Cathepsin B-responsive nanodrug delivery systems for precise diagnosis and targeted therapy of malignant tumors

作     者：Yanan Li Ting Mei Shupeng Han Tao Han Yongbing Sun Hui Zhang Feifei An Yanan Li;Ting Mei;Shupeng Han;Tao Han;Yongbing Sun;Hui Zhang;Feifei An

作者机构：Department of RadiologyFirst Hospital of Shanxi Medical UniversityTaiyuan 030001China College of Medical ImagingShanxi Medical UniversityTaiyuan 030001China Institute of Medical EngineeringDepartment of Biophysicschool of Basic Medical ScienceHeatih Science Center Xi'an Jiaotong UniverstyXi'an 710061China College of Chemistry and Life ScienceInstitute of Functional MoleculesChengdu Normal UniversityChengdu 611130China Division of PharmaceuticsNational Pharmaceutical Engineering Center for Solid Preparation in Chinese Hierbal MedicimeJiamgpri Unverity of Truditional Chinese MedicinveNanchang 330006China 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2020年第31卷第12期

页      面：3027-3040页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 07[理学] 070205[理学-凝聚态物理] 08[工学] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 0702[理学-物理学] 10[医学] 

基　　金：the National Natural Science Foundation of China(Nos.81903662,51903201) China Postdoctoral Science Foundation Grant(Nos.2019M661057,2019M653660) the Applied Basic Research Programs of Shanxi Province(No.201901D211347) the Scientific and Technological Innovation Programs of Higher Education Institutions in Shanxi(No.2019L0428) the Startup Foundation for Doctors of Shanxi Province(No.SD1827) Natural Science Foundation of Shaanxi Province(No.2020JQ-086) College Students’Innovation and Entrepreneurship Training Program(No.SJ201910698121) the Startup Foundation for Doctors of Shanxi Medical University(No.XD1824) 

主　　题：Tumor microenvironment Cathepsin B Theranostics Precise diagnosis Targeted therapy 

摘      要：The tumor microenvironment(TME)significantly influences cancer evolution and therapeutic *** biofunctional molecules to the TME has long been appreciated as a means of raising local drug concentrations and reducing systemic *** booming nanotechnology field has realized the importance of cathepsin B to derive a variety of intelligent enzyme-responsive nanosized drug delivery systems(nanoDDS)to improve treatment responses and clinical *** this tutorial review,after introducing the molecular structure and physiological/pathological functions of cathepsin B,the outstanding achievements of cathepsin B-responsive nanoplatforms in the precise diagnosis,targeted therapy,and synergistic theranostics of malignant tumors are systematically ***,the challenges of enzyme-substrate incompatibility,low diagnostic sensitivity,mass production and biocompatibility of multifunctional nanoDDS are considered in order to successfully promote them to clinical applications.