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Pancreatic fistula may be an important complication following spleen-preserving radical gastrectomy with dissection of No.10 and No.11 lymph nodes

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Chinese Medical Journal 2010年第15期123卷 2135-2137页

作者： zhang Jun zhang zhong-tao WANG Yu WANG Kang-li Department of General Surgery Beijing Friendship Hospital Affiliated to Capital Medical University Beijing 100050 China

In recent years, spleen-preserving radical gastrectomy with dissection of No.10 and No.11 lymph nodes has been gradually accepted because of an improved understanding of immune function of the spleen in the perioperat... 详细信息

关键词： pancreatic fistula gastrectomy postoperative complications

Stercoral colonic diverticulum perforation with jejunal diverticulitis mimicking upper gastrointestinal perforation

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Chinese Medical Journal 2012年第3期125卷 536-538页

作者： Bi Jing-tao Guo Yan-tong Zhao Jing-ming zhang zhong-tao Capital Med Univ Dept Gen Surg Beijing Friendship Hosp Beijing 100050 Peoples R China Peking Univ Dept Gen Surg Beijing Jishuitan Hosp Beijing 100035 Peoples R China

Stercoral perforation of the colon is an unusual pathological condition with fewer than 150 cases reported in the literature to date. We present a case of stercoral colonic perforation mimicking upper gastrointestinal perforation, which was diagnosed by computed tomography preoperatively. However, at laparotomy, stercoral colonic diverticulum perforation with jejunal diverticulitis became the most appropriate diagnosis.

关键词： intestinal perforation diverticulum constipation," peritonitis

Gangliocytic paraganglioma of the duodenum： a case report

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Chinese Medical Journal 2012年第2期125卷 388-389页

作者： Wu Guo-cong Wang Kang-li zhang zhong-tao Capital Med Univ Beijing Friendship Hosp Dept Gen Surg Beijing 100050 Peoples R China

Gangliocytic paraganglioma of the duodenum is an extremely rare *** cases have been reported in the literature from 1957 to *** reported a 67-year-old man with gangliocytic paraganglioma of the duodenum.

关键词： paraganglioma duodenum gastroscopy digestive system surgical procedures

Neoadjuvant chemotherapy in patients with stages II and III breast cancer

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Chinese Medical Journal 2009年第24期122卷 2993-2997页

作者： YUAN Zhu QU Xiang zhang zhong-tao WANG Yu Department of General Surgery Beijing Friendship HospitalCapital Medical University Beijing 100050 China

Background Neoadjuvant chemotherapy has been used as a primary treatment for locally advanced or inflammatory breast cancer, and recently extended to operable breast cancer. However, only a few studies have published data concerning the outcomes of patients with stages II and III breast cancer after neoadjuvant chemotherapy. Methods This study retrospectively investigated the clinical value of neoadjuvant chemotherapy for patients with stages II and III breast cancer. The patients in Group 1 （n=54） were treated with neoadjuvant chemotherapy, followed by definitive surgery and adjuvant therapy. The patients in Group 2 （n=-43） initially received definitive surgery, followed by adjuvant chemotherapy and other therapies. The operability rates for breast conservation and dermatoplasty were observed in Group 1 after neoadjuvant chemotherapy. After follow-up, the recurrence and overall and disease-free survival rates of the two groups were analyzed. Results Neoadjuvant chemotherapy increased the operability rates for breast conservation from 17.1% to 40.0% in stage II （P=0.034） and 0% to 12.6% in stage III （P=0.016）, and decreased the dermatoplasty rates from 17.1% to 2.8% in stage II （P=0.046） and 28.1% to 8.1% in stage Ill （P=0.026）. After a median follow-up of 46.8 months, there were 11 deaths and 13 recurrences in Group 1, and 15 deaths and 19 recurrences in Group 2. The overall and disease-free survival rates of stage III disease were significantly higher in Group 1 than in Group 2 （68.4% vs 31.2%, P=0.028, and 63.2% vs 25.0%, P=0.024, respectively）. There were no significant differences in the overall and disease-free survival rates of stage II disease for Group 1 compared with Group 2 （85.7% vs 85.2%, P=0.953, and 80.6% vs 74.1%, P=0.400, respectively）. Conclusions Neoadjuvant chemotherapy resulted in increased operability for breast conservation and decreased dermatoplasty. Neoadjuvant chemotherapy exhibited better recurrence control, and overall and disease-free s

关键词： neoadjuvant chemotherapy breast cancer breast conservation overall survival

A case of benign symmetrical lipomatosis

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Chinese Medical Journal 2013年第1期126卷 190-191页

作者： WANG Tong-sheng ZHU Bin WANG Yan zhang Neng-wei zhang zhong-tao Department of General Surgery Beijing Friendship HospitalCapital Medical University Beijing 100050 China Department of General Surgery Beijing Shijitan Hospital CapitalMedical University Beijing 100038 China

A51-year-old man from Inner Mongolia, China was admitted to the Department of General Surgery,Beijing Shijitan Hospital on November 28, 2011, with massive thickening of the neck （Figure I A）. The patient had undergone excision of lipoma like egg size in his double shoulders 18 years before. One year later the tumor rectlrred m situ. The increase of the volume of his neck was observed for over 17 years, and the patient had no history of dyspnea and dysphagia.

