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Four and a half LIM domains protein 1 can be as a double-edged sword in cancer progression

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Cancer Biology & Medicine 2020年第2期17卷 270-281页

作者： Xiaofan Wei hongquan zhang Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education) Department of Human AnatomyHistology and Embryologyand State Key Laboratory of Natural and Biomimetic DrugsPeking University Health Science CenterBeijing 100191China

Four and a half LIM domains protein 1(FH L1),as the name suggests,contains four and a half LIM domains capable o f interacting with various molecules,including structural proteins,kinases,and transcriptional ***1 contains a zinc-finger domain and performs diverse roles in regulation of gene transcription,cytoarchitecture,cell proliferation,and signal *** studies have validated the importance of FHL1 in muscle development,myopathy,and cardiovascular *** in the FHL1 gene are associated with various ***,FHL1 was identified as a major host factor for chikungunya virus(CHIKV)infection in both humans and *** on more recent findings over the last decade,FHL1 is proposed to play a dual role in cancer *** the one hand,FHL1 expression is suppressed in several cancer types,which correlates with increased metastatic disease and decreased ***,FHL1 is reported to inhibit tum or cell growth and migration by associating with diverse signals,such as TGF-P and ER,and therefore considered a tumor *** the other hand,FHL1 can function as an oncogenic protein that promotes tumor progression upon phosphorylation,reflecting complex roles in *** review primarily focuses on the dual role and underlying mechanisms of action of FHL1 in human cancer progression and its clinical relevance.

关键词： Four and a half LIM protein 1(FH L1) metastasis tumor cell growth

Elevated 5-hydroxymethycytosine and cell apoptosis induced by tetrachloro-1,4-benzoquinone in mouse embryonic stem cells

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Journal of Environmental Sciences 2017年第1期29卷 1-4页

作者： Albert Zuehlke hongquan zhang Division of Analytical and Environmental Toxicology Department of Laboratory Medicine and PathologyUniversity of AlbertaEdmontonAlbertaT6G 2G3Canada

Pentachlorophenol（PCP）has been extensively used as a fungicide,bactericide,herbicide,*** and insecticide worldwide（Ahlborg and Thunberg,1980：Choudhury et al.,1986）.Although PCP is primarily used as a preservative for wood and wood products,it has been also used in a variety of other products,including adhesives,construction materials,leather and paper.

关键词： Tetrachloro-1 4-benzoquinone (TCBQ) DNA methylation 5-hydroxymethylcytosine(5hmC) Apoptosis Stem cells

Skin inflammation and psoriasis may be linked to exposure of ultrafine carbon particles

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Journal of Environmental Sciences 2020年第10期32卷 206-208页

作者： Huyan Xiao hongquan zhang Department of Laboratory Medicine and Pathology Faculty of Medicine and DentistryUniversity of AlbertaEdmonton T6G 2G3Canada

Air pollution has become the largest environmental risk to human health,estimated to kill seven million people worldwide every *** from the World Health Organization (WHO)showed that 91%of the world population was exp... 详细信息

关键词： inflammation Skin pollution

Single-cell genomic profile-based analysis of tissue differentiation in colorectal cancer

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Science China(Life Sciences) 2021年第8期64卷 1311-1325页

作者： Hao Jiang hongquan zhang Xuegong zhang MOE Key Lab of Bioinformatics and Bioinformatics Division BNRISTDepartment of AutomationTsinghua-Peking Joint Center for Life SciencesCenter for Synthetic and Systems BiologyTsinghua UniversityBeijing 100084China MOE Key Laboratory of Carcinogenesis and Translational Research Department of Human AnatomyHistology and EmbryologyState Key Laboratory of Natural and Biomimetic DrugsPeking University Health Science CenterBeijing 100191China

Colorectal cancer(CRC) progression is associated with cancer cell dedifferentiation and stemness acquisition. Several methods have been developed to identify stemness signatures in CRCs. However, studies that directly measured the degree of dedifferentiation in CRC tissues are limited. It is unclear how the differentiation states change during CRC progression. To address this, we develop a method to analyze the tissue differentiation spectrum in colorectal cancer using normal gastrointestinal singlecell transcriptome data. Applying this method on 281 tumor samples from The Cancer Genome Atlas Colon Adenocarcinoma dataset, we identified three major CRC subtypes with distinct tissue differentiation pattern. We observed that differentiation states are closely correlated with anti-tumor immune response and patient outcomes in CRC. Highly dedifferentiated CRC samples escaped the immune surveillance and exhibited poor outcomes;mildly dedifferentiated CRC samples showed resistance to anti-tumor immune responses and had a worse survival rate;well-differentiated CRC samples showed sustained anti-tumor immune responses and had a good prognosis. Overall, the spectrum of tissue differentiation observed in CRCs can be used for future clinical risk stratification and subtype-based therapy selection.

