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Chinese Chemical Letters 2024年第4期35卷 502-505页

作者： Yan Cheng Hua-Peng Ruan Yan Peng Longhe Li Zhenqiang Xie Lang Liu shiyong zhang Hengyun Ye Zhao-Bo Hu Chaotic Matter Science Research Center Faculty of Materials Metallurgy and ChemistryJiangxi University of Science and TechnologyGanzhou 341000China College of Materials and Chemical Engineering Pingxiang UniversityPingxiang 337055China Jiangxi Provincial Key Laboratory of Functional Molecular Materials Chemistry Jiangxi University of Science and TechnologyGanzhou 341000China Key Laboratory of Jiangxi University for Functional Materials Chemistry School of Chemistry and Chemical EngineeringGannan Normal UniversityGanzhou 341000China

The application of multifunctional materials in various fields such as electronics and signal processors has attracted massive attention. Herein, a new organic-inorganic hybrid material [Et_(3)NCH_(2)Cl]_(2)[MnBr_(4)](1) is reported, which contains two organic amines cations and one [MnBr_(4)] tetrahedral ion. Compound 1 has a dielectric anomaly signal at 338 K, which proves its thermodynamic phase transition. The single crystal measurements at 200 K and 380 K show that the phase transition of compound 1 is caused by the thermal vibration of organic amine cations in the lattice. Moreover, compound 1 shows yellow-green luminescence under UV light irradiation. The magnetism measurements indicate that compound 1 shows switchable magnetic properties. This organic–inorganic material is a multifunctional material with dielectric, optical, and magnetic synergetic switchable effects, which expands a new direction for designing multifunctional materials.

关键词： Synergetic switchable effects Molecular materials Magnetism Dielectric Luminescence

Copper-mediated chemodynamic therapy with ultra-low copper consumption by doping cupric ion on cross-linked(R)-(+)-lipoic acid nanoparticles

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Regenerative Biomaterials 2023年第1期10卷 670-677页

作者： Rong Cui Bing Li Chunyan Liao shiyong zhang College of Biomedical Engineering National Engineering Research Center for BiomaterialsSichuan UniversityChengdu 610064China Hubei Key Laboratory of Wudang Local Chinese Medicine Research School of Pharmaceutical SciencesHubei University of MedicineShiyan 442000HubeiChina

Cu-mediated chemodynamic therapy(CDT)has attracted prominent attention owing to its advantages of pH independence and high efficiency comparing to Fe-mediated CDT,while the application of Cu-based CDT agents was impeded due to the high copper consumption caused by the metabolism loss of copper and the resultant potential ***,we developed a new copper-mediated CDT agent with extremely low Cu usage by anchoring copper on cross-linked lipoic acid nanoparticles(Cu@cLAs).After endocytosis into tumor cells,the Cu@cLAs were dissociated into LA and dihydrolipoic acid(DHLA)(reduced form of LA)and released Cu^(2+)and Cu+(oxidized form of Cu^(2+)),the two redox couples recycled each other in cells to achieve the efficient killing of cancer cells by delaying metabolic loss and increasing the ROS level of tumor *** self-recycling was confirmed in cells by the sustained high Cu/DHLA content and persistent ROS generation *** antitumor study based on the MCF-7/R nude mice gave the Cu@cLAs a tumor inhibitory rate up to 77.9%at the copper of 0.05 mg kg^(−1),the first dosage reported so far lower than that of normal serum copper(0.83±0.21 mg kg^(−1)).This work provides not only a new promising clinical strategy for the copper excessive use in copper-mediated CDT,but also gives a clue for other metal mediated disease therapies with the high metal consumption.

关键词： chemodynamic therapy copper metabolism (R)-(+)-lipoic acid nanodrug

1956-2021年石家庄市人间炭疽病流行特征分析

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医学动物防制 2024年第2期40卷 165-168页

作者：郭建花张世勇孙印旗张海红王炜李怡秋石家庄市疾病预防控制中心河北石家庄050011 河北省疾病预防控制中心

目的回顾分析石家庄市人间炭疽病的流行特征和长期趋势。方法采用年度变化百分比(annual percent change, APC)、集中度和圆形分布定量评估1956-2021年石家庄市人间炭疽病的疫情特征。采用χ2检验和t检验进行组间差异比较。结果 1956-... 详细信息

