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Antitumor effect of recombinant human endostatin combined with cisplatin on rats with transplanted Lewis lung cancer

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Asian Pacific Journal of Tropical Medicine 2015年第8期8卷 652-655页

作者： zhan-wu yu Ying-Hua Ju Cheng-Liang Yang Han-Bing yu Quan Luo Ye-Gang Ma Yong-yu Liu Department of Thoracic Surgery Liaoning Cancer Hospital and Institute Dalian Medical University Affiliated Tumour Hospital Department of Biochemistry and Molecular Biology China Medical University

Objective: To observe the antitumor effect and mechanism of recombinant human endostatin(Endostar) injection in tumor combined with intraperitoneal injection of cisplatin on subcutaneous transplanted Lewis lung cancer in rats. Methods: A total of 30 C57 rats were selected, and the monoplast suspension of Lewis lung cancer was injected into the left axilla to prepare the subcutaneous transplanted tumor models in the axilla of right upper limb. The models were randomly divided into Groups A, B, and C. Medication was conducted when the tumor grew to 400 mm3. Group A was the control group without any interventional treatment. Group B was injected with Endostar 5 ***-1.d for 10 d. Group C was given the injection of Endostar 5 ***-1.d combined with intraperitoneal injection of cisplatin 5 ***-1.d for 10 d. All the rats in three groups were executed the day after the 10-d medication and the tumor was taken off for measurement of volume and mass changes and calculation of antitumor rate, after which the vascular endothelial growth factor(VEGF) concentration in rats' plasma was determined by ELISA. The tumor tissues were cut for the preparation of conventional biopsies. After hematoxylin-eosin staining, the pathologic histology was examined to observe the structures of tumor tissues, VEGF score and microvessel density(MVD) in each group. Results: The volume and mass of tumor in Groups B and C were significantly lower than Group A(P < 0.05) while the tumor volume and mass in Group C were significantly lower than Group B(P < 0.05). The antitumor rate in Group C was significantly higher than Group B(P < 0.05), but the tumor VEGF score, MVD and plasma VEGF level in Group C were significantly lower than Groups A and B(P < 0.05). In Group B, the tumor VEGF score, MVD and plasma VEGF level were significantly lower than Group A(P < 0.05). The microscopic image of Group C showed that its number of active tumor cells and the blood capillary around tumor was significantly smaller

关键词： Lewis lung cancer Cisplatin Recombinant human endostatin Vascular endothelial growth factor Microvessel density

干细胞在骨科多种疾病治疗中的应用:问题及前景

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中国组织工程研究 2018年第17期22卷 2775-2782页

作者：吴展羽叶川贵州医科大学贵州省贵阳市550004 贵州医科大学附属医院骨科贵州省贵阳市550004 贵州医科大学组织工程与干细胞研究中心贵州省贵阳市550004

背景:肌肉骨骼系统疾病的治疗很大一部分是以重建为基础,恢复人体正常的运动系统结构,但单靠手术的帮助,人体自身的修复能力在某些疾病上不能满足于要求。为了解决生命科学中组织再生的问题,干细胞疗法应运而生。目的:综述目前干细胞在... 详细信息

背景:肌肉骨骼系统疾病的治疗很大一部分是以重建为基础,恢复人体正常的运动系统结构,但单靠手术的帮助,人体自身的修复能力在某些疾病上不能满足于要求。为了解决生命科学中组织再生的问题,干细胞疗法应运而生。目的:综述目前干细胞在骨科领域的研究及进展。方法:利用计算机检索中国知网、万方和Pub Med等数据库2000至2017年间关于干细胞应用于骨科疾病的相关文献,选取具有代表性、创新性的研究成果进行内容论证。结果与结论:研究表明干细胞在骨、软骨、脊髓损伤、肌腱韧带损伤、椎间盘退行性疾病的治疗上表现出了优势。但是仍需要样本量更大、随访时间更长、证据等级更高的研究,同时临床医生必须对疾病自然病程有很好的认识,才能更好地在临床上实践干细胞治疗。将干细胞疗法与传统的手术方式相结合,能取得较好的效果。

