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Magnetic resonance imaging-guided and targeted theranostics of colorectal cancer

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Cancer Biology & Medicine 2020年第2期17卷 307-327页

作者： Yanan Li Jingqi Xin Yongbing Sun Tao Han Hui zhang Feifei An Department of Radiology First Hospital of Shanxi Medical UniversityTaiyuan 030001China institute of Medical Engineering Department of BiophysicsSchool of Basic Medical ScienceHealth Science CenterXi’an Jiaotong UniversityXi’an 710061China Division of Pharmaceutics National Pharmaceutical Engineering Center for Solid Preparation in Chinese Herbal MedicineJiangxi University of Traditional Chinese MedicineNanchang 330006China College of Chemistry and Life Science Institute of Functional MoleculesChengdu Normal UniversityChengdu 611130China

Colorectal cancer(CRC)is the most common gastrointestinal tract cancer worldwide and is associated with high morbidity and *** development of nanosized drug delivery systems has provided a new direction in CRC *** these systems,magnetic nanoparticle(MNP)-based multifunctional platforms provide a novel strategy for magnetic resonance imaging(MRI)-related cancer *** the beginning o f this original review,the carcinogenesis and treatment status o f CRC are ***,diversified preparation and functionalization methods of MNPs are systematically analyzed,followed by MRIinvolved theranostic *** latest progress in MRI-mediated multimode diagnosis and image-guided targeted therapy in CRC management is the main ***,the major challenges in promoting MRI-induced precise theranostics of CRC in clinical practice are discussed.

关键词： Carcinogenesis colorectal cancer magnetic resonance imaging multimodal diagnosis targeted theranostics

Impact Increment Based Hybrid Reliability Assessment Method for Transmission Systems

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CSEE Journal of Power and Energy Systems 2022年第1期8卷 317-328页

作者： Yunkai Lei Yeguang Sun Kai Hou Pei zhang Lewei Zhu Xiaoxi Yang Xiaonan Liu State Grid Sichuan Economic Research institute Chengdu610000 China School of Electrical and Information Engineering Tianjin UniversityTianjin 300072China State Grid Customer Service Center Tianjin 300072China School of Electrical and Automation Engineering East China Jiaotong UnviersityNanchang 330052China Maritime College Tianjin University of TechnologyTianjin 300384China College of Economics and Management Southwest Petroleum UniversityChengdu 610000China State Grid Tianjin Electric Power Research institute Tianjin 300072China

This paper proposes an impact-increment-based hybrid(IIHybrid)reliability assessment approach for power transmission *** proposed approach integrates the advantages of the impact-increment-based state enumeration method(IISE)and impact-increment-based Monte Carlo simulation(IIMC)to improve computational efficiency and *** IISE can efficiently assess the impacts of low-order *** accuracy is,however,sacrificed as highorder contingencies are usually *** IIMC is more suitable for large-scale contingency spaces compared with IISE,although the calculation process is *** this paper,the proposed IIHybrid takes advantage of its strengths while avoiding its *** IISE and the IIMC are applied to lower and higher contingency spaces *** high-order contingencies elimination technique proposed in our previous studies is still applicable to the *** addition,efficiency can be controlled by modifying the preset parameters to adapt to various *** studies are performed on the IEEE 118-bus test system and PEGASE *** results show that the proposed approach is more efficient and practicable than traditional methods.

关键词： Hybrid method impact-increment reliability assessment transmission system

Online Identification of Lithium-ion Battery Model Parameters with Initial Value Uncertainty and Measurement Noise

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Chinese Journal of Mechanical Engineering 2023年第1期36卷 305-314页

作者： Xinghao Du Jinhao Meng Kailong Liu Yingmin zhang Shunli Wang Jichang Peng Tianqi Liu College of Electrical Engineering Sichuan UniversityChengdu610044China School of Electrical Engineering Xi’an Jiaotong University710049Xi’anChina Warwick Manufacturing Group University of WarwickCoventryUK southwest university of Science and Technology Mianyang621010China Nanjing institute of Technology Nanjing211103China

Online parameter identification is essential for the accuracy of the battery equivalent circuit model(ECM).The traditional recursive least squares(RLS)method is easily biased with the noise disturbances from sensors,which degrades the modeling accuracy in ***,the recursive total least squares(RTLS)method can deal with the noise interferences,but the parameter slowly converges to the reference with initial value *** alleviate the above issues,this paper proposes a co-estimation framework utilizing the advantages of RLS and RTLS for a higher parameter identification performance of the battery *** converges quickly by updating the parameters along the gradient of the cost *** is applied to attenuate the noise effect once the parameters have *** simulation and experimental results prove that the proposed method has good accuracy,a fast convergence rate,and also robustness against noise corruption.

