检索结果-南通市图书馆

Insight into the molecular mechanisms of gastric cancer stem cell in drug resistance of gastric cancer

在线全文

学校读者我要写书评

暂无评论

Cancer Drug Resistance 2022年第3期5卷 794-813页

作者： Jixian Xiong tiantian zhang Penglin Lan Shuhong zhang Li Fu Guangdong Provincial Key Laboratory of Regional Immunity and Diseases Department of Pharmacology and International Cancer CenterShenzhen University Health Science CenterShenzhen 518060GuangdongChina

Gastric cancer(GC)is one of the most common causes of cancer-related death worldwide,and gastric cancer stem cells(GCSCs)are considered as the major factor for resistance to conventional radio-and *** evidence in recent years implies that GCSCs regulate the drug resistance in GC through multiple mechanisms,including dormancy,drug trafficking,drug metabolism and targeting,apoptosis,DNA damage,epithelial-mesenchymal transition,and tumor *** this review,we summarize current advancements regarding the relationship between GCSCs and drug resistance and evaluate the molecular bases of GCSCs in drug resistance.

关键词： Gastric cancer gastric cancer stem cells drug resistance chemotherapy molecular mechanisms

雅鲁藏布江大峡谷则隆弄高位冰岩崩灾害链动力学特征

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

工程地质学报 2024年第3期32卷 996-1009页

作者：高少华殷跃平李滨高杨万佳威张田田高浩源中国地质科学院地质力学研究所北京100081 中国地质环境监测院北京100081 自然资源部活动构造与地质安全重点实验室北京100081

雅鲁藏布江下游冰川分布广泛,曾发生多次高位冰岩崩事件,引发灾害链,如泥石流或碎屑流,危害巨大。本文通过野外现场调查,结合多时相卫星图像及无人机数据,以则隆弄沟为例,分析了高位灾害的地貌特征及运动动力学效应。研究表明:(1)则隆... 详细信息

雅鲁藏布江下游冰川分布广泛,曾发生多次高位冰岩崩事件,引发灾害链,如泥石流或碎屑流,危害巨大。本文通过野外现场调查,结合多时相卫星图像及无人机数据,以则隆弄沟为例,分析了高位灾害的地貌特征及运动动力学效应。研究表明:(1)则隆弄沟高位灾害垂向落差大,不同海拔区段微地貌形态各有差异,具有典型的垂直分带性,根据地貌展布特征及形态可划分为高陡冰蚀地形、弯曲型沟谷地形、堆积河谷地形,独特的地貌条件和地质环境使高位灾害与中低海拔地区有显著区别。(2)高位冰岩崩灾害链经历冰岩崩、碎屑流运动、堆积堵江、洪水溃决4个阶段,形成高位远程地质灾害链,运动过程中表现出复杂的动力学效应,包括冲击解体效应、散体成拱效应、动力侵蚀效应、碎屑堆积效应,为研究碎颗粒流动行为及动力学过程提供信息。(3)则隆弄冰舌处冰碛物富集,冰舌前缘及后缘分布有大量裂缝,随时间推移内部裂纹扩展累积,应力拱承载力下降而破坏致灾。未来在气候变化及强烈的构造活动影响下,雅鲁藏布江下游高位冰岩崩灾害风险极高,引发次生堵江-洪水灾害危害极大,应加强这类流域性灾害的预警及风险防范。

关键词：高位冰岩崩灾害链地貌垂直分带性动力学效应雅鲁藏布江

Dietary Supplementation with Sea Cucumber Saponins and Exercise Can Significantly Suppress Adipose Accumulation in Mice Fed with High-Fat Diet

在线全文

学校读者我要写书评

暂无评论

Journal of Ocean University of China 2021年第3期20卷 629-640页

作者： LI Rong MENG Jing SHI Haohao WANG Chengcheng LI Zhaojie XUE Changhu WANG Yuming zhang tiantian College of Food Science and Engineering Ocean University of ChinaQingdao 266003China Laboratory for Marine Drugs and Bioproducts Pilot National Laboratory for Marine Science and Technology(Qingdao)Qingdao 266237China Jining Center for Food and Drug Control Jining 272025China

Dietary supplementation with sea cucumber saponins(SCS)and exercise have been confirmed to be effective in pre-venting the development of obesity and its related ***,the combined effectiveness of these interventions has not been ***,we studied whether the beneficial influences of exercise could be further enhanced by dietary supplementation with SCS in high-fat diet-fed KM(Kunming)*** were randomly divided into four groups,including the high-fat diet group(HF),the SCS group(HF-S),the exercise group(HF-E),and the combination of dietary SCS and exercise group(HF-S+E).There were eight mice in every *** results demonstrated that the combination of dietary SCS and exercise could synergistically reduce fat *** particular,white adipose tissue decreased by 63%in the HF-S+E group compared with that in the HF *** supplementation with exercise also improved peripheral markers,such as serum parameters and hepatic TG *** mechani-cal testing indicated that the combined effects of dietary SCS and exercise on inhibiting fat accumulation might be attributed to the inhibition of lipid synthesis in the liver and the activation of lipolysis in white adipose tissue to increase energy consumption.

