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Melatonin Alleviates Liver Fibrosis by Inhibiting Autophagy

Current Medical Science 2022年第3期42卷 498-504页

作者： Lei jIE Ru-tao HONG Yu-jie zhang Lu-lin SHA Wei CHEN Xiao-fei REN Department of Gastroenterology First Affiliated Hospital of Anhui Medical UniversityKey Laboratory of Digestive Disease of Anhui ProvinceHefei 230022China Department of Critical Care Medicine of Cardiothoracic Surgery First Affiliated Hospital of Anhui Medical UniversityHefei 230022China

Objective Melatonin has been reported to suppress inflammation and alleviate liver fibrosis,but its effect on autophagy in liver fibrosis has not been *** study investigated the effect of melatonin on autophagy in an animal model of liver fibrosis and the hepatic stellate cell(HSC)-T6 cell *** The model was established in rats through carbon tetrachloride treatment,and melatonin was administered at three doses(2.5,5.0,and 10.0 mg/kg).Haematoxylin and eosin staining and Van Gieson’s staining were performed to examine the pathological changes of *** expression of alpha-smooth muscle actin(α-SMA)and Beclin1 in liver tissues was detected by immunohistochemical *** protein levels ofα-SMA,Beclin1 and LC3 in the animal model were detected by Western blot analysis,and gene levels of Beclin1 and LC3 were detected by quantitative real-time PCR(qRT-PCR)in the animal ***-T6 cells were activated by platelet-derived growth factor-BB(PDGF-BB).The expression ofα-SMA,Beclin1 and collagen I was detected by Western blot analysis,and the gene expression of Beclin1 and LC3 was detected by *** Melatonin reduced the expression ofα-SMA,Beclin1 and LC3 in liver *** addition,melatonin inhibited the activation of HSC-T6 cells and the expression ofα-SMA,Beclin1 and LC3 in these *** results revealed that melatonin could inhibit autophagy and HSC *** Melatonin might ameliorate liver fibrosis by regulating autophagy,suggesting that melatonin is a potential therapeutic agent for liver fibrosis.

关键词： autophagy liver fibrosis hepatic stellate cells melatonin

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正交设计与Box-Behnken响应面法优化当归多糖抗疲劳饮料制备工艺

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解放军药学学报 2024年第4期37卷 348-354页

作者：张宇轩李勃深李晓琳李茂星西北中藏药省部共建协同创新中心甘肃兰州1730000 甘肃中医药大学药学院甘肃兰州2730000 联勤保障部队第940医院甘肃兰州3730050 军事科学院军事医学研究院北京4100850

目的比较不同原料配方对当归多糖抗疲劳饮料感官指标的影响、不同复合稳定剂配方对当归多糖抗疲劳饮料稳定性的影响,分别利用正交设计与Box-Behnken响应面法优化当归多糖抗疲劳饮料的原料配方及稳定剂配方。方法以当归多糖为原料,研制... 详细信息

目的比较不同原料配方对当归多糖抗疲劳饮料感官指标的影响、不同复合稳定剂配方对当归多糖抗疲劳饮料稳定性的影响,分别利用正交设计与Box-Behnken响应面法优化当归多糖抗疲劳饮料的原料配方及稳定剂配方。方法以当归多糖为原料,研制当归多糖抗疲劳饮料。利用单因素实验和正交试验,考察当归多糖、甜菊糖苷、柠檬酸添加量的原料配比对当归多糖抗疲劳饮料感官指标的影响;采用Box-Behnken响应面优化果胶、海藻酸钠、羧甲基纤维素钠添加量的复合稳定剂对当归多糖抗疲劳饮料稳定性的影响。最终确定该饮料的优选配方参数。结果在当归多糖添加量10.0%,甜菊糖苷添加量0.035%,柠檬酸添加量0.20%时获得了感官评分为(66.333±3.055)分的饮料原料;在此基础上果胶添加量0.015%,海藻酸钠添加量0.080%,羧甲基纤维素钠添加量0.20%时获得了沉淀率预测值为2.272%,实际值为(2.339±0.111)%的当归多糖抗疲劳饮料。结论回归模型的预测值与实测值接近,采用单因素实验、正交试验和响应面法共同优化的当归多糖抗疲劳饮料工艺合理可行,并成功制备出了棕色、澄清、酸甜适宜的当归多糖抗疲劳饮料。

