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Identification of Prognostic Genes for Colon Cancer through Gene Coexpression Network Analysis

Current Medical Science 2021年第5期41卷 1012-1022页

作者： Dan-wen WANG zhang-shuo yang Jian XU Li-jie yang Tie-cheng yang Hua-qiao WANG Mao-hui FENG Fei SU Department of Gastrointestinal Surgery Zhongnan Hospital of Wuhan UniversityWuhan 430071China Key Laboratory of Tumor Biological Behavior of Hubei Province Wuhan 430071China Centerfor Clinical Medicine of Peritoneal Cancer of Wuhan Wuhan 430071China Clinical Cancer Study Center of Hubei Province Wuhan 430071China Department of Pathology Zhongnan Hospital of Wuhan UniversityWuhan 430071China Department of Oncology the First Hospital of Lanzhou UniversityLanzhou 730000Chin

Objective:The present study was aimed to identify novel key genes,prognostic biomarkers and molecular pathways implicated in tumorigenesis of colon ***:The microarray data GSE41328 containing 10 colon cancer samples and 10 adjacent normal tissues was analyzed to identify 4763 differentially expressed ***,another microarray data GSE17536 was performed for weighted gene co-expression network analysis(WGCNA).Results:In present study,12 co-expressed gene modules associated with tumor progression were identified for further *** red module showed the highest association with pathological stage by Pearson's correlation *** enrichment analysis revealed that genes in red module focused on cell division,cell proliferation,cell cycle and metabolic related ***,a total of 26 key hub genes were identified,and GEPIA database was subsequently selected for *** junction-recognizing protein(HJURP)and cell division cycle 25 homolog C(CDC25C)were identified as effective prognosis biomarkers,which were all detrimental to *** set enrichment analyses(GSEA)found the two hub genes were enriched in“oocyte meiosis”,“oocyte maturation that are progesterone-mediated”,“p53 signaling pathway”,and“cell cycle”.Furthermore,the immunohistochemistry and western blotting showed that HJURP was highly expressed in colon cancer ***:HJURP was identified as a key gene associated with colon cancer progression and prognosis by WGCNA,which might influence the prognosis by regulating cell cycle pathways.

关键词： colon cancer biomarkers weighted gene co-expression network analysis prognosis pathological stage

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Process e~-γ→e~-H in Littlest Higgs Model

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Communications in Theoretical Physics 2006年第11期46卷 891-894页

作者： YUE Chong-Xing,~+ zhang Feng, yang shuo, and SUN Yah-Bin Department of Physics, Liaoning Normal University, Dalian 116029, China Department of Physics Liaoning Normal University Dalian 116029 China

In the context of the littlest Higgs (LH) model, we estimatc the production cross section of the process e~-γ→e~-H in the future high-energy linear e~+e~- collider (IL C) with the center-of-mass (CM) energy S=500 *** numerical results show that the contributions of the LH model to this process are very small in most of the parameter space allowed by the electroweak precision measurement data, and are very difficult to be detected in the future ILC experiments.

关键词： littlest Higgs model Higgs boson high-energy linear e~+e~- collider

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Process e^-у→ e^-H in Littlest Higgs Model

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Communications in Theoretical Physics 2006年第5X期46卷 891-894页

作者： YUE Chong-Xing zhang Feng yang shuo SUN Yan-Bin Department of Physics Liaoning Normal University Dalian 116029 China

In the context of the littlest Higgs （LH） model, we estimate the production cross section of the process e^-у→ e^-H in the future high-energy linear e^＋e^- collider （ILC） with the center-of-mass （CM） energy √S = 500 GeV. Our numerical results show that the contributions of the LH model Co this process are very small in most of the parameter space allowed by the electroweak precision measurement data, and are very diffcult to be detected in the future ILC experiments.

