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Investigating the Mechanism of Qu Du Qiang Fei 1 Hao Fang Formula against Coronavirus Disease 2019 Based on Network Pharmacology Method

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World Journal of Traditional Chinese Medicine 2024年第1期10卷 93-103页

作者： Yuan-Hua Wang He-Yang Zhou Jin-Yun Ma Gui-Qing Ding Hua Yu Yong-Sheng Jin Xiao-dong Cheng Institute of Clinical Immunology Yue-Yang Hospital of Integrative MedicineShanghai University of Traditional Chinese MedicineShanghaiChina School of Pharmacy Naval Medical UniversityShanghaiChina

Objective:Qu Du Qiang Fei 1 Hao Fang(QDQF1)is a novel Chinese herbal medicine formula used to treat coronavirus disease 2019(COVID-19).However,the pharmacological mechanisms of action of QDQF1 remain *** objective of this study was to identify the effective ingredients and biological targets of QDQF1 for COVID-19 *** and Methods:The effective ingredients and mechanisms of action of QDQF1 were analyzed by using network pharmacology methods,which included an analysis of the effective ingredients and corresponding targets,COVID-19-related target acquisition,compound-target network analyses,protein-protein interaction network analysis,Kyoto Encyclopedia of Genes and Genomes(KEGG)and Gene Ontology(GO)enrichment analyses,and molecular docking ***:In total,288 effective QDQF1 ingredients were *** identified 51 core targets from the 148 targets through an overlap between putative QDQF1 targets and COVID-19-related *** key components,including formononetin,kaempferol,luteolin,naringenin,quercetin,and wogonin were identified through component-target network *** functional enrichment analysis of the core targets revealed 1296 items,while KEGG pathway enrichment analysis identified 148 signaling *** central targets(CCL2,CXCL8,IL1B,IL6,MAPK1,MAPK3,MAPK8,STAT3,and TNF)related to the COVID-19 pathway were identified in the KEGG pathway enrichment ***,molecular docking analysis suggested that the docking scores of the six key components to the nine central targets were better than those to ***:QDQF1 may regulate multiple immune-and inflammation-related targets to inhibit the progression of severe acute respiratory syndrome coronavirus 2,and thus,may be suitable for the treatment of COVID-19.

关键词： Coronavirus disease 2019 molecular docking molecular mechanism network pharmacology Qu Du Qiang Fei 1 Hao Fang formula

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数字化管控系统在起重机械第三方检查中的应用

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建筑机械化 2024年第3期45卷 9-12页

作者：黄超禄赵冬董恒尧上海市建筑科学研究院有限公司上海201108 上海建筑机械安全智能控制工程技术研究中心上海200032 上海市建设工程安全质量监督总站上海200032

以数字化应用为突破口,通过研究并开发移动端应用程序及数据可视化管理平台,实现数据融合的起重机械数字化隐患排查治理,一定程度上解决检查质量难把控,检查结果难分析的现状。

关键词：起重机械第三方质量隐患排查数字化

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石羊河尾闾青土湖荒漠植物群落种间关联及生态位研究

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水生态学杂志 2024年第2期45卷 121-131页

作者：耿东梅赵鹏陈亚东张裕年段晓峰甘肃省水利水电勘测设计研究院有限责任公司甘肃兰州730010 甘肃省治沙研究所甘肃省荒漠化与风沙灾害防治国家重点实验室甘肃兰州730070 甘肃省农村饮水安全管理办公室甘肃兰州730010

探究荒漠植物群落种间关系,为石羊河尾闾干涸湖泊植被恢复与重建提供理论支撑。2018年9月,在石羊河下游青土湖设置3条调查样带,共调查灌木样方27个,草本样方81个。采用方差比率法、χ^(2)检验、Pearson相关、Spearman秩相关、联结系数Oc... 详细信息

