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The emerging role of nitric oxide in the synaptic dysfunction of vascular dementia

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Neural Regeneration Research 2025年第2期20卷 402-415页

作者： Xiaorong zhang Zhiying Chen Yinyi Xiong Qin Zhou Ling-qiang Zhu Dan Liu Department of Pathology Affiliated Hospital of Jiujiang UniversityJiujiangJiangxi ProvinceChina Jiujiang Clinical Precision Medicine Research Center JiujiangJiangxi ProvinceChina Center for Cognitive Science and Transdisciplinary Studies Jiujiang UniversityJiangxi ProvinceChina Department of Neurology Affiliated Hospital of Jiujiang UniversityJiujiangJiangxi ProvinceChina Department of Rehabilitation Affiliated Hospital of Jiujiang UniversityJiujiangJiangxi ProvinceChina Department of Pathophysiology School of Basic MedicineTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina

With an increase in global aging,the number of people affected by cerebrovascular diseases is also increasing,and the incidence of vascular dementia-closely related to cerebrovascular risk-is increasing at an epidemic ***,few therapeutic options exist that can markedly improve the cognitive impairment and prognosis of vascular dementia *** in Alzheimer’s disease and other neurological disorders,synaptic dysfunction is recognized as the main reason for cognitive *** oxide is one of the ubiquitous gaseous cellular messengers involved in multiple physiological and pathological processes of the central nervous ***,nitric oxide has been implicated in regulating synaptic plasticity and plays an important role in the pathogenesis of vascular *** review introduces in detail the emerging role of nitric oxide in physiological and pathological states of vascular dementia and summarizes the diverse effects of nitric oxide on different aspects of synaptic dysfunction,neuroinflammation,oxidative stress,and blood-brain barrier dysfunction that underlie the progress of vascular ***,we propose that targeting the nitric oxide-sGC-cGMP pathway using certain specific approaches may provide a novel therapeutic strategy for vascular dementia.

关键词： endoplasmic reticulum stress endothelial nitric oxide synthase gene therapy nitric oxide NO-sGC-cGMP pathway synaptic dysfunction vascular dementia

Gamma-glutamyl transferase 5 overexpression in cerebrovascular endothelial cells improves brain pathology,cognition,and behavior in APP/PS1 mice

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Neural Regeneration Research 2025年第2期20卷 533-547页

作者： Yanli zhang Tian Li Jie Miao Zhina zhang Mingxuan Yang Zhuoran Wang Bo Yang Jiawei zhang Haiting Li qiang Su Junhong Guo Department of Neurology First Hospital of Shanxi Medical UniversityTaiyuanShanxi ProvinceChina Department of Neurology Sixth Hospital of Shanxi Medical University(General Hospital of Tisco)TaiyuanShanxi ProvinceChina Department of Physiology Key Laboratory of Cellular PhysiologyMinistry of EducationShanxi Medical UniversityTaiyuanShanxi ProvinceChina Department of Hernia and Abdominal Wall Surgery Shanxi Bethune HospitalShanxi Academy of Medical SciencesTongji Shanxi HospitalThird Hospital of Shanxi Medical UniversityTaiyuanShanxi ProvinceChina Department of Laboratory Medicine of Fenyang College Shanxi Medical UniversityFenyangShanxi ProvinceChina

In patients with Alzheimer’s disease,gamma-glutamyl transferase 5(GGT5)expression has been observed to be downregulated in cerebrovascular endothelial ***,the functional role of GGT5 in the development of Alzheimer’s disease remains *** study aimed to explore the effect of GGT5 on cognitive function and brain pathology in an APP/PS1 mouse model of Alzheimer’s disease,as well as the underlying *** observed a significant reduction in GGT5 expression in two in vitro models of Alzheimer’s disease(Aβ_(1-42)-treated hCMEC/D3 and bEnd.3 cells),as well as in the APP/PS1 mouse ***,injection of APP/PS1 mice with an adeno-associated virus encoding GGT5 enhanced hippocampal synaptic plasticity and mitigated cognitive ***,increasing GGT5 expression in cerebrovascular endothelial cells reduced levels of both soluble and insoluble amyloid-βin the brains of APP/PS1 *** effect may be attributable to inhibition of the expression ofβ-site APP cleaving enzyme 1,which is mediated by nuclear factor-kappa *** findings demonstrate that GGT5 expression in cerebrovascular endothelial cells is inversely associated with Alzheimer’s disease pathogenesis,and that GGT5 upregulation mitigates cognitive deficits in APP/PS1 *** findings suggest that GGT5 expression in cerebrovascular endothelial cells is a potential therapeutic target and biomarker for Alzheimer’s disease.