关键词： littlest Higgs model Higgs boson high-energy linear e^+e^- collider

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DJ-1 Alters Epirubicin-induced Apoptosis via Modulating Epirubicin-activated Autophagy in Human Gastric Cancer Cells

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Current Medical Science 2018年第6期38卷 1018-1024页

作者： Xue-kai PAN Fei SU Li-hua XU zhang-shuo yang Dan-wen WANG Li-jie yang Fan-zheng KONG Wei XIE Mao-hui FENG Department of Gastrointestinal Surgery Zhongnan Hospital of Wuhan UniversityWuhan 430071China Department of Oncology the First Hospital oJ'Lanzhou UniversityLanzhou 730000China

Epirubicin,which is a conventional chemotherapeutic drug for gastric cancer,has innate and adaptive *** studies revealed that epirubicin could induce autophagy as a defensive mechanism in drug resistance of mammary *** study implied that D J-1 may be a chemoresistance-related *** the association between D J-1 and drug resistance of epirubicin in gastric cancer is still *** the present report,we explored whether and how D J-1 conduced to epirubicin-induced apoptosis in gastric *** dose-dependently increased the expression of DJ-1 and induced *** of DJ-1 notably enhanced epirubicin-induced cell apoptosis,whereas overexpression of DJ-1 attenuated epirubicin-induced cell *** studies revealed that down-regulation of DJ-1 modulated epirubicin-activated autophagy which augmented epirubicin-induced *** conclusion,our results validated that DJ-1 reduced epirubicin-induced apoptosis in gastric cancer cells via modulating epirubicin-activated autophagy.

关键词： epirubicin gastric cancer DJ-1 apoptosis autophagy

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Integrated Equipment with Functions of Current Flow Control and Fault Isolation for Multiterminal DC Grids

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Energy Engineering 2025年第1期122卷 85-99页

作者： shuo zhang Guibin Zou School of Electrical Engineering Shandong UniversityJinan250061China Suzhou Research Institute Shandong UniversitySuzhou215123China

The multi-terminal direct current(DC)grid has extinctive superiorities over the traditional alternating current system in integrating large-scale renewable *** the DC circuit breaker(DCCB)and the current flow controller(CFC)are demanded to ensure the multiterminal DC grid to operates reliably and ***,since the CFC and the DCCB are all based on fully controlled semiconductor switches(e.g.,insulated gate bipolar transistor,integrated gate commutated thyristor,etc.),their separation configuration in the multiterminal DC grid will lead to unaffordable implementation costs and conduction power *** solve these problems,integrated equipment with both current flow control and fault isolation abilities is proposed,which shares the expensive and duplicated components of CFCs and DCCBs among adjacent *** addition,the complicated coordination control of CFCs and DCCBs can be avoided by adopting the integrated equipment in themultiterminal DC *** order to examine the current flow control and fault isolation abilities of the integrated equipment,the simulation model of a specific meshed four-terminal DC grid is constructed in the PSCAD/EMTDC ***,the comparison between the integrated equipment and the separate solution is presented a specific result or conclusion needs to be added to the abstract.

关键词： Integrated equipment multiterminal direct current grid current flow control fault isolation

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Nitrogen-cycling processes under long-term compound heavy metal(loids)pressure around a gold mine:Stimulation of nitrite reduction

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Journal of Environmental Sciences 2025年第1期147卷 571-581页

作者： Xuesong Hu Xiaoxia Liu shuo zhang Caihong Yu School of Chemical&Environmental Engineering China University of Mining and Technology(Beijing)Beijing 100083China Beijing Cultivated Land Construction and Protection Center Beijing 100020China

Mining and tailings deposition can cause serious heavy metal(loids)pollution to the surrounding soil *** microorganisms adapt their metabolism to such conditions,driving alterations in soil *** study aims to elucidate the response patterns of nitrogen-cycling microorganisms under long-term heavy metal(loids)*** results showed that the diversity and abundance of nitrogen-cyclingmicroorganisms showed negative feedback to heavy metal(loids)*** microorganisms were shown to be the dominant microorganisms with over 60%of relative abundance and a complex community structure including 27 ***,the key bacterial species in the denitrification process were calculated using a random forest model,where the top three key species(Pseudomonas stutzei,Sphingobium japonicum and Leifsonia rubra)were found to play a prominent role in nitrite *** gene analysis and qPCR revealed that nirK,which is involved in nitrite reduction,significantly accumulated in the most metal-rich soil with the increase of absolute abundance of 63.86%.The experimental results confirmed that the activity of nitrite reductase(Nir)encoded by nirK in the soil was increased at high concentrations of heavy metal(loids).Partial least squares-path model identified three potential modes of nitrite reduction processes being stimulated by heavy metal(loids),the most prominent of which contributed to enhanced nirK abundance and soil Nir activity through positive stimulation of key *** results provide new insights and preliminary evidence on the stimulation of nitrite reduction processes by heavy metal(loids).