关键词： Li-ion battery Equivalent circuit model Recursive least squares Recursive total least squares

基于CBFS-CV算法的煤层气井压裂效果主控因素识别

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油气地质与采收率 2022年第1期29卷 168-174页

作者：闵超张馨慧杨兆中李小刚代博仁西南石油大学理学院四川成都610500 西南石油大学人工智能研究院四川成都610500 西南石油大学油气藏地质及开发工程国家重点实验室四川成都610500

准确识别煤层气井压裂效果的主控因素,进而有效指导重复压裂方案优化,是煤层气井提升重复压裂产能的关键。依托研究区块的地质及工程大数据,利用基于Copula互信息的特征选择和交叉验证算法(CBFS-CV)识别影响压裂效果的主控因素,并结合... 详细信息

准确识别煤层气井压裂效果的主控因素,进而有效指导重复压裂方案优化,是煤层气井提升重复压裂产能的关键。依托研究区块的地质及工程大数据,利用基于Copula互信息的特征选择和交叉验证算法(CBFS-CV)识别影响压裂效果的主控因素,并结合梯度提升回归模型进行产能预测检验,形成了一种改进的煤层气井压裂效果主控因素识别算法。该算法可有效减少冗余性特征且增大相关性,并确定最佳特征数目。结果表明:煤体结构、储层参数(含气量、含气饱和度和临储比)和施工排量参数(最大施工排量)是影响研究区块压裂效果的3个主控因素,通过梯度提升回归模型验证CBFS-CV算法所识别出的主控因素的预测符合率达88%,证明了该算法的有效性。利用结果对该区块典型井进行主控因素分析,采用氮气泡沫解堵方案解决煤体结构差、煤粉堵塞等问题,现场施工后日产气量由288 m^(3)/d增至805 m^(3)/d,压裂效果明显改善。

关键词：煤层气压裂效果主控因素 Copula互信息回归模型大数据

低速提扭对废气涡轮增压柴油机燃烧排放特性的影响

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汽车技术 2019年第5期 53-57页

作者：程小钢周斌张钊杨燕妮黄祎西南交通大学机械工程学院成都610031 四川托普信息技术职业学院成都611743

为解决废气涡轮增压柴油机低速段扭矩过低问题,通过提高电动增压器变频器的频率来提升增压器的转速,进而控制进气流量,提升柴油机低速段扭矩。通过分析额外进气量对提扭后废气涡轮增压柴油机的经济性、燃烧特性和排放特性的影响表明,与... 详细信息

为解决废气涡轮增压柴油机低速段扭矩过低问题,通过提高电动增压器变频器的频率来提升增压器的转速,进而控制进气流量,提升柴油机低速段扭矩。通过分析额外进气量对提扭后废气涡轮增压柴油机的经济性、燃烧特性和排放特性的影响表明,与加装增压器前相同转速的原机外特性工况点的数据相比,提扭后扭矩提升9%～25%。随电动增压器频率的增加,油耗率呈先升后降的趋势,在频率为50 Hz时油耗率比原机增加了1.14%～4.44%;烟度也呈先升后降趋势,但在频率为50 Hz时的烟度比0 Hz时下降了37.4%～44.9%;NO_x排放随电动增压器频率的增加无明显规律。

关键词：柴油机电动增压器排放特性

Exact Solution to Landau System with Time-Dependent Electromagnetic Fields

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Chinese Physics Letters 1999年第6期16卷 391-393页

作者： YING Zu-jian WANG Shun-jin zhang Wen-zhong Department of Modern Physics Lanzhou UniversityLanzhou 730000 institute of Modern Physics Southwest Jiaotong UniversityChengdu 610031

Algebraic dynamics is applied to treat Landau *** consider the case with the vector potential A=B(g)(-y,0,0)and the scalar potentialφ=-E(t)y+k(t)y^(2),and find that the system has the dynamical algebra su(1,1)㊉h⑶.With a gauge transformation the exact solutions of the system are found,of which the quantum motion in y-direction represents a harmonic oscillator with a moving origin and a varying amplitude of width,the paramertes of the gauge transformation are related to the amplitude,the velocity potential and the expectations of y and py,*** energy of the system,the fluctuations of dynamical variables,the transition amplitudes between different states,and the Berry phase are calculated.