关键词： Alzheimer’s disease amyloid-β APP/PS1 mice cerebrovascular endothelial cells cognitive deficits gamma-glutamyl transferase 5 neurovascular unit nuclear factor‐kappa B synaptic plasticity β-site APP cleaving enzyme 1

Investigation of bubbles escape behavior from low basicity mold flux for high-Mn high-Al steels using 3D X-ray microscope

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 102-110页

作者： qiang Liu Xiang Li Shen Du Ming Gao Yanbin Yin Jiongming zhang State Key Laboratory of Advanced Metallurgy University of Science and Technology BeijingBeijing 100083China

During the continuous casting process of high-Mn high-Al steels,various types of gases such as Ar need to escape through the top of the *** which,the behavior of bubbles traversing the liquid slag serves as a restrictive link,closely associated with viscosity and the thickness of liquid *** contrast to two-dimensional surface observation,three-dimensional(3D)analysis method can offer a more intuitive,accurate,and comprehensive ***,this study employs a 3D X-ray microscope(3D-XRM)to obtained spatial distribution and 3D morphological characteristics of residual bubbles in mold flux under different basicity of liquid slag,different temperatures,and different holding *** results indicate that as basicity of slag increases from 0.52 to 1.03,temperature increases from 1423 to 1573 K,the viscosity of slag decreases,the floating rate of bubbles *** addition,when holding time increases from 10 to 30 s,the bubbles floating distance increases,and the volume fraction and average equivalent sphere diameter of the bubbles solidified in the mold flux gradually *** one word,increasing the basicity,temperature,and holding time leading to an increase in the removal rate of bubbles especially for the *** findings of bubbles escape behavior provide valuable insights into optimizing low basicity mold flux for high-Mn high-Al steels.

关键词： mold flux low basicity bubbles three-dimensional X-ray microscope viscosity

Effects of the extrusion parameters on microstructure,texture and room temperature mechanical properties of extruded Mg-2.49Nd-1.82Gd-0.2Zn-0.2Zr alloy

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 136-146页

作者： Chenjin zhang Guangyu Yang Lei Xiao Zhiyong Kan Jing Guo qiang Li Wanqi Jie State Key Laboratory of Solidification Processing Northwestern Polytechnical UniversityXi’an 710072China College of Materials Science and Engineering Fuzhou UniversityFuzhou 350108China College of Chemistry and Environmental Science Qujing Normal UniversityQujing 655011China

Microstructure,texture,and mechanical properties of the extruded Mg-2.49Nd-1.82Gd-0.2Zn-0.2Zr alloy were investigated at different extrusion temperatures(260 and 320℃),extrusion ratios(10:1,15:1,and 30:1),and extrusion speeds(3 and 6 mm/s).The experimental results exhibited that the grain sizes after extrusion were much finer than that of the homogenized alloy,and the second phase showed streamline distribution along the extrusion direction(ED).With extrusion temperature increased from 260 to 320℃,the microstructure,texture,and mechanical properties of alloys changed *** dynamic recrystallization(DRX)degree and grain sizes enhanced as the extrusion ratio increased from 10:1 to 30:1,and the strength gradually decreased but elongation(EL)*** the extrusion speed increased from 3 to 6 mm/s,the grain sizes and DRX degree increased significantly,and the samples presented the typical-rare-earth(RE)*** alloy extruded at 260℃ with extrusion ratio of 10:1 and extrusion speed of 3 mm/s showed the tensile yield strength(TYS)of 213 MPa and EL of 30.6%.After quantitatively analyzing the contribution of strengthening mechanisms,it was found that the grain boundary strengthening and dislocation strengthening played major roles among strengthening *** results provide some guidelines for enlarging the industrial application of extruded Mg-RE alloy.