探究荒漠植物群落种间关系,为石羊河尾闾干涸湖泊植被恢复与重建提供理论支撑。2018年9月,在石羊河下游青土湖设置3条调查样带,共调查灌木样方27个,草本样方81个。采用方差比率法、χ^(2)检验、Pearson相关、Spearman秩相关、联结系数Ochiai和生态位量化方法,开展荒漠植物群落种间关联程度、生态位宽度及生态位重叠特征研究。结果表明:青土湖荒漠植物群落包括24种植物,其中灌木8种,多年生草本8种,一年生草本8种,草本植物占总物种数的66.67%。不同生活型荒漠植物中重要值最大的分别为白刺(Nitraria tangutorum)、芦苇(Phragmites australis)和猪毛菜(Salsola collina)。方差比率分析表明,青土湖荒漠植物群落种间总体上呈不显著负联结关系,群落处于波动演替状态。Ochiai系数0~0.3的种对占总对数的72.83%,种对间的相关性较弱。生态位宽度较大的灌木有白刺(21.728)、梭梭(Haloxylon ammodendron)(10.321)、黑果枸杞(Lycium ruthenicum)(5.711);多年生草本有芦苇(12.556)、黄花补血草(Limonium aureum)(4.874)、荒漠黄耆(Astragalus grubovii)(4.248);一年生草本有猪毛菜(9.340)、盐生草(Halogeton glomeratus)(7.822)、雾冰藜(Bassia dasyphylla)(6.237)。生态位重叠较大的种对有灰绿藜(Chenopodium glaucum)和碟果虫实(Corispermum patelliforme)(0.84)、沙蒿(Artemisia desertorum)和戈壁驼蹄瓣(Zygophyllum gobicum)(0.77)、黄花补血草和画眉草(Eragrostis pilosa)(0.77)、砂蓝刺头(Echinops gmelinii)和红砂(Reaumuria soongarica)(0.75)。群落物种生态位重叠均值为0.12,种间竞争较小。建议在石羊河下游青土湖人工植物群落构建过程中重视种间关系,选择种间竞争小的灌木和多年生草本植物作为生态恢复的植物种。

关键词：荒漠植物种间关联生态位青土湖

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Controlled growth of vertically stacked In_(2)Se_(3)/WSe_(2) heterostructures for ultrahigh responsivity photodetector

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Nano Research 2024年第3期17卷 1856-1863页

作者： Cheng Zhang Biyuan Zheng Guangcheng Wu Xueying Liu Jiaxin Wu Chengdong Yao Yizhe Wang Zilan Tang Ying Chen Lizhen Fang Luying Huang dong Li Shengman Li Anlian Pan Key Laboratory for Micro-Nano Physics and Technology of Hunan Province State Key Laboratory of Chemo/Biosensing and ChemometricsCollege of Materials Science and EngineeringHunan UniversityChangsha 410082China

Transition metal dichalcogenides(TMDCs)are promising candidates for future optoelectronic devices accounting for their high carrier mobility and excellent quantum ***,the limited light absorption efficiency in atomically thin layers significantly hinders photocarrier generation,thereby impairing the optoelectronic performance and hindering practical ***,we successfully synthesized In_(2)Se_(3)/WSe_(2) heterostructures through a typical two-step chemical vapor deposition(CVD)*** In_(2)Se_(3) nanosheet with strong light absorption capability,serving as the light absorption layer,was integrated with the monolayer WSe_(2),enhancing the photosensitivity of WSe_(2) *** laser irradiation with a wavelength of 520 nm,the In_(2)Se_(3)/WSe_(2) heterostructure device shows an ultrahigh photoresponsivity with a value as high as 2333.5 A/W and a remarkable detectivity reaching up to 6.7×10^(12) Jones,which is the highest among almost the reported TMDCs-based heterostructures grown via CVD even some fabricated by mechanical exfoliation(ME).Combing the advantages of CVD method such as large scale,high yield,and clean interface,the In_(2)Se_(3)/WSe_(2) heterostructures would provide a novel path for future high-performance optoelectronic device.

关键词： transition metal dichalcogenides(TMDCs) In_(2)Se_(3) heterostructure photodetector ultrahigh responsivity

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维持性血液透析患者并发皮肤瘙痒的影响因素及其与血清炎性因子、β2-MG的相关性

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现代生物医学进展 2024年第13期24卷 2473-2477,2416页

作者：赵景新浮金晨张东亮王世长赵海岳北京市昌平区中西医结合医院肾病科北京102208 首都医科大学附属北京积水潭医院肾内科北京100035

目的:探讨维持性血液透析患者并发皮肤瘙痒的影响因素及其与血清炎性因子、β2-MG的相关性。方法:选择2019年1月至2023年12月来我院诊治的维持性血液透析患者100例,对比有瘙痒及无瘙痒患者的一般资料及实验室指标水平,有统计学意义的指... 详细信息

