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超声对相转化膜结构和性能的影响

高分子材料科学与工程 2014年第10期30卷 49-52页

作者：屈婷曹兵叶展宏潘凯北京化工大学教育部碳纤维及功能高分子材料重点实验室材料科学与工程学院北京100029

研究了不同超声条件下所制备的聚偏氟乙烯(PVDF)膜的结构和性能。通过傅里叶全反射红外光谱、扫描电子显微镜、广角X射线衍射仪等对所制备的PVDF膜结构和形貌进行了表征。结果表明,超声场的加入在保证膜截留率的同时,能够显著提高PVDF... 详细信息

研究了不同超声条件下所制备的聚偏氟乙烯(PVDF)膜的结构和性能。通过傅里叶全反射红外光谱、扫描电子显微镜、广角X射线衍射仪等对所制备的PVDF膜结构和形貌进行了表征。结果表明,超声场的加入在保证膜截留率的同时,能够显著提高PVDF膜的通量。超声条件为(100kHz/300W)时,膜水通量和玫瑰红水溶液(10mg/L)通量提高幅度较大,分别提高了46.1%和43.4%,并且截留率仍保持在80.0%左右。超声辅助相转化过程中,PVDF有部分β晶型向α晶型转变。

关键词：超声辅助相转化聚偏氟乙烯

旋毛虫诱导的非特异性免疫对伯氏疟原虫感染小鼠小肠组织免疫反应的调节

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中华地方病学杂志 2020年第5期39卷 332-338页

作者：梅旭叶展鸿吕芳丽广州中医药大学青蒿研究中心广州中医药大学科技园 510405 中山大学中山医学院寄生虫学教研室广州510080 中山大学热带病防治研究教育部重点实验室广州510080 广东省媒介生物防控工程技术研究中心广州510080

目的探讨旋毛虫(Trichinella spiralis,Ts)诱导的非特异性免疫对伯氏疟原虫(Plasmodium berghei,Pb)ANKA感染小鼠小肠组织免疫反应的调节作用.方法36只SPF级雌性昆明小鼠(6~8周龄,体重为18~22 g),按体重采用随机数字表法分成4组,分别为... 详细信息

目的探讨旋毛虫(Trichinella spiralis,Ts)诱导的非特异性免疫对伯氏疟原虫(Plasmodium berghei,Pb)ANKA感染小鼠小肠组织免疫反应的调节作用.方法36只SPF级雌性昆明小鼠(6~8周龄,体重为18~22 g),按体重采用随机数字表法分成4组,分别为对照组、Ts单感染组(Ts组)、PbANKA单感染组(Pb组)、Ts与PbANKA共感染组(Ts+Pb组),每组9只.小鼠正常进食、饮水,普通饲料喂养.对照组不做任何实验处理;Ts组在实验第1天经口感染20条Ts幼虫;Pb组在实验第9天经腹腔注射感染1×106个寄生PbANKA的红细胞;Ts+Pb组在实验第1天经口感染20条Ts幼虫,第9天经腹腔注射感染1×106个寄生PbANKA的红细胞.于感染Ts后第22天和/或感染PbANKA后第13天剖杀小鼠,采用透射电镜观察各组小鼠腹腔巨噬细胞的形态变化;采用实时荧光定量PCR(qRT-PCR)检测各组小鼠小肠组织M1型巨噬细胞标记物[诱导型一氧化氮合酶(iNOS)、白细胞介素-6(IL-6)]以及M2型巨噬细胞标记物[C型甘露糖受体2(Mrc-2)、类几丁质酶3(Ym1)]mRNA表达水平,并比较M2/M1型巨噬细胞标记物mRNA表达水平的比值.结果透射电镜观察发现,对照组小鼠腹腔巨噬细胞形态结构正常;Ts组小鼠腹腔巨噬细胞呈现较多伪足;Pb、Ts+Pb组小鼠腹腔巨噬细胞除呈现较多伪足外,并吞噬有疟原虫.4组小鼠小肠组织iNOS(1.000±0.290、1.277±0.251、3.088±1.110、2.604±0.773)、IL-6 mRNA表达水平(1.000±0.393、2.180±0.629、1.650±0.612、3.242±1.780)比较,差异有统计学意义(F=12.420、5.270,P均<0.05).与对照组比较,Pb、Ts+Pb组iNOS mRNA表达水平明显升高(P均<0.05);与Ts组比较,Ts+Pb组iNOS mRNA表达水平明显升高(P<0.05).与对照组比较,Ts+Pb组IL-6 mRNA表达水平明显升高(P<0.05).4组小鼠小肠组织Mrc-2、Ym1 mRNA表达水平比较,差异有统计学意义(F=9.890、20.500,P均<0.05).Ts+Pb组Mrc-2 mRNA表达水平明显高于对照、Ts、Pb组(P均<0.05).Pb组Ym1 mRNA表达水平明显高于对照组(P<0.05);Ts+Pb组Ym1 mRNA表达水平明显高于对照、Ts、Pb组(P均<0.05).4组小鼠小肠组织Mrc-2/iNOS、Ym1/iNOS比较,差异有统计学意义(F=3.642、22.360,P均<0.05).Ts+Pb组Mrc-2/iNOS明显高于对照、Pb组(P均<0.05).Ts+Pb组Ym1/iNOS高于对照、Ts、Pb组(P均<0.05).结论Ts诱导的宿主非特异性免疫参与PbANKA感染小鼠肠道免疫应答的调节,并促使其小肠组织巨噬细胞向M2型极化.

