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Immunotherapeutic hydrogel for co-delivery of STAT3 siRNA liposomes and lidocaine hydrochloride for postoperative comprehensive management of NSCLC in a single application

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Asian Journal of Pharmaceutical Sciences 2024年第3期19卷 115-130页

作者： Xianglei Fu Yanbin Shi Zili gu Hengchang Zang Lian Li Qingjie Wang yongjun Wang Xiaogang Zhao Hang Wu Shengnan Qiu Yankun zhang Jiamin Zhou Xiangqin Chen Hua Shen guimei Lin Department of Pharmaceutics School of Pharmaceutical SciencesCheeloo College of MedicineShandong UniversityJinan 250012China School of Mechanical and Automotive Engineering Qilu University of Technology(Shandong Academy of Sciences)Jinan 250353China Department of Radiology Leiden University Medical CenterAlbinusdreef 22333 ZA LeidenNetherlands NMPA Key Laboratory for Technology Research and Evaluation of Drug Products School of Pharmaceutical SciencesCheeloo College of MedicineShandong UniversityJinan 250012China Laboratory of Basic Medical Sciences Qilu HospitalShandong UniversityJinan 250063China Wuya College of Innovation Shenyang Pharmaceutical UniversityShenyang 110016China Department of Thoracic Surgery The Second Hospital of Shandong UniversityJinan 250033China

Despite standard treatment for non-small cell lung cancer(NSCLC)being surgical resection,cancer recurrence and complications,such as induction of malignant pleural effusion(MPE)and significant postoperative pain,usually result in treatment *** this study,an alginate-based hybrid hydrogel(SOG)is developed that can be injected into the resection surface of the lungs during ***,endoplasmic reticulum-modified liposomes(MSLs)pre-loaded with the signal transducer and activator of transcription 3(STAT3)small interfering RNA and lidocaine hydrochloride are encapsulated in *** applied,MSLs strongly downregulated STAT3 expression in the tumor microenvironment,resulting in the apoptosis of lung cancer cells and polarization of tumor-associated macrophages towards the M1-like ***,the release of lidocaine hydrochloride(LID)was beneficial for pain relief and natural killer cell *** data demonstrated MSL@LID@SOG not only efficiently inhibited tumor growth but also potently improved the quality of life,including reduced MPE volume and pain relief in orthotopic NSCLC mouse models,even with a single ***@LID@SOG shows potential for comprehensive clinical management upon tumor resection in NSCLC,and may alter the treatment paradigms for other cancers.

关键词： Liposome Hydrogel Signal transducer and activator of transcription 3 Non-small cell lung cancer Macrophage

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城市发展思考:基于城市发展理念演变的分析

现代城市研究 2024年第5期39卷 42-49页

作者：张昊余春雪辜智慧苏美蓉深圳大学建筑与城市规划学院东莞理工学院生态环境工程技术研发中心广东工业大学广东省高等学校湾区生态安全与绿色发展基础研究卓越中心广东工业大学大湾区城市环境安全与绿色发展教育部重点实验室广东工业大学生态环境与资源学院

城市发展理念是引领城市前进方向的准则,也是人类对城市发展诉求的凝练。在城市发展的不同阶段,为应对特定的城市问题与诉求,出现了不同的城市发展理念。文章首先初步梳理了城市发展理念的演变历史,随后构建了4W城市发展理念演变特征分... 详细信息

城市发展理念是引领城市前进方向的准则,也是人类对城市发展诉求的凝练。在城市发展的不同阶段,为应对特定的城市问题与诉求,出现了不同的城市发展理念。文章首先初步梳理了城市发展理念的演变历史,随后构建了4W城市发展理念演变特征分析框架,并从提出背景(Why)、发展阶段(When)、提出者(Who)和核心要义(What)4个角度,具体解析了城市发展理念提出的内在逻辑,以及在不同发展阶段与经济社会的关系,分析其主要提出国家/组织的类别。此外依据发展理念核心要义的侧重点将其划分为生态型与社会型两类理念,归纳其关键特征。最后,基于城市发展理念的历史演变特征,提出了管理建议和研究展望。

关键词：城市发展理念演变特征 4W框架核心要义

植物叶际好氧反硝化细菌的筛选及其脱氮性能研究

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微生物学报 2024年第5期64卷 1521-1537页