目的:探讨维持性血液透析患者并发皮肤瘙痒的影响因素及其与血清炎性因子、β2-MG的相关性。方法:选择2019年1月至2023年12月来我院诊治的维持性血液透析患者100例,对比有瘙痒及无瘙痒患者的一般资料及实验室指标水平,有统计学意义的指标进行Logistic分析。根据5D-IS量表评估有瘙痒者的评分,根据评分将瘙痒者者分为轻度、中度及重度组,对比三组患者的血清炎性因子、β2-MG水平。给予皮肤瘙痒组患者普瑞巴林治疗,分析治疗效果,对比治疗前后有效组、无效组的血清β2-MG、CRP、TNF-α、IL-6水平。结果:皮肤瘙痒组年龄、透析前血肌酐水平、透析龄、钙磷乘积、血磷水平、甲状旁腺激素水平、皮肤干燥患病情况、血清β2-MG、CRP、TNF-α、IL-6水平明显较无瘙痒组的高,SF水平、Kt/V≥1.2占比明显比无瘙痒组低(P0.05);治疗后有效组以上指标明显较无效组低(P<0.05)。结论:维持性血液透析患者并发皮肤瘙痒的危险因素包括年龄≥60岁、透析龄≥1年、钙磷乘积≥65(mg^(2)/dl^(2))、Kt/V<1.2、甲状旁腺激素水平≥300 pg/mL、皮肤干燥患病、血清β2-MG≥4.06 mg/L、血清CRP≥10 mg/L、血清TNF-α≥1.54ng/mL、血清IL-6≥0.46 ng/L,血清CRP、TNF-α、IL-6、β2-MG与维持性血液透析患者并发皮肤瘙痒严重程度及预后相关。

关键词：维持性血液透析皮肤瘙痒严重程度危险因素炎症因素 β2-MG

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土壤和地下水中重金属污染物迁移模型:以某有色金属冶炼厂为例

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Journal of Central South University 2024年第4期31卷 1092-1106页

作者：张海丽赵鹏高文艳肖保华杨雪枫宋磊冯翔郭林陆永平李海峰孙静 State Key Laboratory of Environmental Geochemistry Institute of GeochemistryChinese Academy of SciencesGuiyang 550081China College of Earth and Planetary Sciences University of Chinese Academy of SciencesBeijing 101408China School of Metallurgy and Environment Central South UniversityChangsha 410083China Henan Academy of Geology Zhengzhou 450001China China Railway Seventh Bureau Group Nanjing Engineering Co. Ltd.Nanjing 210000China

冶炼厂表层土壤重金属污染严重。由于数据采集和计算量的限制,大多数数值模拟将土壤和地下水分开,这与实际情况不符。本文以某冶炼厂为研究对象,将土壤和地下水视为一个整体系统,建立了土壤-地下水反应性溶质迁移三维耦合数值模型,以定... 详细信息

冶炼厂表层土壤重金属污染严重。由于数据采集和计算量的限制,大多数数值模拟将土壤和地下水分开,这与实际情况不符。本文以某冶炼厂为研究对象,将土壤和地下水视为一个整体系统,建立了土壤-地下水反应性溶质迁移三维耦合数值模型,以定量表征重金属在土壤和地下水中的迁移规律。模型采用反应系数(λ)和滞留系数(R)来描述重金属的释放和吸附能力。模型结果与现场实际污染分布一致,表明土壤-地下水修复技术对严重污染土壤和局部污染地下水均有良好的修复效果。所构建的土壤-地下水反应性溶质迁移三维耦合模型很好地描述和预测研究地点重金属的分布和迁移扩散行为。

关键词：有色金属冶炼场重金属污染迁移和转化机制扩散通量预测修复技术模拟

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Enhanced optimal delaunay triangulation methods with connectivity regularization

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Applied Mathematics(A Journal of Chinese Universities) 2022年第3期37卷 453-469页

作者： hai Yong-qing GUO Yu-fei dong Mo zhao Rong-li SUN Ke-wu SHANG Fei-fei Intelligent Science and Technology Academy of CASIC Beijing 100854China Department of Mechanics and Engineering Science Peking UniversityBeijing 100871China Institute of Industry Technology Guangzhou&Chinese Academy of SciencesGuangzhou 511458China