关键词： exercise sea cucumber saponins fat accumulation lipogenesis lipolysis

Comparison of the Digestion and Absorption Characteristics of Docosahexaenoic Acid-Acylated Astaxanthin Monoester and Diester in Mice

在线全文

学校读者我要写书评

暂无评论

Journal of Ocean University of China 2021年第4期20卷 973-984页

作者： LI Ye YU Jie XU Jie CHE Hongxia WANG Yuming XUE Changhu HUANG Qingrong zhang tiantian College of Food Science and Engineering Ocean University of ChinaQingdao 266003China College of Marine Science and Biological Engineering Qingdao University of Science and TechnologyQingdao 266042China Laboratory for Marine Drugs and Bioproducts Pilot National Laboratory for Marine Science and TechnologyQingdao 266237China Rutgers State University Department of Food ScienceNew Jersey 08901USA

Docosahexaenoic acid-acylated astaxanthin(DHA-AST)esters exhibit distinct bioactivities in improving brain ***,the digestion and absorption characteristics of DHA-AST esters in vivo are unclear,thereby restricting the molecular mechanism analysis of their superior *** study compared the digestion and absorption characteristics of DHA-AST monoester and diester by determining the levels of AST and DHA in the serum,liver,small intestinal content and wall,and feces at different time points after a single-dose oral administration of the *** oral gavage with 2 mg AST equivalent of the DHA-AST monoester and diester for 18 h,the excretion rates were approximately 51%and 84%,*** result indicates that DHA-AST monoester was better than diester for the absorption of *** results in serum,liver,and small intestinal content and wall also agreed with this ***,the excretion rates of DHA in the feces at 24 h in the DHA-AST monoester and diester groups were approximately 40%and 36%after gavage with 5 mg DHA equivalent,*** result indicates that DHA-AST diester exhibited a better tendency than monoester for the absorption of ***,the results in the liver and small intestinal wall showed an apparent difference,indicating that DHA-AST diester was better than monoester for the absorption of *** findings provide a scientific basis for the molecular mechanism analysis and utilization of DHA-AST monoester and diester as functional ingredients.

关键词： DHA-acylated astaxanthin monoester DHA-acylated astaxanthin diester digestion absorption

A Comparative Study About the Neuroprotective Effects of EPA-Enriched Phosphoethanolamine Plasmalogen and Phosphatidylethanolamine Against Oxidative Damage in Primary Hippocampal Neurons

在线全文

学校读者我要写书评

暂无评论

Journal of Ocean University of China 2021年第5期20卷 1207-1214页

作者： ZHU Yunfang zhang tiantian DING Lin SHI Haohao XUE Changhu XIE Wancui CHE Hongxia WANG Yuming College of Food Science and Engineering Ocean University of ChinaQingdao 266003China Shandong Provincial Key Laboratory of Biochemical Engineering College of Marine Science and Biological EngineeringQingdao University of Science and TechnologyQingdao 266042China Laboratory for Marine Drugs and Bioproducts Pilot National Laboratory for Marine Science and Technology(Qingdao)Qingdao 266237China

s Oxidative stress is involved in the progression of neurodegenerative *** evidences showed that plasma-logens could improve neurodegenerative *** this study,we investigated the function of phosphoethanolamine plasmalogens enriched with EPA(EPA-pPE)and phosphatidylethanolamine enriched with EPA(EPA-PE)on oxidative damage prevention after hy-drogen peroxide(H2O2)and tert-butylhydroperoxide(t-BHP)challenge in primary hippocampal *** showed that neurons pretreated with EPA-pPE and EPA-PE demonstrated the ability to alleviate oxidative damage,which was proved by the in-creased cell ***,the shape and number of neurons were more similar to those of the control *** acti-vity,apoptosis,as well as TrkB/ERK/CREB signaling pathway were investigated to explore the *** results suggested that EPA-PE was superior to EPA-pPE in regulating mitochondrial ***-pPE was more prominent than EPA-PE in upre-gulating TrkB/ERK/CREB signaling *** with EPA exerted neuroprotective effects via inhibiting oxidative stress,suppressing apoptosis,and regulating TrkB/ERK/CREB signaling ***,the results provide a scientific basis for utili-zation of phospholipids enriched with EPA on the treatment of neurodegenerative disease.

