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Predictions of mortality related to four major cancers in China,2020 to 2030

Cancer Communications 2021年第5期41卷 404-413页

作者： Ning Li Peng Wu Yubing Shen Cuihong Yang luwen zhang Yali Chen Zixing Wang Jingmei Jiang Department of Epidemiology and Biostatistics Institute of Basic Medicine SciencesChinese Academy of Medical Sciences/School of Basic MedicinePeking Union Medical CollegeBeijing 100005P.R.China

Background:Cancer has become a global health problem,and assessments of cancer mortality are important for effective public health policy-making and adequate resource *** this study,we aimed to predict the mortality rates and numbers of deaths related to four common cancers(lung,liver,stomach,and esophagus)in China from 2020 to 2030 and to estimate the corresponding cancer burden caused by population aging and tobacco ***:Cancer mortality data(2004-2017)were extracted from China’s death surveillance datasets,and China’s population figures(2020-2030)were obtained from the United Nations population *** prevalence data were retrieved from a World Health Organization global report,and relative risks of smoking and cancers were derived from large-scale Asian *** predicted the deaths related to the four major cancers and age-standardized mortality rates using joinpoint regression and linear regression *** tobacco smoking related burden of these four major cancers was estimated using the population attributable ***:Unlike lung cancer mortality which was predicted to continue to increase,the age-standardized mortality rates for digestive cancers(liver,stomach,and esophageal cancers)are predicted to decline over the next *** number of deaths caused by the four major cancers is predicted to increase from 1,490,304 in 2020 to 1,823,960 in *** age-specific mortality rates of the four major cancers are predicted to increase with age after 40-45 years,peaking in the age groups of 80-84 and ≥85 *** 2030,the combined number of deaths from the four examined cancers among adults aged ≥65 years is predicted to be 1,167,153,accounting for 64% of all deaths from these *** smoking is predicted to contribute to nearly 29% of deaths fromthese cancers,corresponding to 527,577 ***:The overall trend in the combined total mortality from four major cancers is predicted to decline over th

关键词： cancer mortality China esophageal cancer liver cancer lung cancer population aging prediction smoking stomach cancer

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Seroprevalence of Toxoplasma gondii infection among patients with hand, foot and mouth disease in Henan, China: a hospital-based study

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Infectious Diseases of Poverty 2015年第1期4卷 460-464页

作者： Shuai Wang Chunwei Lan luwen zhang Haizhu zhang Zhijun Yao Dong Wang Jingbo Ma Jiarong Deng Shiguo Liu Department of Human Parasitology Xinxiang Medical UniversityXinxiangHenan 453003PR China First People’s Hospital of Pingdingshan PingdingshanHenan 467000PR China

Background:The prevalence of infection with Toxoplasma gondii(***)in humans has been increasing in China due to the growing number of cats in the ***,foot and mouth disease(HFMD)is a serious public health issue in China and still one of the leading causes of child ***,little is known about the epidemiology of *** infection among HFMD ***:A case–control study of 281 HFMD patients from the First People’s Hospital of Pingdingshan in Pingdingshan city,Henan province,central China,and 222 controls from Pingdingshan city was *** antibodies were serologically detected using the enzyme-linked immunosorbent ***:We found that the overall *** immunoglobulin G(IgG)antibody prevalence among HFMD patients was 12.46%,which was significantly higher than that in clinically healthy children(1.80%).The highest *** seroprevalence was detected in critical cases(22.58%),followed by severe cases(11.50%),and the lowest was detected in mild cases(8.33%).Conclusion:The present study is the first survey of *** seroprevalence among HFMD patients in China;12.46%were defined as *** is imperative that improved integrated measures are taken to prevent and control *** infection among HFMD patients.

关键词： Toxoplasma gondii Hand Foot and mouth disease Seroprevalence Enzyme-linked immunosorbent assay China

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Network prediction of surgical complication clusters:a prospective multicenter cohort study

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Science China(Life Sciences) 2023年第7期66卷 1636-1646页

作者： Xiaochu Yu Peng Wu Zixing Wang Wei Han Yuguang Huang Shijie Xin Qiang zhang Shengxiu Zhao Hong Sun Guanghua Lei Taiping zhang luwen zhang Yubing Shen Wentao Gu Hongwei Li Jingmei Jiang Peking Union Medical College Hospital Chinese Academy of Medical SciencesBeijing100730China Institute of Basic Medical Sciences Chinese Academy of Medical Sciences/School of Basic MedicinePeking Union Medical CollegeBeijing100005China The First Hospital of China Medical University Shenyang110001China Qinghai Provincial People’s Hospital Xining810007China Xiangya Hospital of Central South University Changsha410008China Research Department PaodingAIBeijing100083China