关键词： benign symmetrical lipomatosis Madelung's disease

A new exploration on the creation of grafted breast cancer model for MA891 cells in TA2 mice

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Chinese Medical Journal 2005年第21期118卷 1830-1833页

作者： GU Jun-chao YU Wei-bo zhang zhong-tao WANG Yu Department of General Surgery Beijing Friendship Hospital Affiliated with Capital University of Medical Sciences Beijing 100050 China

Animal experimental systems are particularly useful for the study of human breast cancer. An ideal model shoulcl be easy to use, closely mimicking human physiopathology and has a stable tumor morbidity. The cell line MA891 was established from a spontaneous TA2 mouse mammary carcinoma by Cancer Institute of Chinese Academy of Medical Sciences. 3 Some researches indicated that MA891 had a very low immunogenecity and maintained a high metastatic potential in vivo. So it has been used as a better grafted mouse tumor model for studying cancer physiopathology and metastasis in human for years. However, about the biological characteristic and the histopathologic feature of this model there has been a lack of investigations.

关键词： breast cancer MA891 cell animal model

Relapse of acute lymphoblastic leukemia in the pancreas after allogeneic bone marrow transplantation

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Chinese Medical Journal 2010年第22期123卷 3364-3366页

作者： ZHAO Xiao-mu zhang zhong-tao LI Jian-she HAN Wei Department of General Surgery Beijing Friendship Hospital Capital Medical University Beijing 100050 China

The occurrence of metastatic lesions in the pancreas of patients with cancer, including hematological cancers,is uncommon （1.6%-37.5%） and of these, the majority of patients will have widespread disease.1-7 Isolated potentially resectable pancreatic metastases are rarely seen. Resection of metastatic tumors of the pancreas has been reported, but its role in improving survival rates or quality of life is not clear.7,8 However,

关键词： pancreas acute leukemia relapse allogeneic bone marrow transplantation

Effects of hepatotrophic factors on the liver after portacaval shunt in rats with portal hypertension

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Chinese Medical Journal 2006年第20期119卷 1727-1733页

作者： zhang zhong-tao JIANG Peng WANG Yu LI Jian-she XUE Jian-guo ZHOU Yan-zhong YUAN Zhu Department of General Surgery Beijing Friendship HospitalCapital Medical University Beijing 100050 China

Background Portacaval shunt （PCS） prevent hepatotrophic factors from flowing into the liver, but they enter directly the systemic circulation and worsen liver injury. This study was designed to investigate the effects of hepatotrophic factors through the portal vein on the liver in rats with portal hypertension after portacaval shunt. Methods Intrahepatic portal hypertension （IHPH） was induced by intragastric administration of carbon tetrachloride, and end-to-side PCS was performed. Eight normal rats served as controls, and eight rats with IHPH served as IHPH model （IHPH group）. Another 32 rats with IHPH-PCS were randomly subdivided into 4 groups： normal saline （NS） given to 8 rats, hepatocyte growth factor （HGF） 8, insulin （INS） 8, hepatocyte growth factor and insulin （HGF＋INS） 8. Hepatotrophic factors were infused into the portal vein through an intravenous catheter. Portal venous pressure （PVP） was measured. The levels of serum alanine aminotransferase （ALT） and aspartate aminotransferase （AST） were tested biochemically and those of hyaluronic acid （HA） and laminin （LN） were measured by radioimmunoassay. Hepatic fibrosis was assessed histologically and the expression of collagens type I and In were detected immunohistochemically. Ultrastructural change of hepatocytes and the number of mitochondria were observed under an electron microscope. The data were compared between groups and subgroups by Student-Newman-Keuls procedure with SPSS 10.0.Results PVP was significantly higher in the IHPH rats than in the control rats （P〈0.05）. The levels of serum ALT, AST, HA, and LN, hepatic fibrosis score, the amount of collagen deposition, collagens type I and III increased more significantly in the IHPH group than in the control rats （P〈0.05）. The number of mitochondria decreased more significantly in the IHPH rats than in the control rats （P〈0.05）. The levels of serum ALT, AST, HA and LN as well as hepatic fibrosis score, the amount of collagen deposition, and the amount

关键词： hepatocyte growth factor hypertension, portal portacaval shunt, surgical

Effects of human interleukin 10 gene transfer on the expression of Bcl-2 Bax and apoptosis of hepatocyte in rats with acute hemorrhagic necrotizing pancreatitis

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Chinese Medical Journal 2005年第19期118卷 1658-1660页

作者： GU Jun-chao WANG Yu zhang zhong-tao XUE Jian-guo LI Jian-she ZHOU Yan-zhong Department of General Surgery Beijing Friendship HospitalCapital University of Medical Sciences Beijing 100050 China

Acute necrotising pancreatitis is characterized by inflammatory and necrotic events, which followthe initial intra-acinar injury involving enzyme activation, and disruption of the acinar cytoskeleton. At present, apoptosis has become a hot topic in many kinds of disease. Bax and Bcl-2 are the important control gene during cell apoptosis. 2 Previous study has shown that interleukin 10 （IL-10） is a kind of important antiinflammatory cytokine and plays a role of selfdefense mechanism,

关键词： acute necrotizing pancreatitis cell apoptosis interleukin 10 gene transfer