Impaired Parahippocampal Gyrus-Orbitofrontal Cortex Circuit Associated with Visuospatial Memory Deficit as a Potential Biomarker and Interventional Approach for Alzheimer Disease

作     者：Lin Zhu Zan Wang Zhanhong Du Xinyang Qi Hao Shu Duan Liu Fan Su Qing Ye Xuemei Liu Zheng Zhou Yongqiang Tang Ru Song Xiaobin Wang Li Lin Shijiang Li Ying Han Liping Wang Zhijun Zhang Lin Zhu;Zan Wang;Zhanhong Du;Xinyang Qi;Hao Shu;Duan Liu;Fan Su;Qing Ye;Xuemei Liu;Zheng Zhou;Yongqiang Tang;Ru Song;Xiaobin Wang;Li Lin;Shijiang Li;Ying Han;Liping Wang;Zhijun Zhang

作者机构：Department of NeurologyAffiliated ZhongDa HospitalSchool of MedicineSoutheast UniversityNanjing 210009China Shenzhen Key Laboratory of Neuropsychiatric ModulationGuangdong Provincial Key Laboratory of Brain Connectome and BehaviorChinese Academy of Science(CAS)Key Laboratory of Brain Connectome and Manipulationthe Brain Cognition and Brain Disease Institute(BCBDI)Shenzhen Institutes of Advanced TechnologyChinese Academy of SciencesShenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research InstitutionsShenzhen 518055China Laboratory Animal CenterSoutheast UniversityNanjing 210009China Department of NeurologyXuan Wu Hospital of Capital Medical UniversityBeijing 100053China Department of BiophysicsMedical College of WisconsinMilwaukeeWI 53226USA University of the Chinese Academy of SciencesBeijing 100049China Beijing Institute of GeriatricsBeijingChina National Clinical Research Center for Geriatric DisordersBeijingChina Center of Alzheimer’s DiseaseBeijing Institute for Brain DisordersBeijingChina 

出 版 物：《Neuroscience Bulletin》 (神经科学通报（英文版）)

年 卷 期：2020年第36卷第8期

页      面：831-844页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100203[医学-老年医学] 10[医学] 

基　　金：Supported by the National Natural Science Foundation of China (81420108012,81671046,91832000,and 31700936) the Program of Excellent Talents in Medical Science of Jiangsu Province,China (JCRCA2016006) a Special Project of Clinical Medicine Science and Technology in Jiangsu Province,China (BL2014077) a Guangdong Province Grant (2017A030310496) Key-Area Research and Development Program of Guangdong Province,China (2018B030331001) a National Special Support Grant (W02020453) Guangdong Provincial Key Laboratory of Brain Connectome and Behavior (2017B030301017) 

主　　题：Alzheimer’s disease Amnestic mild cognitive impairment Postrhinal cortex Visuospatial memory Ventral lateral orbitofrontal cortex Uncinate fasciculus 

摘      要：The parahippocampal gyrus-orbitofrontal cortex(PHG-OFC)circuit in humans is homologous to the postrhinal cortex(POR)-ventral lateral orbitofrontal cortex(vlOFC)circuit in *** are associated with visuospatial malfunctions in Alzheimer’s disease(AD).However,the underlying mechanisms remain to be *** this study,we explored the relationship between an impaired POR-vlOFC circuit and visuospatial memory deficits through retrograde tracing and in vivo local field potential recordings in 5XFAD mice,and investigated alterations of the PHG-OFC circuit by multi-domain magnetic resonance imaging(MRI)in patients on the AD *** demonstrated that an impaired glutamatergic POR-vlOFC circuit resulted in deficient visuospatial memory in 5XFAD ***,MRI measurements of the PHG-OFC circuit had an accuracy of 77.33%for the classification of amnestic mild cognitive impairment converters versus ***,the PHG-OFC circuit explains the neuroanatomical basis of visuospatial memory deficits in AD,thereby providing a potential predictor for AD progression and a promising interventional approach for AD.