目的回顾分析石家庄市人间炭疽病的流行特征和长期趋势。方法采用年度变化百分比(annual percent change, APC)、集中度和圆形分布定量评估1956-2021年石家庄市人间炭疽病的疫情特征。采用χ2检验和t检验进行组间差异比较。结果 1956-2021年,除1986-1999年无人间炭疽病病例报告外,石家庄市累计报告人间皮肤炭疽病例245例,病死率为8.57%;无其他类型炭疽病病例报告。20~<50岁年龄组的病例占62.86%,男女性别比为8.07∶1,农民病例占85.31%,7~8月病例占57.14%,城乡发病例数比为1∶8.08。年均发病率为0.05/10万,APC为-18.48(t=-6.67,P<0.001);1964-1985年和2000-2021年人间炭疽病的APC分别为-27.54(t=-6.54,P<0.001)和32.17(t=3.12,P=0.020)。集中度为0.635 4。人间炭疽病的发病高峰为7月1日(5月6日~8月26日)(Z=98.93,P<0.001)。1956-1985年和2000-2021年人间炭疽病病例的年龄(t=0.77,P=0.452)、性别(χ^(2)=0.01,P=0.934)、城乡(χ^(2)=1.20,P=0.273)和发病时间(χ^(2)=0.37,P=0.545)差异均无统计学意义。结论 1956-2021年,石家庄市人间炭疽病疫情呈明显下降趋势,但2000-2021年有所上升。疫情有明显的人群和时间特征,需在高发季加强对高危人群的疾病监测。

关键词：炭疽病年度变化百分比圆形分布流行特征长期趋势分析

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3D技术在眶壁重建中的相关应用进展

国际耳鼻咽喉头颈外科杂志 2024年第2期48卷 112-115页

作者：张世勇徐志华安徽医科大学第三附属医院南区耳鼻咽喉科合肥230091

由于鼻眼相关解剖的复杂性,使得眶壁重建的治疗方案相对复杂。而3D技术可以将患者影像学检查结果立体化,便于临床医师多角度了解疾病。3D技术作为能辅助实现外科个体化重建修复和精准化治疗的新方法,在眶壁重建中展示出极高的临床应用... 详细信息

由于鼻眼相关解剖的复杂性,使得眶壁重建的治疗方案相对复杂。而3D技术可以将患者影像学检查结果立体化,便于临床医师多角度了解疾病。3D技术作为能辅助实现外科个体化重建修复和精准化治疗的新方法,在眶壁重建中展示出极高的临床应用价值及前景,能够为鼻眼外科的发展提供新的思路及技术动力。现阶段3D技术在眶壁重建中的应用主要为利用患者影像学结果进行三维重建和打印,本文将在手术模拟、术前规划及沟通、术中指导及术后评估等方面综述3D技术在眶壁重建中的应用进展。

关键词：成像,三维轨道,眶腔,眼眶重建

Performance study on Gossip-based group key distribution protocal

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Journal of Systems Engineering and Electronics 2006年第3期17卷 699-704,F0003页

作者： Yao Yan Ma Jianqing Zhong Yiping zhang shiyong Dept. of Computing and Information Technology Fudan Univ. Shanghai 200433 P. R. China

Group key distribution is faced with two important problems, i.e. reliability and scalability, to support security multicast for large and dynamic groups. With group member increasing, traditional reliable multicast protocol can not deal with them fully. Gossip-based group key distribution idea for wide-area dissemination was provided. It is based on an gossip-based loss recovery control mechanism. It can provide a probabilistic reliable guarantee for a information dissemination to reach every group member, which can achieve scalability and reliability. To achieve full reliability, three layers protocol model in group key distribution was provided. One is best effect layer, which provides unreliable dissemination. Other is gossip-based loss recovery layer, which provides probabilistic reliable guarantee. Last is vsync-based layer, which provide deterministic loss recovery. We integrate probabilistic loss recovery method with deterministic one. The model possess scalability that probabilistic method has and full reliability prosthesis by vsync-based. To evaluate the effectiveness of gossip technique in scalable and reliable multicast protocols. We have compared gossip protocol with other reliable multicast protocols. Experimental result shows that gossip protocol has better scalability than other.

关键词： key management group key distribution gossip-based reliable multicast reliability scalability.