作者：张建云谷立坤王亚西李潇扬宁志琪孙淼焜张欣白志辉河南工程学院环境与生物工程学院河南郑州451191 中国科学院生态环境研究中心北京100085

【目的】探索叶际微生物协同植物削减大气氮氧化物的机制,了解叶际可培养好氧反硝化细菌的存在及多样性,获得高效的叶际好氧反硝化细菌资源。【方法】采用富集培养结合格里斯试剂检测、溴百里酚蓝(bromothymol blue,BTB)培养基筛选的方... 详细信息

【目的】探索叶际微生物协同植物削减大气氮氧化物的机制,了解叶际可培养好氧反硝化细菌的存在及多样性,获得高效的叶际好氧反硝化细菌资源。【方法】采用富集培养结合格里斯试剂检测、溴百里酚蓝(bromothymol blue,BTB)培养基筛选的方法从景观植物叶际分离筛选好氧反硝化细菌,对好氧反硝化细菌的16SrRNA基因序列进行系统发育分析,并选取其中一株高效好氧反硝化细菌进行脱氮性能研究。【结果】从6种景观植物石楠、女贞、木樨、樟树、卫矛冬青、荷花玉兰的叶际中分离到好氧反硝化细菌13株,经16SrRNA基因序列分析发现,13株细菌分别属于4门7科7属,其中4株为肠杆菌属(Enterobacter),3株为无色杆菌属(Achromobacter),2株为假单胞菌属(Pseudomonas),其余4株分别属于鞘氨醇杆菌属(Sphingobacterium)、不动杆菌属(Acinetobacter)、微杆菌属(Microbacterium)和假节杆菌属(Pseudarthrobacter)。定量分析发现菌株SF的反硝化效果较好。通过单因素试验和响应面设计试验,对菌株SF的脱氮性能进行了一系列研究,探究了碳源、温度、初始pH、碳氮比和转速等因素对菌株SF脱氮效果的影响。结果表明,菌株SF的最佳脱氮条件:碳源为葡萄糖,初始pH值为7.5,碳氮比为9.7,转速180 r/min,温度为33.5℃。在此条件下,当初始硝酸盐浓度为361 mg/L时,72 h总氮去除率可达到93.3%。【结论】景观植物叶际中存在较多种类的可培养好氧反硝化细菌,丰富了叶际氮循环相关微生物的类型,为探索叶际微生物协同削减大气氮氧化物的机制奠定了基础。通过高效脱氮菌株的筛选,为进一步应用微生物协同植物削减空气氮氧化物污染提供了候选菌株。

关键词：叶际好氧反硝化细菌分离与鉴定脱氮反硝化特性

Research on wind-induced responses of a large-scale membrane structure

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Earthquake Engineering and Engineering Vibration 2013年第2期12卷 297-305页

作者： Zhou Xuanyi Han zhihui gu Ming zhang An-an zhang Weiyu Fang Wei State key Laboratory of Disaster Reduction in Civil Engineering Tongji University Shanghai Institute of Meteorological Science Shanghai World Expo Land Holding Co. Ltd East China Architectural Design and Research Institute Co. Ltd

The wind-induced responses of a large-scale membrane structure, Expo Boulevard, are evaluated in this study. To obtain the wind pressure distribution on the roof surface, a wind tunnel test is performed. A brief analysis of wind pressure on the membrane roof is conducted first and then an analysis of the wind-induced responses of the structure is carried out using a numerical integral method in the time domain. In the process of calculation, the geometrical nonlinearity is taken into account. Results indicate that mean, RSM and peak values of the structure responses increase nonlinearly while the approaching flow velocity increases. Strong nonlinear characteristics are observed in the displacement responses, whereas the responses of nodal stress and cable axial force show minimal nonlinear properties when the membrane structure is subjected to wind loads. Different values of the damping ratio only have a minimal impact on the RSM response of the structure because the background component is a dominant part of the total dynamic response and the resonant component is too small. As the damping ratio increases from 0.02 to 0.05, the RMS responses of vertical displacement, nodal stress and cable axial force decrease by 8.1%, 6.7% and 17.9%, respectively. Since the mean component plays a significant role in the wind-induced response, the values of the gust response factor are not high for Expo Boulevard.

