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Chinese Journal of Cancer Research 2011年第1期23卷 3-9页

作者： Wan-qing Chen Si-wei zhang xiao-nong Zou ping Zhao National Office for Cancer Prevention and Control/National Central Cancer Registry Cancer InstituteChinese Academy of Medical SciencesBeijing 100021China

Objective：To describe the cancer incidence and mortality rates in 2006 and evaluate the cancer burden in ***：Cancer registration data in 2006 from 34 cancer registries were collected,evaluated and pooled to calculate cancer incidence and mortality *** data analyses included mortality to incidence ratio（MI）,morphological verification percentage（MV%） and proportion of death certification only（DCO%）.Cumulative incidence and mortality rates were calculated using crude data,age-standardized data,and specific data for cancer site,age,sex and area（urban or rural）.Results：In 2006,34 registries with qualified registration data covered a total population of 59,567,322（46,558,108 in urban areas and 13,009,214 in rural areas）.The crude and age-standardized cancer incidence rates were 273.66 per 100,000 and 190.54 per 100,000,*** crude and age-standardized cancer mortality rates were 175.70 per 100,000 and 117.67 per 100,000,*** of lung,stomach,colon and rectum,liver,and breast in female were the five most common forms of cancer in China,which accounted for 58.99% of all new cancer *** cancer was the leading cause of cancer death,followed by stomach cancer,liver cancer,esophageal cancer and colorectal ***：Cancer is still an important public health issue in China with an increasing disease ***,the incidence rates for lung cancer,colorectal cancer and breast cancer were increasing,but those for stomach cancer and esophageal cancer were ***,age-specific incidence rate remained stable,indicating that the aging population was the major source of the increasing cancer burden.

关键词： Cancer Cancer registration Incidence Mortality

Vertical transmission of the Yq AZFc microdeletion from father to son over two or three generations in infertile Han Chinese families

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Asian Journal of Andrology 2010年第2期12卷 240-246页

作者： xiao-Bin Zhu Yu-Lin Liu Wei zhang ping ping xiao-Rong Cao Yong Liu Yi-Ran Huang Zheng Li Shanghai Human Sperm Bank Renji Hospital Shanghai Institute of Andrology Shanghai Jiao Tong University School ofMedicine Shanghai 200001 China

This study was carried out to analyze the vertical transmission of Yq AZFc microdeletions from father to son in infertile Han Chinese families to investigate genetic factors and family background affecting fertility *** peripheral blood of infertile males in 19 Han families was extracted and screened with modified multiplex polymerase chain reaction （PCR）. Family trees were drawn according to fertility status and clinical characteristics of the subjects. The vertical transmission of Yq AZFc microdeletions was detected in six cases of 19 investigated families （31.6%,6/19）. Although both fathers and sons showed a similar type of Yq AZFc deletion,the fathers were fertile,whereas the sons were infertile and showed severe oligozoospermia. The vertical transmission of Yq AZFc microdeletion from fertile fathers to infertile sons over generations is not rare. This has different effects on fertility status in fathers and sons in Han Chinese families. Both genetic factors and family background affect spermatogenetic phenotypes.

关键词： infertility microdeletion vertical transmission Y chromosome

某基坑位移、沉降和内力实测结果及预警值讨论

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岩土力学 2008年第4期29卷 1045-1052页

作者：李俊张小平南京航空航天大学土木工程系南京210016

以某深基坑支护结构位移、沉降、内力及水位的施工监测数据为依据,探讨了位移、沉降与内力大小及变化规律。实测表明:支护桩及外侧土体各点随着基坑开挖深度和时间的递增,水平位移逐步增大,增大速度由快逐步趋于平稳。另外,位移大小还... 详细信息

以某深基坑支护结构位移、沉降、内力及水位的施工监测数据为依据,探讨了位移、沉降与内力大小及变化规律。实测表明:支护桩及外侧土体各点随着基坑开挖深度和时间的递增,水平位移逐步增大,增大速度由快逐步趋于平稳。另外,位移大小还与周围建筑物位置和支撑条件有关。周围建筑物的沉降随时间增大,且离基坑越近则越大;立柱沉降及土的隆起量与承受的支撑重量及基坑形状有关;支撑轴力的大小及变化与地质条件、支撑刚度和施工开挖顺序及速度等因素有很大关系;桩身偏心较小,底部可按轴心受力计算。最后,对预警值进行了讨论。

关键词：深基坑支护位移沉降监测预警值

Apigenin's anticancer properties and molecular mechanisms of action： Recent advances and future prospectives

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Chinese Journal of Natural Medicines 2017年第5期15卷 321-329页

作者： Jumah Masoud Mohammad SALMANI zhang xiao-ping Joe Antony JACOB CHEN Bao-An Department of Hematology and Oncology Zhongda Hospital School of Medicine Southeast University

Cancer is a major health concern and leading burden on economy worldwide. An increasing effort is devoted to isolation and development of plant-derived dietary components as effective chemo-preventive products. Phytochemical compounds from natural resources such as fruits and vegetables are responsible for decreasing the risk of certain cancers among the consuming populations. Apigenin, a flavonoid phytochemical found in many kinds of fruits and vegetables, has been shown to exert significant biological effects, such as anti-oxidant, anti-inflammatory and most particularly anti-neoplastic properties. This review is intended to summarize the most recent advances in the anti-proliferative and chemo-preventive effects of apigenin in different cancer models. Analysis of the data from the studied cancer models has revealed that apigenin exerts its anti-proliferative effects through multiple and complex pathways. This guided us to discover some controversial results about the exact role of certain molecular pathways such as autophagy in the anticancer effects of apigenin. Further, there were cumulative positive evidences supporting the involvement of certain pathways such as apoptosis, ROS and DNA damage and repair. Apigenin possesses a high potential to be used as a chemosensitizing agent through the up-regulation of DR5 pathway. According to these preclinical findings we recommend that further robust unbiased studies should consider the possible interactions between different molecular pathways.

