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Association of Cytokines with Clinical Indicators in Patients with Drug-Induced Liver Injury

Biomedical and Environmental Sciences 2024年第5期37卷 494-502页

作者： CAO Wei Hua JIANG Ting Ting SHEN Ge DENG Wen WANG Shi Yu zhang Zi Yu LI xin xin LU Yao zhang Lu LIU Ru Yu CHANG Min WU Shu Ling GAO Yuan Jiao HAO Hong Xiao CHEN Xiao Xue HU Lei Ping XU Meng Jiao yi Wei XIE Yao LI Ming Hui Department of Hepatology Division 2 Beijing Ditan HospitalCapital Medical UniversityBeijing 100015China Department of Hepatology Division 2 Peking University Ditan Teaching HospitalBeijing 100015China Department of Gynecology and Obstetrics Beijing Ditan HospitalCapital Medical UniversityBeijing 100015China

Objective To explore characteristics of clinical parameters and cytokines in patients with drug-induced liver injury(DILI)caused by different drugs and their correlation with clinical *** The study was conducted on patients who were up to Review of Uncertainties in Confidence Assessment for Medical Tests(RUCAM)scoring criteria and clinically diagnosed with *** on Chinese herbal medicine,cardiovascular drugs,non-steroidal anti-inflammatory drugs(NSAIDs),antiinfective drugs,and other drugs,patients were divided into five *** were measured by Luminex *** characteristics of clinical biochemical indicators and cytokines in DILI patients and their correlation were *** 73 patients were *** among five groups was statistically different(P=0.032).Alanine aminotransferase(ALT)(P=0.033)and aspartate aminotransferase(AST)(P=0.007)in NSAIDs group were higher than those in chinese herbal medicine ***-6(IL-6)and tumor necrosis factor alpha(TNF-α)in patients with Chinese herbal medicine(IL-6:P<0.001;TNF-α:P<0.001)and cardiovascular medicine(IL-6:P=0.020;TNF-α:P=0.001)were lower than those in NSAIDs *** was a positive correlation between ALT(r=0.697,P=0.025),AST(r=0.721,P=0.019),and IL-6 in NSAIDs *** Older age may be more prone to *** with NSAIDs have more severe liver damage in early stages of DILI,TNF-αand IL-6 may partake the inflammatory process of DILI.

关键词： Drug-induced liver injury Cytokines Non-steroidal anti-inflammatory drugs Inflammation

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Fabrication and Characteristics of Nano-Floating Gate Memories with ZnO Nano-Crystals as Charge-Storage Layer

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Chinese Physics Letters 2018年第6期35卷 102-105页

作者： Lu Liu Yong Su Jing-Ping Xu yi-Xian zhang School of Optical and Electronic Information Huazhong University of Science and Technology

Nano-floating gate memory devices with ZnO nano-crystals as charge storage layers are fabricated,and the influence of post-deposition annealing temperature and thickness of the ZnO layer are *** force microscopy and scanning electron microscopy reveal the morphology of discrete ZnO *** capacitance-voltage measurements,it is found that the memory device with 1.5 nm ZnO and annealed at 700℃shows a larger memory window of 4.3 V（at±6 V）and better retention characteristics than memoriy devices with2.5 nm ZnO or annealed at other *** results indicate that the nano-floating gate memory with ZnO nano-crystals can obtain good trade-off memory properties.