IL-10-592和IL-4-589基因多态性在慢性HBV/HCV感染者肝脏炎症中的交互作用

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医学动物防制 2024年第1期40卷 65-67页

作者：张世勇仇艳光袁阳贾敏王丁军高秋菊石家庄市疾病预防控制中心流行病防治所河北石家庄050011 陆军军医大学士官学校河北省人民医院检验科

目的探讨白介素-10(interleukin-10,IL-10)-592位点和白介素-4(interleukin-4,IL-4)-589位点的基因多态性在慢性乙型肝炎病毒(Hepatitis B virus, HBV)和/或丙型肝炎病毒(Hepatitis C virus, HCV)感染者肝脏炎症中的交互作用。方法对20世纪80年代后期河北某农村单采血浆还输血细胞献血员中的HBV和/或HCV感染者进行分析,用多因子降维法(multifactor dimensionality reduction method, MDR)分析IL-10-592和IL-4-589基因多态性在慢性HBV/HCV感染者肝脏炎症中有无交互作用,用比值比(odds ratio,OR)和95%置信区间(confidence interval, 95%CI)评价肝脏炎症风险,交互作用大小用交互作用指数(synergy index,SI)、交互作用归因比(attributable proportion of interaction,API)、交互作用超额相对危险度(relative excess risk of interaction,RERI)及95%CI评价。结果 (1)MDR分析显示IL-10-592和IL-4-589基因位点对慢性HBV/HCV感染者肝脏炎症有明显的交互作用(检验准确度=0.711 2,交叉验证一致性=10/10,P0.05)、1.79(0.52~6.15)(χ^(2)=0,P>0.05)。(3)IL-4-589 CC/CT和IL-10-592 AC基因型共存时对HBV/HCV慢性感染者肝脏炎症的OR值及95%CI为5.47(1.93~15.49)(χ^(2)=20.310,P<0.01),SI为5.81,API为67.64%,RERI为3.70(2.55~5.37)。结论 IL-10-592 AC和IL-4-589 CC/CT基因型共存对慢性HBV/HCV感染者的肝脏炎症有明显的交互作用。

关键词： HBV感染 HCV感染肝脏炎症细胞因子基因多态性交互作用

Cross-linked lipoic acid nanocapsules serve as H_(2)O_(2) amplifier to strengthen the H_(2)O_(2)-sensitive prodrug activation

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中国科学:化学英文版 2023年第9期66卷 2654-2663页

作者： Jiangbing Tan Pei Jing Xiao Xiao Yulong Liao Chunyan Liao shiyong zhang College of Biomedical Engineering and National Engineering Research Center for Biomaterials Sichuan UniversityChengdu 610064China Department of Pharmacy the Affiliated Hospital of Southwest Medical UniversityLuzhou 646000China

The H_(2)O_(2) -triggered prodrug activation represents a hot topic while the low H_(2)O_(2) level of cancer cells hindered the complete activation of parent drugs and resulted in the poor therapeutic effect. Here, we developed an H_(2)O_(2) amplifier fabricated by crosslinked lipoic acid nanocapsules(cLANCs), which would selectively elevate the intracellular H_(2)O_(2) level of cancer cells 3.4-fold higher than that of untreated cancer cells so as to speed up the activation of parent drug from the loaded prodrugs(Pro-5-FU). The cytotoxicity showed that the killing effect of Pro-5-FU loaded in cLANCs(Pro-5-FU@cLANCs) arrived up to 1.6-time higher than that of Pro-5-FU alone against A549 cells, and was even close to free 5-FU. The in vivo anticancer evaluation gave the tumor inhibition rate(TIR) and survival rate(SR) of Pro-5-FU@cLANCs against A549 tumor-bearing nude mice up to 73.1% and 80%,respectively, much higher than those of Pro-5-FU(TIR: 41.2%, SR: 20%) or free 5-FU(TIR: 50.6%, SR: 0%). This nanodrug constructed the first example that utilizes the drug carriers as H_(2)O_(2) amplifier to strengthen the prodrug activation.