关键词：小鼠小肠巨噬细胞伯氏疟原虫旋毛虫

Uncertainty in TC Maximum Intensity with Fixed Ratio of Surface Exchange Coefficients for Enthalpy and Momentum

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Journal of Meteorological Research 2022年第1期36卷 128-139页

作者： Hexin ye zhanhong MA Jianfang FEI College of Meteorology and Oceanography National University of Defense TechnologyChangsha 410005

The classical tropical cyclone(TC)maximum intensity theory of Emanuel suggests that the maximum azimuthal wind of TC depends linearly on the ratio of surface exchange coefficients for enthalpy and momentum(C_(k)and C_(d)).In this study,a series of sensitivity experiments are conducted with the three-dimensional Cloud Model 1(CM1),by fixing the ratio of C_(k)/C_(d)but varying the specific values of C_(k)and C_(d)*** results show significant variations in the simulated TC maximum intensity by varying C_(k)and C_(d),even if their ratio is ***,the maximum intensity increases steadily with increasing C_(k)and C_(d)when their value is smaller than 1.00×10^(-3),and then this increasing trend slows down with further increases in the *** previous theoretical frameworks—one based on gradient wind balance and the other incorporating the unbalanced terms-are applied to calculate the maximum potential intensity(PI).The calculated value of the former shows little variation when varying the specific values of C_(k)and C_(d),while the latter shows larger values with increases in both C_(k)and C_(d).Further examination suggests that the unbalanced effect plays a key role in contributing to the increasing intensity with increasing C_(k)and C_(d).

关键词： tropical cyclone maximum intensity surface exchange coefficients unbalanced effect

S100钙结合蛋白A8在人慢性牙周炎牙龈组织巨噬细胞中表达的研究

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口腔医学 2020年第6期40卷 486-490,495页

作者：刘利思杨婷叶展鸿孙澎王刚黄世光暨南大学口腔医学院口腔内科教研室广东广州510632 中山大学中山医学院寄生虫学教研室广东广州510080 暨南大学第二临床医学院深圳市人民医院口腔医学中心广东深圳518020 中山大学附属中山医院口腔分院牙体牙髓病科广东中山528404

目的观察S100钙结合蛋白A8(S100 calcium binding protein A8,S100A8)在人慢性牙周炎牙龈组织中巨噬细胞上的表达情况,探讨S100A8在慢性牙周炎发病机制中的作用。方法将60例受试者牙龈组织标本按牙周炎的病变程度分为3组:正常对照组20... 详细信息

目的观察S100钙结合蛋白A8(S100 calcium binding protein A8,S100A8)在人慢性牙周炎牙龈组织中巨噬细胞上的表达情况,探讨S100A8在慢性牙周炎发病机制中的作用。方法将60例受试者牙龈组织标本按牙周炎的病变程度分为3组:正常对照组20例、轻度牙周炎组20例、重度牙周炎组20例。组织标本经4%多聚甲醛溶液固定,包埋、切片、HE染色。各组标本在光学显微镜下观察其组织学变化;经免疫荧光双染色(double immunofluorescence,DIF),在荧光显微镜下观察S100A8在巨噬细胞的表达情况并计算。结果与正常对照组比较,人慢性牙周炎牙龈组织中CD68-S100A8双阳性细胞表达水平均显著升高(P<0.05);重度牙周炎组CD68-S100A8双阳性细胞数明显高于轻度牙周炎组(P<0.05)。结论CD68-S100A8双阳性细胞与人慢性牙周炎的发生、发展及致病机制有关。