关键词： ZnO Fabrication and Characteristics of Nano-Floating Gate Memories with ZnO Nano-Crystals as Charge-Storage Layer

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Co_xNi_(1-x)O合金纳米晶的合成与表征（英文）

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2017年第4期18卷 306-312页

作者： xin WANG Zhi-zhen YE yi-zheng JIN State Key Laboratory of Silicon Materials School of Materials Science and Engineering Zhejiang University Hangzhou 310027 China Center for Chemistry of High-Performance and Novel Materials State Key Laboratory of Silicon Materials Department of Chemistry Zhejiang University Hangzhou 310027 China

目的:合成成分连续可调的Co_xNi_(1-x)O合金纳米晶,揭示Co_xNi_(1-x)O合金纳米晶的形貌和晶体结构随纳米晶中钴离子含量的变化规律以及考察金属离子在合金纳米晶的分布情况。创新点:1.利用金属羧酸盐在有机体系中的醇解反应制备Co_xNi_(... 详细信息

目的:合成成分连续可调的Co_xNi_(1-x)O合金纳米晶,揭示Co_xNi_(1-x)O合金纳米晶的形貌和晶体结构随纳米晶中钴离子含量的变化规律以及考察金属离子在合金纳米晶的分布情况。创新点:1.利用金属羧酸盐在有机体系中的醇解反应制备Co_xNi_(1-x)O合金纳米晶,其反应温度仅为270°C,显著低于文献报道中所使用的温度;2.成功实现Co_xNi_(1-x)O纳米晶成分的调节,发现纳米晶形貌随成分的变化规律;3.揭示了金属离子在合金纳米晶中的均匀分布。方法:1.在硬脂酸锂的"配体保护"作用下,利用金属羧酸盐的醇解反应制备Co_xNi_(1-x)O合金纳米晶;2.利用透射电子显微镜、X射线衍射、原子发射光谱和X射线光电子等手段研究Co_xNi_(1-x)O合金纳米晶的形貌、晶体结构、成分和金属离子价态等信息。结论:1.成功地制备出高质量的Co_xNi_(1-x)O(x?[0,1])合金纳米晶;2.发现Co_xNi_(1-x)O合金纳米晶的形貌和晶体结构随纳米晶中钴离子浓度的提高呈现出由Ni O特征过渡到CoO特征的趋势;3.对单颗Co_xNi_(1-x)O合金纳米晶的元素扫描揭示了金属离子在纳米晶中的均匀分布。

关键词：合金化氧化镍氧化钴胶体纳米晶

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Research on the Interior Decoration Characteristics of Peking Union Medical College Phase I Project

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Journal of Architectural Research and Development 2023年第1期7卷 33-42页

作者： Qiqi Xiong Bo zhang yi Zheng xin Li Yaqing Liang School of Architecture and Art North China University of TechnologyBeijing 100144China Beijing Ancient Architectural Design Institute Co. Ltd.Beijing 100050China

Peking Union Medical College was founded in the late Qing Dynasty and the early Republic of *** then,society and politics have been rapidly changing,and its architectural aesthetics reflect the idea of advocating the West and inheriting *** research and actual investigation,this paper summarizes the current status of its building from two aspects,interior decoration art and interior decoration technology,analyzes the interior decoration characteristics of Peking Union Medical College Phase I Project,and records the archives of Peking Union Medical College’s decoration technology.

关键词： Peking Union Medical College Healthcare architecture Interior decoration features

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Procedural generation and real-time rendering of a marine ecosystem

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Journal of Zhejiang University-Science C(Computers and Electronics) 2014年第7期15卷 514-524页

作者： Rong LI xin DING Jun-hao YU Tian-yi GAO Wen-ting ZHENG Rui WANG Hu-jun BAO State Key Lab of CAD & CG Zhejiang University PLA Unit 61741

Underwater scene is one of the most marvelous environments in the world. In this study, we present an efficient procedural modeling and rendering system to generate marine ecosystems for swim-through graphic applications. To produce realistic and natural underwater scenes, several techniques and algorithms have been presented and introduced. First, to distribute sealife naturally on a seabed, we employ an ecosystem simulation that considers the influence of the underwater environment. Second, we propose a two-level procedural modeling system to generate sealife with unique biological features. At the base level, a series of grammars are designed to roughly represent underwater sealife on a central processing unit(CPU). Then at the fine level, additional details of the sealife are created and rendered using graphic processing units(GPUs). Such a hybrid CPU-GPU framework best adopts sequential and parallel computation in modeling a marine ecosystem, and achieves a high level of ***, the proposed system integrates dynamic simulations in the proposed procedural modeling process to support dynamic interactions between sealife and the underwater environment, where interactions and physical factors of the environment are formulated into parameters and control the geometric generation at the fine level. Results demonstrate that this system is capable of generating and rendering scenes with massive corals and sealife in real time.

