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Investigation of the Service Properties of the Electroslag Cast Metal

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Journal of Iron and Steel Research International 1998年第2期5卷 17-23页

作者： Li Zhengbang zhang jiawen Lin Gongwen Central Fron&Steel Research Institute MMIBeijing(100081)China

The electroslag cast metal features its cleanness,sound structure,consistent composition,smooth surface,high metal yield,excellent mechanical properties and service *** advantages have been applied to turbine discs,ai... 详细信息

关键词： electroslag casting service properties

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Modification of Inclusions in ESR Bearing Steel

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Journal of Iron and Steel Research International 1998年第1期5卷 34-37页

作者： Li Zhengbang zhang jiawen Li Ying Wang Changsheng Central Iron and Steel Research Institute MMI Daye Special Steel Corporation Ltd.

Electroslag remelting (ESR) process using consumable electrode deoxidized with Ca-Si and Fe-Si instead of Al, and acid slag (CaF_2SiO_2Al_2O_3CaO) instead of universal slag ANF_6(CaF_2. 70 %+A1_2O_3.30 %) could change brittle inclusion (alumina) to ductile inclusion (silicate) in remelted steel. Fatigue life of bearing steel could be increased significantly in this way.

关键词： deoxidant acid slag ESR inclusion bearing steel

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Emerging mechanisms and implications of c GAS-STING signaling in cancer immunotherapy strategies

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Cancer Biology & Medicine 2024年第1期21卷 45-64页

作者： jiawen zhang Sihui Yu Qiao Peng Ping Wang Lan Fang Tongji University Cancer Center Shanghai Tenth People’s HospitalSchool of MedicineTongji UniversityShanghai 200072China Reproductive Medicine Center Department of Obstetrics and GynecologyShanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai 201620China Department of Obstetrics and Gynecology Zhongshan HospitalFudan UniversityShanghai 200032China

The intricate interplay between the human immune system and cancer development underscores the central role of immunotherapy in cancer *** this landscape,the innate immune system,a critical sentinel protecting against tumor incursion,is a key *** cyclic GMP-AMP synthase(c GAS)and stimulator of interferon genes(STING)pathway has been found to be a linchpin of innate immunity:activation of this signaling pathway orchestrates the production of type I interferon(IFN-α/β),thus fostering the maturation,differentiation,and mobilization of immune effectors in the tumor ***,STING activation facilitates the release and presentation of tumor antigens,and therefore is an attractive target for cancer *** strategies to activate the STING pathway,including use of pharmacological agonists,have made substantial advancements,particularly when combined with immune checkpoint *** approaches have shown promise in preclinical and clinical settings,by enhancing patient survival *** review describes the evolving understanding of the c GAS-STING pathway's involvement in tumor biology and ***,this review explores classical and non-classical STING agonists,providing insights into their mechanisms of action and potential for optimizing immunotherapy *** challenges and complexities,the c GAS-STING pathway,a promising avenue for enhancing cancer treatment efficacy,has the potential to revolutionize patient outcomes.

关键词： cGAS-STING pathway type I interferon cyclic dinucleotide STING agonist cancer immunotherapy

Research on D2D Co-localization Algorithm Based on Clustering Filtering

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China Communications 2020年第8期17卷 121-132页

作者： jiawen zhang Fuxing Yang Zhongliang Deng Xiao Fu Jiazhi Han School of Automation Beijing University of Posts and TelecommunicationsBeijing 100876China School of Electronic Engineering Beijing University of Posts and TelecommunicationsBeijing 100876China

Nowadays, most positioning systems carry out locational calculation based on the accurate location information of some devices in the network. However there is a deviation in the locational information of the part of the device, we need to reduce it in order to obtain higher positioning accuracy. In this paper, we proposed a new centralized D2D(Device-to-Device) co-location algorithm. This algorithm uses DBSACN(Density-Based Spatial Clustering of Applications with Noise) clustering to reduce the deviation of device location information. Numerical results show that the positioning accuracy of the centralized D2D co-localization algorithm is improved by 62.7% compared with the SPAWN algorithm, which positioning performance superior to the traditional co-localization algorithm.

