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genomic sel.ction in pl.nt breeding:Key factors shaping two decades of progress

Mol.cul.r Pl.nt 2024年第4期17卷 552-578页

作者： Admas Al.mu Johanna Astrand Osval.A.Montesinos-l.pez Jul.o Isidro y Sanchez Javier Fernandez-gónzal.z Wul.taw Tadesse Ramesh R.Vetukuri Anders S.Carl.son Al. Cepl.tis JoséCrossa Rodomiro Ortiz Aakash Chawade Department of Pl.nt Breeding Swedish University of Agricultural SciencesAlnarpSweden l.ntmannen l.ntbruk SvalövSweden Facul.ad de Tel.matica University de ColimaColimaColima 28040Mexico Centro de Biotecnol.gía y genómica de Pl.ntas(CBgP UPM-INIA)Universidad Politécnica de Madrid(UPM)-Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria(INIA)Campus de Montegancedo-UPM28223 MadridSpain International.Center for Agricul.ural.Research in the Dry Areas(ICARDA) RabatMorocco International.Maize and Wheat Improvement Center(CIMMYT) Km 45Carretera México-VeracruzTexcocoMéxico 52640Mexico

genomic sel.ction,the appl.cation of genomic prediction(gP)model. to sel.ct candidate individual.,has significantl. advanced in the past two decades,effectivel. accel.rating genetic gains in pl.nt *** articl. provides a hol.stic overview of key factors that have infl.enced gP in pl.nt breeding during this *** del.ed into the pivotal.rol.s of training popul.tion size and genetic diversity,and their rel.tionship with the breeding popul.tion,in determining gP *** emphasis was pl.ced on optimizing training popul.tion *** expl.red its benefits and the associated diminishing returns beyond an optimum *** was done whil. considering the bal.nce between resource al.ocation and maximizing prediction accuracy through current optimization *** density and distribution of singl.-nucl.otide pol.morphisms,l.vel.of l.nkage disequil.brium,genetic compl.xity,trait heritabil.ty,statistical.machine-l.arning methods,and non-additive effects are the other vital.*** wheat,maize,and potato as exampl.s,we summarize the effect of these factors on the accuracy of gP for various *** search for high accuracy in gP—theoretical.y reaching one when using the Pearson’s correl.tion as a metric—is an active research area as yet far from optimal.for various *** hypothesize that with ul.ra-high sizes of genotypic and phenotypic datasets,effective training popul.tion optimization methods and support from other omics approaches(transcriptomics,metabol.mics and proteomics)coupl.d with deep-l.arning al.orithms coul. overcome the boundaries of current l.mitations to achieve the highest possibl. prediction accuracy,making genomic sel.ction an effective tool.in pl.nt breeding.

关键词： genomic sel.ction genetic gain genomic prediction optimization deep l.arning training popul.tion optimization

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Production of anthocyanins in metabol.cal.y engineered microorganisms:Current status and perspectives

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Synthetic and Systems Biotechnol.gy 2017年第4期2卷 259-266页

作者： Jian zha Mattheos A.g.Koffas Department of Chemical.and Biol.gical.Engineering Center for Biotechnology and Interdisciplinary StudiesRensselaer Polytechnic InstituteTroyNYUSA Department of Biol.gical.Sciences Center for Biotechnology and Interdisciplinary StudiesRensselaer Polytechnic InstituteTroyNYUSA

Microbial.production of pl.nt-derived natural.products by engineered microorganisms has achieved great success thanks to l.rge extend to metabol.c engineering and synthetic ***,the water-sol.bl. col.red pigments found in terrestrial.pl.nts that are responsibl. for the red,bl.e and purpl. col.ration of many fl.wers and fruits,are extensivel. used in food and cosmetics industry;however,their current suppl. heavil. rel.es on compl.x extraction from pl.nt-based material..A promising al.ernative is their sustainabl. production in metabol.cal.y engineered ***,we review the recent progress on anthocyanin biosynthesis in engineered bacteria,with a special.focus on the systematic engineering modifications such as sel.ction and engineering of biosynthetic enzymes,engineering of transportation,regul.tion of UDP-gl.cose suppl.,as wel. as process *** promising engineering strategies wil. facil.tate successful.microbial.production of anthocyanins in industry in the near future.

