DJ-1 Alters Epirubicin-induced Apoptosis via Modulating Epirubicin-activated Autophagy in Human Gastric Cancer Cells
作者机构：Department of Gastrointestinal SurgeryZhongnan Hospital of Wuhan UniversityWuhan 430071China Department of Oncologythe First Hospital oJ'Lanzhou UniversityLanzhou 730000China
出 版 物：《Current Medical Science》 (当代医学科学（英文）)
年 卷 期：2018年第38卷第6期
页 面：1018-1024页
核心收录：
学科分类：10[医学]
基 金：grants from the National Natural Science Foundation of China(No.81072152 and No.81770283) Natural Science Foundation of Hubei Province(No.2015CFA027) Research Foundation of Health and Family Planning Commission of Hubei Province(No.WJ2015MA010 and No.WJ2017M249) Clinical Medical Research Center of Peritoneal Cancer of Wuhan (No.2015060911020462)
主 题：epirubicin gastric cancer DJ-1 apoptosis autophagy
摘 要：Epirubicin,which is a conventional chemotherapeutic drug for gastric cancer,has innate and adaptive *** studies revealed that epirubicin could induce autophagy as a defensive mechanism in drug resistance of mammary *** study implied that D J-1 may be a chemoresistance-related *** the association between D J-1 and drug resistance of epirubicin in gastric cancer is still *** the present report,we explored whether and how D J-1 conduced to epirubicin-induced apoptosis in gastric *** dose-dependently increased the expression of DJ-1 and induced *** of DJ-1 notably enhanced epirubicin-induced cell apoptosis,whereas overexpression of DJ-1 attenuated epirubicin-induced cell *** studies revealed that down-regulation of DJ-1 modulated epirubicin-activated autophagy which augmented epirubicin-induced *** conclusion,our results validated that DJ-1 reduced epirubicin-induced apoptosis in gastric cancer cells via modulating epirubicin-activated autophagy.
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