关键词： co-location D2D clustering DBSACN

Upconversion nano-photosensitizer targeting into mitochondria for cancer apoptosis induction and cyt c fluorescence monitoring

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Nano Research 2016年第11期9卷 3257-3266页

作者： Yanyan Liu jiawen zhang Changjing Zuo Zhen zhang Dalong Ni Chen zhang Jing Wang Hui zhang Zhenwei Yao Wenbo Bu State Key Laboratory of High Performance Ceramics and Superfine Microstructures Shanghai Institute of Ceramics Chinese Academy o Sciences 1295 Dingxi Road Shanghai 200050 China Department of Radiology Huashan Hospital Fudan University 12 Urumqi Zhong Road Shanghai200040 China Department of Nuclear Medicine Changhai Hospital of Shanghai 168 Changhai Road Shanghai200433 China Cancer Research Institute Fudan University Shanghai Cancer Center 270 Dongan Road Shanghai200032 China Shanghai Key Laboratory of Green Chemistry and Chemical Processes School of Chemistry and Molecular Engineering East China Normal University 3663 Zhongshan North Road Shanghai200062 China

Disruption of mitochondrial reactive oxygen species （mitoROS） plays a major role in cancer cell apoptosis. Here, we designed a core/shell-structured mitochondriatargeting upconversion-based nano-photosensitizer （TPP-UC（PS）） with a lanthanidedoped upconversion nanoparticle （UCNP） core coated by a photosensitizer （PS）-incorporated dense silica shell. Following irradiation with external nearinfrared laser （NIR）, TPP-UC（PS） in mitochondria caused serious mitochondrial matrix swelling for the activated upconversion-based photodynamic therapy （UC-PDT）, and the mobilization of cytochrome c （cyt c） was amplified in response to the increased mitoROS. Specifically, this heme-containing cyt c could be monitored by varying TPP-UC（PS）＇s upconversion luminescence signal （UCL）, which may facilitate the in situ detection of cyt c for apoptosis research. As a proof of concept, our designed TPP-UC（PS） may provide significant opportunities for controlling cancer cell apoptosis under NIR stimulation and for studying apoptosis using the dynamic UCL, which is influenced by local cyt c.

关键词： mitochondrial reactiveoxygen species (mitoROS) upconversion-based photodynamic therapy(PDT) cytochrome c (cyt c) mitochondrial apoptosis

Human health ambient water quality criteria for 13 heavy metals and health risk assessment in Taihu Lake

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Frontiers of Environmental Science & Engineering 2022年第4期16卷 15-25页

作者： Liang Cui Ji Li Xiangyun Gao Biao Tian jiawen zhang Xiaonan Wang Zhengtao Liu State Key Laboratory of Environmental Criteria and Risk Assessment Chinese Research Academy of Environmental SciencesBeijing 100012China Faculty of Land and Resources Engineering Kunming University of Science and TechnologyKunming 650093China

Heavy metals are widely concerning because of their toxicity,persistence,non-degradation and bioaccumulation *** health ambient water quality criteria(AWQC)are specific levels of chemicals that can occur in water without harming human *** present,most countries do not consider the effects of aquatic vegetables in deriving human health ***,the intake of aquatic vegetables(Brasenia schreberi)was added to the derivation of human health AWQC and a health risk assessment for 13 heavy metals in Taihu *** human health AWQC(consumption of water,fish and aquatic vegetables)values of 13 heavy metals ranged from 0.04(Cd)to 710.87μg/L(Sn),and the intake of *** had a very significant effect on the human health AWQC for Cu,with a more than 62-fold *** hazard quotients of As(2.8),Cd(1.6),Cr(1.4)and Cu(4.86)were higher than the safe level(HQ=1),indicating that As,Cd,Cr and Cu in Taihu Lake posed a significant health *** analysis showed that the contribution rate of *** intake to the human health risk from Cu was 91.6%,and all results indicated that the risk of Cu in *** to human health should be of particular *** study adds the consideration of aquatic vegetable consumption to the traditional method of human health AWQC derivation and risk assessments for the first time,and this approach can promote the development of risk assessments and water quality criteria.

关键词： Heavy metals Human health ambient water quality criteria Taihu Lake Health risk assessment Contribution rate

Switched Three-Dimensional Decoupling Stabilization of Underactuated Autonomous Underwater Vehicles

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Journal of Shanghai Jiaotong university(Science) 2022年第3期27卷 383-392页

作者： FANG Haolin zhang jiawen LI Jiawang Faculty of Maritime and Transportation Ningbo UniversityNingbo 315211ZhejiangChina

A three-dimensional stabilization problem for underactuated autonomous underwater vehicles(AUVs)is addressed in this paper.A novel coordinate transformation form consisting of state modifications and input transformations is introduced such that the whole system is divided into two decoupled one-order *** switching functions are presented to further decouple the underactuated dynamics and to produce persistently exciting(PE)signals for those underactuated *** on the aforementioned results,a quite simple control law is designed to achieve global three-dimensional asymptotic convergence of all states of underactuated *** simulations are carried out to validate the effectiveness and performance of the proposed control scheme.