关键词：当归多糖抗疲劳饮料正交设计 Box-Behnken设计

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Corrigendum to“MXene-coated silk-derived carbon cloth toward flexible electrode for supercapacitor application”[***.27(2018)161–166]

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journal of Energy Chemistry 2022年第8期31卷 652-654页

作者： Minmin Hu Tao Hua Renfei Cheng jinxing Yang Cong Cui Chao zhang Xiaohui Wang Shenyang National Laboratory for Materials Science Institute of Metal ResearchChinese Academy of SciencesShenyang 110016LiaoningChina School of Materials Science and Engineering University of Science and Technology of ChinaShenyang 110016LiaoningChina University of Chinese Academy of Sciences Beijing 100049China

The authors regret that the printed version of the above article contained some errors.(1)The SEM images of CSC and CSC@Ti3C2Tx electrode in Fig.1 are corrected to reflect the originality of the images.

关键词： electrode corrected MXene

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Graded Automorphism Group of TKK Lie Algebra over Semilattice

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Acta Mathematica Sinica,English Series 2011年第3期27卷 537-544页

作者： zhang Sheng XIA School of Sciences Hubei University for Nationalities Enshi 445000 P. R. China

Every extended affine Lie algebra of type A1 and nullity v with extended affine root system R（A1, S）, where S is a semilattice in Rv, can be constructed from a TKK Lie algebra T（j（S）） which is obtained from the jordan algebra ,：7（S） by the so-called Tits-Kantor-Koecher construction. In this article we consider the Zn-graded automorphism group of the TKK Lie algebra T（j（S））, where S is the ＂smallest＂ semilattice in Euclidean space Rn.

关键词： Graded automorphism group TKK Lie algebra semilattice

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Fungi for future foods

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journal of Future Foods 2021年第1期1卷 25-37页

作者： Tyler j.Barzee Lin Cao Zhongli Pan Ruihong zhang Deparment of Biosytems and Agricuitural Engineering Universiny of Kenucky128 CE Bamhart Building.LexingtonKr40546-0276.USA Deparnment of Biological and Agricultural Engineering Thriversity of Califomnia DanisOme Shields AvemueDarisCA95616USA

The rapid growth of human civilizations has 1ed to imminent pressures to develop new food products with increased nutitiona1 characteristics and decreased environmenta1 *** fungi,a class of microorganisms that have been utilized in a wide variety of foods for thousands of years,have recently gamered widespread attention in research communities and commercia1 ventures seeking to explore new and innovative applications in a diverse aray of food products including,but not 1imited to,their more established applications as alterative *** advances in the cultivation and processing of flamentous fungi have created new frontiers in the control of textures,flavors,and nutritional properties of fungi-based *** review highlights technological advances in the production of fungi-based foods from cultivation to product manufacturing,presents the current state of the ant in fungi-based food products,and offters thoughts on their future *** is given to circular bioprocessing concepts for the sustainable utilization of agricultural and food processing byproducts.

关键词： Filamentous fungi Mycoprotein Fermentation 3D printing Biomanufacturing Nove1 foods

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Prostate cancer screening in Europe and Asia

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Asian journal of Urology 2017年第2期4卷 86-95页

作者： Kai zhang Chris H.Bangma Monique j.Roobol Department of Urology Erasmus University Medical CenterRotterdamThe Netherlands

Prostate cancer(PCa)is the second most common cancer among men worldwide and even ranks first in *** Asia is known as the region with the lowest PCa incidence,it has been rising rapidly over the last 20 years mostly due to the introduction of prostate-specific antigen(PSA)*** PCa screening studies in Europe show a mortality reduction in favor of PSA-based screening but coincide with high proportions of unnecessary biopsies,overdiagnosis and subsequent *** data on the value of PSA-based screening and hence the balance between harms and benefits in Asia is still *** of known racial variations,Asian countries should not directly apply the European screening *** in the western world also in Asia,new predictive markers,tools and risk stratification strategies hold great potential to improve the early detection of PCa and to reduce the worldwide existing negative aspects of PSA-based PCa screening.

