检索结果-南通市图书馆

HNRNPC as a pan-cancer biomarker and therapeutic target involved in tumor progression and immune regulation

在线全文

学校读者我要写书评

暂无评论

Oncology Research 2025年第1期33卷 83-102页

作者： YUEZHOU zhang ZHAO zhang JINXIN DONG CHANGAN LIU Department of Hepatobiliary Surgery The Second Affiliated Hospital of Chongqing Medical UniversityChongqing400016China Department of Hepatobiliary Surgery The First Affiliated Hospital of Chongqing Medical UniversityChongqing400016China

Background:Aberrant expression of RNA-binding proteins(RBPs)has been linked to a variety of diseases,including hematological disorders,cardiovascular diseases,and multiple types of *** nuclear ribonucleoprotein C(HNRNPC),a member belonging to the heterogeneous nuclear ribonucleoprotein(hnRNP)family,plays a pivotal role in nucleic acid *** studies have underscored the significance of HNRNPC in tumorigenesis;however,its specific role in malignant tumor progression remains inadequately ***:We leveraged publicly available databases,including The Cancer Genome Atlas(TCGA),to explore the potential involvement of HNRNPC across various ***,we performed experimental validation studies focused on liver ***:Our analysis revealed that HNRNPC is overexpressed in a wide range of common malignancies,including liver and lung cancers,and is strongly linked to unfavorable ***,HNRNPC was observed to be closely linked to tumor *** immune checkpoint analysis and immune cell infiltration assessment,HNRNPC emerged as a potential target for modulating tumor ***,silencing of HNRNPC markedly inhibited the proliferation,metastasis,and infiltration of liver cancer ***:In summary,our findings highlight HNRNPC as a prognostic marker in various cancers,including liver cancer,and suggest its involvement in shaping the tumor immune *** insights offer potential avenues for improving clinical outcomes in tumors with elevated HNRNPC expression,particularly through immunotherapeutic strategies.

关键词： Heterogeneous nuclear ribonucleoprotein C(HNRNPC) Pan-cancer analysis Tumor immunity Prognostic biomarker Immunotherapeutic target Hepatocellular carcinoma

记忆性CD8^(+)T细胞在白癜风复发中的作用研究进展

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

甘肃医药 2022年第4期41卷 293-295页

作者：王燕青潘红张宝祥潍坊市益都中心医院山东青州262500

白癜风是自身反应性CD8^(+)T细胞介导黑素细胞破坏导致的皮肤病,部分患者会在停止治疗后复发,往往需要终生干预。最近的研究提示记忆性CD8^(+)T细胞在白癜风皮损保持稳定和复发中起重要作用。本文综述了记忆性CD8^(+)T细胞在白癜风中的... 详细信息

白癜风是自身反应性CD8^(+)T细胞介导黑素细胞破坏导致的皮肤病,部分患者会在停止治疗后复发,往往需要终生干预。最近的研究提示记忆性CD8^(+)T细胞在白癜风皮损保持稳定和复发中起重要作用。本文综述了记忆性CD8^(+)T细胞在白癜风中的作用,并讨论了潜在治疗靶点与远期疗效的关系。

关键词：白癜风 CD8^(+)T细胞记忆性T细胞皮肤驻留T细胞

Control of Corner Separation for a Linear Compressor Cascade via Bionic Slanting Riblets at the Endwall

在线全文

学校读者我要写书评

暂无评论

Journal of Thermal Science 2025年第1期34卷 129-144页

作者： zhang Peng LI Yonghong CHENG Rixin Key Laboratory of Civil Aircraft Airworthiness Technology Civil Aviation University of China College of Aeronautical Engineering Civil Aviation University of China

A new passive control approach,utilizing bionic slanting riblets,is employed to mitigate the flow close to the blade endwall in a linear cascade,and its effectiveness and mechanism in controlling corner separation are investigated through numerical *** slanting riblets are positioned at the endwall upstream of the cascade channel,and the influence of riblet height,yaw angle and relative position on the control of corner separation is *** findings indicate that the application of slanting riblets can efficiently counteract corner separation across the stable operational ***,the introduction of riblets with a height of merely 0.1 times the boundary layer thickness results in a significant reduction in total pressure loss by up to 14.53%,while simultaneously enhancing the static pressure coefficient by 21.74%.Flow analysis reveals that minute vortices produced within the riblet channels tend to coalesce,forming a potent large-scale vortex near the boundary layer's base *** phenomenon results in reduced additional losses compared to conventional vortex ***,the induced vortex promotes enhanced mixing between the mainstream flow and boundary layer,inhibiting the lateral displacement of low-energy fluids within the endwall boundary ***,this delays the onset of separation vortex formation and eliminates vortex rings in the corner region,ultimately enhancing the aerodynamic efficiency of the cascade.