关键词： oxidative stress EPA-enriched phosphoethanolamine plasmalogens EPA-enriched phosphatidylethanolamine primary hippocampal neurons

Synergetic enhancement of selectivity for electroreduction of CO_(2)to C_(2)H_(4)by crystal facet engineering and tandem catalysis over silver-incorporated-cuprous oxides

在线全文

学校读者我要写书评

暂无评论

Materials Reports(Energy) 2023年第2期3卷 164-172,I0004页

作者： Gang Dong Chuang Xue Meng Li tiantian zhang Dongsheng Geng Li-Min Liu Beijing Advanced Innovation Center for Materials Genome Engineering Beijing Key Laboratory for Magneto-Photoelectrical Composite and Interface ScienceSchool of Materials Science and EngineeringUniversity of Science and Technology BeijingBeijing100083PR China School of Physics Beihang UniversityBeijing100083PR China

Electrochemical CO_(2)reduction to C_(2)H_(4)can provide a sustainable route to reduce globally accelerating CO_(2)emissions and produce energy-rich chemical ***,the poor selectivity in C_(2)H_(4)electrosynthesis limits its implementation in industrially interesting ***,we report a composite structured catalyst composed of Ag and Cu_(2)O with different crystal faces to achieve highly efficient reduction of CO_(2)to C_(2)H_(4).The catalyst composed of Ag and octahedral Cu_(2)O enclosed with(111)facet exhibits the best CO_(2)electroreduction performance,with the Faradaic efficiency(FE)and partial current density reaching 66.8%and 17.8 mA cm2 for C_(2)H_(4)product at-1.2 VRHE in 0.5 M KHCO_(3),*** characterization and electrochemical test analysis indicate that the high selectivity for C_(2)H_(4)product stems from the synergistic effect of crystal faces control engineering and tandem ***,Ag can provide optimal availability of CO intermediate by suppressing hydrogen evolution;subsequently,C-C coupling is promoted on the intimate surface of Cu_(2)O with facetdependent *** insights gained from this work may be beneficial for designing efficient multicomponent catalysts for improving the selectivity of electrochemical CO_(2)reduction reaction to generate C2þproducts.

关键词： Cu_(2)O/Ag tandem catalysts Facet-dependent selectivity CO_(2)reduction reaction C_(2)H_(4) Electrocatalysis Synergistic effect

Characteristics and dynamic analysis of the February 2021 long-runout disaster chain triggered by massive rock and ice avalanche at Chamoli, Indian Himalaya

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Rock Mechanics and Geotechnical Engineering 2023年第2期15卷 296-308页

作者： tiantian zhang Yueping Yin Bin Li Xiaojie Liu Meng Wang Yang Gao Jiawei Wan Kaushal Raj Gnyawali Institute of Geomechanics Chinese Academy of Geological SciencesBeijing100081China China Institute of Geological Environment Monitoring China Geological SurveyBeijing100081China College of Geology Engineering and Geomatics Chang’an UniversityXi’an710100China Sichuan Geological Survey Institute Chengdu610081China Natural Hazards Section Himalayan Risk Research Institute(HRI)Bhaktapur44800Nepal

A massive rock and ice avalanche occurred on the western slope of the Ronti Gad valley in the northern part of Chamoli,Indian Himalaya,on 7 February 7,*** avalanche on the high mountain slope at an elevation of 5600 m above sea level triggered a long runout disaster chain,including rock mass avalanche,debris avalanche,and *** disaster chain had a horizontal travel distance of larger than 17,600 m and an elevation difference of 4300 *** this study,the disaster characteristics and dynamic process were analyzed by multitemporal satellite *** results show that the massive rock and ice avalanche was caused by four large expanding discontinuity *** disaster chain was divided into five zones by satellite images and field observation,including source zone,transition zone,dynamic entrainment zone,flow deposition zone,and flood *** entrainment effect and melting water were recognized as the main causes of the long-runout *** on the seismic wave records and field videos,the time progress of the disaster was analyzed and the velocity of frontal debris at different stages was *** total analyzed disaster duration was 1247 s,and the frontal debris velocity colliding with the second hydropower station was approximately 23 m/*** study also carried out the numerical simulation of the disaster by rapid mass movement simulation(RAMMS).The numerical results reproduced the dynamic process of the debris avalanche,and the mechanism of long-runout avalanche was further verified by parametric ***,this study discussed the potential causes of disaster and flood and the roles of satellite images and seismic networks in the monitoring and early-warning.