关键词： Mg-rare earth alloys extrusion temperature extrusion ratio extrusion speed strengthening mechanisms

Deformation and Failure Analysis of River Levee Induced by Coal Mining and Its Influence Factor

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Computer Modeling in Engineering & Sciences 2017年第2期113卷 183-194页

作者： Meng Li jixiong zhang Nan Zhou qiang zhang State Key Laboratory of Coal Resources and Safe Mining School of MinesChina University of Mining&TechnologyXuzhou221116China

To study the influence of coal mining on the stability of river levees,a mechanical model of mining-induced river levee deformation was *** was based on the mining-induced deformation characteristics of river levees and the application of a typical surface subsidence ***,a failure criterion was proposed for river *** some examples,the deformation of,and stress distribution through,river levees under the influence of mining were obtained:the maximum tensile stress on the bottom of the river levee was less than the tensile strength,under which circumstance the river levee remained ***,this research analyzed the influence of three factors including the maximum surface subsidence wmax,half-length of surface subsidence basin L,and foundation coefficient k on the stability of river *** showed that reducing the mining height of the working face and the foundation co-efficient,and increasing the strike length of the working face could reduce the influence of mining on river *** results provided a theoretical basis for predicting the mining-induced deformation and failure of river levees.

关键词： Mining river levee surface subsidence mechanical model Winkler foundation beam

Green coal mining technique integrating mining-dressing-gas draining-backfilling-mining

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International Journal of Mining Science and Technology 2017年第1期27卷 17-27页

作者： zhang jixiong zhang qiang Spearing A.J.S.(Sam) Miao Xiexing Guo Shuai Sun qiang Ministry of Education's Key Laboratory of Deep Coal Resource Mining School of MinesChina University of Mining and TechnologyXuzhou 221116China Western Australian School of Mines Curtin UniversityKalgoorlie 6433Australia State Key Laboratory for GeoMechanics and Deep Underground Engineering China University of Mining and TechnologyXuzhou 221116China

Aiming to address the following major engineering issues faced by the Pingdingshan No. 12 mine:(1) difficulty in implementing auxiliary lifting because of its depth(i.e., beyond 1000 m);(2) highly gassy main coal seam with low permeability;(3) unstable overlying coal seam without suitable conditions for implementing conventional mining techniques for protective coal seam; and(4) predominant reliance on ‘‘under three" coal resources to ensure production output. This study proposes an integrated, closed-cycle mining-dressing-gas draining-backfilling-mining(MDGBM) technique. The proposed approach involves the mining of protective coal seam, underground dressing of coal and gangue(UDCG), pressure relief and gas drainage before extraction, and backfilling and mining of the protected coal seam. A system for draining gas and mining the protective seam in the rock stratum is designed and implemented based on the geological conditions. This system helps in realizing pressure relief and gas drainage from the protective seam before extraction. Accordingly, another system, which is connected to the existing production system, is established for the UDCG based on the dense medium-shallow trough process. The mixed mining workface is designed to accommodate both solid backfill and conventional fully mechanized coal mining, thereby facilitating coal mining, USCG, and backfilling. The results show that: The mixed mining workface length for the Ji15-31010 protected seam was 220 m with coal production capacity 1.2 million tons per year, while the backfill capacity of gangue was 0.5 million tons per year. The gas pressure decreased from 1.78 to 0.35 MPa, and the total amount of safely mined coal was 1.34 million tons. The process of simultaneously exploiting coal and draining gas was found to be safe, efficient, and *** process also yielded significant economic benefits.

关键词： Integrated green mining technique Protective and protected coal seams Mixed workface Solid backfill with gangueGas drainage

Backfilling technology and strata behaviors in fully mechanized coal mining working face

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International Journal of Mining Science and Technology 2012年第2期22卷 151-157页

作者： zhang qiang zhang jixiong Huang Yanli Ju Feng School of Mines China University of Mining&TechnologyXuzhou 221116China State Key Laboratory of Coal Resources&Mine Safety Xuzhou 221008China

Based on the principle of fully mechanized backflling and coal mining technology and combined with the Xingtai Coal Mine conditions, we mainly optimized the coal mining equipment and adjusted the coal mining method in the Xingtai Coal Mine 7606 working face for implementation this technology. Firstly, we define the practical backfilling process as the ＂（from backfilling scraper conveyor＇s） head to tail back- filling, step by step swinging up of the tamping arm, gradual compacting, moving formed backfilling scra- per conveyor when the second tamping arm cannot pass and connecting the immediate roof by back material push front material movement＂. Meanwhile, the stress changes of backfill body in coal mined out area was monitored by stress sensors, and the roof caving law was analyzed by monitoring the dynamic subsidence of -210 west roadway of this face. The site tests results show that using this new backfilling and coal mining integrated technology, the production capacity in the 7606 working face can reach to 283,000 ton a year, and 282,000 ton of solid materials （waste and fly ash） is backfilled, which meets the needs of high production and efficiency. The goaf was compactly backfilled with solid material and the strata behavior was quite desirable, with an actual maximum vertical stress of the backfill body of 5.5 MPa. Backfill body control the movement of overburden within a certain range, and there is no col- lapses of major areas in the overlying strata upon backfilled gob. The maximum subsidence and speed were 231 mm and 15.75 mm/d respectively, which proved the practical significance of this integrated technology.

