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Association between vascular endothelial growth factor gene promoter polymorphisms and sporadic amyotrophic lateral sclerosis in a Han Chinese population Case-control study

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Neural Regeneration Research 2009年第12期4卷 1110-1115页

作者： Na Liu Nan zhang Jun zhang Liping Wang Xiaoyan zhang Wei Sui Huagang zhang Lingsong Li Dafang Chen Dongsheng Fan Department of Neurology Peking University Third Hospital Beijing 100191 China Peking University Stem Cell Research Center Beijing 100191 China Department of Epidemiology and Statistics School of Public Health Peking University Beijing 100191 China

BACKGROUND： Studies have shown that vascular endothelial growth factor （VEGF） gene polymorphisms highly correlate with sporadic amyotrophic lateral sclerosis （ALS）, although this remains controversial. To date, the relationship between VEGF gene polymorphism and sporadic ALS in a Han Chinese population remains unclear. OBJECTIVE： To explore the relationship between sporadic ALS and VEGF gene promoter 7 locus polymorphisms in a Hart Chinese population, and to investigate whether this relationship exhibits gender differences. DESIGN, TIME AND SETTING： A case-control study regarding genetic association was performed at the Central Laboratory of Peking University Third Hospital from 2002 to 2006. PARTICIPANTS： A total of 93 patients, who were diagnosed with definite or probable ALS according to E1 Escorial-revised diagnostic criteria, were selected from the Outpatient Department of Neurology, Peking University Third Hospital from 2002 to 2006. All patients were from Hart populations, with no family history of ALS. In addition, 103 gender- and age-matched healthy volunteers were selected as controls. METHODS： Peripheral venous blood was collected, and whole blood genomic DNA was extracted. VEGF gene promoter 7 locus polymorphisms were analyzed by PCR using the fluorescent Taqman system. The relationship between VEGF gene promoter single nucleotide polymorphisms and ALS was analyzed using Logistic regression model analysis and was stratified according to gender. MAIN OUTCOME MEASURES： 7 VEGF gene promoter polymorphisms genotype distribution and allele frequencies. RESULTS： There were no significant differences in VEGF gene promoter 7 locus genotype distribution and allele frequency between case and control groups （P 〉 0.05）. Stratified analysis based on gender demonstrated that female Han subjects carrying the VEGF genotype -1154AA, -2549TT, -634CC genotype were more susceptible to ALS than those carrying -1154GG, -2549CC, -634GG （VEGF-1154AA： OR= 8.9, 95%CI= 1 .0-77.3, P

关键词： amyotrophic lateral sclerosis genetic polymorphisms vascular endothelial growth factor

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Resource allocation based on subcarrier exchange in multiuser OFDM system

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Science China(Information Sciences) 2013年第1期56卷 184-197页

作者： WANG Ye zhang QinYu zhang NaiTong Harbin Institute of Technology Shenzhen Graduate School Communication Engineering Research Center Harbin Institute of Technology Communication Research Center

Multi-user orthogonal frequency division multiplexing(OFDM) is one of the most important techniques for next-generation wireless communication *** sum capacity and proportional fairness index are two important metrics in OFDM adaptive resource *** existing researches,the two metrics have individually yielded approximately optimal ***,as the two goals seem to contradict each other,it means that they cannot achieve optima *** paper presents a resource allocation algorithm based on subcarrier *** relaxing the fairness index,the proposed algorithm can dynamically adjust the fairness ***,By considering a criterion that minimizes the loss of sum capacity,the proposed algorithm can balance the tradeoff between fairness and sum *** contrast to existing algorithms,our proposal improves performance by approximately 30% in terms of sum capacity,at the expense of approximately 10% reduction in proportional ***,if a malicious user exists,each user in the system can obtain higher ergodic capacity compared with the conventional *** decrease the complexity,a low-complexity simplified alternative is presented,which outperforms the conventional algorithm with an increase in the number of *** numerical simulations are carried out to verify the efficiency and ***,we discuss in detail the computational complexity of the proposed algorithm.