关键词： Prostate cancer Early detection Biomarkers Imaging Risk prediction Europe Asia

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川西亚高山森林不同恢复途径物种组成和群落结构动态变化

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生态学报 2024年第8期44卷 3471-3482页

作者：李婧怡陈晓霞李梦玮张楠楠周志琼李晓明丁建林何其华石福孙中国科学院成都生物研究所成都610041 中国科学院大学北京100049 中国科学院茂县山地生态系统定位研究站茂县623200

川西亚高山森林作为西南林区主体,是长江上游的生态屏障,该区域植被恢复方式主要为人工恢复和自然恢复,比较不同恢复方式下森林的物种组成和群落结构动态变化,对于川西亚高山森林恢复与重建有重要的意义,可以为制定合理的森林管理策略... 详细信息

川西亚高山森林作为西南林区主体,是长江上游的生态屏障,该区域植被恢复方式主要为人工恢复和自然恢复,比较不同恢复方式下森林的物种组成和群落结构动态变化,对于川西亚高山森林恢复与重建有重要的意义,可以为制定合理的森林管理策略提供科学依据。基于茂县山地生态系统定位研究站不同恢复模式形成的的华山松人工林、油松人工林和自然恢复的次生林野外调查数据,分析了2005—2020年乔、灌、草三个层次的群落结构特征和多样性。结果表明:(1)不同恢复途径下,乔木层物种数都呈现增加趋势,华山松人工林、油松人工林、自然恢复的次生林乔木层物种数分别增加了11种、7种、8种;(2)华山松人工林中华山松重要值从48.06%降低到31.1%,乡土阔叶树种四川蜡瓣花进入乔木层,2020年重要值增大至21.62%,油松人工林中油松重要值逐渐降低,从43.59%降至29.76%;自然恢复的次生林中,乡土树种锐齿槲栎逐渐成为第一优势种,2020年重要值增至19.9%。(3)华山松人工林、油松人工林和自然恢复的次生林中,温带区系成分分别占总属数的71.43%,80.77%和84%,温带区系特征明显。(4)华山松人工林和油松人工林乔木层径级结构均为偏正态分布;而自然恢复的次生林径级分布呈倒“j”形,以小径级个体为主。(5)不同林型的乔木层高度在15年间呈现增加的趋势,具体表现为油松人工林>华山松人工林>自然恢复的次生林。(6)乔木层Shannon⁃wiener指数和Simpson指数均表现为自然恢复的次生林显著大于两个人工林,丰富度指数和均匀度指数表现为油松人工林最大;灌木层4个多样性指数均表现为油松人工林最大;草本层的丰富度指数、Shannon⁃wiener指数和Simpson指数均表现为油松人工林较大,均匀度指数没有显著差异。结论:人工林恢复速度大于自然恢复的次生林,但自然恢复的次生林更新能力更强,且更有利于多样性的保存。两个人工林逐渐由常绿针叶林演替为以常绿针叶树为主的针阔混交林,自然恢复的次生林演替为以常绿阔叶树为主的针阔混交林。

关键词：群落演替物种组成群落结构恢复模式亚高山森林

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EFFECT OF ANNEALING ON DAMPING CAPACITIES OF AS-CAST ZA27 ALLOY

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Acta Metallurgica Sinica(English Letters) 2006年第5期19卷 379-384页

作者： Z.M. zhang j. C. Wang H.Z. Liu X.F. Guo School of Materials Science ＆ Engineering Xi＇an University of TechnologyXi＇an 710048 China State Key Laboratory of Solidification Processing Northwestern PolytechnicalUniversity Xi＇an 710072 China

ZA27 alloy was prepared by casting with permanent mold and then annealed at 250℃ for 1-4h. The damping capaciG of the alloy was measured using a testing apparatus based on the cantilever beam technique. It was found that the as-cast ZA27 alloy possesses high damping capacity with the value of 1.3 × 10^4 at 320Hz. After annealed at 250℃ for lh, the damping capacity decreases to 1.1 × 10^-3 and then remains constant even when the annealing time is increased to 4h. The microstructure of the as-cast ZA27 alloy consists of large dendrites of Al-rich PrimaG （x-phases, eutectoid （α ＋ η） and nonequilibrium eutectic phases （α ＋ η ＋ ε）. After annealing at 250℃ for lh, the e phase disappears due to dissolution into the matrix, and the spacing between the flakes of eutectoid increases. The further increase in the annealing time has little effect on the spacing. The damping mechanism of the alloy was discussed considering the thermoelastic damping and defect damping. The value of thermoelastic damping accounts only for 7%-8% in the overall damping in cantilever beam damping measurements and the damping capacity of the ZA27 alloy came mainly from defect damping.