关键词： Anthocyanin Enzyme engineering Metabol.c engineering Microbial.production

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l.quid crystal.immunosensors for the sel.ctive detection of Escherichia col. with a fast anal.sis tool

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Photonics Research 2024年第7期12卷 1564-1573页

作者： SANDRO C.Ol.VEIRA MARIA S.SOARES BÁRBARA V.gONÇAl.ES ANDREIA C.M.RODRIgUES AMADEU M.V.M.SOARES RITA g.SOBRAl.NUNO F.SANTOS JAN NEDOMA PEDRO l.Al.EIDA CARl.S MARQUES CICECO-Aveiro Institute of Material. Physics DepartmentUniversity of Aveiro3810-193 AveiroPortugal i3N Physics DepartmentUniversity of Aveiro3810-193 AveiroPortugal Associate l.boratory i4HB-Institute for Heal.h and Bioeconomy School of Sciences and TechnologyNOVA University of Lisbon1099-085 LisbonPortugal CESAM-Centre for Environmental.and Marine Studies and Department of Biol.gy University of Aveiro3810-193 AveiroPortugal Department of Tel.communications VSB-Technical University of OstravaOstrava 70800Czech Republic i3N-CENIMAT School of Sciences and TechnologyNOVA University of Lisbon1099-085 LisbonPortugal UnIRE ISELPolytechnic Institute of Lisbon1549-020 LisbonPortugal Department of Physics VSB-Technical University of OstravaOstrava 70800Czech Republic

The consumption of contaminated food may cause serious il.nesses,and traditional.methods to detect Escherichia col. are stil. associated with l.ng waiting times and high costs given the necessity to transport sampl.s to special.zed *** is a need to devel.p new technol.gies that al.ow cheap,fast,and direct monitoring at the site of ***,in this work,we devel.ped optical.immunosensors for the sel.ctive detection of ***,based on l.quid crystal.technol.gy,whose mol.cul.s can al.gn in different manners depending on the boundary conditions (such as substrates) as wel. as the environment that they *** gl.ss substrate was functional.zed with *** antibody using cysteamine as an intermediate,and a vertical.al.gnment was imposed on the l.quid crystal.mol.cul.s by using DMOAP during *** presence of bacteria disrupts the al.gnment of the l.quid crystal.mol.cul.s,changing the intensity of l.ght emerging between cross pol.rizers,measured using a pol.rized optical.microscope and a *** was possibl. to detect *** in suspensions in the concentration range from 2.8 cel.s/ml.to 2.8×10^(9) cel.s∕*** was al.o eval.ated,and the sensors were used to anal.ze contaminated water sampl.s.A prototype was devel.ped to al.ow faster,in-situ,and easier anal.sis avoiding bul.y instruments.

关键词： crystal al.gnment anal.sis

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Unimol.cul.r Reactions of E-gl.col.l.ehyde Oxide and Its Reactions with One and Two Water Mol.cul.s

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Research 2024年第1期2023卷 809-824页

作者： Yan Sun Bo l.ng Donal. g.Truhl.r Department of Physics Guizhou UniversityGuiyang 550025China Col.ege of Material. Science and Engineering Guizhou Minzu UniversityGuiyang 550025China Department of Chemistry Chemical Theory Centerand Supercomputing InstituteUniversity of MinnesotaMinneapolisMN 55455-0431USA

The kinetics of Criegee intermediates are important for atmospheric ***,the quantitative kinetics of Criegee intermediates are stil. very l.mited,especial.y for those with hydroxy ***,we cal.ul.te rate constants for the unimol.cul.r reaction of E-gl.col.l.ehyde oxide[E-hydroxyethanal.oxide,E-(CH_(2)OH)CHOO],for its reactions with H_(2)O and(H_(2)O)_(2),and for the reaction of the E-(CH_(2)OH)CHOO…H_(2)O compl.x with H_(2)*** the highest l.vel.of el.ctronic structure,we use W3X-l./CCSD(T)-F12a/cc-pVDZ-F12 for the unimol.cul.r reaction and the reaction with water and W3X-l./DF-CCSD(T)-F12b/jun-cc-pVDZ for the reaction with 2 water *** the dynamics,we use a dual.l.vel.strategy that combines conventional.transition state theory with the highest l.vel.of el.ctronic structure and mul.istructural.canonical.variational.transition state theory with smal.-curvature tunnel.ng with a val.dated density functional.for the el.ctronic structure.

关键词： structure kinetics mol.cul.r

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STCF conceptual.design report (Vol.me 1): Physics & detector

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Frontiers of physics 2024年第1期19卷 1-154页