关键词： Procedural generation Marine ecosystem Biological feature Graphic processing unit acceleration

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Corrosion behaviors of the copper alloy electrodes in Ar F excimer laser operation process

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High Power Laser Science and Engineering 2018年第1期6卷 51-57页

作者： xin Guo Jinbin Ding yi Zhou Yu Wang Academy of Opto-Electronics Chinese Academy of Sciences Beijing 100094 China Beijing Excimer Laser Technology and Engineering Center Beijing 100094 China

The corrosion behaviors of the Ar F excimer laser copper alloy electrodes were studied. The morphology, composition and impurities were characterized by optical microscope, scanning electron microscopy, electron microprobe and glow discharge mass spectrometer methods. The anode produces the reef, the corrosion pits, the hole layer and the 1–10 μm level flake impurity. The cathode produces the particles, the sputtering pits, the element reduce layer and the 1 μm level particle impurity. Besides the Cu element, other elements in the alloy participate in the corrosion: Al element in the reef is over 1.5 times of the anode, Zn element in the particles is 1.3 times of the cathode, many trace elements congregate on the copper surface several and even hundreds of times. These elements are responsible to a great degree for the impurities and the rapid energy decline of the long-time idled laser.

关键词： Ar F excimer laser corrosion behavior electrode impurity trace element

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Multiplicity dependence of charged particle,? meson, and multistrange particle productions in p + p collisions at s^(1/2) = 200 GeV from PYTHIA simulation

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Nuclear Science and Techniques 2018年第9期29卷 236-241页

作者： Sheng-Hui zhang Long Zhou yi-Fei zhang Ming-Wei zhang Cheng Li Ming Shao Yong-Jie Sun Ze-Bo Tang University of Science and Technology of China Hefei 230026China

We report the multiplicity dependence of charged particle production for the n~±, K~±, p, , and ? mesons at |y|<1:0 in p + p collisions at s^(1/2) = 200 GeV from a PYTHIA simulation. The impact of multiple parton ... 详细信息

We report the multiplicity dependence of charged particle production for the n~±, K~±, p, , and ? mesons at |y|yields as a function of p_T with respect to the multiplicity. No obvious particle species dependence of the splitting is *** multiplicity dependence of the ratios Kˉ/πˉ, K^+/π^+,/πˉ, p/π^+, and K_s^0 at mid-rapidity in p+ p collisions is found to follow a tendency similar to that in Au t Au collisions at (s_(NN))^(1/2) = 200 GeV at the Relativistic Heavy Ion Collider, indicating similar underlying initial production mechanisms despite the differences in the initial colliding systems.

关键词： Particle production Heavy-ion collisions Small system Multiple parton interactions Gluon contributions

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杭州市机动车污染物排放的减排情景研究(英文)

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2014年第9期15卷 753-760页

作者： Qing-yu zhang xin-xing LI Wei-li TIAN Ang-yi FU Wei-fei DU Cui WANG Department of Environmental Engineering Ecological Civilization Research Center Zhejiang University

研究目的:预测机动车保有量;根据机动车污染特征,预测机动车污染物排放量;评估不同管理措施下机动车污染物的削减效果。创新要点:综合不同管理措施,整合评价多种管理措施并行条件下,机动车污染物排放量的削减情况。研究方法:通过长期能... 详细信息

