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Synthesis and Reactivity of (β-Amino-α-acylalkenyl)phenyliodonium Salts

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有机化学 2003年第Z1期23卷 87-89页

作者： zhang peng-Fei chen Zhen-Chu Department of Chemistry Hangzhou Teachers College Zhejiang 3100362 Department of Chemistry(XiXi Campus) Zhejiang University Zhejiang 310028

　　During the last few years alkenyl(phenyl)iodonium salts have risen from mere chemical curiosities to valuable synthetic intermediates. [1] Because of an excellent leaving group ability of a phenyliodonyl moiety, alkenyl(phenyl) iodonium salts undergo nucleophilic vinyl substitutions under mild conditions, thus providing a useful route for the synthesis of various kinds of olefins. Recently, some of functionalized alkenyl iodonium salts have been prepared. [2]……

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Orexin Directly Enhances the Excitability of Globus Pallidus Internus Neurons in Rat by Co-activating OX1 and OX2 Receptors

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Neuroscience Bulletin 2017年第4期33卷 365-372页

作者： He-Ren Gao Qian-Xing Zhuang Yong-Xiao zhang zhang-peng chen Bin Li Xiao-Yang zhang Yi-Ting Zhong Jian-Jun Wang Jing-Ning Zhu State Key Laboratory of Pharmaceutical Biotechnology and Department of Biological Science and Technology School ofLife SciencesNanjing UniversityNanjing 210023China

Orexin, released from the hypothalamus, has been implicated in various basic non-somatic functions including feeding, the sleep-wakefulness cycle, emotion,and cognition. However, the role of orexin in somatic motor control is still little known. Here, using whole-cell patch clamp recording and immunostaining, we investigated the effect and the underlying receptor mechanism of orexin-A on neurons in the globus pallidus internus（GPi）,a critical structure in the basal ganglia and an effective target for deep brain stimulation therapy. Our results showed that orexin-A induced direct postsynaptic excitation of GPi neurons in a concentration-dependent *** orexin-A-induced excitation was mediated via co-activation of both OX1 and OX2 receptors. Furthermore, the immunostaining results showed that OX1 and OX2 receptors were co-localized in the same GPi neurons. These results suggest that the central orexinergic system actively modulates the motor functions of the basal ganglia via direct innervation on GPi neurons and presumably participates in somatic-non-somatic integration.

关键词： Orexin OX1 receptor OX2 receptor Globus pallidus internus Basal ganglia

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临界点视阈下民法典继承编基本原则之建构

法学杂志 2017年第10期38卷 37-48页

作者：张力陈鹏西南政法大学民商法学院重庆401120

囿于我国现行继承法对基本原则表述的文本性缺失,学界对继承法基本原则的存在形式、内容取舍与条文表述等产生了巨大争议。在法典化态势下,继承编基本原则的建构事关法典形式理性、继承本体存在之证成与政治国家之预防。继承编基本原则... 详细信息

囿于我国现行继承法对基本原则表述的文本性缺失,学界对继承法基本原则的存在形式、内容取舍与条文表述等产生了巨大争议。在法典化态势下,继承编基本原则的建构事关法典形式理性、继承本体存在之证成与政治国家之预防。继承编基本原则的建构应以继承权本体为实质取舍标准,以"线性"逻辑进路为技术支撑,并辅之以继承法律制度的临界点为制度基准,以此在继承线性法律关系的动态化模型下形成"保护私有财产继承权"和"养老育幼"的二原则体系并贯穿于整个继承法律制度,从而在桥接民法基本原则之时形成私法体系内部的板块区分效应。

关键词：民法典编纂继承法(编)基本原则 “线性”进路临界点

Correlation of CD105 and Vascular Endothelial Growth Factor in Laser-induced Choroidal Neovascularization in Rats

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眼科学报 2006年第3期22卷 166-174,183页

作者： Jianfeng Xu Yusheng Wang Xiumei Yang peng zhang Lijun chen Department of Ophthalmology Institute of Ophthalmology of Chinese PLA X~ing HospitalFourth Military Medical University XUan 710032 China