关键词： Landau gauge system

Cathepsin B-responsive nanodrug delivery systems for precise diagnosis and targeted therapy of malignant tumors

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Chinese Chemical Letters 2020年第12期31卷 3027-3040页

作者： Yanan Li Ting Mei Shupeng Han Tao Han Yongbing Sun Hui zhang Feifei An Department of Radiology First Hospital of Shanxi Medical UniversityTaiyuan 030001China College of Medical Imaging Shanxi Medical UniversityTaiyuan 030001China institute of Medical Engineering Department of Biophysicschool of Basic Medical ScienceHeatih Science Center Xi'an Jiaotong UniverstyXi'an 710061China College of Chemistry and Life Science Institute of Functional MoleculesChengdu Normal UniversityChengdu 611130China Division of Pharmaceutics National Pharmaceutical Engineering Center for Solid Preparation in Chinese Hierbal MedicimeJiamgpri Unverity of Truditional Chinese MedicinveNanchang 330006China

The tumor microenvironment(TME)significantly influences cancer evolution and therapeutic *** biofunctional molecules to the TME has long been appreciated as a means of raising local drug concentrations and reducing systemic *** booming nanotechnology field has realized the importance of cathepsin B to derive a variety of intelligent enzyme-responsive nanosized drug delivery systems(nanoDDS)to improve treatment responses and clinical *** this tutorial review,after introducing the molecular structure and physiological/pathological functions of cathepsin B,the outstanding achievements of cathepsin B-responsive nanoplatforms in the precise diagnosis,targeted therapy,and synergistic theranostics of malignant tumors are systematically ***,the challenges of enzyme-substrate incompatibility,low diagnostic sensitivity,mass production and biocompatibility of multifunctional nanoDDS are considered in order to successfully promote them to clinical applications.

关键词： Tumor microenvironment Cathepsin B Theranostics Precise diagnosis Targeted therapy

考虑频率因子的VMD-GRA-BP库区滑坡位移预测模型

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中国安全生产科学技术 2024年第9期20卷 96-104页

作者：贺明晓刘阳唐怡杨辉宗吴卓恩张建经罗宏森四川师范大学工学院四川成都610101 四川师范大学公共安全与应急研究院四川成都610066 西南交通大学土木工程学院四川成都610031

为了减少库区滑坡失稳可能带来的损失,确保水电工程的安全稳定运行及保障周边民众的生命财产安全,探讨提升库区滑坡位移预测精度的方法。提出结合频率因子(frequency factor,FF)和变分模态分解-灰色关联度分析-误差反向传播神经网络(var... 详细信息

为了减少库区滑坡失稳可能带来的损失,确保水电工程的安全稳定运行及保障周边民众的生命财产安全,探讨提升库区滑坡位移预测精度的方法。提出结合频率因子(frequency factor,FF)和变分模态分解-灰色关联度分析-误差反向传播神经网络(variational mode decomposition-grey relational analysis-back propagation neural network,VMD-GRA-BP)模型的库区滑坡位移预测方法,并应用于三峡库区滑坡。研究结果表明:FF对周期位移分量的预测效果有一定的提升,VMD-GRA-BP模型能够简化复杂非线性库区滑坡位移预测问题,BP模型预测性能优异,预测精度多高于支持向量机(support vector machine,SVM)和k最近邻(k-nearest neighbor,KNN)模型。研究结果可为库区滑坡位移预测和预警提供参考。

关键词：库区滑坡频率因子(FF) VMD-GRA-BP模型位移预测

生态因子对川渝地区壳斗科植物物种丰富度的影响

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应用与环境生物学报 2020年第3期26卷 689-696页

作者：张凤英冯毅廖梓延伍小刚潘开文谭雪熊勤犁唐天文张兴华虞超张林中国科学院成都生物研究所成都610041 中国科学院大学北京100049 成都市龙泉山城市森林公园管委会成都 610100 成都市农林科学研究院成都611130

西南川渝地区是我国壳斗科植物分布最为丰富的地区之一.以川渝地区壳斗科植物为研究对象,以皮尔逊相关系数(r<0.8)以及方差膨胀因子(VIF<10)为准则,选取代表现代气候、生境异质性和历史气候变化的9个生态因子,基于地理加权回归模型(GWR... 详细信息

西南川渝地区是我国壳斗科植物分布最为丰富的地区之一.以川渝地区壳斗科植物为研究对象,以皮尔逊相关系数(r<0.8)以及方差膨胀因子(VIF<10)为准则,选取代表现代气候、生境异质性和历史气候变化的9个生态因子,基于地理加权回归模型(GWR)探究生态因子对壳斗科植物物种丰富度的影响,并与经典的全局最小二乘回归法(OLS)进行比较.结果显示:(1)分布在川渝地区的壳斗科植物有6属共74种,主要以栎属(Quercus)和柯属(Lithocarpus)为主;(2)物种丰富度(SR)表现为南部最高,物种丰富度中心为川西南锦屏山东南部—鲁南山西侧、横断山中部的邛崃山南段—大凉山北段以及四川盆地东南缘大娄山东段,可达到29-35种;(3)GWR模型预测精度优于OLS,其预测结果表明海拔变幅、潜在蒸散量和最暖季降雨量是影响川渝壳斗科植物物种丰富度的主要因子,且影响程度表现出明显的空间差异性.整体来看,GWR模型可为探究物种-生态因子关系的空间异质特征提供一种新的方法,在生物多样性研究中具有较好的应用前景.

关键词：壳斗科植物地理加权模型川渝地区物种丰富度生态因子