研究目的:预测机动车保有量;根据机动车污染特征,预测机动车污染物排放量;评估不同管理措施下机动车污染物的削减效果。创新要点:综合不同管理措施,整合评价多种管理措施并行条件下,机动车污染物排放量的削减情况。研究方法:通过长期能源替代计划(LEAP)模型对机动车保有量进行预测,相关排放因子采用校正的能源替代(AER)模型进行估算。最后设计四个情景模式,评估不同情景的减排效果,并与基础情景进行对比。重要结论:1.至2015年杭州市机动车将增长60.7%。2.淘汰超标机动车和提高机动车污染排放标准能有效控制CO和VOCs,而对NOx和PM的总量削减效果不明显。3.采用多种控制手段,如淘汰劣化超标机动车、提高机动车排放标准、提供低硫代燃油及引进能源替换型机动车将大大减少机动车污染物的排放量。

关键词：削控策略减排情景分析机动车保有量

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Cutting-Edge FAK-targeting PROTACs:design,synthesis,and biological evaluation

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Journal of Chinese Pharmaceutical Sciences 2024年第9期33卷 767-782页

作者： Ruifeng Wang xin Zhao Hongbao Hou Ke Chen Shuihua Liu Ruyue Ren Yunfeng Liu yi zhang Medicinal Basic Research Innovation Center of Chronic Kidney Disease Ministry of EducationShanxi Medical UniversityTaiyuan 030001ShanxiChina Department of Pharmacology Shanxi Medical UniversityTaiyuan 030001ShanxiChina Department of Endocrinology First Hospital of Shanxi Medical UniversityShanxi Medical UniversityTaiyuan 030001ShanxiChina Department of Pharmacy Shanxi Medical UniversityTaiyuan 030001ShanxiChina

Focal adhesion kinase(FAK)is an intracellular tyrosine kinase that plays a critical role in the occurrence,development,and metastasis of cancer through both its kinase-dependent catalytic functions and kinase-independent scaffolding *** kinase inhibitors target only its catalytic activity,leaving the scaffolding functions ***,proteolysis targeting chimeras(PROTACs)offers a promising approach by degrading the entire FAK protein,thereby inhibiting both functions *** this study,we designed and synthesized novel PROTAC degraders,utilizing a defactinib derivative(compound 12)as the FAK ligand and a lenalidomide analog as the E3 ligase *** structures of these compounds were confirmed through^(1)H NMR,^(13)C NMR,and high-resolution mass spectrometry(HRMS).Among the synthesized compounds,the optimized compound 16b exhibited potent degradation activity against FAK protein in A549 cells,with a DC_(50)of 6.16±1.13 n M,significantly inhibiting the proliferation and colony formation of these *** to defactinib,16b showed enhanced inhibition of A549 cell migration and ***,our research demonstrated that the rapid and effective FAK degradation induced by 16b was mediated by a CRBN-dependent proteasome mechanism.

关键词： FAK PROTAC Migration Invasion

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Priority Rule Based Heuristics for Project Scheduling Problems with Multi-skilled Workforce Constraints

Priority Rule Based Heuristics for Project Scheduling Proble...

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第25届中国控制与决策会议

作者： CHEN Di SUN Fu-quan LIU Shi-xin WANG yi-fan College of Information Science & Engineering Northeastern University Northeastern University at Qinhuangdao

ISBN: (纸本)9781467355339

With the arrival of the knowledge economy society, the knowledge workforce has become the key resource in business activities replacing capital, equipment, raw material and other traditional resources. Project scheduling problems with multi-skilled workforce constraints （PSPMSWC） has been becoming a hot spot in project management. In this paper, according to the present research development, and the characteristics of the PSPMSWC, we present a two-stage heuristic algorithm, which is based on "work - skills - human" three layers. The goal is to minimize the makespan. The algorithm provides different choices to the same problem, and the computational results show that the algorithm is satisfactory.

关键词： Project scheduling Workforce-constrained Multi-skilled Two-stage heuristics algorithm

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