关键词： additional losses compressor cascade corner separation slanting riblets vortex generator

Preparation of silver nanoparticles through the reduction of straw-extracted lignin and its antibacterial hydrogel

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 504-514页

作者： Lou zhang Shuo Li Fu Tang Jingkai zhang Yuetong Kang Hean zhang Lidong Li State Key Laboratory for Advanced Metals and Materials School of Materials Science and EngineeringUniversity of Science and Technology BeijingBeijing 100083China

Silver nanoparticles(Ag NPs)have attracted attention in the field of biomaterials due to their excellent antibacterial ***,the reducing and stabilizing agents used for the chemical reduction of Ag NPs are usually toxic and may cause water *** this work,Ag NPs(31.2 nm in diameter)were prepared using the extract of straw,an agricultural waste,as the reducing and stabilizing *** analysis revealed that the straw extract contained lignin,the structure of which possesses phenolic hydroxyl and methoxy groups that facilitate the reduction of silver salts into Ag *** surfaces of Ag NPs were negatively charged due to the encapsulation of a thin layer of lignin molecules that prevented their *** the prepared Ag NPs were added to the precursor solution of acrylamide,free radical polymerization was triggered without the need for extra heating or light irradiation,resulting in the rapid formation of an Ag NP-polyacrylamide composite *** inhibition zone test proved that the composite hydrogel possessed excellent antibacterial ability due to the presence of Ag *** prepared hydrogel may have potential applications in the fabrication of biomedical materials,such as antibacterial dressings.

关键词： silver nanoparticles hydrogel straw extraction antibacterial

Structural and microwave absorption properties of CoFe_(2)O_(4)/residual carbon composites

在线全文

学校读者我要写书评

暂无评论

International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 221-232页

作者： Yuanchun zhang Shengtao Gao Xingzhao zhang Dacheng Ma Chuanlei Zhu Jun He Joint National-Local Engineering Research Centre for Safe and Precise Coal Mining Anhui University of Science and TechnologyHuainan 232001China School of Chemical and Blasting Engineering Anhui University of Science and TechnologyHuainan 232001China

Electromagnetic interference,which necessitates the rapid advancement of substances with exceptional capabilities for bsorbing electromagnetic waves,is of urgent concern in contemporary *** this work,CoFe_(2)O_(4)/residual carbon from coal gasification fine slag(CFO/RC)composites were created using a novel hydrothermal *** mechanisms for microwave absorption,including conductive loss,natural resonance,interfacial dipole polarization,and magnetic flux loss,are involved in these ***,compared with pure residual carbon materials,this composite offers superior capabilities in microwave *** 7.76GHz,the CFO/RC-2 composite achieves an impressive minimum reflection loss(RL_(min))of-43.99 dB with a thickness of 2.44 ***,CFO/RC-3 demonstrates an effective absorption bandwidth(EAB)of up to 4.16 GHz,accompanied by a thickness of *** study revealed the remarkable capability of the composite to diminish electromagnetic waves,providing a new generation method for microwave absorbing materials of superior quality.

关键词： coal gasification slag residual carbon hydrothermal method microwave absorption CoFe_(2)O_(4)

在线全文

学校读者我要写书评

暂无评论

扩张型心肌病患者心肌纤维化指标的观察

上海医学检验杂志 2002年第2期17卷 77-78页

作者：叶飞段宝祥张贞胜张丰富耿其吉南京医科大学附属南京第一医院心内科南京210006 上海梅山二院内科南京210041

目的　观察扩张型心肌病 (DCM )患者血清中组织纤维化指标的变化 ,以期探讨心肌纤维化的DCM病程中的临床意义。方法　以放免法测定DCM患者 4 5例 ,分别于心力衰竭和病情控制后 ,以及正常对照组 30例血清中透明质酸 (HA)、Ⅲ型前胶原 (PC... 详细信息

目的　观察扩张型心肌病 (DCM )患者血清中组织纤维化指标的变化 ,以期探讨心肌纤维化的DCM病程中的临床意义。方法　以放免法测定DCM患者 4 5例 ,分别于心力衰竭和病情控制后 ,以及正常对照组 30例血清中透明质酸 (HA)、Ⅲ型前胶原 (PCⅢ )和层粘连蛋白 (Laminin ,LN)的浓度 ,并将上述各参数作相关分析。结果　DCM患者血清中HA、PCⅢ、LN水平分别为 (130 .12± 32 .72 ) μg/L、(183.99± 36 .79) μg/L、(196 .72±39.6 3) μg/L ,较正常对照组水平显著增高 ,而且心力衰竭发作 [分别为 (338.37± 30 .74 ) μg/L、(2 81.39± 37.38)μg/L、(2 92 .93± 38.72 ) μg/L]时更为显著。结论　血清HA、PCⅢ、LN可作为DCM患者心肌纤维化的血清学指标。

关键词：透明质酸 Ⅲ型前胶原层粘连蛋白充血性心力衰竭扩张型心肌病心肌纤维化

Nano high-entropy oxide cathode with enhanced stability for direct borohydride fuel cells

在线全文

学校读者我要写书评

暂无评论

Journal of Energy Chemistry 2025年第1期100卷 309-316页

作者： Lei zhang Lingfeng Kuang Lianke zhang Wen Chu Haiying Qin Jing zhang Junjing He Hualiang Ni Hongzhong Chi New Energy Materials Research Center College of Materials and Environmental Engineering Hangzhou Dianzi University School of Materials Science and Engineering Zhejiang University Key Laboratory of MEMS of Ministry of Education School of Integrated Circuits Southeast University