Complicated relationships exist in both occurrence and progression of surgical complications,which are difficult to account for using a separate quantitative method such as prediction or *** of 51,030 surgical inpatients were collected from four academic/teaching hospitals in a prospective cohort study in *** relationship between preoperative factors,22 common complications,and death was *** input from 54 senior clinicians and following a Bayesian network approach,a complication grading,cluster-visualization,and prediction(GCP)system was designed to model pathways between grades of complication and preoperative risk factor *** the GCP system,there were 11 nodes representing six grades of complication and five preoperative risk factor clusters,and 32 arcs representing a direct *** critical targets were pinpointed on the *** status was a fundamental cause widely associated(7/32 arcs)with other risk factor clusters and *** Society of Anesthesiologists(ASA)score≥3 was directly dependent on all other risk factor clusters and influenced all severe *** III complications(mainly pneumonia)were directly dependent on4/5 risk factor clusters and affected all other grades of *** of grade,complication occurrence was more likely to increase the risk of other grades of complication than risk factor clusters.

关键词： surgical complication network system complication grading complication prediction complication management

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分子碘催化氧化C(sp^(3))—H功能化反应的研究进展

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有机化学 2021年第4期41卷 1359-1395页

作者：张露文何炜第四军医大学药学院化学教研室西安710032

现代有机合成中,C—H功能化反应可以用于直接构建各种生物活性骨架以及增加目标分子结构的复杂性,是对传统合成方法的有效补充,其中惰性C(sp^(3))—H功能化长期以来是该领域的难点.目前,碘试剂已被确定为经济和生态上无害的过渡金属替代... 详细信息

现代有机合成中,C—H功能化反应可以用于直接构建各种生物活性骨架以及增加目标分子结构的复杂性,是对传统合成方法的有效补充,其中惰性C(sp^(3))—H功能化长期以来是该领域的难点.目前,碘试剂已被确定为经济和生态上无害的过渡金属替代品,在具有挑战性的C(sp^(3))—H功能化反应中已经取得了卓有成效的进展.分子碘与高价芳基碘试剂、二甲基亚砜(DMSO)、过氧化物以及氧气等组合,能够高效地催化不同反应类型的C(sp^(3))—H功能化反应,在不同氧化体系下具有不同的反应特点和机制.另外,近年来,过渡金属/分子碘协同催化以及含碘电化学催化等新型碘催化体系在C(sp^(3))—H功能化反应中也得到了前所未有的发展.综述了2015年至今分子碘在不同氧化体系下催化的C(sp^(3))—H功能化反应,希望能进一步了解分子碘的绿色催化体系,为深入研究C(sp^(3))—H功能化反应提供帮助.

关键词：分子碘 C(sp^(3))—H功能化氧化体系绿色化学电化学

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Nuclear factor κB represses the expression of latent membrane protein 1 in Epstein-Barr virus transformed cells

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World Journal of Virology 2014年第4期3卷 22-29页

作者： Mingxia Cao Qianli Wang Amy Lingel luwen zhang School of Biological Sciences University of NebraskaLincolnNE 68588United States 238 Morrison Center School of Biological SciencesNebraska Center for VirologyUniversity of NebraskaLincolnNE 68583-0900United States

AIM: To investigate the role of nuclear factor κB(NF-κB) in the regulation of Epstein-Barr virus(EBV) latent membrane protein 1(LMP1) in EBV transformed cells. METHODS: LMP1 expression was examined in EBV transformed human B lymphocytes with modulation of NF-κB activity. RESULTS: EBV infection is associated with several human cancers. EBV LMP1 is required for efficient transformation of adult primary B cells in vitro, and is expressed in several pathogenic stages of EBVassociated cancers. Regulation of EBV LMP1 involves both viral and cellular factors. LMP1 activates NF-κB signaling pathway that is a part of the EBV transformation program. However, the relation between NF-κB and LMP1 expression is not well established yet. In this report, we found that blocking the NF-κB activity by Inhibitor of κB stimulated LMP1 expression, while the overexpression of NF-κB repressed LMP1 expression in EBV-transformed IB4 cells. In addition, LMP1 repressed its own promoter activities in reporter assays, and the repression was associated with the activation of NF-κB. Moreover, NF-κB alone is sufficient to repress LMP1 promoter activities. CONCLUSION: Our data suggest LMP1 may repress its own expression through NF-κB in EBV transformed cells and shed a light on LMP1 regulation during EBV transformation.

关键词： Nuclear factorκB Epstein-Barr virus Latent membrane protein 1 Latency Transformation

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Iodoarene-Catalyzed Oxyamination of Unactivated Alkenes to N-substituted furanmethanamines Synthesis

Iodoarene-Catalyzed Oxyamination of Unactivated Alkenes to N...

