphere imaging nanoprobe dityrosine

Controlled plasmon-enhanced fluorescence by spherical microcavity

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Chinese Physics B 2021年第11期30卷 76-81页

作者： jingyi zhao Weidong Zhang Te Wen Lulu Ye Hai Lin Jinglin Tang Qihuang Gong Guowei Lyu State Key Laboratory for Mesoscopic Physics Frontiers Science Center for Nano-optoelectronics&Collaborative Innovation Center of Quantum MatterSchool of PhysicsPeking UniversityBeijing 100871China Collaborative Innovation Center of Extreme Optics Shanxi UniversityTaiyuan 030006China Peking University Yangtze Delta Institute of Optoelectronics Nantong 226010China

A surrounding electromagnetic environment can engineer spontaneous emissions from quantum emitters through the Purcell *** instance,a plasmonic antenna can efficiently confine an electromagnetic field and enhance the fluorescent *** this study,we demonstrate that a photonic microcavity can modulate plasmon-enhanced fluorescence by engineering the local electromagnetic ***,we constructed a plasmon-enhanced emitter(PE-emitter),which comprised a nanorod and a nanodiamond,using the nanomanipulation ***,we controlled a polystyrene sphere approaching the PE-emitter and investigated in situ the associated fluorescent spectrum and *** emission of PE-emitter can be enhanced resonantly at the photonic modes as compared to that within the free spectral *** spectral shape modulated by photonic modes is independent of the separation between the PS sphere and *** band integral of the fluorescence decay rate can be enhanced or suppressed after the PS sphere couples to the PE-emitters,depending on the coupling strength between the plasmonic antenna and the photonic *** findings can be utilized in sensing and imaging applications.

关键词： localized surface plasmon resonance photonic microcavity

A Preliminary Discussion on the Mechanism of Abnormal Intensity Zones of the M5.1 Wen'an Earthquake in 2006

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Earthquake Research in China 2009年第4期23卷 448-457页

作者： Zhang Suling zhao jingyi Lin Jie China Earthquake Networks Center China Earthquake Administration Beijing 100045 China Institute of Crustal Dynamics China Earthquake Administration Beijing 100085 China

An earthquake measuring 5.1 on the Richter scale struck Wen'an county,Hebei Province on July 4,2006. No casualties have been reported,with only slight damage. The disaster level of this event is the slightest on the M4.9～5.1 events record tally since the CCDSN (China Center of Digital Seismic Network) was built in 1999. The epicenter intensity of this earthquake was low,while in areas like Beijing,which is 100km far away,abnormal high intensity zones appeared. This article discusses the reasons behind this abnormal phenomenon,with the diagrams of intensity isolines drawn by the intense seismic stations and networks in the capital circle area as references,as well as the seismogenic mechanism in the source,the seismic histories,the geological structures and the ray pathways of seismic waves in areas within 150km around the epicenter. It was concluded that the special dynamic and geological situations were the main causes for the lower intensity degree and slight damage in the epicenter area,but higher intensity in the surrounding areas.

关键词： Wen'an earthquake Intensity anomaly Discussion on mechanism

Analysis of Pharmacokinetic/Pharmacodynamic Parameters and Dosage Regimen of Posaconazole against Candidaspp. and Aspergillusspp. Using Monte Carlo Simulation

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Pharmacology & Pharmacy 2020年第1期11卷 17-28页

作者： Ying Wang jingyi zhao Junhui Hu Xinhong zhao Yinhui Yao Department of Pharmacy Affiliated Hospital of Chengde Medical College Chengde China Department of Functional Center Chengde Medical College Chengde China.

Invasive fungal infections (IFI) have recently become increasingly more prevalent, resulting in an increased risk of morbidity and mortality. Both Candida spp. and Aspergillus spp. are major causes of IFI. In this study, we aimed to evaluate the cumulative fraction of response of various dosage regimens of posaconazole against nine Candida spp. and six Aspergillus spp. in both children and adults. Monte Carlo simulation (MCS) was performed to optimize selection of posaconazole dosage regimens. For children, a dosage regimen of 120 mg/m2 posaconazole tid was sufficient to treat fungal infections caused by all six Aspergillus spp. and six of the nine Candida spp. (but was not effective against C. glabrata, C. guilliermondii and C. krusei). In contrast, a 400 mg dosage regimen of posaconazole bid achieved the target pharmacokinetic/pharmacodynamics (PK/PD) parameters against all six Aspergillus spp. and eight of the nine Candida spp. (but was not effective against C. glabrata) in the adults. Dosage regimens of 50 mg bid, 100 mg bid, or 200 mg bid were not effective. Posaconazole dosage regimens are likely to achieve their desired PK/PD targets against Candida spp. and Aspergillus spp. in both children and adults.