High-entropy materials have become high-activity electrocatalysis owing to their high-entropy effect and multiple active ***,we synthesize a series of carbon-supported nano high-entropy oxides（HEOs/C）,specifically （PtFeCoNiCu）O/C,using a carbothermal shock （CTS） method for application as a cathode catalyst in direct borohydride fuel cells （DBFCs）.The microstructure of the prepared catalysts was characterized by X-ray photoelectron spectroscopy,X-ray absorption fine structure,and transmission electron *** prepared （PtFeCoNiCu）O/C,with particle sizes ranging from 2 to 4 nm,demonstrates 3.94 transferred electrons towards the oxygen reduction reaction in an alkaline environment,resulting in a minimal H2O2yield of 2.6%.Additionally,it exhibits a Tafel slope of 61 mV dec-1,surpassing that of commercial Pt/C (82 mV dec-1).Furthermore,after 40,000 cycles of cyclic voltammetry（CV） testing,the half-wave potential of （PtFeCoNiCu）O/C shows a positive shift of 3 mV,with no notable decline in the limiting current *** （PtFeCoNiCu）O/C is used as a cathode catalyst in DBFCs,the DBFC achieves a maximum power density of 441 mW cm-2at 60°C and sustains a cell voltage of approximately 0.73 V after 52 h at 30°*** findings confirm that HEO/C is a promising cathode catalyst for DBFCs.

关键词： Direct borohydride fuel cells (DBFC)

延迟采收对北冰红葡萄及蒸馏酒中挥发性成分的影响

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

中国酿造 2020年第12期39卷 140-145页

作者：金宇宁舒楠谢苏燕张宝香肖家美路文鹏中国农业科学院特产研究所吉林长春130112

探讨延迟采收对北冰红葡萄果实、原酒以及蒸馏酒的品质与挥发性物质的影响,以期确定合理的采收期。分别对正常采收期(9月17日)、延迟采收期(10月13日)采收的北冰红葡萄进行果实外观与产量检测、果实品质测试,并进行酿酒、蒸馏试验,测定... 详细信息

探讨延迟采收对北冰红葡萄果实、原酒以及蒸馏酒的品质与挥发性物质的影响,以期确定合理的采收期。分别对正常采收期(9月17日)、延迟采收期(10月13日)采收的北冰红葡萄进行果实外观与产量检测、果实品质测试,并进行酿酒、蒸馏试验,测定基本理化指标以及挥发性物质的含量。结果表明,延迟采收的葡萄总糖含量(173.18 g/L)显著提升,挥发性成分总量(9.58 mg/L)更高;原酒中挥发性物质含量较果实有大幅提升,且种类丰富,两次采收的原酒挥发性物质总含量差异不大;延迟采收的蒸馏酒中挥发性成分总含量低于正常采收,但挥发性物质的种类多于正常采收。北冰红延迟采收具有更佳的果实品质,而正常采收果实所制蒸馏酒中挥发性物质含量更高。

关键词：北冰红延迟采收蒸馏酒挥发性成分

2个葡萄品种越冬抗寒性比较及其生理响应分析

在线全文

学校读者我要写书评

暂无评论

中国果树 2021年第9期 30-35,41页

作者：赵滢杨义明张宝香李昌禹王衍莉路文鹏中国农业科学院特产研究所吉林长春130112

以山葡萄品种‘左山一’和葡萄砧木品种‘贝达’为试材,通过比较2个品种越冬后的田间萌芽率,测定分析了在自然低温过程中,2个品种叶片和枝条中的脱落酸(ABA)、渗透调节物质和酚类物质含量及活性的变化。结果表明,‘左山一’和‘贝达’... 详细信息

以山葡萄品种‘左山一’和葡萄砧木品种‘贝达’为试材,通过比较2个品种越冬后的田间萌芽率,测定分析了在自然低温过程中,2个品种叶片和枝条中的脱落酸(ABA)、渗透调节物质和酚类物质含量及活性的变化。结果表明,‘左山一’和‘贝达’枝条经露地自然越冬后田间萌芽率分别为80.81%和30.12%。在9月底前低温驯化初期,2个品种叶片中的ABA含量均有所升高,且在此期间‘左山一’的ABA含量高于‘贝达’,‘左山一’叶片和枝条中的可溶性糖含量也较‘贝达’升高明显。同时,‘左山一’枝条中的淀粉含量随气温降低急速下降,从9月底开始,‘左山一’叶片和枝条中的总酚含量始终高于‘贝达’。而‘贝达’经低温驯化后仅诱导了叶片和枝条中的脯氨酸含量大幅升高,并保持了较高的PPO活性,使得‘贝达’对冬季低温具有一定的抵御能力,但仍不足以支撑其枝条的露地安全越冬,所以‘贝达’枝条经露地自然越冬后的萌芽率明显低于‘左山一’。可见,山葡萄品种‘左山一’对冬季低温的抵御能力和抗寒性明显强于葡萄砧木品种‘贝达’。

关键词：葡萄抗寒性 ABA 渗透调节物质酚类