关键词： autonomous underwater vehicle(AUV) underactuated systems three-dimensional stabilization switching function

2,5-Diformylfuran production by photocatalytic selective oxidation of 5-hydroxymethylfurfural in water using MoS_(2)/CdIn_(2)S_(4) flower-like heterojunctions

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Chinese Journal of Chemical Engineering 2023年第2期54卷 180-191页

作者： Qian Zhu Yan Zhuang Hongqing Zhao Peng Zhan Cong Ren Changsheng Su Wenqiang Ren jiawen zhang Di Cai Peiyong Qin National Energy R&D Center for Biorefinery Beijing University of Chemical TechnologyBeijing 100029China Collage of Life Science and Technology Beijing University of Chemical TechnologyBeijing 100029China Research Center for Eco-environmental Sciences Chinese Academy of ScienceBeijing 100085China

The selective oxidation of 5-hydroxymethylfurfural(HMF) into 2,5-diformylfuran(DFF) is an important reaction for renewable biomass building blocks. Compared with thermal catalytic processes, photocatalytic production of DFF from HMF has attracted tremendous attention. Herein, the MoS_(2)/CdIn_(2)S_(4)(MC)flower-like heterojunctions were prepared and considered as photocatalysts for selective oxidation of HMF into DFF under visible-light irradiation in aqueous solution. Results demonstrated MoS_(2) in MC heterojunction could promote the separation of photoexcited electron-hole pairs, while the amount of MoS_(2) dropping was proved influenced on the photocatalytic performance. 80.93% of DFF selectivity was realized when using 12.5% MC as photocatalyst. In addition, the MC catalyst also showed great potential in transformation of other biomass derived benzyl-and furyl-alcohols. The catalytic mechanism suggested that ·O_(2)^(-) was the decisive active radical for HMF oxidation. Therefore, the MC heterojunction could be applied in photocatalytic conversion of biomass to valuable chemicals under ambient condition.

关键词： 2 5-Diformylfuran(DFF) Photocatalysis MoS_(2)/CdIn_(2)S_(4)(MC) Selective oxidation Visible light irradiation

Spontaneous hierarchical surface engineering of minerals through coupled dissolution-precipitation chemistry

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Aggregate 2024年第1期5卷 460-472页

作者： Jinyang Jiang jiawen zhang Lanxin Wang Zeyu Lu Fengjuan Wang Zhiyong Liu Hongbo Zeng Jiangsu Key Laboratory of Construction Materials School of Materials Science and EngineeringSoutheast UniversityNanjingChinal 2Chemical and Materials EngineeringUniversity of AlbertaEdmontonAlbertaCanada

Peculiar hierarchical microstructures in creatures inspire modern material design with distinct *** can effortlessly construct sophisticated yet long-range ordered microstructure across bio-membrane through ion secretion and ***,microstructure biomimicry in current technology generally requires elaborate,point-by-point ***,a spontaneous yet controllable strategy is developed to achieve surface microstructure engineering through a natural surface phenomenon similar to ion secretion-precipitation,that is,coupled dissolution-precipitation.A series of hierarchical microstructures on mineral surfaces in fluids with tunable morphology,orientation,dimension,and spatial distribution are achieved by simply controlling initial dissolution and fluid *** seawater,long-range ordered film of vertically aligned brucite flakes forms through interfacial dissolution,nucleation,and confinement-induced orientation of flakes with vertically grown{110}plane,on the edge of which,fusiform aragonite epitaxially *** negligible initial surface dissolution,prismatic aragonite epitaxially grows on a calcite polyhedron-packed *** tuning fluid chemistry,closely packed calcite polyhedron and loosely packed calcite micro-pillars are engineered through rapid and retarded precipitation,***,the spontaneously grown microstructures resemble those deliberately created by human or found in nature,and tremendously modulate surface *** findings open new possibilities for facile and customizable engineering of microstructural surfaces,hierarchical heterostructures,and biomimetic materials.

关键词： directional crystallization dissolution-precipitation chemistry hierarchical microstructures spontaneous growth surface engineering