关键词： cancer therapy prodrug activation H_(2)O_(2)amplifier drug carrier

Biodegradable polymeric nanoparticles based on amphiphilic principle:construction and application in drug delivery

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Science China Chemistry 2014年第4期57卷 461-475页

作者： zhang shiyong WU Yao HE Bin LUO Kui GU ZhongWei National Engineering Research Center for Biomaterials Sichuan University

The use of nanotechnology in drug-delivery systems(DDS) is attractive for advanced diagnosis and treatment of cancer diseases. Biodegradable polymeric nanoparticles, for example, have promising applications as advanced drug carriers in cancer treatment. In this review, we discuss the development of drug-delivery systems based on an amphiphilic principle mainly conducted by our group for anti-cancer drug delivery. We first briefly address the synthetic chemistry for amphiphilic biodegradable polymers. In the second part, we summarize progress in the application of self-assembled polymer micelles using amphiphilic biodegradable copolymers as anti-tumor drug carriers.

关键词： biodegradable polymer miceUe amphiphilicity drug-delivery system cancer

Flooding attack and defence in Ad hoc networks

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Journal of Systems Engineering and Electronics 2006年第2期17卷 410-416页

作者： Yi Ping Hou Yafei Zhong Yiping zhang shiyong Dai Zhoulin School of Information Security Engineering Shanghai Jiaotong Univ. Shanghai 200030 P. R. China Dept. of Computing and Information Technology Fudan Univ. Shanghai 200433 P. R. China Graduate School of Engineering Kochi University of Technology Rochi 782-8502 Japan.

Mobile ad hoc networks are particularly vulnerable to denial of service （DOS） attacks launched through compromised nodes or intruders. In this paper, we present a new DOS attack and its defense in ad hoc networks. The new DOS attack, called AA hoc Flooding Attack（AHFA）, is that intruder broadcasts mass Route Request packets to exhaust the communication bandwidth and node resource so that the valid communication can not be kept. After analyzed AM hoc Flooding Attack, we develop Flooding Attack Prevention （FAP）, a genetic defense against the AM hoc Flooding Attack. When the intruder broadcasts exceeding packets of Route Request, the immediate neighbors of the intruder record the rate of Route Request. Once the threshold is exceeded, nodes deny any future request packets from the intruder. The results of our implementation show FAP can prevent the AM hoe Flooding attack efficiently.

关键词： computer networks security mobile Ad hoe networks routing protocol denial of service Ad hoc flooding attack.

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光响应纳米材料在骨组织再生中的应用

中国组织工程研究 2025年第16期29卷 3469-3475页

作者：冯淑琦张诗咏姚珂奕唐渝菲王锴周雪梅向琳口腔疾病防治全国重点实验室国家口腔医学中心国家口腔疾病临床医学研究中心四川大学华西口腔医院四川省成都市610041 四川大学化学工程学院四川省成都市610065

背景:光响应纳米材料兼具纳米材料的优点以及光响应的独特优势,在组织再生、生物成像、疾病诊断、药物递送和靶向治疗等生物医学领域广泛应用,是目前功能材料领域的研究热点。目的:综述光响应纳米材料及其在骨组织再生中的应用优势和研... 详细信息

背景:光响应纳米材料兼具纳米材料的优点以及光响应的独特优势,在组织再生、生物成像、疾病诊断、药物递送和靶向治疗等生物医学领域广泛应用,是目前功能材料领域的研究热点。目的:综述光响应纳米材料及其在骨组织再生中的应用优势和研究进展。方法:应用计算机检索中国知网和PubMed数据库,主要的英文检索词为“light-responsive,photoresponsive,nanomaterials,bone defect,bone regeneration,osteogenesis,osseointegration”,主要的中文检索词为“光响应,纳米材料,骨缺损,骨再生,骨结合”,根据纳入和排除标准筛选相关文献,最终纳入59篇文献进行综述。结果与结论:光响应纳米材料的表面形貌可通过直接调节成骨细胞及间接调节免疫相关细胞的基因表达及生物学行为来促进骨组织再生。光响应纳米材料可利用光热抗菌、光动力抗菌促进感染性骨缺损的修复。光响应纳米材料产生的温和光热刺激可通过上调成骨相关基因、蛋白质的表达及功能性成骨来有效增强成骨作用。光响应纳米材料在光照下可产生电子,进而通过调节细胞局部电位变化达到无创促进骨组织再生的目的。基于光响应纳米材料的药物释放系统可在特定光源照射下发生结构变化,以促进药物释放,为骨组织再生提供靶向治疗策略。

关键词：光响应纳米材料骨缺损骨再生骨结合综述