Comparison of the Digestion and Absorption Characteristics of Docosahexaenoic Acid-Acylated Astaxanthin Monoester and Diester in Mice

作     者：LI Ye YU Jie XU Jie CHE Hongxia WANG Yuming XUE Changhu HUANG Qingrong ZHANG Tiantian LI Ye;YU Jie;XU Jie;CHE Hongxia;WANG Yuming;XUE Changhu;HUANG Qingrong;ZHANG Tiantian

作者机构：College of Food Science and EngineeringOcean University of ChinaQingdao 266003China College of Marine Science and Biological EngineeringQingdao University of Science and TechnologyQingdao 266042China Laboratory for Marine Drugs and BioproductsPilot National Laboratory for Marine Science and TechnologyQingdao 266237China Rutgers State UniversityDepartment of Food ScienceNew Jersey 08901USA 

出 版 物：《Journal of Ocean University of China》 (中国海洋大学学报（英文版）)

年 卷 期：2021年第20卷第4期

页      面：973-984页

核心收录：

学科分类：0710[理学-生物学] 0832[工学-食品科学与工程（可授工学、农学学位）] 0908[农学-水产] 0707[理学-海洋科学] 08[工学] 0815[工学-水利工程] 0824[工学-船舶与海洋工程] 083201[工学-食品科学] 

基　　金：The work was supported by the National Key R&D Program of China(No.2018YFD0901103) the National Natural Science Foundation of China(Nos.31901688 and 31571864) the Natural Science Youth Foundation of Shandong Province(Nos.ZR2019QC004 and ZR2020QC236) the Laboratory for Marine Drugs and Bioproducts of Pilot National Laboratory for Marine Science and Technology(Qingdao,No.LMDBKF201807) 

主　　题：DHA-acylated astaxanthin monoester DHA-acylated astaxanthin diester digestion absorption 

摘      要：Docosahexaenoic acid-acylated astaxanthin(DHA-AST)esters exhibit distinct bioactivities in improving brain ***,the digestion and absorption characteristics of DHA-AST esters in vivo are unclear,thereby restricting the molecular mechanism analysis of their superior *** study compared the digestion and absorption characteristics of DHA-AST monoester and diester by determining the levels of AST and DHA in the serum,liver,small intestinal content and wall,and feces at different time points after a single-dose oral administration of the *** oral gavage with 2 mg AST equivalent of the DHA-AST monoester and diester for 18 h,the excretion rates were approximately 51%and 84%,*** result indicates that DHA-AST monoester was better than diester for the absorption of *** results in serum,liver,and small intestinal content and wall also agreed with this ***,the excretion rates of DHA in the feces at 24 h in the DHA-AST monoester and diester groups were approximately 40%and 36%after gavage with 5 mg DHA equivalent,*** result indicates that DHA-AST diester exhibited a better tendency than monoester for the absorption of ***,the results in the liver and small intestinal wall showed an apparent difference,indicating that DHA-AST diester was better than monoester for the absorption of *** findings provide a scientific basis for the molecular mechanism analysis and utilization of DHA-AST monoester and diester as functional ingredients.