In this paper,we study the underlying properties of optimal Delaunay triangulations(ODT)and propose enhanced ODT methods combined with connectivity *** on optimizing node positions and Delaunay triangulation iteratively,ODT methods are very effective in mesh *** paper demonstrates that the energy function minimized by ODT is nonconvex and unsmooth,thus,ODT methods suffer the problem of falling into a local minimum *** general ways that minimize the ODT energy function in terms of mathematics directly,we take an outflanking strategy combining ODT methods with connectivity regularization for this *** regularization reduces the number of irregular nodes by basic topological operations,which can be regarded as a perturbation to help ODT methods jump out of a poor local *** the enhanced ODT methods cannot guarantee to obtain a global minimum,it starts a new viewpoint of minimizing ODT energy which uses topological operations but mathematical *** in terms of practical effect,several experimental results illustrate the enhanced ODT methods are capable of improving the mesh furtherly compared to general ODT methods.

关键词： mesh optimization connectivity regularization ODT methods triangular mesh

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Trifunctional robust electrocatalysts based on 3D Fe/N-doped carbon nanocubes encapsulating Co4N nanoparticles for efficient battery-powered water electrolyzers

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Carbon Energy 2024年第6期6卷 124-139页

作者： Hyung Wook Choi Hongdae Lee Jun Lu Seok Bin Kwon dong In Jeong Beum Jin Park Jiwon Kim Bong Kyun Kang Gun Jang Dae Ho Yoon Ho Seok Park SKKU Advanced Institute of Nano Technology(SAINT) Sungkyunkwan UniversitySuwon-siGyeonggi-doRepublic of Korea School of Chemical Engineering Sungkyunkwan UniversitySuwon-siGyeonggi-doRepublic of Korea School of Advanced Materials Science and Engineering Sungkyunkwan UniversitySuwon-siGyeonggi-doRepublic of Korea Department of Electronic Materials Devicesand Equipment EngineeringSoonchunhyang UniversityAsan CityChungnamRepublic of Korea SKKU Institute of Energy Science and Technology(SIEST) Sungkyunkwan UniversitySuwon-siGyeonggi-doRepublic of Korea Department of Health Sciences and Technology Samsung Advanced Institute for Health Sciences and Technology(SAIHST)Sungkyunkwan UniversitySuwonRepublic of Korea

Herein,we have designed a highly active and robust trifunctional electrocatalyst derived from Prussian blue analogs,where Co_(4)N nanoparticles are encapsulated by Fe embedded in N-doped carbon nanocubes to synthesize hierarchically structured Co_(4)N@Fe/N-C for rechargeable zinc-air batteries and overall water-splitting *** confirmed by theoretical and experimental results,the high intrinsic oxygen reduction reaction,oxygen evolution reaction,and hydrogen evolution reaction activities of Co_(4)N@Fe/N-C were attributed to the formation of the heterointerface and the modulated local electronic ***,Co_(4)N@Fe/N-C induced improvement in these trifunctional electrocatalytic activities owing to the hierarchical hollow nanocube structure,uniform distribution of Co_(4)N,and conductive encapsulation by Fe/***,the rechargeable zinc-air battery with Co_(4)N@Fe/N-C delivers a high specific capacity of 789.9 mAh g-1 and stable voltage profiles over 500 ***,the overall water electrolyzer with Co_(4)N@Fe/N-C achieved better durability and rate performance than that with the Pt/C and IrO2 catalysts,delivering a high Faradaic efficiency of 96.4%.Along with the great potential of the integrated water electrolyzer powered by a zinc-air battery for practical applications,therefore,the mechanistic understanding and active site identification provide valuable insights into the rational design of advanced multifunctional electrocatalysts for energy storage and conversion.

关键词： battery-powered electrolyzers hierarchical structure Prussian blue analog trifunctional electrocatalyst zinc-air battery

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Effects of biofertilizer and water-saving irrigation interactions on the leaf photosynthesis and plant growth of tomatoes

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International Journal of Agricultural and Biological Engineering 2024年第2期17卷 177-185页

