A new exploration on the creation of grafted breast cancer model for MA891 cells in TA2 mice

作     者：GU Jun-chao YU Wei-bo ZHANG Zhong-tao WANG Yu 

作者机构：Department of General Surgery Beijing Friendship Hospital Affiliated with Capital University of Medical Sciences Beijing 100050 China 

出 版 物：《Chinese Medical Journal》 (中华医学杂志（英文版）)

年 卷 期：2005年第118卷第21期

页      面：1830-1833页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：breast cancer MA891 cell animal model 

摘      要：Animal experimental systems are particularly useful for the study of human breast cancer. An ideal model shoulcl be easy to use, closely mimicking human physiopathology and has a stable tumor morbidity. The cell line MA891 was established from a spontaneous TA2 mouse mammary carcinoma by Cancer Institute of Chinese Academy of Medical Sciences. 3 Some researches indicated that MA891 had a very low immunogenecity and maintained a high metastatic potential in vivo. So it has been used as a better grafted mouse tumor model for studying cancer physiopathology and metastasis in human for years. However, about the biological characteristic and the histopathologic feature of this model there has been a lack of investigations.