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NONISOTHERMAL CRYSTALLIZATION AND MORPHOLOGY OF POLY(BUTYLENE SUCCINATE)/LAYERED DOUBLE HYDROXIDE NANOCOMPOSITES

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Chinese Journal of Polymer Science 2013年第1期31卷 187-200页

作者： Mei-qiu Zhan Guang-yi Chen 魏志勇 Yu-mei Shi Wan-xi zhang School of Material Science and Engineering Jilin University School of Automotive Engineering Dalian University of Technology

Biodegradable poly（butylene succinate）（PBS） and layered double hydroxide （LDH） nanocomposites were prepared via melt blending in a twin-screw extruder. The morphology and dispersion of LDH nanoparticles within PBS matrix were characterized by transmission electron microscopy （TEM）, which showed that LDH nanoparticles were found to be well distributed at the nanometer level. The nonisothermal crystallization behavior of nanocomposites was extensively studied using differential scanning calorimetry （DSC） technique at various cooling rates. The crystallization rate of PBS was accelerated by the addition of LDH due to its heterogeneous nucleation effect; however, the crystallization mechanism and crystal structure of PBS remained almost unchanged. In kinetics analysis of nonisothermal crystallization, the Ozawa approach failed to describe the crystallization behavior of PBS/LDH nanocomposites, whereas both the modified Avrami model and the Mo method well represented the crystallization behavior of nanocomposites. The effective activation energy was estimated as a function of the relative degree of crystallinity using the isoeonversional analysis. The subsequent melting behavior of PBS and PBS/LDH nanocomposites was observed to be dependent on the cooling rate. The POM showed that the small and less perfect crystals were formed in nanocomposites.

关键词： Poly(butylene succinate) Layered double hydroxide Nonisothermal crystallization.

RuO_(2)-PdO nanowire networks with rich interfaces and defects supported on carbon toward the efficient alkaline hydrogen oxidation reaction

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Journal of Energy Chemistry 2023年第8期83卷 255-263,I0008页

作者： Yuanyuan Cong Fanchao Meng Haibin Wang Di Dou Qiuping Zhao Chunlei Li Ningshuang zhang Junying Tian School of Petrochemical Technology Lanzhou University of TechnologyLanzhou 730050GansuChina Key Laboratory of Low Carbon Energy and Chemical Engineering of Gansu Province Lanzhou University of TechnologyLanzhou 730050GansuChina

Interfacial engineering is a promising approach for enhancing electrochemical performance,but rich and efficient interfacial active sites remain a challenge in ***,RuO_(2)-PdO heterostructure nanowire networks(NWs) with rich interfaces and defects supported on carbon(RuO_(2)-PdO NWs/C) for alkaline hydrogen oxidation reaction(HOR) was formed by a seed induction-oriented attachment-thermal treatment method for the first *** expected,the RuO_(2)-PdO NWs/C(72.8% Ru atomic content in metal) exhibits an excellent activity in alkaline HOR with a mass specific exchange current density(jo,m) of 1061 A gRuPd-1,which is 3.1 times of commercial Pt/C and better than most of the reported nonPt noble metal HOR *** at the high potential(~0.5 V ***) or the presence of CO(5 vol%),the RuO_(2)-PdO NWs/C still effectively catalyzes the alkaline ***/electrochemical analysis and theoretical calculations reveal that the interfaces between RuO_(2) and PdO act as the active *** electronic interactions between the two species and the rich defects for the interfacial active sites weaken the adsorption of Had,also strengthen the adsorption of OHad,and accelerate the alkaline HOR ***,OHadon RuO_(2) can spillover to the interfaces,keeping the RuO_(2)-PdO NWs/C with the stable current density at higher potential and high resistance to CO poisoning.

关键词： Hydrogen oxidation reaction Heterostructure Nanowire networks Defects Interfacial active sites

The toxic natural product tutin causes epileptic seizures in mice by activating calcineurin

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Signal Transduction and Targeted Therapy 2023年第4期8卷 1916-1925页

作者： Qing-Tong Han Wan-Qi Yang Caixia Zang Linchao Zhou Chong-Jing zhang Xiuqi Bao Jie Cai Fangfei Li Qinyan Shi Xiao-Liang Wang Jing Qu Dan zhang Shi-Shan Yu State Key Laboratory of Bioactive Substances and Functions of Natural Medicines Institute of Materia MedicaPeking Union Medical College and Chinese Academy of Medical SciencesBeijing 100050China

Tutin,an established toxic natural product that causes epilepsy in rodents,is often used as a tool to develop animal model of acute epileptic ***,the molecular target and toxic mechanism of tutin were *** this study,for the first time,we conducted experiments to clarify the targets in tutin-induced epilepsy using thermal proteome *** studies showed that calcineurin(CN)was a target of tutin,and that tutin activated CN,leading to *** site studies further established that tutin bound within the active site of CN catalytic *** inhibitor and calcineurin A(CNA)knockdown experiments in vivo proved that tutin induced epilepsy by activating CN,and produced obvious nerve ***,these findings revealed that tutin caused epileptic seizures by activating ***,further mechanism studies found that N-methyl-D-aspartate(NMDA)receptors,gammaaminobutyric acid(GABA)receptors and voltage-and Ca2+-activated K+(BK)channels might be involved in related signaling *** study fully explains the convulsive mechanism of tutin,which provides new ideas for epilepsy treatment and drug development.