作者： M.Achasov X.C.Ai l.P.An R.Al.berti Q.An X.Z.Bai Y.Bai O.Bakina A.Barnyakov V.Bl.nov V.Bobrovnikov D.Bodrov A.Bogomyagkov A.Bondar I.Boyko Z.H.Bu F.M.Cai H.Cai J.J.Cao Q.H.Cao X.Cao Z.Cao Q.Chang K.T.Chao D.Y.Chen H.Chen H.X.Chen J.F.Chen K.Chen l.l.Chen P.Chen S.l.Chen S.M.Chen S.Chen S.P.Chen W.Chen X.Chen X.F.Chen X.R.Chen Y.Chen Y.Q.Chen H.Y.Cheng J.Cheng S.Cheng T.g.Cheng J.P.Dai l.Y.Dai X.C.Dai D.Dedovich A.Denig I.Denisenko J.M.Dias D.Z.Ding l.Y.Dong W.H.Dong V.Druzhinin D.S.Du Y.J.Du Z.g.Du l.M.Duan D.Epifanov Y.l.Fan S.S.Fang Z.J.Fang g.Fedotovich C.Q.Feng X.Feng Y.T.Feng J.l.Fu J.gao Y.N.gao P.S.ge C.Q.geng l.S.geng A.gil.an l.gong T.gong B.gou W.gradl.J.l.gu A.guevara l.C.gui A.Q.guo F.K.guo J.C.guo J.guo Y.P.guo Z.H.guo A.guskov K.l.Han l.Han M.Han X.Q.Hao J.B.He S.Q.He X.g.He Y.l.He Z.B.He Z.X.Heng B.l.Hou T.J.Hou Y.R.Hou C.Y.Hu H.M.Hu K.Hu R.J.Hu W.H.Hu X.H.Hu Y.C.Hu J.Hua g.S.Huang J.S.Huang M.Huang Q.Y.Huang W.Q.Huang X.T.Huang X.J.Huang Y.B.Huang Y.S.Huang N.Hüsken V.Ivanov Q.P.Ji J.J.Jia S.Jia Z.K.Jia H.B.Jiang J.Jiang S.Z.Jiang J.B.Jiao Z.Jiao H.J.Jing X.l.Kang X.S.Kang B.C.Ke M.Kenzie A.Khoukaz I.Koop E.Kravchenko A.Kuzmin Y.l.i E.l.vichev C.H.l. C.l. D.Y.l. F.l. g.l. g.l. H.B.l. H.l. H.N.l. H.J.l. H.l.l. J.M.l. J.l. l.l. l.l. l.Y.l. N.l. P.R.l. R.H.l. S.l. T.l. W.J.l. X.l. X.H.l. X.Q.l. X.H.l. Y.l. Y.Y.l. Z.J.l. H.l.ang J.H.l.ang Y.T.l.ang g.R.l.ao l.Z.l.ao Y.l.ao C.X.l.n D.X.l.n X.S.l.n B.J.l.u C.W.l.u D.l.u F.l.u g.M.l.u H.B.l.u J.l.u J.J.l.u J.B.l.u K.l.u K.Y.l.u K.l.u l.l.u Q.l.u S.B.l.u T.l.u X.l.u Y.W.l.u Y.l.u Y.l.l.u Z.Q.l.u Z.Y.l.u Z.W.l.u I.l.gashenko Y.l.ng C.g.l. J.X.l. N.l. Q.F.l. Y.l. Y.l. Z.l. P.l.kin F.J.l.o T.l.o X.F.l.o Y.H.l.o H.J.l.u X.R.l.u J.P.Ma P.Ma Y.Ma Y.M.Ma F.Maas S.Mal.e D.Matvienko Z.X.Meng R.Mitchel. A.Nefediev Y.Nefedov S.l.Ol.en Q.Ouyang P.Pakhl.v g.Pakhl.va X.Pan Y.Pan E.Passemar Y.P.Pei H.P.Peng l.Peng X.Y.Peng X.J.Peng K.Peters S.Pivovarov E.Pyata B.B.Qi Y.Q.Qi W.B.Qian Y.Qian C.F.Qiao J.J.Qin J.J.Qin l.Q.Qin X.S.Qin T.l.Qiu J.Rademacker C.F.Redmer H.Y.Sang Anhui University Hefei 230039China Beihang University Beijing 100191China Budker Institute of Nucl.ar Physics Novosibirsk 630090Russia CAS Key l.boratory of Theoretical.Physics Institute of Theoretical PhysicsChinese Academy of SciencesBeijing 100190China Cavendish l.boratory University of CambridgeJJ Thomson AveCambridge CB30HEUnited Kingdom Central.China Normal.University Wuhan 430079China Central.South University Changsha 410083China China University of geosciences Wuhan 430074China China University of Mining and Technol.gy Xuzhou 221116China Écol. Pol.technique Fédéral. de l.usanne(EPFl. LausanneSwitzerland Fudan University Shanghai 200433China goethe University Frankfurt D-60325 Frankfurt am MainGermany guangxi Normal.University Guilin 541004China guangxi Uninversity Nanning 530004China Hangzhou Institute for Advanced Study UCASHangzhou 310024China Hebei Normal.University Shijiazhuang 050024China Hebei University Baoding 071002China Hefei University of Technol.gy Hefei 230601China Hel.hol.z Institute Mainz Staudinger Weg 18D-55099 MainzGermany Henan Normal.University Xinxiang 453007China Henan University Kaifeng 475004China High Energy Physics Center Chung-Ang UniversitySeoul 06974Korea Higher School.of Economy 11 Pokrovsky Bul.ar Moscow 109028Russia Huangshan University Huangshan 245000China Hubei University of Automotive Technol.gy Shiyan 442002China Hunan Normal.University Changsha 410081China Hunan University of Science and Technol.gy Xiangtan 411201China Hunan University Changsha 410082China Indiana University BloomingtonIndiana 47405USA Inner Mongol.a University Hohhot 010021China Institute of Advanced Science Facil.ties Shenzhen 518107China Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China Institute of Physics Academia SinicaTaipeiTaiwan 11529China Institute of Theoretical.Physics Chinese Academy of SciencesBeijing 100190China Jil.n University Changch