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中国化学会·第十六届全国应用化学年会

作者： Xiaojun Deng Huixia Liu luwen zhang 何炜 Department of Chemistry The Fourth Military Medical University 第四军医大学

Alkene difunctionalization is one of the most important approach to the rapid assembly of molecular complexity. In particularly, an alkene oxyamination process to useful 1,2-amino alcohol derivatives synthesis. Given their importance, many powerful transition metal catalyzed strategies have been developed recently, such as copper, palladium, osmium, rhodium, iron and so on. However, in most cases, the coupling components employed in these reactions requires prior synthesis and electron-rich amines as the nitrogen source or high reaction temperature. Herein, An iodoarene-catalyzed intramolecular oxyamination of unactivated alkenes is accomplished, utilizing HNTs2 as nitrogen source and m-CPBA as the oxidant in room temperature. More than 40 N-bistosyl substituted 5-phenylimino-2-furanmethanamines were synthesized in good yields. Preliminary experiment for the asymmetric variants of the reaction shows enormous potential of chiral iodoarene compounds in catalyzing asymmetric difunctionalization of alkenes.

关键词： Iodoarene Oxyamination Unactivated Alkenes N-substituted furanmethanamines

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Targeting TRMT5 suppresses hepatocellular carcinoma progression via inhibiting the HIF-1αpathways

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2023年第1期24卷 50-63页

作者： Qiong ZHAO luwen zhang Qiufen HE Hui CHANG Zhiqiang WANG Hongcui CAO Ying ZHOU Ruolang PAN Ye CHEN Department of Genetics and Department of Genetic and Metabolic DiseaseThe Children's HospitalZhejiang University School of MedicineNational Clinical Research Center for Child HealthHangzhou 310052China Zhejiang Provincial Key Laboratory of Genetic and Developmental Disorders Institute of GeneticsZhejiang UniversityHangzhou 310058China State Key Laboratory for Diagnosis and Treatment of Infectious Diseases National Clinical Research Center for Infectious Diseasesthe First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Xiangshan Hospital of TCM Medical and Health Group Ningbo 315700China Zhejiang Provincial Key Laboratory of Cell-Based Drug and Applied Technology Development Hangzhou 311121China

Accumulating evidence has confirmed the links between transfer RNA(tRNA)modifications and tumor *** present study is the first to explore the role of tRNA methyltransferase 5(TRMT5),which catalyzes the m1G37 modification of mitochondrial tRNAs in hepatocellular carcinoma(HCC)***,based on bioinformatics and clinical analyses,we identified that TRMT5 expression was upregulated in HCC,which correlated with poor *** TRMT5 attenuated HCC proliferation and metastasis both in vivo and in vitro,which may be partially explained by declined extracellular acidification rate(ECAR)and oxygen consumption rate(OCR).Mechanistically,we discovered that knockdown of TRMT5 inactivated the hypoxia-inducible factor-1(HIF-1)signaling pathway by preventing HIF-1αstability through the enhancement of cellular oxygen ***,our data indicated that inhibition of TRMT5 sensitized HCC to doxorubicin by adjusting HIF-1α.In conclusion,our study revealed that targeting TRMT5 could inhibit HCC progression and increase the susceptibility of tumor cells to chemotherapy ***,TRMT5 might be a carcinogenesis candidate gene that could serve as a potential target for HCC therapy.

关键词： Transfer RNA(tRNA) tRNA methyltransferase 5(TRMT5) Hepatocellular carcinoma(HCC) Hypoxia-inducible factor-1α(HIF-1α)

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Prediction of H7N9 epidemic in China

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Chinese Medical Journal 2014年第2期127卷 254-260页

作者： zhang Zhaojie Xia Yao Lu Yi Yang Jingchao zhang luwen Su Hui Lin Lili Wang Guoling Wang Tongmei Lin Shao Guo Zhongmin Lu Jiahai School of Public Health Sun Yat-sen University GuangzhouGuangdong 510030 China Department of Earth Science Sun Yat-sen University Guangzhou Guangdong 510275 China School of Public Health Southern Medical University Guangzhou Guangdong 510515 China Key Laboratory of Tropical Disease Control Ministry of Education Guangzhou Guangdong 510080 China Haizhu District Center for Disease Control and Prevention Guangzhou Guangdong 510288 China Department of Atmospheric Science School of Environmental Science and Engineering Sun Yat-sen University Guangzhou Guangdong 510275 China School of Public Health University at Albany State University of New York Rensselaer New York USA