Purpose: Choroidal neovascularization (CNV) plays an important role in pathogenesis of age-related macular degeneration (AMD), ocular histoplasmosis syndrome (OHS) and so on. However, mechanisms of CNV formation are not fully understood. The aim of this study is to investigate the correlation between expressions of CD105 and vascular endothelial growth factor (VEGF) in experimental laser-induced CNV in rats. Methods: CNV model was established by 532 nm laser photocoagulation in Brown-Norway rats. The expression of CD105 and VEGF in CNV was observed by immunohistochemistry at 3, 7, 14, 21, 28 and 56 days after laser photocoagulation. The image analysis was performed with the professional software of Image-Pro Plus. Results: Fluorescein angiography showed fluorescein leakage in CNV from days 7 to 56 after photocoagulation. VEGF expression was mainly observed in vascular endothelial cells, ganglion cells, inner nuclear layers and retinal pigment epithelial cells in normal retina and vascular endothelial cells in normal choroid of the rats. On day 3 after photocoagulation, VEGF began to express in laser-induced lesions. VEGF was strongly expressed in CNV after 7 days (P0.05). CD105 was initially presented in CNV at 7 days and obviously expressed at 14 days after photocoagulation (P0.05). There was notablely direct correlation between CD105-positive-microvessel density and positively semiquantitative scoring of VEGF in the CNV(r=0.989, P<0.01). Conclusions: There is direct correlation between the expression of CD105 and VEGF in the laser-induced CNV in rat. It suggests that CD105 and VEGF might participate in the new blood vessel formation and promote the growth of CNV.

关键词： CD105 VEGF Choroidal neovascularization Brown-Norway rat

Construction of 3D porous Cu_(1.81)S/nitrogen-doped carbon frameworks for ultrafast and long-cycle life sodium-ion storage

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 191-200页

作者： chen chen Hongyu Xue Qilin Hu Mengfan Wang Pan Shang Ziyan Liu Tao peng Deyang zhang Yongsong Luo Key Laboratory of Microelectronics and Energy of Henan Province Henan Joint International Research Laboratory of New Energy Storage TechnologyCollege of Physics and Electronic EngineeringXinyang Normal UniversityXinyang 464000China School of Physics and Electronic Engineering Nanyang Normal UniversityNanyang 473061China

Transition metal sulfides have great potential as anode mterials for sodium-ion batteries(SIBs)due to their high theoretical specific ***,the inferior intrinsic conductivity and large volume variation during sodiation-desodiation processes seriously affect its high-rate and long-cyde performance,unbeneficial for the application as fast-charging and long-cycling SIBs ***,the three-dimensional porous Cu_(1.81)S/nitrogen-doped carbon frameworks(Cu_(1.81)S/NC)are synthesized by the simple and facile sol-gel and annealing processes,which can accommodate the volumetric expansion of Cu_(1.81)S nanoparticles and accelerate the transmission of ions and electrons during Na^(+)insertion/extraction processes,exhibiting the excellent rate capability(250.6 mA·g^(-1)at 20.0 A·g^(-1))and outstanding cycling stability(70% capacity retention for 6000 cycles at 10.0 A·g^(-1))for ***,the Na-ion full cells coupled with Na_(3)V_(2)(PO_(4))_(3)/C cathode also demonstrate the satisfactory reversible specific capacity of 330.5 mAh·g^(-1)at 5.0 A·g^(-1)and long-cycle performance with the 86.9% capacity retention at 2.0 A·g^(-1)after 750 *** work proposes a promising way for the conversionbased metal sulfides for the applications as fast-charging sodium-ion battery anode.

关键词： copper sulfide nanoparticles porous carbon framework fast charging long-cycle performance sodium-ion full batteries

Contribution of histamine H1 receptor to vestibular compensation

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Contribution of histamine H1 receptor to vestibular compensa...

Histamine H1 receptor in the medial vestibular nucleus contributes to vestibular compensation

中国生理学会张锡钧基金会第十四届全国青年优秀生理学学术论文交流及评奖会议、中国生理学会第十二届全国青年生理学工作者学术会议

作者： zhang-peng chen Xiao-Yang zhang Shi-Yu peng Yan-Bo Wang Yang-Xun zhang Jian-Jun Wang Jing-Ning Zhu State Key Laboratory of Pharmaceutical Biotechnology and Department of Biological Science and Technology School of Life SciencesNanjing University

Vestibular compensation is the process of natural recovery of crude postural and locomotor deficits caused by vestibular *** investigation of vestibular compensation is of great importance in both developing therapeutic strategies for vestibular disorders and understanding the functional plasticity in the adult mammalian central nervous *** decades have witnessed significant progress in revealing the role of presynaptic histamine H3 receptor in vestibular ***,betahistine,a widely used clinical drug for treatment of vestibular disorders,exerts not only antagonistic action on the presynaptic H3 receptor,but also agonistic effect on postsynaptic H1 receptor,which is abundantly expressed in the medial vestibular nucleus(MVN) and actively mediates the excitatory effect of histamine on MVN ***,we show that i) blockage of H1 receptor in the MVN aggravates static symptoms and locomotor dysfunction,and retards recovery of dynamic motor balance and coordination after unilateral labyrinthectomy(UL);ii) in early compensation,there is a remarkable increase in the expression of H1 receptor in the ipsilesional MVN;iii) the increase in the expression of H1 receptor is restrictedly to the ipsilesional MVN GABAergic rather than glutamatergic commissural neurons;iv) the excitation induced by H1 receptor activation is enhanced in the ipsilesional MVN neurons of the commissural inhibitory *** results strongly suggest that postsynaptic H1 receptor plays a critical role in the recovery of both static and dynamic vestibular symptoms after *** asymmetric activation of vestibular commissural inhibitory system mediated by H1 receptor may contribute to vestibular compensation.