关键词： N cycle Nitrite reduction Nitrite reductase Metagenome Key species

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A review of functions and mechanisms of clay soil conditioners and catalysts in thermal remediation compared to emerging photo-thermal catalysis

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Journal of Environmental Sciences 2025年第1期147卷 22-35页

作者： Juan zhang shuo Wang Xin Wang Wentao Jiao Minghua zhang Fujun Ma State Key Laboratory of Advanced Metallurgy School of Metallurgical and Ecological EngineeringUniversity of Science and Technology BeijingBeijing 100083China Research Center for Eco-Environmental Sciences Chinese Academy of SciencesBeijing 100085China College of Agricultural and Environmental Sciences University of CaliforniaDavisCA 95616USA State Key Laboratory of Environmental Criteria and Risk Assessment Chinese Research Academy of Environmental SciencesBeijing 100012China

High temperatures and providing sufficient time for the thermal desorption of persistent organic pollutants(POPs)from contaminated clay soils can lead to intensive energy ***,this article provides a critical review of the potential additives which can improve soil texture and increase the volatility of POPs,and then discusses their enhanced mechanisms for contributing to a green ***-based additives have been used to reduce plasticity of bentonite clay,absorb water and replenish system *** contrast,non-Ca-based additives have been used to decrease the plasticity of kaolin *** soil structure and soil plasticity can be changed through cation exchange and flocculation *** transitionmetal oxides and alkalimetal oxides can be applied to catalyze and oxidize polycyclic aromatic hydrocarbons,petroleum and emerging *** this system,reactive oxygen species(•O_(2)^(-)and•OH)are generated fromthermal excitation without strong chemical ***,multiple active ingredients in recycled solid wastes can be controlled to reduce soil plasticity and enhance thermal ***,the alkali,nano zero-valent iron and nano-TiN can catalyze hydrodechlorination of POPs under reductive ***,photo and photo-thermal catalysis are discussed to accelerate replacement of fossil fuels by renewable energy in thermal remediation.

关键词： Persistent organic contaminants Clay soils Thermal remediation Soil conditioning Synergistic catalysis

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Preparation of silver nanoparticles through the reduction of straw-extracted lignin and its antibacterial hydrogel

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 504-514页

作者： Lou zhang shuo Li Fu Tang Jingkai zhang Yuetong Kang Hean zhang Lidong Li State Key Laboratory for Advanced Metals and Materials School of Materials Science and EngineeringUniversity of Science and Technology BeijingBeijing 100083China

Silver nanoparticles(Ag NPs)have attracted attention in the field of biomaterials due to their excellent antibacterial ***,the reducing and stabilizing agents used for the chemical reduction of Ag NPs are usually toxic and may cause water *** this work,Ag NPs(31.2 nm in diameter)were prepared using the extract of straw,an agricultural waste,as the reducing and stabilizing *** analysis revealed that the straw extract contained lignin,the structure of which possesses phenolic hydroxyl and methoxy groups that facilitate the reduction of silver salts into Ag *** surfaces of Ag NPs were negatively charged due to the encapsulation of a thin layer of lignin molecules that prevented their *** the prepared Ag NPs were added to the precursor solution of acrylamide,free radical polymerization was triggered without the need for extra heating or light irradiation,resulting in the rapid formation of an Ag NP-polyacrylamide composite *** inhibition zone test proved that the composite hydrogel possessed excellent antibacterial ability due to the presence of Ag *** prepared hydrogel may have potential applications in the fabrication of biomedical materials,such as antibacterial dressings.