Background In March 2013,human cases of infection with a novel A （H7N9） influenza virus emerged in *** epidemic spread quickly and as of 6 May 2013,there were 129 confirmed *** purpose of this study was to analyze the epidemiology of the confirmed cases,determine the impacts of bird migration and temperature changes on the H7N9 epidemic,predict the future trends of the epidemic,explore the response patterns of the government and propose preventive *** The geographic,temporal and population distribution of all cases reported up to 6 May 2013 were described from available *** assessment standard was established by analysing the temperature and relative humidity records during the period of extensive outbreak in three epidemic regions in eastern China,including Shanghai,Zhejiang and Jiangsu *** assessment maps were created by combining the bird migration routes in eastern China with the monthly average temperatures from May 1993 to December 2012 *** Among the confirmed cases,there were more men than women,and 50.4％ were elderly adults （age ＞61 years）.The major demographic groups were retirees and *** temperature on the days of disease onset was concentrated in the range of 9℃-19℃; we defined 9℃-19℃ as the high-risk temperature range,0℃-9℃ or 19℃-25℃ as medium risk and ＜0℃ or ＞25℃ as low *** relative humidity on the days of disease onset ranged widely from 25％ to 99％,but did not correlate with the incidence of *** on the temperature analysis and the eastern bird migration routes,we predicted that after May,the high-risk region would move to the northeast and inland,while after September,it would move back to north *** Temperature and bird migration strongly influence the spread of the H7N9 *** order to control the H7N9 epidemic effectively,Chinese authorities should strengthen the surveillance of migrating birds,increase poultry and environmental sampling,improve l

关键词： H7N9 prediction bird migration passive response pattern

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基于Python分析中老年人群多重慢病患者现状的研究

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内蒙古大学学报（自然科学版） 2022年第1期53卷 92-97页

作者：张朋张露文郭改枝内蒙古师范大学计算机科学技术学院呼和浩特010020 南方医科大学卫生管理学院广州510000

随着我国快速的人口老龄化和疾病谱的变化情况,为预防多重慢性病的发生并提高中老年人生活质量,同时更好地实现健康中国2030,以中国健康与养老追踪调查(China Health and Retirement Longitudinal Study,简称CHARLS)数据为基础,选择性... 详细信息

随着我国快速的人口老龄化和疾病谱的变化情况,为预防多重慢性病的发生并提高中老年人生活质量,同时更好地实现健康中国2030,以中国健康与养老追踪调查(China Health and Retirement Longitudinal Study,简称CHARLS)数据为基础,选择性别、年龄、城乡分布、是否识字、婚姻状态及慢病情况等多维变量,使用Python编程进行统计及卡方检验,分析中老年人多重慢病患者疾病构成和多重慢病的组合,得到多重慢病的患病率与人口年龄和城乡分布有关。该研究结果希望可以引起人们对慢病及多重慢病的高度关注,提升居民健康意识,同时为减轻政府医疗卫生支出提出一些合理的建议。

关键词：慢性病多重疾病中国健康与养老追踪调查 Python

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Seroprevalence of Toxoplasma gondii infection among patients with hand, foot and mouth disease in Henan, China:a hospital-based study

Seroprevalence of Toxoplasma gondii infection among patients...

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中国动物学会寄生虫学专业委员会第十届全国寄生虫学青年工作者学术研讨会

作者： Shuai Wang Chunwei Lan luwen zhang Haizhu zhang Zhijun Yao Dong Wang Jingbo Ma Jiarong Deng Shiguo Liu Department of Human Parasitology School of Basic Medical Sciences Xinxiang Medical University First People's Hospital of Pingdingshan

The prevalence of infection with Toxoplasma gondii(T. gondii) in humans has been increasing in China due to the growing number of cats in the country. Hand, foot and mouth disease(HFMD) is a serious public health issue in China and still one of the leading causes of child mortality. However, little is known about the epidemiology of T. gondii infection among HFMD patients. A case-control study of 281 HFMD patients from the First People’s Hospital of Pingdingshan in Pingdingshan city, Henan province, central China, and 222 controls from Pingdingshan city was conducted. Anti-T. gondii antibodies were serologically detected using the enzyme-linked immunosorbent assay. We found that the overall anti-T. gondii immunoglobulin G(Ig G) antibody prevalence among HFMD patients was 12.46%, which was significantly higher than that in clinically healthy children(1.80%). The highest T. gondii seroprevalence was detected in critical cases(22.58%), followed by severe cases(11.50%), and the lowest was detected in mild cases(8.33%). The present study is the first survey of T. gondii seroprevalence among HFMD patients in China;12.46% were defined as seropositive. It is imperative that improved integrated measures are taken to prevent and control T. gondii infection among HFMD patients.

关键词： Toxoplasma gondii hand foot and mouth disease seroprevalence enzyme-linked immunosorbent assay China

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