关键词： Posaconazole Monte Carlo Simulation Candida spp. Aspergillus spp. Pharmacokinetics/Pharmacodynamics

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漏斗型结晶器漏斗形状的设计

钢铁 1998年第3期33卷 21-32,32页

作者：盛义平赵静一燕山大学

分析了ＳＭＳ漏斗型结晶器在使用中出现局部高温、产生热裂纹、寿命低的原因，提出了结晶器漏斗形状的更为合理的设计要求和设计方法。

关键词：漏斗型结晶器漏斗曲面薄板坯连铸连铸机

To Explore the Potential Mechanism of Yiqing Capsule in the Treatment of COVID-19 Based on Network Pharmacology

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Chinese Medicine 2020年第2期11卷 96-104页

作者： Ying Wang jingyi zhao Yinhui Yao Song Jiang Xinhong zhao Junhui Hu Department of Pharmacy The Affiliated Hospital of Chengde Medical College Chengde China Department of Functional Center Chengde Medical College Chengde China

Objective: To select the ingredients and targets of Yiqing capsule in treating COVID-19 based on network pharmacology, then to explore the potential mechanism of Yiqing capsule in treating COVID-19. Methods: We screened the ingredients and targets of Yiqing capsule on Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP), and target genes for COVID-19 in GeneCards database, constructed drug-ingredient-target network through software Cytoscape 3.7.2, and constructed protein protein interaction network (PPI) network through STRING database. Gene Ontology (GO) enrichment analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis of key gene targets of Yiqing capsule are used to treat COVID-19 through software R5.3.2. Results: We got 42 ingredients, 42 potential therapeutic targets, 1643 GO items and 970 pathways in our study. The main pathway including IL-17 signaling pathway, Chagas disease (American trypanosomiasis), Influenza A, and TNF signaling pathway. Conclusion:

关键词： Yiqing Capsule Network Pharmacology COVID-19

Optimizing the Dosage Regimen of Micafungin against Candida sppin HIV Positive Patients with EC Based on Mote Carlo Simulation

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Open Journal of Preventive Medicine 2020年第6期10卷 120-125页

作者： Ying Wang jingyi zhao Song Jiang Yinhui Yao Hainan Wen Department of Pharmacy The Affiliated Hospital of Chengde Medical College Chengde China Department of Functional Center Chengde Medical College Chengde China Department of Clinical Laboratory The Affiliated Hospital of Chengde Medical College Chengde China

The objective of our study was to explore the possibility of the antifungal efficacy of various micafungin dosage regimens against Candida spp in HIV positive patients with EC. According to pharmacokinetic/pharmacodynamics parameters of micafungin in HIV positive patients and MICs distribution of micafungin against Candida spp. in published studies, the dosage regimens of micafungin were 50, 100 and 150 mg QD iv. Monte Carlo Simulation analysed the probability of target attainment and cumulative fraction of response. The results showed that micafungin has good antifungal effect in treating HIV positive patients with EC when pathomycetes are Candida albicans, Candida glabrata or Candida tropicalis, in dosage at 100 mg QD and 150 mg QD.

关键词： Monte Carlo Simulation Micafungin HIV Positive Patients Esophageal Candidiasis

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角度分辨光谱技术及其应用

光学学报 2023年第16期43卷 253-276页

作者：赵景怡赵茂雄石磊资剑复旦大学应用表面物理国家重点实验室上海200433 复旦大学微纳光子结构教育部重点实验室上海200433 上海微纳制程智能检测工程技术研究中心上海200433 复旦大学-光检测与光集成校企联合研究中心上海200433

光谱是物质的光学指纹信息,是研究光与物质相互作用的重要手段。角度分辨光谱技术是对光谱在角度维度的进一步解析,能够分辨光的强度、偏振态和相位等信息,从而在生物医学、材料科学和微纳光子学等研究领域得到广泛应用。为了实现角度... 详细信息

光谱是物质的光学指纹信息,是研究光与物质相互作用的重要手段。角度分辨光谱技术是对光谱在角度维度的进一步解析,能够分辨光的强度、偏振态和相位等信息,从而在生物医学、材料科学和微纳光子学等研究领域得到广泛应用。为了实现角度分辨光谱,目前已经开发了多种实验系统,并涌现出了大量数据处理算法。本文将介绍角度分辨光谱的生成方法、数据处理技术及其在不同研究领域中的应用。

关键词：角度分辨光谱光学逆散射问题光学散射成像光学特征尺寸缺陷检测

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电液伺服系统的动压反馈网络校正方法研究

钢铁 1999年第7期34卷 58-61页

作者：李久彤赵静一燕山大学

为提高板带轧机电液伺服系统的动态品质，设计了蓄能器加可调阻尼器组成的动压反馈网络。在四辊板带轧机液压弯辊系统中，对其进行了计算机仿真和频率响应实验研究。证明了采用动压反馈网络校正配合调整系统增益的方法，不仅能够有效地... 详细信息

为提高板带轧机电液伺服系统的动态品质，设计了蓄能器加可调阻尼器组成的动压反馈网络。在四辊板带轧机液压弯辊系统中，对其进行了计算机仿真和频率响应实验研究。证明了采用动压反馈网络校正配合调整系统增益的方法，不仅能够有效地抑制供油压力波动干扰，提高系统的控制精度。

关键词：板带轧机电液伺服系统动压反馈网络校正方法