关键词： Rock and ice avalanche Disaster chain Long-runout Entrainment Flood

A cross-sectional study on nurse turnover intention and influencing factors in Jiangsu Province, China

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Nursing Sciences 2018年第4期5卷 396-402页

作者： Hongying Chen Guohong Li Mengting Li Lei Lyu tiantian zhang Medical School Southeast UniversityNanjingChina Nursing Department Zhongda HospitalAffiliated to Southeast UniversityNanjingChina Emergency Department Women's Hospital School of Medicine Zhejiang UniversityHangzhouChina

Background:Nurses'turnover has been a major concern globally,which is strongly influenced by nurses'intent to ***,only a few large sample studies on the predictive factors associated with nurses'turnover intention were conducted in Jiangsu *** study mainly aims to examine the level and factors that influence nurses to leave their work in Jiangsu Province of Eastern ***:A cross-sectional survey of 1978 nurses was conducted at 48 hospitals in 14 key cities throughout Jiangsu *** turnover intention in nurses was measured by the scale of intent to leave the *** work environment of nurses was measured by the Chinese version of the Practice Environment Scale.A multiple linear regression model was applied to analyse the factors associated with turnover ***:The resignation rate of nurses in the hospitals of Jiangsu Province ranged from 0.64%to 12.71%in *** mean scores were 15.50±3.44 for turnover intention,and 3.06±0.51 for work *** in hospital affairs,resource adequacy,age,professional title,year(s)working,employment type and education level were the predictors of nurse intent to leave(P<0.05).Conclusion:The work environment of nurses in hospitals must be improved in staffing and resource and nurses'involvement in hospital *** current study corroborates that nurses have high turnover ***,effective measures are needed to improve nurse accomplishment,professional status,participation in hospital affairs and career planning to reduce their turnover intention.

关键词： China Nurse Root cause analysis Turnover intention Work environment

基于CiteSpace的中性粒细胞在糖尿病领域研究进展可视化分析

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

中国比较医学杂志 2024年第6期34卷 28-39页

作者：王瑾茜喻嵘黄娟刘洋洋张田田郭纯李薇杨蕙雷诗卉湖南中医药大学第一附属医院长沙410007 湖南中医药大学长沙410208 天津市滨海新区北塘街社区卫生服务中心天津300453 湖南省中医药研究院长沙410031

目的本文旨在阐明中性粒细胞和糖尿病领域的发展以及中性粒细胞在糖尿病研究领域的演变特征、潜在趋势及研究热点。方法检索Web of Science(科学引文索引)中2010~2023年收录的中性粒细胞在糖尿病领域相关的2998篇文献,采用CiteSpace 6.1... 详细信息

目的本文旨在阐明中性粒细胞和糖尿病领域的发展以及中性粒细胞在糖尿病研究领域的演变特征、潜在趋势及研究热点。方法检索Web of Science(科学引文索引)中2010~2023年收录的中性粒细胞在糖尿病领域相关的2998篇文献,采用CiteSpace 6.1.R6对中性粒细胞在糖尿病领域的相关文献进行可视化分析。结果自2012年以来,有关这一主题的出版物迅速增长。Bayat Mohammad、Liu Tong、Amini Abdollah和zhang Rui均为高产作者,有7篇相关领域的文章发表。中国和上海交通大学分别是发表论文最多的国家和机构。该领域最有影响力的期刊是《NATURE MEDICINE》。文献共被引分析显示,目前与糖尿病相关的主题中,焦点最高的是“extracellular trap(细胞外诱捕网)”“COVID-19 patient(新冠肺炎患者)”。关键词共现分析、聚类分析和关键词爆发分析表明,lymphocyte ratio(淋巴细胞比值)(13.08)、neutrophil extracellular trap(中性粒细胞胞外诱捕网)(7.2)是目前中性粒细胞和糖尿病领域研究最多的主题。这一领域的文献主要分布在“myocardial infarction(心肌梗死)”“endothelial(内皮细胞)”“oxidative stress(氧化应激)”和“apoptosis(细胞凋亡)”之间。结论本文运用CiteSpace对中性粒细胞在糖尿病领域的演变趋势进行分析,为研究人员今后开展糖尿病领域相关研究提供新思路。

关键词：糖尿病中性粒细胞文献计量分析 CiteSpace