关键词： multiuser OFDM resource allocation capacity proportional fairness computational complexity

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Metafabrics for cooling under a scorching sun

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Light(Science & Applications) 2021年第11期10卷 2024-2025页

作者： Shuang zhang Department of Physics The University of Hong KongPokfulam RoadHong KongChina Department of Electrical and Electronic Engineering The University of Hong KongPokfulam RoadHong KongChina

Engineering the spectral response of composite materials in a broad range from ultraviolet to infrared can lead to a significant passive cooling *** principle is applied to the design of a novel type of metafabric for cooling the human body under direct *** cooling effect,the metafabric features other merits including superior mechanical and wetting properties.

关键词： properties. composite ultraviolet

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Physical Processes Responsible for the Interannual Variability of Sea Ice Concentration in Arctic in Boreal Autumn since 1979

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Journal of Meteorological Research 2017年第3期31卷 468-475页

作者： Lei zhang Tim LI Climate Dynamics Research Center and Earth System Modeling Center International Laboratory on Climate and Environment ChangeNanjing University of Information Science & Technology Department of Atmospheric Sciences University of Hawaii

Arctic sea ice concentration （ASIC） in boreal autumn exhibits prominent interannual variability since 1979. The physical mechanism responsible for the year-to-year variation of ASIC is investigated through observational data analyses and idealized numerical modeling. It is found that the ASIC interannual variability is closely associated with the anomalous meridional circulations over the Northern Hemisphere, which is further linked with the tropical sea surface temperature （SST） forcing. A tropics-wide SST cooling anomaly leads to an enhanced meridional SST gradi- ent to the north of the equator in boreal summer, generating strengthened and northward shifting Hadley circulation over the Northern Hemisphere. Consequently, the meridional circulations are enhanced and pushed poleward, lead- ing to an enhanced descending motion at the North Pole, surrounded by an ascending motion anomaly; the surface outflow turns into easterly anomalies, opposing the mean-state winds. As a result, positive cloudiness and weakened surface wind speed emerge, which reduce ASIC through changes in the surface latent heat flux and the downward longwave radiation.

关键词： Arctic sea ice variability interannual variability tropical forcing meridional circulations

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Uncertainty in Projection of Climate Extremes:A Comparison of CMIP5 and CMIP6

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Journal of Meteorological Research 2021年第4期35卷 646-662页

作者： Shaobo zhang Jie CHEN State Key Laboratory of Water Resources&Hydropower Engineering Science Wuhan University299 Bayi RoadWuchang DistrictWuhan 430072 Hubei Provincial Key Lab of Water System Science for Sponge City Construction Wuhan UniversityWuhan 430072

Climate projections by global climate models(GCMs)are subject to considerable and multi-source *** study aims to compare the uncertainty in projection of precipitation and temperature extremes between Coupled Model Intercomparison Project(CMIP)phase 5(CMIP5)and phase 6(CMIP6),using 24 GCMs forced by 3 emission scenarios in each phase of *** this study,the total uncertainty(T)of climate projections is decomposed into the greenhouse gas emission scenario uncertainty(S,mean inter-scenario variance of the signals over all the models),GCM uncertainty(M,mean inter-model variance of signals over all emission scenarios),and internal climate variability uncertainty(V,variance in noises over all models,emission scenarios,and projection lead times);namely,T=S+M+*** results of analysis demonstrate that the magnitudes of S,M,and T present similarly increasing trends over the 21 st *** magnitudes of S,M,V,and T in CMIP6 are 0.94-0.96,1.38-2.07,1.04-1.69,and 1.20-1.93 times as high as those in *** CMIP5 and CMIP6 exhibit similar spatial variation patterns of uncertainties and similar ranks of contributions from different sources of *** uncertainty for precipitation is lower in midlatitudes and parts of the equatorial region,but higher in low latitudes and the polar *** uncertainty for temperature is higher over land areas than oceans,and higher in the Northern Hemisphere than the Southern *** precipitation,T is mainly determined by M and V in the early 21 st century,by M and S at the end of the 21 st century;and the turning point will appear in the 2070 *** temperature,T is dominated by M in the early 21 st century,and by S at the end of the 21 st century,with the turning point occuring in the 2060 *** relative contributions of S to T in CMIP6(12.5%-14.3%for precipitation and 31.6%-36.2%for temperature)are lower than those in CMIP5(15.1%-17.5%for precipitation and 38.6%-43.8%for temperature).By contrast,the re

关键词： climate projection uncertainty uncertainty contribution Coupled Model Intercomparison Project(CMIP)phase 5(CMIP5)and phase 6(CMIP6) extreme precipitation and temperature

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Moments of integral-type downward functionals for single death processes

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Frontiers of Mathematics in China 2020年第4期15卷 749-768页

作者： Jing WANG Yuhui zhang School of Mathematical Sciences Beijing Normal UniversityLaboratory of Mathematics and Complex SystemsMinistry of EducationBeijing 100875China School of Mathematics and Statistics Yili Normal UniversityYili 835000China

We get an explicit and recursive representation for high order moments of integral-type downward functionals for single death ***,main results are applied to more general integral-type downward functionals.

