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Effectiveness of onsite and online education in enhancing knowledge and use of human immunodeficiency virus pre-and postexposure prophylaxis

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World Journal of Clinical Cases 2024年第22期12卷 5042-5050页

作者： Ying Shao Mei zhang li-Jun Sun Hong-Wei zhang An liu Xi wang Ruo-Lei Xin Jian-Wei li Jiang-Zhu Ye Yue Gao zhang-li wang Zai-Cun li Tong zhang Clinic of Center for Infection Beijing Youan HospitalCapital Medical UniversityBeijing 100069China Department of Infectious Diseases and Medical Immunology Beijing Youan HospitalCapital Medical UniversityBeijing 100069China Chinese Association of STD and AIDS Prevention and Control Beijing 100050China Institute of STD/AIDS Prevention and Control Beijing Center for Disease Prevention and ControlBeijing 100013China

BACKGROUND Enhancing awareness and use of pre-exposure prophylaxis(PrEP)and postexposure prophylaxis(PEP)is vital to curb human immunodeficiency virus(HIV)***-risk behaviors prevalent among sexually transmitted infection clinic outpatients underscore the need for increased PrEP/PEP education in this *** To investigate the effects of both onsite and online health education on the knowledge of,and willingness to use,PrEP and PEP among individuals receiving PEP *** Participants were drawn from a cohort study on PEP service intervention at an STD/AIDS outpatient clinic in designated HIV/AIDS hospitals in Beijing,conducted from January 1 to June 30,*** education was provided both onsite and online during *** assessing knowledge of,and willingness to use,PrEP/PEP were administered at baseline and again at 24 wk *** A total of 112 participants were enrolled in the study;105 completed the follow-up at week *** percentage of participants with adequate knowledge of,and willingness to use,PrEP significantly increased from 65.2%and 69.6%at baseline to 83.8%and 82.9%at the end of the intervention(both Plingness to use,PEP increased from 74.1%and 77.7%at baseline to 92.4%and 89.5%at week 24(Pline health education significantly improved the knowledge of,and increased willingness to use,PrEP and PEP in individuals utilizing PEP services.

关键词： Human immunodeficiency virus Pre-exposure prophylaxis Post-exposure prophylaxis Health education Intervention

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Improved algorithm for RDO in JPEG2000 encoder and its IC design

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Journal of Systems Engineering and Electronics 2006年第2期17卷 430-436页

作者： Xie Xiang li Cruolin zhang Chun zhang li wang Zhihua Dept. of Electronic Engineering Tsinghua Univ.Beijing 100084 P. R. China

An improved rate distortion optimization （RDO） algorithm in JPEG2000 is proposed. The proposed algorithm is suitable for integrated circuit （IC） implementation and can reduce 30% computational cost. A hardware architecture which includes control unit, memory, divider, data converter is also given to implement the algorithm. The circuit based on the improved algorithm is tested on FPGAs and integrated in a JPG2000 chip codec core.

关键词： rate distortion optimization JPEG2000 integrated circuit (IC) codec core.

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Estimation of interfacial damage in composites with reinforced particles based on ultrasonic data

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Journal of University of Science and Technology Beijing 2007年第3期14卷 280-285页

作者： Xiqiang liu Peijun Wei li zhang Hang wang Applied Science School University of Science and Technology Beijing Beijing 100083 China

The scattering of elastic waves by a spherical particle with imperfect interface and the nondestructive detection of interfacial damage were studied. First, the scattering of elastic waves by a spherical particle with imperfect interface, i.e. spring interface model, was studied. Then, multiple scattering by random distributed particles was investigated and the equations to evaluate the velocity and attenuation of effective waves defined by statistic averaging were given. Furthermore, on the basis of the established relation between the velocity and interfacial constants, a method to evaluate the interfacial damage nondestructively from the ultrasonic data was pro- posed. Numerical simulation was performed for the SiC-Al composites. The velocities of the effective waves were computed to show the influence of the interface constants. Using the genetic algorithm, the interfacial damage was evaluated from the synthetic experi- mental data with various noise levels. The numerical results showed the feasibility of the method proposed.