作者： Danyan Chen Yuchun Ai Peizhe Li Yue dong hailing Li Changyi Wang Xiaorui Jiang Shilong Li Yan Shen Aijun Dai Yuanyuan Feng College of Horticulture Jinling Institute of TechnologyNanjing 210038China Co-Innovation Center for Sustainable Forestry in Southern China College of Forestry and GrasslandCollege of Soil and Water ConservationNanjing Forestry UniversityNanjing 210037China Institute of Agricultural Resources and Environment Jiangsu Academy of Agricultural SciencesNanjing 210014China Agriculture Exchange and Cooperation Center of Shandong Province Jinan 250100China Murdoch Applied Innovation Nanotechnology Research Group College of ScienceHealthEngineering and EducationMurdoch UniversityPerthWA 5150Australia

Irrigation and fertilizer interaction is an efficient cultivation management strategy for facility ***,the effects of irrigation and fertilizer management on tomato growth and its physiological factors remain *** this study,two irrigation patterns(W1,conventional irrigation;W2,water-saving irrigation)and four fertilizer application patterns(CF,chemical fertilizer;BOF,biological organic fertilizer;NPK,nutrient compound fertilizer;BOF+NPK)were selected to observe the effects of their interaction on cherry tomato plant growth,leaf photosynthesis and fruit quality through pot *** results showed that W2 treatments promoted plant height growth compared to W1 under the same fertilizer ***,irrigation and fertilizer management had significant effects on net photosynthetic rate,intercellular oxidation concentration,stomatal conductance and transpiration rate at the first sequence flowering and fruiting *** maximum tomato plant height(99.0 cm)was achieved under the irrigation and fertilizer pattern of BOF and W2,along with the highest fruit yield of 1.98 kg/plant,which was approximately 31.1%higher than the minimum yield under the combined CF and W2 *** W2 treatments,the application of either NPK or BOF increased the soluble sugar content of *** structural equation models showed that the soil alkali hydrolyzed nitrogen could directly significantly affect the yield and soluble *** findings suggest that optimization of irrigation-fertilizer interactions positively regulates tomato growth,providing an efficient model for tomato irrigation and fertilizer management and a reference for sustainable development of facility agriculture.

关键词： irrigation-fertilization interaction cherry tomato plant height leaf photosynthesis fruit yield and quality

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Safety and efficacy of a programmed cell death 1 inhibitor combined with oxaliplatin plus S-1 in patients with Borrmann large type III and IV gastric cancers

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World Journal of Gastrointestinal Oncology 2024年第4期16卷 1281-1295页

作者： Zhe-Han Bao Can Hu Yan-Qiang Zhang Peng-Cheng Yu Yi Wang Zhi-Yuan Xu Huan-Ying Fu Xiang-dong Cheng Department of Interventional Radiology Zhejiang Cancer HospitalHangzhou 310004Zhejiang ProvinceChina Department of Gastric Surgery Zhejiang Cancer HospitalHangzhou 310022Zhejiang ProvinceChina Department of Colonic Surgery Jinhua Central HospitalJinhua 321000Zhejiang ProvinceChina Department of Breast Surgery Lin’an People’s HospitalHangzhou 311300Zhejiang ProvinceChina

BACKGROUND Gastric cancer(GC)is the fifth most common and the fourth most lethal malignant tumour in the *** patients are already in the advanced stage when they are diagnosed,which also leads to poor overall *** effect of posto-perative adjuvant chemotherapy for advanced GC is unsatisfactory with a high rate of distant metastasis and local *** To investigate the safety and efficacy of a programmed cell death 1(PD-1)inhibitor combined with oxaliplatin and S-1(SOX)in the treatment of Borrmann large type III and IV *** A retrospective analysis(IRB-2022-371)was performed on 89 patients with Borrmann large type III and IV GCs who received neoadjuvant therapy(NAT)from January 2020 to December *** to the different neoadjuvant treatment regimens,the patients were divided into the SOX group(61 patients)and the PD-1+SOX(P-SOX)group(28 patients).RESULTS The pathological response(tumor regression grade 0/1)in the P-SOX group was significantly higher than that in the SOX group(42.86%vs 18.03%,P=0.013).The incidence of ypN0 in the P-SOX group was higher than that in the SOX group(39.29%vs 19.67%,P=0.05).The use of PD-1 inhibitors was an independent factor affecting tumor regression ***,the use of PD-1 did not increase postoperative complications or the adverse effects of *** A PD-1 inhibitor combined with SOX could significantly improve the rate of tumour regression during NAT for patients with Borrmann large type III and IV GCs.

关键词： Neoadjuvant therapy Immunotherapy Gastric cancer Borrmann type Tumor regression grade

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