关键词：慢性牙周炎巨噬细胞 S100钙结合蛋白A8 免疫荧光双染色

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金线莲发酵液的抗氧化和美白功效研究

日用化学工业（中英文） 2024年第6期54卷 656-662页

作者：陈来成陈冬杰邹洁丁红叶宇鹏杨占红广州麻尚会生物科技有限公司广东广州510800 福建靖芝莲生物科技有限公司福建漳州363600 中南大学化学化工学院湖南长沙410083

为开发金线莲发酵提取物在化妆品领域的应用,筛选合适的乳酸菌与酵母菌,对金线莲水提液与水提后滤渣酶解液分别进行发酵,结果表明:在采用Gb-12、Mls-34与CC-1三种菌株进行不同的单菌、复合菌发酵方式中,金线莲水提液经Mls-34与CC-1联合... 详细信息

为开发金线莲发酵提取物在化妆品领域的应用,筛选合适的乳酸菌与酵母菌,对金线莲水提液与水提后滤渣酶解液分别进行发酵,结果表明:在采用Gb-12、Mls-34与CC-1三种菌株进行不同的单菌、复合菌发酵方式中,金线莲水提液经Mls-34与CC-1联合发酵后,其多酚含量、抗氧化活性与美白活性提升最高。金线莲酶解液经CC-1单菌发酵后,其多酚含量提升最高,DPPH自由基与ABTS自由基清除率分别提高了56.30%和85.58%,而羟自由基清除率和总还原力有所下降,而金线莲酶解液经Mls-34与CC-1联合发酵后,其美白活性提升最高。

关键词：金线莲发酵液化妆品抗氧化美白

Raman imaging-assisted customizable assembly of MOFs on cellulose aerogel

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Nano Research 2022年第3期15卷 2599-2607页

作者： zhanhong Yuan Dingding Meng Yingzhu Wu Guangqing Tang Ping Liang John HXin Dongdong ye School of Textile Materials and Engineering Wuyi UniversityJiangmen 529020China School of Applied Physics and Materials Wuyi UniversityJiangmen 529020China Institute of Textiles&Clothing The Hong Kong Polytechnic UniversityHung HomKowloonHong KongChina

Because of a weak interface-bonding force between metal–organic frameworks(MOFs)and substrates and the loss of customization in structural designs owing to the lack of the regulation of ion sites,MOFs tend to escape from the constructed composite *** this study,the as-prepared 2,2,6,6-tetramethylpiperidyl-1-oxyl(TEMPO)-oxidized algae cellulose nanofibers(TACFs)were used to chelate metal ions at controllable sites and subsequently firmly entangle the assembled MOF *** distribution of ions and synthesized MOFs inside the gel was monitored using Raman imaging technology,which provided an intuitive approach for visually observing the ions and MOF *** this technology,the synthesized customizable TACFs@ZIF-67 aerogels exhibited a high specific surface area(734.7 m^(2)/g),low density(6.18 mg/cm^(3)),controlled particle distribution,good underwater structural stability,and excellent adsorption of *** study provides a way for solving the dispersion problem of MOFs in nanofibrous aerogels using Raman imaging technology–assisted microcosmic fixed-point design.

关键词： cellulose nanofiber aerogel Raman imaging ion distribution metal–organic framework

Long-duration chemotherapy,switch to endocrine therapy or watch only? A single-center retrospective study of metastasis breast cancer with ER/PR(+) and CerbB2(-)

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Long-duration chemotherapy,switch to endocrine therapy or wa...

Impaired Parahippocampal Gyrus-Orbitofrontal Cortex Circuit Associated with Visuospatial Memory Deficit as a Potential Biomarker and Interventional Approach for Alzheimer Disease

2013华东胸部肿瘤论坛暨第六届浙江省胸部肿瘤论坛

作者： Jian Huang Weiwu ye zhanhong chen Xiaojia Wang Department of Breast Oncology Zhejiang Cancer Hospital