关键词： spring model average waves scattering genetic algorithm inverse problem

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A Modern Method for Analyzing Thermal Energy System with System State Equation and Analytical Formula of Performance Index

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Journal of Thermal Science 2007年第1期16卷 90-96页

作者： Chunfa zhang liping li Huijie wang Ning ZHAO School of Energy and Power North China Electric Power University Baoding 071003

This paper addresses overall performance analysis of coal-fired power unit. From the point of view of system engineering, a general steam-water distribution equation of the thermal plant system is presented. This system state equation is an exact expression combining system topological structure and system properties. Through proper mathematic transform, the inner relationship and interaction between the main system and auxiliary system are revealed and its general form is given. An analytical formula for the heat consumption rote of thermal power plant is one direct fruit of the equation, which greatly facilitate the online analyzing and optimizing of complex thermal system. The new approach, with the aid of modem data acquiring technology, is a perfect extension of the traditional analysis method based on the First Law of Thermodynamics.

关键词： steam-water distribution equation heat consumption rate thermal system thermodynamic analysis.

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False Negative Sample Detection for Graph Contrastive Learning

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Tsinghua Science and Technology 2024年第2期29卷 529-542页

作者： Binbin zhang li wang College of Data Science Taiyuan University of TechnologyJinzhong 030600China

Recently,self-supervised learning has shown great potential in Graph Neural Networks (GNNs) through contrastive learning,which aims to learn discriminative features for each node without label information. The key to graph contrastive learning is data augmentation. The anchor node regards its augmented samples as positive samples,and the rest of the samples are regarded as negative samples,some of which may be positive samples. We call these mislabeled samples as “false negative” samples,which will seriously affect the final learning effect. Since such semantically similar samples are ubiquitous in the graph,the problem of false negative samples is very significant. To address this issue,the paper proposes a novel model,False negative sample Detection for Graph Contrastive Learning (FD4GCL),which uses attribute and structure-aware to detect false negative samples. Experimental results on seven datasets show that FD4GCL outperforms the state-of-the-art baselines and even exceeds several supervised methods.

关键词： graph representation learning contrastive learning false negative sample detection

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A Compact System of Capacitively Coupled Contactless Conductivity Detection Based on the Square Wave Excitation Signal for Capillary Electrophoresis

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Chinese Chemical Letters 2006年第9期17卷 1229-1232页

作者： Shui Feng zhang li Shi wang Zhi DANG College of Environmental Science and Engineering South China University of Technology Guangzhou 510640

This paper reported a compact system of capacitively coupled contactless conductivity detection （C4D） based on the square wave excitation voltage for capillary electrophoresis, and it exhibited excellent sensitivity at the optimal frequency of 198 kHz. The feasibility and sensitivity of this detector was demonstrated by simultaneous detection of thirteen ions including alkali, alkaline earth and heavy metal ions. And the detection limits （S/N 3） were in the range of 0.2-1μmol/L for Mn^2＋, K^＋, Na^＋, Mg^2＋, Ca^2＋, li^＋, Ba^2＋, and 7-25 μmol/L for Ni^2＋, Cu^2＋, Cd^2＋, Pb^2＋, Co^2＋, Zn^2＋.

关键词： Capillary electrophoresis square wave excitation signal contactless conductivitydetector metal ions.

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Sensing Escherichia coli O157:H7 via frequency shift through a self-assembled monolayer based QCM immunosensor

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2008年第2期9卷 121-131页

作者： li-jiang wang Chun-sheng WU Zhao-ying HU Yuan-fan zhang Rong li Ping wang Biosensor National Special Laboratory Key Laboratory of Biomedical Engineering of Ministry of Education Department of Biomedical Engineering Zhejiang University Hangzhou 310027 China

By means of the specific immuno-recognition and ultra-sensitive mass detection, a quartz crystal microbalance (QCM) biosensor for Escherichia coli O157:H7 detection was developed in this work. As a suitable surfactant, 16-mercaptohexadecanoic acid (MHDA) was introduced onto the Au surface of QCM, and then self-assembled with N-hydroxysuccinimide (NHS) raster as a reactive intermediate to provide an active interface for the specific antibody immobilization. The binding of target bacteria with the immobilized antibodies decreased the sensor’s resonant frequency, and the frequency shift was correlated to the bacterial concentration. The stepwise assembly of the immunosensor was characterized by means of the electrochemical techniques. Using the immersion-dry-immersion procedure, this QCM biosensor could detect 2.0×102 colony forming units (CFU)/ml E. coli O157:H7. In order to reduce the fabrication time, a polyelectrolyte layer-by-layer self-assembly (LBL-SA) method was adopted for fast construction. Finally, the reproducibility of this biosensor was discussed.