关键词： colorectal cancer sustained

Long-term effects of sliver nanoparticles on the abundance and activity of soil microbiome

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Journal of Environmental Sciences 2018年第7期30卷 3-4页

作者： Jing Yang Xu hongquan zhang Division of Analytical and Environmental Toxicology Department of Laboratory Medicine and Pathology University of Alberta

Silver nanoparticles（Ag NPs）are among the most extensively used engineered nanomaterials because of their wellestablished antimicrobial and unique physicochemical properties（Yin et al.,2015）.Applications of AgNPs ... 详细信息

关键词： Silver nanoparticle Soil microbiome Nitrogen cycle Microbial biomass 16S rRNA

Comparative study of the mechanical properties,micro-structure,and composition of the cranial and beak bones of the great spotted woodpecker and the lark bird

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Science China(Life Sciences) 2011年第11期54卷 1036-1041页

作者： WANG LiZhen zhang hongquan FAN YuBo Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education School of Biological Science and Medical Engineering Beihang University Beijing 100191 China School of Materials Science and Engineering Wuhan University o（Technology Wuhan 430000 China

Woodpeckers are well able to resist head injury during repeated high speed impacts at 6-7 m s-1 with decelerations up to 1000 *** study was designed to compare the mechanical properties,microstructures and compositions of cranial bone and beak bone of great spotted woodpecker(Dendrocopos major) and the Mongolian sky lark(Melanocorypha mongolica).Microstructures were observed using micro-computed tomography and scanning electron microscopy and their compositions were characterized by X-ray powder diffraction and Fourier-transform infrared *** high stress,the cranial bone and the beak of the woodpecker exhibited distinctive mechanical features,which were associated with differences in micro-structure and composition,compared with those of the *** optimization of bone micro-structure has enabled functional adaptation to the woodpecker's specific *** characteristic micro-structure efficiently avoids head impact injury and may provide potential clues to the prevention of brain injury using bio-inspired designs of shock-absorbing materials.

关键词： woodpecker head mechanical property micro-structure composition

Integrated Gas Sensor Based on MEMS

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稀有金属材料与工程 2006年第A3期35卷 173-175页

作者： hongquan zhang Tong zhang Likai Sun Yunbo Shi Jianying Guo Harbin University of Science and Technology Harbin 150080 China Automobile Electronic Engineering Technology Research and Development Center Harbin 150001 China Northeast Transducer Technology Research Institute Harbin 150001 China

Integrated gas sensor suspending bridge style micro-structure has been developed on Al_2O_3 new type membrane based on ***_4 gas sensing unit and CO gas sensing unit were fabricated separately on 4 unit array style suspending bridge *** have studied on time-sequence modulation form voltage pulse heating method which forms different work temperature

关键词： Al2O3 membrane micro-structure gas sensor

Acetylated HOXB9 at lysine 27 is of differential diagnostic value in patients with pancreatic ductal adenocarcinoma

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Frontiers of Medicine 2020年第1期14卷 91-100页

作者： Xiaoran Sun Jiagui Song Jing zhang Jun Zhan Weigang Fang hongquan zhang Department of Human Anatomy Histology and EmbryologyKey Laboratory of Carcinogenesis and Translational ResearchMinistry of Educationand State Key Laboratory of Natural and Biomimetic DrugsPeking University Health Science CenterBeijing 100191China Department of Pathology Peking University Health Science CenterBeijing 100191China

Pancreatic ductal adenocarcinoma(PDAC)is the ninth most common human malignancy and the sixth leading cause of cancer-related death in ***27-HOXB9 is a newly identified HOXB9 post-transcriptional modification that can predict the outcome in lung adenocarcinoma and colon cancer ***,the role of AcK27-HOXB9 in PDAC is *** present study aims to investigate the differential diagnostic role of patients with AcK27-HOXB9 *** microarrays consisting of 162 pancreatic tumor tissue samples from patients with PDAC and paired normal subjects were used to examine HOXB9 and AcK27-HOXB9 levels and localizations by immunohistochemical analysis and Western blot assay,***9 was upregulated(P<0.0001),and AcK27-HOXB9(P=0.0023)was downregulated in patients with ***9 promoted(P=0.0115),while AcK27-HOXB9(P=0.0279)inhibited PDAC ***27-HOXB9 predicted favorable outcome in patients with PDAC(P=0.0412).AcK27-HOXB9 also suppressed PDAC cell migration in a cell migration *** results of this study showed that HOXB9 promoted and AcK27-HOXB9 suppressed PDAC *** determination of ratio between HOXB9 and AcK27-HOXB9 exhibited potential diagnostic value in patients with PDAC.

关键词： HOXB9 AcK27-HOXB9 PDAC

Study on Environmental Multi-parameter Sensor Based on MEMS

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稀有金属材料与工程 2006年第A3期35卷 377-380页

A new membrane type Al_2O_3 micromachining material is *** develop an environmental multi-parameter detection micro-system,which implements the detection to temperature,humidity,wind speed,and *** test results illustrate that the heat-release unit in micro-system intercross greatly affects other sensing units on the *** study the method of etching process,which formed cavity to reduce the heat exchange efficiency and decrease temperature intercross effect.

关键词： Al2O3 membrane sensing unit environmental multi-parameter microsystem