Quick photofabrication of functional nanospheres from de novo designed peptides for NIR fluorescence and MR imaging
作者机构：School of Pharmaceutical SciencesCapital Medical UniversityBeijing 100069China Key Laboratory of Photochemical Conversion and Optoelectronic MaterialsTechnical Institute of Physics and ChemistryChinese Academy of SciencesBeijing 100190China
出 版 物：《Nano Research》 (纳米研究（英文版）)
年 卷 期：2023年第16卷第3期
页 面：4029-4038页
核心收录：
学科分类：0710[理学-生物学] 080901[工学-物理电子学] 0809[工学-电子科学与技术（可授工学、理学学位）] 08[工学] 080401[工学-精密仪器及机械] 0804[工学-仪器科学与技术] 0805[工学-材料科学与工程（可授工学、理学学位）] 0703[理学-化学] 0803[工学-光学工程] 0702[理学-物理学]
基 金：supported by Beijing Natural Science Foundation(No.2222051) the National Natural Science Foundation of China(No.81973442)
主 题：synthetic peptide photocrosslinking de novo design encapsulable nanosphere imaging nanoprobe dityrosine
摘 要：Combining the noncovalent and covalent interactions,a series of peptide amphiphiles were designed de novo and synthesized to architect functional assemblies by means of *** strand of peptide sequence was structurally capped with photoactive tyrosine-tyrosine(YY)motifs at both termini,and the spacing was filled by alternating of hydrophilic D(L-aspartate)and hydrophobic X(ε-aminocaproic acid)*** visible-light irradiation,these de novo designed peptides underwent rapid photocrosslinking within merely 10 ***,the modulation of alternating D-X pairs in occupying spacer would adjust molecular amphiphilicity,regulate charge distribution,and control particle size and loading capacity of peptide nanospheres(PNS)in aqueous *** entirely peptide-based matrix,this PNS system could host cationic indicators of fluorescent rhodamine and magnetic GdIII for exemplar near infrared(NIR)fluorescence and magnetic resonance(MR)imaging,which paves a pathway to biomaterial and biomedical applications using de novo designed peptides.
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