关键词： Single death process integral-type functional moment

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Genome-wide Analysis of Plant-specific Dof Transcription Factor Family in Tomato

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Journal of Integrative Plant Biology 2013年第6期55卷 552-566页

作者： Xiaofeng Cai Yuyang zhang Chanjuan zhang Tingyan zhang Tixu Hu Jie Ye Junhong zhang Taotao Wang Hanxia Li Zhibiao Ye Key Laboratory of Horticultural Plant Biology Ministry of Education Huazhong Agricultural University National Key Laboratory of Crop Genetic Improvement Huazhong Agricultural University

The Dof （DNA binding with One Finger） family encoding single zinc finger proteins has been known as a family of plant-specific transcription factors. These transcription factors are involved in a variety of functions of importance for different biological processes in plants. In the current study, we identified 34 Dof family genes in tomato （Solanum lycopersicum L.）, distributed on 11 chromosomes. A complete overview of SlDof genes in tomato is presented, including the gene structures, chromosome locations, phylogeny, protein motifs and evolution pattern. Phylogenetic analysis of 34 SlDof proteins resulted in four classes constituting six clusters. In addition, a comparative analysis between these genes in tomato, Arabidopsis （Arabidopsis thaliana L.） and rice （Oryza sativa L.） was also performed. The tomato Dof family expansion has been dated to recent duplication events, and segmental duplication is predominant for the SlDof genes. Furthermore, the SlDof genes displayed differential expression either in their transcript abundance or in their expression patterns under normal growth conditions. This is the first step towards genome-wide analyses of the Dof genes in tomato. Our study provides a very useful reference for cloning and functional analysis of the members of this gene family in tomato and other species.

关键词： Dof tomato duplication gene expression motif phylogenetic analysis.

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Editorial:Bilingual (multilingual) publications and duplicate publications: for or against?

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2013年第9期14卷 687-690页

作者： Yue-hong (Helen) zhang Journals of Zhejiang University-SCIENCE (A/B/C)

From the professional perspective of journal publishing, whether a bilingual (multilingual) publication is suspicious from an ethical point of view has been a topic of debate. Indeed this problem has

关键词：出版物多语言双语期刊编辑期刊出版作者出版业

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Relative efficiency of marker assisted selection when marker and QTL are incom-pletely linked

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Chinese Science Bulletin 2001年第24期46卷 2058-2063页

作者： Liu Huiying zhang Qin zhang Yuan China Agr Univ Coll Anim Sci & Technol Beijing 100094 Peoples R China

The relative superiority in selection response of two basic marker-assisted selection strategies, marker-assisted BLUP (MBLUP) and two-stage selection, in comparison to standard BLUP was investigated using stochastic simulation of a closed nucleus herd. In marker-assisted BLUP the marker information and the phenotypic information were utilized simultaneously for selecting parental animals, whereas in two-stage selection they were utilized separately in two stages. Different heritabilities and QTL sizes were considered in the simulation. The QTL was assumed to be referred only via flanking markers, which were incompletely linked to the QTL. It was shown that both MBLUP and two-stage selection increased the QTL response but decreased the polygenic response. When the heritability was low or the QTL effect was large MBLUP was superior to standard BLUP by up to 5% with respect to total genetic response. While the two-stage selection did not show any superiority although it gave extremely large increase in

关键词： marker-assisted BLUP two-stage selection simulation.

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AI empowered metasurfaces

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Light(Science & Applications) 2020年第1期9卷 1104-1107页

作者： Shuang zhang School of Physics and Astronomy University of BirminghamBirminghamUK

Dynamic metasurfaces are endowed with self-adaptive and learning capabilities,enabling an array of important applications ranging from satellite communications to the monitoring of human health and activities.

关键词： endowed abilities meta

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