关键词：干细胞肌肉骨骼系统综述组织工程骨软骨肌腱韧带脊髓椎间盘

Diagnosis and surgical treatment of pancreatic endocrine tumors in 36 patients:a single-center report

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Chinese Medical Journal 2007年第17期120卷 1487-1490页

作者： LIU Hong zhanG Su-zhan wu yu-lian FANG He-qing LI Jiang-tao SHENG Hong-wei WANG Yong Department of Surgery Second Affiliated Hospital ZhejiangUniversity School of Medicine Hangzhou 310006 China

Background Pancreatic endocrine tumors （PETs） are rare and their surgical treatment is often debated. The purpose of this retrospective study was to analyze the diagnosis and surgical strategy of functioning and non-functioning PETs. Methods From May 1980 to March 2006, 36 patients with pancreatic endocrine tumors at the Second Affiliated Hospital of Zhejiang University were retrospectively studied. Results Among the 36 patients, 29 （81%） had functioning tumors, and 7 （19%） had nonfunctioning tumors. Ninety-two percent of insulinomas were benign, whereas 4 （57%） of nonfunctioning PETs were malignant. The size of functioning tumors was （2.3i-0.3） cm, that of nonfunctioning tumors was less than （5.1^-0.5） cm. The combination CT and transabdominal ultrasonography resulted in a diagnostic sensitivity of 84%. Thirty-three primary lesions were precisely located in 32 patients （89%）. Atypical tumor resection was performed for 73% of functioning tumors, while typical pancreatectomy was performed for 6 （85%） of nonfunctioning tumors. Moreover, 5 liver resections and 1 lymph node dissection were performed. During the follow-up, fifteen complications occurred in 12 （36%） patients after operation. The 5-year survival rate for patients with benign tumors was 92% compared to 50% for those with malignant tumors. Surgical cure was achieved in 95% of patients with benign insulinomas. Conclusions Surgical strategy for PETs depends on the size and location of the tumor and the risk of malignancy. The optimal surgical procedure is key to prevent postoperative complication. Radical resection including initial and metastatic lesion may benefit patients with maliqnant PETs.

关键词： pancreatic endocrine tumor, insulinoma diagnosis surgery

Dynamic Regulation of Hydrogen Bonding Networks and Solvation Structures for Synergistic Solar‑Thermal Desalination of Seawater and Catalytic Degradation of Organic Pollutants

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Nano-Micro Letters 2025年第2期17卷 548-565页

作者： Ming‑yuan yu Jing wu Guang Yin Fan‑Zhen Jiao Zhong‑Zhen yu Jin Qu Beijing Key Laboratory of Advanced Functional Polymer Composites Beijing University of Chemical TechnologyBeijing 100029People’s Republic of China State Key Laboratory of Organic‑Inorganic Composites College of Materials Science and EngineeringBeijing University of Chemical TechnologyBeijing 100029People’s Republic of China

Although solar steam generation strategy is efficient in desalinating seawater,it is still challenging to achieve continuous solar-thermal desalination of seawater and catalytic degradation of organic ***,dynamic regulations of hydrogen bonding networks and solvation structures are realized by designing an asymmetric bilayer membrane consisting of a bacterial cellulose/carbon nanotube/Co_(2)(OH)_(2)CO_(3)nanorod top layer and a bacterial cellulose/Co_(2)(OH)_(2)CO_(3)nanorod(BCH)bottom ***,the hydrogen bonding networks inside the membrane can be tuned by the rich surface–OH groups of the bacterial cellulose and Co_(2)(OH)_(2)CO_(3)as well as the ions and radicals in situ generated during the catalysis ***,both SO_(4)^(2−)and HSO_(5)−can regulate the solvation structure of Na^(+)and be adsorbed more preferentially on the evaporation surface than Cl^(−),thus hindering the de-solvation of the solvated Na^(+)and subsequent nucleation/growth of ***,the heat generated by the solar-thermal energy conversion can accelerate the reaction kinetics and enhance the catalytic degradation *** work provides a flow-bed water purification system with an asymmetric solar-thermal and catalytic membrane for synergistic solar thermal desalination of seawater/brine and catalytic degradation of organic pollutants.

