Azobenzene quaternary ammonium salt for photo-controlled and reusable disinfection without drug resistance

作     者：Yuhong Zhu Pengfei Li Caikun Liu Mengqi Jia Yadong Luo Dengfeng He Chunyan Liao Shiyong Zhang Yuhong Zhu;Pengfei Li;Caikun Liu;Mengqi Jia;Yadong Luo;Dengfeng He;Chunyan Liao;Shiyong Zhang

作者机构：College of ChemistrySichuan UniversityChengdu 610064China College of Biomedical Engineering and National Engineering Research Center for BiomaterialsSichuan UniversityChengdu 610064China 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2023年第34卷第2期

页      面：440-445页

核心收录：

学科分类：081702[工学-化学工艺] 08[工学] 0817[工学-化学工程与技术] 

基　　金：supported by grants from the National Natural Science Foundation of China (No. 21975165) Innovative Research Team Program of Sichuan Province (No. 2021JDTD0015) China Postdoctoral Science Foundation (No. 2021TQ0228) 

主　　题：Azobenzene Quaternary ammonium salt Photosensitivity Repeatability Antibacterial agent 

摘      要：The abuse of antibiotics causes severe bacterial resistance, and the shortage of antibiotics has created a global public health crisis. This situation has prompted people to develop new antibacterial agents independent of traditional antibiotics. Here, we created a series of photosensitive azobenzene-quaternary ammonium salt smart antibacterial agents by connecting azobenzene with amines with different chain lengths to improve the antibacterial selectivity of quaternary ammonium salt(QAS) and prevent the accumulation of active QAS in the environment. After trans-cis isomerization, the solubility of the title compound(compound 4) increased and the antibacterial property enhanced. The experimental results suggested that the antibacterial effect of compound 4 was significantly enhanced after 365 nm light irradiation, and it had photosensitive intelligent antibacterial activity and could be reused. Notably, we did not obtain any mutants of Staphylococcus aureus or Escherichia coli resistant to compound 4. In general,compound 4 has the advantages of high yield, photo-controllable antibacterial properties, reusability, and does not induce bacterial resistance. This photosensitive antibacterial compound provides a new idea for the construction of intelligent disinfectants and is expected to be a candidate for disinfectants in public facilities and medical architecture.