关键词： damping capacity ZA27 alloy annealing

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C型卡槽抗剪连接件力学性能分析

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兰州工业学院学报 2024年第4期31卷 1-6页

作者：张敏韦文婧钟翔朱翔宇陈宜虎卢旦广西绿色建材与建筑工业化重点实验室广西桂林541004 桂林理工大学土木工程学院广西桂林541004 广西壮族自治区建筑科学研究设计院广西南宁530000 中交浚浦建筑科技(上海)有限公司上海200002 贺州学院建筑与电气工程学院广西贺州542899 华东建筑设计研究院有限公司上海200002

为解决传统柱-柱连接精度要求高而导致施工效率低下的问题,设计了一种C型卡槽抗剪连接件。通过6组C型卡槽抗剪连接件的推出试验,分析新型连接件的荷载-滑移特性,探讨型钢的预埋长度、黏结周长以及型钢的位置对卡槽极限承载力和黏结滑移... 详细信息

为解决传统柱-柱连接精度要求高而导致施工效率低下的问题,设计了一种C型卡槽抗剪连接件。通过6组C型卡槽抗剪连接件的推出试验,分析新型连接件的荷载-滑移特性,探讨型钢的预埋长度、黏结周长以及型钢的位置对卡槽极限承载力和黏结滑移性能的影响,并给出了试件的本构模型。结果表明:C型卡槽抗剪连接件极限平均黏结应力较文中对比的型钢混凝土提高了45%~87%;型钢的预埋长度和黏结周长的增加能够有效的提高试件的黏结滑移性能,型钢的位置变化对黏结滑移性能影响不大;较传统型钢混凝土,C型卡槽更好地约束了灌浆料的横向变形,赋予试件良好的延性,能够有效避免灌浆料的开裂。

关键词：柱-柱节点 C型卡槽抗剪连接件型钢混凝土黏结滑移本构关系

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Nitrogen pollution and source identification of urban ecosystem surface water in Beijing

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Frontiers of Environmental Science & Engineering 2014年第1期8卷 106-116页

作者： Yufen REN Zhiwei XU Xinyu zhang Xiaoke WANG Xiaomin SUN D. j. BALLANTINE Shengzhong WANG State Key Laboratory of Urban and Regional Ecology Research Center for Eco-Environmental Sciences Chinese Academy of Sciences Beijing 100085 China Key Laboratory of Ecosystem Network Observation and Modeling Institute of Geographic Sciences and Natural Resources Research Chinese Academy of Sciences Beijing 100101 China College of Urban and Environmental Science Northeast Normal University Changchtm 130024 China National Institute of Water and Atmospheric Research Hamilton 3216 New Zealand

Nitrogen contamination of surface water is a worldwide environmental problem with intensive agricul- ture and high population densities. We assessed the spatial and seasonal variation in concentrations of total nitrogen and different nitrogen species present in surface-water in Beijing, China. Also, chemical （NO3-N/C1-） and isotopic （615Nnitrate） indicators were used to identify nitrate sources. The results showed that, during 2009 and 2010, nitrate nitrogen concentrations ranged from 0.7 to 7.6 mg· L^-1, ammonium nitrogen from 0. I to 3.4 mg· L^-1, and total nitrogen from 2.4 to 17.0mg· L^-1. Inorganic nitrogen accounted for between 60 and 100% of total nitrogen at the ten monitoring sites. Nitrate nitrogen, ammonium nitrogen, and total nitrogen concentrations at the 2 downstream monitoring sites in south-eastern Beijing were significantly higher than those at the other eight upstream monitoring sites （P 〈 0.01）. Examination of seasonal variation showed that there was a significant inverse relationship between nitrate nitrogen concentrations and precipitation, and that nitrate nitrogen concentrations peaked in the dry seasons. The information given by the 15Nnitrate values and nitrate nitrogen concentrations, combined with the NO3-N/C1- ratio distribution, showed that domestic sewage was the major source of nitrate in Beijing. Methods to control and reduce sewage pollution are urgently needed to help manage surface water quality in Beijing.

关键词： nitrogen concentration spatial and seasonalvariation stable nitrogen isotope urban ecosystem source

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