关键词： Apigenin Anticancer Flavonoid Mechanism of action

Atypical presentations of choroidal melanocytoma

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Chinese Medical Journal 2009年第10期122卷 1238-1240页

作者： zhang xiao DAI Rong-ping CHAO Wei-jing DONG Fang-tian Department of Ophthalmology Peking Union Medical College Hospital Peking Union Medical College & Chinese Academy of Medical Sciences Beijing 100730 China

Melanocytoma is a specific variant of melanocytic nevus, located in the optic disk or anywhere in the uveal tract, characterized clinically by a dark-brown to black color, and composed histopathologically of deeply pigmented round to oval cells with small, round, uniform nuclei. In this report, we described a case of large juxtapapillary melanocytoma with atypical presentations.

关键词： choroidal melanocytoma histopathology immunohistochemistry

光脉冲传输模拟的快速数值差分递推算法及其应用研究

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物理学报 2007年第5期56卷 2678-2683页

作者：张冠茂张晓萍兰州大学信息科学与工程学院现代通信技术研究所兰州730000

利用零邻域的马克劳林展开对归一化非线性薛定谔方程的频域差分形式进行分析,得出一个能够同时考虑光学媒质的色散作用以及非线性克尔作用的时域快速数值差分递推公式.选取若干算例,将运用该公式的数值计算结果与已知的解析结果和传统... 详细信息

利用零邻域的马克劳林展开对归一化非线性薛定谔方程的频域差分形式进行分析,得出一个能够同时考虑光学媒质的色散作用以及非线性克尔作用的时域快速数值差分递推公式.选取若干算例,将运用该公式的数值计算结果与已知的解析结果和传统分步傅里叶方法所得的计算结果做了相应的比较,结果表明这种快速数值差分递推公式不但拥有相当快的计算速度,也有很高的计算精度,而且在物理上符合光脉冲在光学媒质中传输时色散和非线性作用同时施加影响的客观实际,这说明它是研究非线性光学媒质中光脉冲传输的一种科学、合理而快速有效的数值计算方法.

关键词：快速数值差分递推公式零邻域马克劳林展开非线性薛定谔方程光脉冲传输

Application of frequency estimation algorithm based on a single vector sensor in underwater acoustic communication

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Journal of Marine Science and Application 2006年第3期5卷 46-50页

作者： QIAO Gang zhang xiao-ping ZHAO Xin College of Underwater Acoustic Engineering Harbin Engineering University Harbin 150001 China

A method of high resolution frequency estimation based on a single vector sensor using ESPRIT （Estimating Signal Parameters via Rotational Invariance Techniques） algorithm is proposed and applied to the underwater acoustic （UWA） communication system of frequency modulation. Higher resolution frequency estimation can be obtained by this algorithm using fewer snapshots comparing with the sound intensity frequency estimation. Results of simulation and lake experiment show that the proposed algorithm can improve the communication data rate and reduce the bandwidth of the system. Because higher signal-to-noise ratio （SNR） is demanded, range UWA communication at oresent. this algorithm can be used in high speed short

关键词： vector sensor ESPRIT algorithm frequency estimation sound intensity

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拉伸速率对NEPE推进剂力学性能的影响

固体火箭技术 2007年第4期30卷 321-323,327页

作者：郭翔张小平张炜国防科技大学航天与材料工程学院长沙410073 中国航天科技集团公司四院四十二所襄樊441003

运用单向拉伸手段,研究了不同拉伸速率(0.5～500 mm/min)、测试温度(25～70℃)对NEPE推进剂最大抗拉强度σm和最大伸长率εm的影响。试验结果发现,NEPE推进剂σm和εm均与拉伸速率v呈幂律函数关系,建立了相关性较好的幂函数方程σm=k(T... 详细信息

运用单向拉伸手段,研究了不同拉伸速率(0.5～500 mm/min)、测试温度(25～70℃)对NEPE推进剂最大抗拉强度σm和最大伸长率εm的影响。试验结果发现,NEPE推进剂σm和εm均与拉伸速率v呈幂律函数关系,建立了相关性较好的幂函数方程σm=k(T)va和εm=f(T)vb。利用该方程,对极慢拉伸速率下NEPE推进剂σm和εm进行了预示,计算结果可为固体火箭发动机设计及推进剂贮存性能研究提供技术支持。

关键词： NEPE推进剂拉伸速率力学性能

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高压强指数NEPE推进剂研究

固体火箭技术 2009年第2期32卷 188-191,196页

作者：汪越张炜张小平国防科技大学航天与材料工程学院长沙410073 中国航天科技集团公司四院四十二所襄樊441003

分析了AP含量、增塑剂含量、催化剂种类、含能粘合剂体系等对NEPE推进剂燃烧性能的影响,找出了提高其燃速压强指数的有效方法。同时,采用DSC、单幅摄影、燃烧波测试等方法,研究了ZH-2催化NEPE推进剂的机理。实验结果表明,NEPE推进剂燃... 详细信息

分析了AP含量、增塑剂含量、催化剂种类、含能粘合剂体系等对NEPE推进剂燃烧性能的影响,找出了提高其燃速压强指数的有效方法。同时,采用DSC、单幅摄影、燃烧波测试等方法,研究了ZH-2催化NEPE推进剂的机理。实验结果表明,NEPE推进剂燃速压强指数提高至0.67,同时在宽压强(1.5～30 MPa)范围内消除了压强指数拐点。

关键词： NEPE推进剂燃速压强指数催化燃烧燃烧机理