关键词： wind tunnel test wind-induced response time domain method geometrical nonlinear analysis

Design,Ultrasonic-assisted Synthesis and Evaluation In vitro Antimicrobial Activity of Bis-isoxazole Derivatives Bearing Chloro-pyridinyl Group

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Chemical Research in Chinese Universities 2021年第3期37卷 668-673页

作者： FENG Fan LI Jing zhang zhihui FU Jiaxu zhang Yumin gu Qiang College of Chemistry Jilin UniversityChangchun130012P.R.China Drilling and Exploitation Technology for Oil Shale National-Local Joint Engineering Laboratory of In-situ ConversionChangchun130021P.R.China

An ultrasonic-assisted synthesis of bis-isoxazole derivatives was *** 3-(6-chloropyridin-3-yl)-5-{[(3-arylisoxazol-5-yl)methoxy]methyl}isoxazoles were synthesized by 1,3-dipolar cycloaddition reaction between substituted isoxazolyl alkyne compounds and 6-chloro-N-hydroxynicotinimidoyl *** structures of the synthesized compounds were confirmed by HRMS,FTIR,^(1)H and^(13)C NMR ***,the antifungal and antibacterial activities of target compounds were *** synthesized compounds 6a and 6h exhibited better antifungal activity in comparison with the standard drug *** minimum inhibitory concentrations(MICs)of both compound 6a and compound 6h were both 4µg/mL against Candida albicans ATCC 10231.

关键词： Ultrasonic-assisted Bis-isoxazole 1,3-Dipolar cycloaddition Antimicrobial activity

Production of a newly isolated Paenibacillus polymyxa biocontrol agent using monosodium glutamate wastewater and potato wastewater

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Journal of Environmental Sciences 2010年第9期22卷 1407-1412页

作者： Likun gu zhihui Bai Bo Jin Jianyun zhang Wenying Li guoqiang Zhuang Hongxun zhang Research Centre for Eco-Environmental Sciences Chinese Academy of Sciences Beijing 100085 China Graduate University of Chinese Academy of Sciences Beijing 100049 China Institute of BioEnergy and Bioprocess Technology Chinese Academy of Sciences Qingdao 266101 China School of Earth and Environment Sciences the University of Adelaide Adelaide SA 5005 Australia

A phyllosphere bacterial strain EBL-06 was isolated from wheat leaves. The morphology, cultural characteristics, phospholipid fatty acids, physiological and antagonistic fungus activities of this strain were investigated. A phylogenetic tree was constructed by comparing with the published 16S rDNA sequences of the relevant bacteria. The results showed that the isolate EBL-06 was a strain of Paenibacillus polymyxa; this strain performed a high level of antagonistic fungus activity toward a broad spectrum of phytopathogens, such as Botrytis cinerea, Cladosporium cucumerinum, Fusarium spp. The isolate EBL-06 can grow well using monosodium glutamate wastewater （MGW） and potato wastewater （PW） as culture medium. The maximum yield of 6.5 × 10^9 CFU/mL of the isolate EBL-06 anti-fungus biocontrol agent was reached in 15 hr cultivation at 28℃, pH 6.0-7.5 using the mixture of MGW and PW （1：9）.

关键词： phyllosphere Paenibacillus polymyxa wastewater phospholipid fatty acids biocontrol agent

Study on the challenge and influence of the built thermal environment on elderly health in rural areas:Evidence from Shandong,China

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建筑模拟(英文) 2023年第8期16卷 1345-1360页

作者： Yanxue Li Yue gu zhihui Li Xiaoyi zhang Weijun Gao Fu Xiao Innovation Institute for Sustainable Maritime Architecture Research and Technology Qingdao University of TechnologyFushun Road 11Qingdao 266033China Department of Building Environment and Energy Engineering The Hong Kong Polytechnic UniversityHong KongChina Qingdao Women and Children’s Hospital Tongfu Road 6Qingdao 266000China Faculty of Environmental Engineering The University of KitakyushuKitakyushu808-0135Japan

Elderly health is increasingly recognized as a worldwide challenge with the continuous social aging *** study aimed to investigate the thermal conditions of the elderly in rural areas of Shandong,*** thermal sensation and physiological response performances of elderly participants were examined in their own *** show a clear seasonal pattern in cardiovascular disease mortality,cold stress increases the cardiovascular disease *** coal-based stoves serve as the main source of home heating and their limited coverage of the room area gave rise to poor quality of thermal *** analysis of skin temperature for those under 65 and above did not reveal any significant difference in response to different indoor *** regression results confirm that a colder home leads to a rising value of the elderly’s systolic blood pressure,rising by more than 1 mmHg for every 1℃decrease in indoor temperature and thus posing a greater risk of cardiovascular *** systolic blood pressure value of older subjects rise more when they are exposed to decreasing indoor temperatures,possibly due to an age-related decline in their ability to maintain stability of blood *** is noteworthy that the average blood velocity of older subjects reduces less in response to decreasing indoor temperatures,indicating a weakened capacity to resist cold stress and its associated high risk of *** investigation provides evidence in favor of improving the thermal environment of the elderly and reducing their risk of cardiovascular diseases.