关键词： epilepsy seizures epileptic

Liposome trade-off strategy in mitochondria-targeted NIR-cyanine: balancing blood circulation and cell retention for enhanced antitumor phototherapy in vivo

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Nano Research 2021年第7期14卷 2432-2440页

作者： Xianghan zhang Sumei Zhao Zhiqing Gao Jialin Zhou Yuqiong Xia Jie Tian Changhong Shi Zhongliang Wang Engineering Research Center of Molecular&Neuroimaging Ministry of EducationSchool of Life Science and TechnologyXidian UniversityXi’an 710026China Key Laboratory of Molecular Imaging Institute of AutomationChinese Academy of SciencesBeijing 100190China Laboratory Animal Center Fourth Military Medical UniversityXi’an 710032China

Cancer phototheranostics involving optical imaging-guided photodynamic therapy(PDT)and photothermal therapy(PTT)is a localized noninvasive approach in treating ***-targeted near-infrared(NIR)cyanines are excellent therapeutic photosensitizers of ***,most mitochondria-targeted cyanines exist in the form of hydrophobic structures,which in vivo may cause cyanine aggregation during blood circulation,resulting in poor biocompatibility and limited therapeutic ***,we developed a trade-off strategy by encapsulating mitochondria-targeted cyanines into liposomal bilayers(CyBI7-LPs),which balanced hydrophilicity that favored blood circulation and hydrophobicity that enhanced mitochondria tumor ***,CyBI7-LPs greatly minimized photobleaching of cyanine as self-generated reactive oxygen species(ROS)could rapidly escape from the liposomal bilayer,affording enhanced PTT/PDT ***-mediated targeting strategy was further employed to improve uptake of tumor cells by modifying the liposomal surface to generate *** CyBI7-LPB probe produced a tumor-to-background ratio(TBR)of approximately 6.4 at 24 *** by highly sensitive imaging resulted in excellent anti-tumor therapy outcomes using CyBI7-LPB due to the enhanced photothermal and photodynamic *** proposed liposomal nanoplatform exhibited a simple and robust approach as an imaging-guided synergistic anti-tumor therapeutic strategy.

关键词： cancer phototheranostics NIR cyanine liposome mitochondria-targeted phototherapy

Iron/B_(2)pin_(2)catalytic system enables the generation of alkyl radicals from inert alkyl C-O bonds for amine synthesis

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Chinese Chemical Letters 2024年第1期35卷 227-232页

作者： Yanqing Zhu Shuai Chen Zhen Zhou Yun He Zhengli Liu Yang Liu zhang Feng Chongqing Key Laboratory of Natural Product Synthesis and Drug Research School of Pharmaceutical SciencesChongqing UniversityChongqing 401331China Department of Medicinal Chemistry School of PharmacyFujian Medical University(FMU)Fuzhou 350005China Affiliated Hospital of North Sichuan Medical College and Medical Imaging Key Laboratory of Sichuan Province Nanchong 637503China

A method for the generation of alkyl radicals from inert alkyl C-o bonds has been developed via an iron/borane reagent/alkoxide catalytic system,which can be employed for the synthesis of amines from nitroarenes with excellent *** reductive amination features good functional group compatibility and enables the late-stage amination of bio-relevant compounds,thus providing good opportunities for applications in medicinal *** mechanistic studies reveal that the amine synthesis may be involving a Fe/Li cation-assisted single electron transfer pathway to form alkyl radicals,and the low-valent iron speciesmaybetheactive intermediates.

关键词： C-N bond formation Reductive amination Borane reagent Iron catalysis Green chemistry

African Swine Fever Virus MGF360-12L Inhibits Type Ⅰ Interferon Production by Blocking the Interaction of Importin α and NF-κB Signaling Pathway

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Virologica Sinica 2021年第2期36卷 176-186页

作者： Yisha Zhuo Zeheng Guo Tongtong Ba Cheng zhang Lihua He Cuiping Zeng Hanchuan Dai College of Veterinary Medicine Huazhong Agricultural UniversityWuhan 430070China

African swine fever(ASF)is an infectious transboundary disease of domestic pigs and wild boar and spreading throughout *** is no vaccine and treatment *** immune escape strategies of African swine fever virus(ASFV)are crucial factors affecting immune prevention and vaccine ***360 genes have been implicated in the modulation of the IFN-Ⅰ*** molecular mechanisms contributing to innate immunity are poorly *** this study,we demonstrated that ASFV MGF360-12 L(MGF360 families 12 L protein)significantly inhibited the mRNA transcription and promoter activity of IFN-βand NF-κB,accompanied by decreases of IRF3,STING,TBK1,ISG54,ISG56 and AP-1 m RNA ***,MGF360-12 L might suppress the nuclear localization of p50 and p65 mediated by classical nuclear localization signal(NLS).Additionally,MGF360-12 L could interact with KPNA2,KPNA3,and KPNA4,which interrupted the interaction between p65 and KPNA2,KPNA3,*** further found that MGF360-12 L could interfere with the NF-κB nuclear translocation by competitively inhibiting the interaction between NF-κB and nuclear transport *** findings suggested that MGF360-12 L could inhibit the IFN-Ⅰproduction by blocking the interaction of importinαand NF-κB signaling pathway,which might reveal a novel strategy for ASFV to escape the host innate immune response.