关键词： vestibular compensation medial vestibular nucleus histamine H1 receptor commissural inhibitory system umlateral labyrinthectomy

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Histamine H1 receptor in the medial vestibular nucleus contr...

Glucocorticoid receptor signaling in the brain and its involvement in cognitive function

中国神经科学学会第十二届全国学术会议

作者： zhang-peng chen Xiao-Yang zhang Shi-Yu peng Yan-Bo WANG Yang-Xun zhang Jian-Jun WANG Jing-Ning ZHU State Key Laboratory of Pharmaceutical Biotechnology and Department of Biological Science and Technology School of Life Sciences Nanjing University

Vestibular compensation is responsible for the spontaneous recovery of crude postural and locomotor deficits in vestibular loss patients. Mechanistic investigation of vestibular compensation is of great importance in both developing potential therapeutic strategies for vestibular disorders and understanding the functional plasticity in the adult mammalian central nervous system. Past decades have witnessed significant progress in revealing the role of presynaptic histamine H3 receptor in vestibular compensation. However, betahistine, a widely used clinical drug for treatment of vestibular disorders, exerts not only antagonistic action on the presynaptic H3 receptor, but also agonistic effect on postsynaptic H1 receptor. Here, we show that i) blockage of histamine H1 receptor in the medial vestibular nucleus（MVN） aggravates static symptoms and locomotor dysfunction, and retards recovery of motor balance and coordination after unilateral labyrinthectomy（UL）;ii) in early compensation, there is a remarkable increase in the expression of H1 receptor in the ipsi-lesional MVN;iii) the increase in the expression of H1 receptor is restrictedly to the GABAergic commissural neurons in the ipsi-lesional MVN;iv) the excitation induced by H1 receptor activation is enhanced in the ipsi-lesional MVN neurons of the commissural inhibitory system. These results strongly suggest that postsynaptic H1 receptor plays a critical role in the recovery of both static and dynamic vestibular symptoms after UL. The asymmetric activation of vestibular commissural inhibitory system mediated by H1 receptor may contribute to vestibular compensation.

关键词： vestibular compensation medial vestibular nucleus histamine H1 receptor commissural inhibitory system unilateral labyrinthectomy

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Neural Regeneration Research 2025年第9期20卷 2520-2537页

作者： Chonglin Su Taiqi Huang Meiyu zhang Yanyu zhang Yan Zeng Xingxing chen Brain Science and Advanced Technology Institute Hubei Province Key Laboratory of Occupational Hazard Identification and ControlSchool of MedicineWuhan University of Science and TechnologyWuhanHubei ProvinceChina

The hypothalamic-pituitary-adrenal axis regulates the secretion of glucoco rticoids in response to environmental *** the brain,a nuclear receptor transcription fa ctor,the glucocorticoid recepto r,is an important component of the hypothalamicpituitary-a d renal axis's negative feedback loop and plays a key role in regulating cognitive equilibrium and *** glucoco rticoid receptor influences cognitive processes,including glutamate neurotransmission,calcium signaling,and the activation of brain-derived neurotrophic factor-mediated pathways,through a combination of genomic and non-genomic *** interactions within the central nervous system can alter the expression and activity of the glucocorticoid receptor,there by affecting the hypothalamic-pituitary-a d renal axis and stress-related cognitive *** appropriate level of glucocorticoid receptor expression can improve cognitive function,while excessive glucocorticoid receptors or long-term exposure to glucoco rticoids may lead to cognitive *** with cognitive impairment-associated diseases,such as Alzheimer's disease,aging,depression,Parkinson's disease,Huntington's disease,stroke,and addiction,often present with dysregulation of the hypothalamic-pituitary-adrenal axis and glucocorticoid receptor *** review provides a comprehensive overview of the functions of the glucoco rticoid receptor in the hypothalamic-pituitary-a d renal axis and cognitive *** emphasizes that appropriate glucocorticoid receptor signaling fa cilitates learning and memory,while its dysregulation can lead to cognitive *** provides clues about how glucocorticoid receptor signaling can be targeted to ove rcome cognitive disability-related disorders.

关键词： brain-derived neurotrophic factor calcium signaling glucocorticoid receptor glucocorticoid glutamate transmission hypothalamic-pituitary-adrenal axis long-term potentiation neurocognitive disorders neuroplasticity stress

Role of orexin in cerebellar motor-emotional integration

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Role of orexin in cerebellar motor-emotional integration