关键词： rural house thermal environment cardiovascular diseases physiological parameters elderly

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智慧警务创新体系方案设计

信息通信技术与政策 2024年第5期50卷 92-96页

作者：单莉莉谷志慧张杰儒张东中国信息通信研究院产业与规划研究所北京100037

智慧警务是公安警务模式升级的核心手段,推进打防犯罪、风险防控和社会治理从事后被动处置响应向事前主动预知预警转变,是公安警务信息化的高级发展阶段。以“感知—云网—数基—应用—安全—运营”为脉络,提出了一套全景化、体系化的... 详细信息

智慧警务是公安警务模式升级的核心手段,推进打防犯罪、风险防控和社会治理从事后被动处置响应向事前主动预知预警转变,是公安警务信息化的高级发展阶段。以“感知—云网—数基—应用—安全—运营”为脉络,提出了一套全景化、体系化的智慧警务体系方案,助推公安警务信息化建设。

关键词：智慧警务警务信息化大数据生态

东北亚地区白粉菌的物种多样性与寄主物种多样性

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生物多样性 2024年第4期32卷 103-116页

作者：池玉杰张心甜田志炫关成帅谷新治刘智会王占斌王金杰东北林业大学林学院哈尔滨150040 浙江省长三角标准技术研究院杭州311202 长春市园林植物保护站长春130022

对不同地理区域的菌物进行系统的编目和分类研究是生物多样性研究的核心内容。白粉菌是一类植物专性寄生病原真菌,广泛分布在世界各地,能引起多种植物的白粉病。为了全面了解中国东北与东北亚其他地区白粉菌的物种多样性和寄主多样性,... 详细信息

对不同地理区域的菌物进行系统的编目和分类研究是生物多样性研究的核心内容。白粉菌是一类植物专性寄生病原真菌,广泛分布在世界各地,能引起多种植物的白粉病。为了全面了解中国东北与东北亚其他地区白粉菌的物种多样性和寄主多样性,本文通过文献收集、数据分析,并结合作者2022–2023年野外调查结果,按照最新的分类系统,整理出中国东北和东北亚其他各国和地区的白粉菌物种名录、寄主名录和地理分布信息。通过整理分析发现,中国东北地区有白粉菌142种和17变种,隶属于1科5族、10个有性属和1个无性属,分布在572种(含37变种)寄主植物上,隶属64科243属;日本有白粉菌258种和46变种,隶属于1科5族,12个有性属和2个无性属,分布在1,171种(含163变种)寄主植物上,隶属108科449属;韩国有白粉菌150种和15变种,隶属于1科5族,11个有性属和1个无性属,分布在515种(含53变种)寄主植物上,隶属79科255属;俄罗斯远东地区有白粉菌89种和22变种,隶属于1科5族,8个有性属和2个无性属。中国东北地区、日本、韩国和俄罗斯远东地区共有的白粉菌种类有50个,归属于8个共有的有性属(布氏白粉菌属(Blumeria)、单囊壳属(Podosphaera)、叉钩丝壳属(Sawadaea)、白粉菌属(Erysiphe)、高氏白粉菌属(Golovinomyces)、新白粉菌属(Neoerysiphe)、内丝白粉菌属(Leveillula)和球针壳属(Phyllactinia)),它们分布在相同或相近的寄主植物上。日本和韩国的白粉菌共有种最多(136种)。中国东北地区、日本和韩国白粉菌的特有种分别为28种、116种和17种。东北亚地区白粉菌的寄主植物总共有1,760种(含263个变种),隶属112科541属。虽然东北亚地区约占全球陆地面积的8%,但是该地区共有318种和53变种白粉菌,占全球已知白粉菌总数的40.33%。因此,东北亚地区属于白粉菌多样性研究的重点地区与区系单元。研究结果为建立东北亚地区白粉菌多样性与区系研究格局、系统发育关系、寄主多样性概貌等提供了白粉菌物种和寄主物种的数据支持。

关键词：白粉菌多样性寄主多样性中国东北东北亚