关键词： Solar steam generation Seawater desalination Catalytic degradation Bacterial cellulose Cobalt hydroxycarbonate nanorods

Mechanism Study on the Effect of Retarder on Polyurethane Setting Time Based on Molecular Simulation

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Journal of wuhan University of Technology(Materials Science) 2025年第1期40卷 224-231页

作者： wu yuxuan XU Wenyuan yu Tianlai JI Yongcheng School of Civil Engineering Northeast Forestry UniversityHarbin 150040China

This study identified castor oil and phosphate ester as effective retarders through setting time,tensile,and flexural tests,and determined their optimal *** mechanism by which phosphate ester affects the setting time of polyurethane was further investigated using molecular dynamics *** transform infrared spectroscopy was also employed to systematically study the physical and chemical interactions between phosphate esters and polyurethane *** results demonstrate that a 1%concentration of phosphate ester provides the most effective retarding effect with minimal impact on the strength of *** phosphate ester is added to the B component of the two-component polyurethane system,its interaction energy with component A decreases,as do the diffusion coefficient and aggregation degree of component B on the surface of component *** reduction in interaction slows the setting ***,the addition of phosphate ester to polyurethane leads to the disappearance or weakening of functional groups,indicating competitive interactions within the phosphate ester components that inhibit the reaction rate.

关键词： polyurethane retarder setting time molecular dynamics diffusion coefficient

A new horizon for neuroscience:terahertz biotechnology in brain research

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Neural Regeneration Research 2025年第2期20卷 309-325页

作者： Zhengping Pu yu wu Zhongjie Zhu Hongwei Zhao Donghong Cui Shanghai Key Laboratory of Psychotic Disorders Shanghai Mental Health CenterShanghai Jiao Tong University School of MedicineShanghaiChina Department of Psychiatry Kangci Hospital of JiaxingTongxiangZhejiang ProvinceChina Shanghai Synchrotron Radiation Facility Shanghai Advanced Research InstituteChinese Academy of SciencesShanghaiChina Key Laboratory of Interfacial Physics and Technology Shanghai Institute of Applied PhysicsChinese Academy of ScienceShanghaiChina National Facility for Protein Science in Shanghai Shanghai Advanced Research InstituteChinese Academy of SciencesShanghaiChina

Terahertz biotechnology has been increasingly applied in various biomedical fields and has especially shown great potential for application in brain *** this article,we review the development of terahertz biotechnology and its applications in the field of *** evidence indicates promising prospects for the use of terahertz spectroscopy and terahertz imaging techniques in the diagnosis of amyloid disease,cerebrovascular disease,glioma,psychiatric disease,traumatic brain injury,and myelin *** vitro and animal experiments have also demonstrated the potential therapeutic value of terahertz technology in some neuropsychiatric *** the precise underlying mechanism of the interactions between terahertz electromagnetic waves and the biosystem is not yet fully understood,the research progress in this field shows great potential for biomedical noninvasive diagnostic and therapeutic ***,the biosafety of terahertz radiation requires further exploration regarding its two-sided efficacy in practical *** review demonstrates that terahertz biotechnology has the potential to be a promising method in the field of neuropsychiatry based on its unique advantages.