关键词： African swine fever virus(ASFV) MGF360-12L IFN-Ⅰ NF-κB Nuclear transport

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基于混合遗传算法的HEV控制策略优化

汽车工程 2012年第4期34卷 292-296,300页

作者：张昕张欣田毅张良北京交通大学机械与电子控制工程学院北京100044

结合遗传算法的群体进化和模拟退火算法可避免迂回搜索的特点,在多目标遗传优化方法的基础上,引入混合优化算法,对HEV能量管理控制参数进行了优化。结果表明,所提出的混合优化算法在解决HEV控制策略多目标优化问题中,避免了传统遗传优... 详细信息

结合遗传算法的群体进化和模拟退火算法可避免迂回搜索的特点,在多目标遗传优化方法的基础上,引入混合优化算法,对HEV能量管理控制参数进行了优化。结果表明,所提出的混合优化算法在解决HEV控制策略多目标优化问题中,避免了传统遗传优化早熟收敛和无方向性等缺点,提高了收敛速度和计算效率。

关键词：混合动力电动汽车能量管理控制策略多目标优化混合遗传算法模拟退火算法

Application of GC-qqqMS/MS in Gasoline Grades and Regions Identification

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China Petroleum Processing & Petrochemical Technology 2022年第1期24卷 48-58页

作者： Wang Xin zhang Guannan Zhu Jun Wan Yifu Jiang Hong Liu Zhanfang People’s Public Security University of China Beijing 100038 Material Evidence Center of the Ministry of Public Security Beijing 100038

Based on GC-qqqMS/MS,a qualitative and quantitative analysis method for identifying characteristic markers in gasoline samples was *** to the established method,different grades(#92,#95,#98)of gasoline samples collected from different regions(southern,central,northeastern,and northwestern China)were studied and *** results show that the gasolines can be classified by the relative contents of aromatics,naphthalene series,indene and other characteristic *** the basis of the high sensitivity and selectivity of GC-qqqMS/MS,the experiment has identified the characteristic substances,and used the characteristic-ratios methods as well as stoichiometric tools to study the grades and regional differences of gasoline *** is conducive to the identification and classification of ILR in public security in fire cases,and can also meet the actual handling demand.

关键词： GC-qqqMS/MS gasoline characteristic markers identification and classification

Expression and prognosis of inducible T-cell co-stimulator and its ligand in Chinese stage I–III lung adenocarcinoma patients

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Animal Models and Experimental Medicine 2023年第5期6卷 464-473页

作者： Xiao-Kai Zhan Xi-Kun Liu Sen zhang Hong Chen Division of Oncology and Hematology Beijing Chao-Yang HospitalCapital Medical UniversityBeijingP.R.China State Key Laboratory of Bioactive Substances and Functions of Natural Medicines Institute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingP.R.China Pathology Department Beijing Chao-Yang HospitalCapital Medical UniversityBeijingP.R.China

Background:Immunotherapy has become the fastest-adopting treatment paradigm for lung cancer with improved *** binding with its ligand(inducible T-cell costimulator and its ligand[ICOSL]),an inducible T-cell co-stimulator(ICOS)could contribute to reversing immunosuppression and improving immune response and thus be a potential target for cancer ***:We selected 54 formalin-fixed,paraffin-embedded tumor tissues from cases with stage I–III lung adenocarcinoma *** expression of ICOS and ICOSL was *** correlation with clinical parameters in Chinese patients was also compared with TCGA ***:The positive rates of ICOS and ICOSL were 68%and 81.5%,respectively,in lung tumor *** these,9 cases had a low expression of ICOS,and 22 cases had a high expression of ICOS;ICOSL expression was low in 20 cases and high in 24 *** to the International Association for the Study of Lung Cancer(8th edition),phase I lesions were detected in 21 cases,phase II lesions in 15 cases,and phase III lesions in 18 *** median survival time of all patients was 44.5 months,and the median disease-free survival was 32 *** analysis showed that the factors significantly associated with overall survival were tumor size,regional lymph node involvement,stage,and expression level of ICOS/*** analysis using log-rank test indicated that the lower ICOS+cell infiltration may predict poor prognosis,whereas lower ICOSL protein expression may be associated with better prognosis,but ICOSL data need further validation in larger samples due to inconsistency in TCGA mRNA ***:ICOS/ICOSL might be associated with prognosis of lung cancer,and ICOS and its ligand may be potential therapeutic targets in non-small cell lung cancer.

关键词： Chinese patients ICOS ICOSL lung adenocarcinoma prognostic factor