咨询与建议

看过本文的还看了

相关文献

该作者的其他文献

文献详情 >Apigenin's anticancer properti... 收藏

Apigenin's anticancer properties and molecular mechanisms of action: Recent advances and future prospectives

Apigenin's anticancer properties and molecular mechanisms of action: Recent advances and future prospectives

作     者:Jumah Masoud Mohammad SALMANI ZHANG Xiao-Ping Joe Antony JACOB CHEN Bao-An 

作者机构:Department of Hematology and Oncology Zhongda Hospital School of Medicine Southeast University 

出 版 物:《Chinese Journal of Natural Medicines》 (中国天然药物(英文版))

年 卷 期:2017年第15卷第5期

页      面:321-329页

核心收录:

学科分类:1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 100706[医学-药理学] 100602[医学-中西医结合临床] 10[医学] 

基  金:supported by the key medical project of Jiangsu province(No.BL2014078) the key discipline of Jiangsu province(2011-2015) 

主  题:Apigenin Anticancer Flavonoid Mechanism of action 

摘      要:Cancer is a major health concern and leading burden on economy worldwide. An increasing effort is devoted to isolation and development of plant-derived dietary components as effective chemo-preventive products. Phytochemical compounds from natural resources such as fruits and vegetables are responsible for decreasing the risk of certain cancers among the consuming populations. Apigenin, a flavonoid phytochemical found in many kinds of fruits and vegetables, has been shown to exert significant biological effects, such as anti-oxidant, anti-inflammatory and most particularly anti-neoplastic properties. This review is intended to summarize the most recent advances in the anti-proliferative and chemo-preventive effects of apigenin in different cancer models. Analysis of the data from the studied cancer models has revealed that apigenin exerts its anti-proliferative effects through multiple and complex pathways. This guided us to discover some controversial results about the exact role of certain molecular pathways such as autophagy in the anticancer effects of apigenin. Further, there were cumulative positive evidences supporting the involvement of certain pathways such as apoptosis, ROS and DNA damage and repair. Apigenin possesses a high potential to be used as a chemosensitizing agent through the up-regulation of DR5 pathway. According to these preclinical findings we recommend that further robust unbiased studies should consider the possible interactions between different molecular pathways.

读者评论 与其他读者分享你的观点

用户名:未登录
我的评分