关键词： Biosensor Escherichia coli O157:H7 Immunosensor Layer-by-layer self-assembly (LBL-SA) Quartz crystalmicrobalance (QCM)

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A NOTE ON MERRIS'CONJECTURES

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Applied Mathematics(A Journal of Chinese Universities) 1999年第2期14卷 197-202页

作者： zhang Xiaodong\ li Jiongsheng\ wang Ping Dept. of Math. University of Science and Technology of China Hefei

The Merris conjectures for threshold graphs and d regular graphs are *** the one of the conjectures of Merris holds for trees is also proved.

关键词： Merris推测极限图 d-规则图图论

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EFFECTS OF RAPAMYCIN ON INTRACELLULAR CHOLESTEROL HOMEOSTASIS OF GLOMERULAR MESANGIAL CELL IN THE PRESENCE OF INTERLEUKIN-1β

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Chinese Medical Sciences Journal 2008年第4期23卷 205-211页

作者： Guo-iuan zhang Hang li Xue-wang li Department of Nephrology Peking Union Medical College Hospital Chinese Academy of Medical Sciences ＆ Peking Union Medical College Beijing 100730

Objective To investigate the effects of rapamycin on cholesterol homeostasis of glomerular mesangial cells and the underlying mechanisms. Methods Intracellular cholesterol accumulation was measured by Oil Red O staining and high performance liquid chromatography. The effects of rapamycin on interleukin-1β（1L-1β）-induced mRNA and protein changes of low-density lipoprotein receptor （LDLR） and ATP-binding cassette transporter Al （ABCAl） were assayed by quantitative real-time PCR and Western blot. Transient expressions of 3 types of mammalian target of rapamycin （mTOR）, including mTOR-WT （wild type）, mTOR-RR （rapamycin resistant, with kinase activity）, and mTOR-RR-KD （rapamycin resistant, without kinase activity）, were obtained by plasmid transfection. Results Rapamycin had no significant influence on intracellular cholesterol concentration trader normal condition, but it significantly decreased the intracellular cholesterol concentration in the presence of IL-1β. Rapamycin dose-dependently suppressed the increased expression of LDLR induced by IL-1β and up-regulated the suppressed expression of ABCAl caused by IL-1β Transient expression of 3 types of mTOR all reduced ABCAl mRNA expression significantly, which all could be overroded by rapamycin. Conclusions Rapamycin may contribute to the maintaining of glomerular mesangial cell intracellular cholesterol homeostasis under inflammatory state by both reducing cholesterol uptake and increasing cholesterol effiux. And the effect may be not completely mediiated by mTOR.

关键词： rapamycin glomerular mesangial cell cholesterol low-density lipoprotein receptor ATP-binding ca, sette transporter A1

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Semi-supervised remote sensing image scene classification with prototype-based consistency

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Chinese Journal of Aeronautics 2024年第2期37卷 459-470页

作者： Yang li zhang li Zi wang Kun wang Qifeng YU College of Aerospace Science and Engineering National University of Defense TechnologyChangsha 410073China

Deep learning significantly improves the accuracy of remote sensing image scene classification,benefiting from the large-scale ***,annotating the remote sensing images is time-consuming and even tough for *** neural networks trained using a few labeled samples usually generalize less to new unseen *** this paper,we propose a semi-supervised approach for remote sensing image scene classification based on the prototype-based consistency,by exploring massive unlabeled *** this end,we,first,propose a feature enhancement module to extract discriminative *** is achieved by focusing the model on the foreground ***,the prototype-based classifier is introduced to the framework,which is used to acquire consistent feature *** conduct a series of experiments on NWPU-RESISC45 and Aerial Image Dataset(AID).Our method improves the State-Of-The-Art(SOTA)method on NWPU-RESISC45 from 92.03%to 93.08%and on AID from 94.25%to 95.24%in terms of accuracy.

关键词： Semi-supervised learning Remote sensing Scene classification Prototype network Deep learning

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