关键词： silver nanoparticles hydrogel straw extraction antibacterial

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Synthesis of energetic materials by microfluidics

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Defence Technology(防务技术) 2025年第2期44卷 306-319页

作者： shuo Liu Chuanyu zhang Yanlan Wang Xueyong Wei School of Mechanical Engineering Xi'an Jiaotong UniversityXi'an 710049China School of Instrument Science and Technology Xi'an Jiaotong UniversityXi'an 710049China Science and Technology on Applied Physical Chemistry Laboratory Xi'an 710061China

Energetic materials,characterized by their capacity to store and release substantial energy,hold pivotal significance in some fields,particularly in defense ***,with its ability to manipulate fluids and facilitate droplet formation at the microscale,enables precise control of chemical *** scholarly endeavors have increasingly harnessed microfluidic reactors in the realm of energetic materials,yielding morphologically controllable particles with enhanced uniformity and explosive ***,crucial insights into microfluidic-based methodologies are dispersed across various publications,necessitating a systematic ***,this review addresses this gap by concentrating on the synthesis of energetic materials through ***,the methods based on micro-mixing and droplets in the previous papers are summarized and the strategies to control the critical parameters within chemical reactions are discussed in ***,the comparison in terms of advantages and disadvantages is *** demonstrated in the last section regarding perspectives,challenges such as clogging,dead zones,and suboptimal production yields are non-ignoble in the promising fields and they might be addressed by integrating sound,optics,or electrical energy to meet heightened *** comprehensive overview aims to consolidate and analyze the diverse array of microfluidic approaches in energetic material synthesis,offering valuable insights for future research directions.

关键词： Microfluidic technology Energetic materials synthesis Micro-mixing Micro-droplets

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AAV mediated carboxyl terminus of Hsp70 interacting protein overexpression mitigates the cognitive and pathological phenotypes of APP/PS1 mice

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Neural Regeneration Research 2025年第1期20卷 253-264页

作者： Zhengwei Hu Jing yang shuo zhang Mengjie Li Chunyan Zuo Chengyuan Mao Zhongxian zhang Mibo Tang Changhe Shi Yuming Xu Department of Neurology The First Affiliated Hospital of Zhengzhou UniversityZhengzhou UniversityZhengzhouHenan ProvinceChina Academy of Medical Sciences of Zhengzhou University ZhengzhouHenan ProvinceChina NHC Key Laboratory of Prevention and treatment of Cerebrovascular Diseases The First Affiliated Hospital of Zhengzhou UniversityZhengzhou UniversityZhengzhouHenan ProvinceChina Henan Key Laboratory of Cerebrovascular Diseases The First Affiliated Hospital of Zhengzhou UniversityZhengzhou UniversityZhengzhouHenan ProvinceChina Institute of Neuroscience Zhengzhou UniversityZhengzhouHenan ProvinceChina Sino-British Research Centre for Molecular Oncology National Centre for International Research in Cell and Gene TherapySchool of Basic Medical SciencesAcademy of Medical SciencesZhengzhou UniversityZhengzhouHenan ProvinceChina Department of Gerontology The First Affiliated Hospital of Zhengzhou UniversityZhengzhou UniversityZhengzhouHenan ProvinceChina

The E3 ubiquitin ligase,carboxyl terminus of heat shock protein 70(Hsp70)interacting protein(CHIP),also functions as a co-chaperone and plays a crucial role in the protein quality control *** this study,we aimed to investigate the neuroprotective effect of overexpressed CHIP on Alzheimer’s *** used an adeno-associated virus vector that can cross the blood-brain barrier to mediate CHIP overexpression in APP/PS1 mouse *** overexpression significantly ameliorated the performance of APP/PS1 mice in the Morris water maze and nest building tests,reduced amyloid-βplaques,and decreased the expression of both amyloid-βand phosphorylated *** also alleviated the concentration of microglia and astrocytes around *** APP/PS1 mice of a younger age,CHIP overexpression promoted an increase in ADAM10 expression and inhibitedβ-site APP cleaving enzyme 1,insulin degrading enzyme,and neprilysin *** of HSP70 and HSP40,which have functional relevance to CHIP,were also *** nuclei transcriptome sequencing in the hippocampus of CHIP overexpressed mice showed that the lysosomal pathway and oligodendrocyte-related biological processes were up-regulated,which may also reflect a potential mechanism for the neuroprotective effect of *** research shows that CHIP effectively reduces the behavior and pathological manifestations of APP/PS1 ***,overexpression of CHIP could be a beneficial approach for the treatment of Alzheimer’s disease.

关键词： adeno-associated virus Alzheimer’s disease APP/PS1 mice carboxyl terminus of Hsp70 interacting protein gene therapy

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