关键词： Fully mechanized backfilling and coalmining technologyHydraulic supportFormed backfilling scraper conveyorBackfilling technologyStrata behaviors

Design and application of solid, dense backfill advanced mining technology with two pre-driving entries

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International Journal of Mining Science and Technology 2015年第1期25卷 127-132页

作者： zhang qiang zhang jixiong Guo Shuai Gao Rui Li Weikang School of Mines China University of Mining & Technology Key Laboratory of Deep Coal Resource Mining Ministry of Education of China China University of Mining & Technology

New solid backfill mining technology provides unique technical advantages for ‘‘three-under'' coal mining which refers to coal resources trapped under buildings, railways, and water bodies. This technology has a much higher recovery rate and can effectively control the surface subsidence. However, successful application of this technology depends heavily on geological conditions. To avoid the disadvantages associated with downward mining and overhead backfilling with this new technology, a new advanced solid backfill mining design with two pre-driving entries is proposed here to ensure the backfill effect. Taking Huayuan coal mine as an example, this paper tests the double gob-side entries retaining with no pillar left scheme and optimizes an integrated technology setup for backfill mining and gob-side entry retaining. Field applications show that the recovery rate increased from 40% for strip mining to 85% for backfill mining. Moreover, the new backfill technology allowed for better control over the surrounding rock deformation caused by the gob-side entry retaining effect and better control of ground subsidence as compared to strip mining.

关键词： Two pre-driving entriesGob-side entry retainingSolid backfill miningStrip miningGround subsidence contro

Laser direct writing of flexible multifunctional airflow sensors on the Kevlar fabric

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Nano Research 2025年第1期18卷 443-454页

作者： Wei Wang Zi-Qing Chen Yong-Qi Li Yu-Long Wang Mei-Chen Liu Yun-Bo Ruan Yang zhang Shu-Juan Liu qiang Zhao College of Electronic and Optical Engineering and College of Flexible Electronics(Future Technology) Nanjing University of Posts and TelecommunicationsNanjing 210023China State Key Laboratory of Organic Electronics and Information Displays and Jiangsu Key Laboratory for Biosensors Institute of Advanced Materials(IAM)Nanjing University of Posts and TelecommunicationsNanjing 210023China Zhe Jiang Topsun Logistic Control CO. LTD.Yuhuan 317600China Department of Rehabilitation Medicine School of Acupuncture-Moxibustion and Tuina and School of Health Preservation and RehabilitationNanjing University of Chinese MedicineNanjing 210023China

The growing interest in flexible devices has emerged as a global trend due to their advantages in flexibility,lightweight structure,and wearability,addressing the limitations of traditional *** wearable airflow sensors have been previously reported,the development of flexible fabric-based airflow sensors capable of functioning in environments with open flames—critical for fire rescue operations—has yet to be explored,largely due to the poor fire resistance of conventional *** this work,we first present a flexible,wearable,and multifunctional airflow sensor with excellent fire-resistant properties,fabricated through a simple direct laser writing *** sensor maintains airflow detection capabilities even in the presence of open ***,the fabrication of fabric-based sensors involves complex procedures such as carbon materials doping or vapor-phase deposition,leading to lengthy preparation cycles and high ***,fabric-based devices are inherently prone to *** address these challenges,we introduce twice-vertical laser-induced graphene(TVLIG)as a sensitive and reliable component for fire-resistant airflow *** resulting TVLIG/Kevlar fabric can be integrated into various garments,particularly protective suits,to form sensitive and fire-resistant airflow sensors capable of detecting airflow velocity and direction in both two-dimensional(2D)and three-dimensional(3D)spaces during fire ***,the TVLIG patterns can be expanded to multifunctional platforms,such as glucose detection for injured individuals,offering further applications in rescue *** functional expansion reduces the burden on rescue personnel and streamlines device *** its outstanding sensing capabilities,fire resistance,and expandability,the developed flexible airflow sensor shows great potential for various real-world rescue scenarios,promising advancements in wearable sensing technology for rescue enginee

关键词： flexible airflow sensor direct laser writing twice-vertical laser-induced graphene fire accident rescue Kevlar fabric