关键词： biological effect brain neuron neuropsychiatry neuroscience non-thermal effect terahertz imaging terahertz radiation terahertz spectroscopy terahertz technology

Broadband and perfect terahertz absorber based on multilayer metamaterial with cross-ring patterned structures

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Optoelectronics Letters 2025年第1期21卷 1-6页

作者： WEN Jin LIU zhanzhi wu Zhengwei PAN yu zhanG Ying School of Science Xi'an Shiyou University Shaanxi Key Laboratory of Measurement and Control Technology for Oil and Gas Wells

Broadband and perfect terahertz absorber based on multilayer metamaterial using cross-ring patterned structures is proposed and investigated. The structure of the absorber is double absorption layers consisting of a chromium cross ring and eight isosceles right triangles. The unique structure of the double absorbing layers excites the electric dipole multimode resonance, giving rise to high absorption performance. Meanwhile, the influence of construal parameters on absorber behavior is also discussed. The numerical results show that the absorption achieves over 90% ranging from 2.45 THz to 6.25 THz and 99% absorption in the range of 3.7—5.3 THz. The realization of broadband and perfect absorber is described using the impedance matching principle. It is obviously found that the absorber is insensitive to the high angle of incidence for both transverse electric(TE) and transverse magnetic(TM) polarizations. Compared with the former reports, this absorber has remarkable improved absorption efficiency and smaller period. The terahertz absorber may be found applications in the fields of energy capture and thermal detection.

关键词： Metamaterials

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基于三坐标测量的螺旋锥齿轮检测关键技术

合肥工业大学学报（自然科学版） 2015年第4期38卷 437-440页

作者：武冠宏赵韩吴占雨余晗合肥工业大学机械与汽车工程学院安徽合肥230009

文章从齿面方程的建立、网格点的划分、网格点的测量及齿面误差修正方法等方面对螺旋锥齿轮检测的关键技术进行了研究,通过实验得出三坐标测量机测量螺旋锥齿轮齿面偏差与齿距累计误差,并对测量中的数据进行处理。结果表明:基于三坐标... 详细信息

文章从齿面方程的建立、网格点的划分、网格点的测量及齿面误差修正方法等方面对螺旋锥齿轮检测的关键技术进行了研究,通过实验得出三坐标测量机测量螺旋锥齿轮齿面偏差与齿距累计误差,并对测量中的数据进行处理。结果表明:基于三坐标测量的螺旋锥齿轮检测的齿面偏差与齿距累积误差明显小于普通齿轮检测仪的测量结果,测量精度高,可为指导螺旋锥齿轮的齿面修正与机床参数修正提供依据。

关键词：三坐标测量螺旋锥齿轮检测齿面方程

GFRF R-CNN:Object Detection Algorithm for Transmission Lines

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Computers, Materials & Continua 2025年第1期82卷 1439-1458页

作者： Xunguang Yan Wenrui Wang Fanglin Lu Hongyong Fan Bo wu Jianfeng yu Shanghai Advanced Research Institute Chinese Academy of SciencesShanghai201210China University of Chinese Academy of Sciences Beijing100049China Jingwei Textile Machinery Co. Ltd.Beijing100176China

To maintain the reliability of power systems,routine inspections using drones equipped with advanced object detection algorithms are essential for preempting power-related *** increasing resolution of drone-captured images has posed a challenge for traditional target detection methods,especially in identifying small objects in high-resolution *** study presents an enhanced object detection algorithm based on the Faster Regionbased Convolutional Neural Network(Faster R-CNN)framework,specifically tailored for detecting small-scale electrical components like insulators,shock hammers,and screws in transmission *** algorithm features an improved backbone network for Faster R-CNN,which significantly boosts the feature extraction network’s ability to detect fine *** Region Proposal Network is optimized using a method of guided feature refinement(GFR),which achieves a balance between accuracy and *** incorporation of Generalized Intersection over Union(GIOU)and Region of Interest(ROI)Align further refines themodel’s *** results demonstrate a notable improvement in mean Average Precision,reaching 89.3%,an 11.1%increase compared to the standard Faster *** highlights the effectiveness of the proposed algorithm in identifying electrical components in high-resolution aerial images.

关键词： Faster R-CNN transmission line object detection GIOU GFR