Are intracellular bacteria hallmarks for human tumors?

作     者：Hongquan Zhang Hongquan Zhang

作者机构：Peking University International Cancer InstituteBeijing 100191China 

出 版 物：《Science China(Life Sciences)》 (中国科学（生命科学英文版）)

年 卷 期：2020年第63卷第10期

页      面：1615-1616页

核心收录：

学科分类：0710[理学-生物学] 0830[工学-环境科学与工程（可授工学、理学、农学学位）] 1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：tumors cancer al. 

摘      要：There are ten major characteristics that are used to differentiate cancer from normal cells and tissue (Hanahan and Weinberg, 2011);detection of bacterial species associated with cancer cells is not included among these characteristics, and at first glance this might seem to be irrelevant. The existence of bacterial cells within tumors was first reported over a century ago;however, to this day, little is known about the relationship between bacterial species, neoplasia, and neoplastic disease. Several years ago, Dr. Leore Geller working in the laboratory of Dr. Ravid Straussman at the Department of Molecular Cell Biology at the Weizmann Institute of Science in Israel discovered that bacteria associated with colon cancer can mediate its resistance to the chemotherapeutic drug gemcitabine (Geller et al., 2017).