[Backgound]To evaluate the efficiency of long-duration chemotherapy used Capecitabine or switch to endocrine therapy in metastasis breast cancer(MBC) patients with ER/PR(+) and CerbB2(-).[Methods]We retrospectively analyzed 112 patients of our center from 01/Jan/2009 to 30/April/2012,who with ER/PR(+) and CerbB2(-) *** these patients accepted capecitabine -based regimen as first-line or 2nd-line *** regimens included long-duration chemotherapy(LC) used capecitabine,switch to endocrine therapy (STET) or watch only(WO) were given after capecitabine-based *** compared the differences among these three regimens.[Results]In these patients,the median age is 49 years old.70/112 were first-line chemotherapy,52/112 were 2nd-line *** these patients used capecitabine-based regimen(include single-agent or in combination with another chemotherapy drug),and the response were:CR,PR,SD≥24 weeks.29 patients were LC,28 patients were STET and 55 patients were WO after capecitabine-based *** median progression-free survival(mPFS) was 7 months,one year survival rate was 32.0%,response rate (RR) was 35.7%(95%CI:26.9%to 45.3%) in all these *** mPFS were 22 months, 12 months and 5 months in LC group,STET group and WO group *** one year survival rate were 67.6%,46.5%and 5.1%in these three groups *** group was significantly worse than LC and STET groups on mPFS(Pyear survival rate(Pyear survival rate(P=0.5012).The RR were 51.7%(95%CI:32.5%to 70.6%),39.3%(95%CI: 21.5%to 59.4%) and 25.5%(95%CI:14.7%to 39.0%) in these three groups *** group was significant better than WO group(P=0.0287).No significance different between LC and STET groups(P=0.4287) or STET groups and WO group(P=0.2145).[Conclusions]Long-duration treatment is significant better than watch only(WO).Patients with ER/PR(+) and CerbB2 (-

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Neuroscience Bulletin 2020年第8期36卷 831-844页

作者： Lin Zhu Zan Wang zhanhong Du Xinyang Qi Hao Shu Duan Liu Fan Su Qing ye Xuemei Liu Zheng Zhou Yongqiang Tang Ru Song Xiaobin Wang Li Lin Shijiang Li Ying Han Liping Wang Zhijun Zhang Department of Neurology Affiliated ZhongDa HospitalSchool of MedicineSoutheast UniversityNanjing 210009China Shenzhen Key Laboratory of Neuropsychiatric Modulation Guangdong Provincial Key Laboratory of Brain Connectome and BehaviorChinese Academy of Science(CAS)Key Laboratory of Brain Connectome and Manipulationthe Brain Cognition and Brain Disease Institute(BCBDI)Shenzhen Institutes of Advanced TechnologyChinese Academy of SciencesShenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research InstitutionsShenzhen 518055China Laboratory Animal Center Southeast UniversityNanjing 210009China Department of Neurology Xuan Wu Hospital of Capital Medical UniversityBeijing 100053China Department of Biophysics Medical College of WisconsinMilwaukeeWI 53226USA University of the Chinese Academy of Sciences Beijing 100049China Beijing Institute of Geriatrics BeijingChina National Clinical Research Center for Geriatric Disorders BeijingChina Center of Alzheimer’s Disease Beijing Institute for Brain DisordersBeijingChina

The parahippocampal gyrus-orbitofrontal cortex(PHG-OFC)circuit in humans is homologous to the postrhinal cortex(POR)-ventral lateral orbitofrontal cortex(vlOFC)circuit in *** are associated with visuospatial malfunctions in Alzheimer’s disease(AD).However,the underlying mechanisms remain to be *** this study,we explored the relationship between an impaired POR-vlOFC circuit and visuospatial memory deficits through retrograde tracing and in vivo local field potential recordings in 5XFAD mice,and investigated alterations of the PHG-OFC circuit by multi-domain magnetic resonance imaging(MRI)in patients on the AD *** demonstrated that an impaired glutamatergic POR-vlOFC circuit resulted in deficient visuospatial memory in 5XFAD ***,MRI measurements of the PHG-OFC circuit had an accuracy of 77.33%for the classification of amnestic mild cognitive impairment converters versus ***,the PHG-OFC circuit explains the neuroanatomical basis of visuospatial memory deficits in AD,thereby providing a potential predictor for AD progression and a promising interventional approach for AD.

关键词： Alzheimer’s disease Amnestic mild cognitive impairment Postrhinal cortex Visuospatial memory Ventral lateral orbitofrontal cortex Uncinate fasciculus

TMS320C67x的信号处理系统USB接口扩展实现

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计算机工程与应用 2005年第16期41卷 100-102,126页

作者：骆展鸿冯穗力叶梧华南理工大学电子与信息学院广州510641

文章首先介绍了EZ-USBFX系列USB控制器的通用可编程接口(GPIF)和TMS320C67x系列DSP的主机口(HPI)的性能特点,提出了一种利用这两个接口实现USB控制器与DSP之间通信的实现方案,并讨论了GPIF接口的USB固件编程。

关键词： USB控制器与DSP通信 GPIF接口 HPI接口固件鳊程