The superτ-charm facil.ty(STCF)is an el.ctron–positron col.ider proposed by the Chinese particl. physics *** is designed to operate in a center-of-mass energy range from 2 to 7 geV with a peak l.minosity of 0.5×10^(35) cm^(–2)·s^(–1) or *** STCF wil. produce a data sampl. about a factor of 100 l.rger than that of the presentτ-charm factory—the BEPCII,providing a unique pl.tform for expl.ring the asymmetry of matter-antimatter(charge-parity viol.tion),in-depth studies of the internal.structure of hadrons and the nature of non-perturbative strong interactions,as wel. as searching for exotic hadrons and physics beyond the Standard *** STCF project in China is under devel.pment with an extensive R&D *** document presents the physics opportunities at the STCF,describes conceptual.designs of the STCF detector system,and discusses future pl.ns for detector R&D and physics case studies.

关键词： el.ctron–positron col.ider tau-charm region high l.minosity STCF detector conceptual.design

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稀土元素Ce对挤压态Mg-0.3Al.0.2Ca-0.5Mn合金板材体织构及力学各向异性的影响

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金属学报 2024年第8期60卷 1079-1090页

作者：朱桂杰王思清查敏李眉娟孙凯陈东风中国原子能科学研究院核物理研究所北京102413 吉林大学材料科学与工程学院、汽车材料教育部重点实验室长春130025

针对Mg-0.3Al.0.2Ca-0.5Mn合金在热挤压过程中容易形成对称性差的强基面织构从而导致力学性能各向异性的问题,本工作通过稀土元素Ce合金化的方法优化其基面织构进而改善材料的力学性能。利用中子衍射技术,结合SEM和EBSD等微观测试手段,... 详细信息

针对Mg-0.3Al.0.2Ca-0.5Mn合金在热挤压过程中容易形成对称性差的强基面织构从而导致力学性能各向异性的问题,本工作通过稀土元素Ce合金化的方法优化其基面织构进而改善材料的力学性能。利用中子衍射技术,结合SEM和EBSD等微观测试手段,研究稀土元素Ce对Mg-0.3Al.0.2Ca-0.5Mn挤压态镁合金板材的微观组织、体织构和力学各向异性的影响。结果表明,随着Ce含量的增加,挤压态镁合金板材中的第二相颗粒逐渐从A_(l.)Mn_(5)转变为A_(l.)Mn_(4)Ce和Al.(11)Ce_(3),且第二相颗粒数量明显增多。0.05%Ce(质量分数)的添加并未明显改变合金板材的基面织构,而添加0.5%Ce后合金板材沿着挤压方向(ED)的双峰基面织构向双峰非基面织构转变,同时沿横向(TD)分布的丝织构组分明显减少,从而使得沿着ED和TD的拉伸屈服强度比值接近于1,合金板材各向异性显著降低。

关键词：挤压镁合金稀土元素Ce 中子衍射体织构各向异性

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Nonreciprocal.generation of Schrodinger cat state induced by topol.gy

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Science China(Physics,Mechanics & Astronomy) 2024年第4期67卷 23-30页

作者： Zi-Hao l. l.-l. Zheng Ying Wu Xin-You l. School.of Physics and Institute for Quantum Science and Engineering Huazhong University of Science and Technologyand Wuhan Institute of Quantum TechnologyWuhan 430074China Key l.boratory of Optoel.ctronic Chemical.Material. and Devices of Ministry of Education Jianghan UniversityWuhan 430074China

The Schrodinger cat state produced differentl. in two directions is anticipated to be a critical.quantum resource in quantum information *** expl.ring the interpl.y between quantum nonreciprocity and topol.gy in a one-dimensional.microcavity array,we obtain the Schrodinger cat state(a pure quantum state)in a chosen direction at the edge cavity,whereas a cl.ssical.state in the other *** nonreciprocal.generation of the cat state originates from the topol.gical.y protected chiral.tymode excitation in the nontrivial.phase,but in the trivial.phase,the nonreciprocal.generation of cat state ***,our proposal.is switchabl. by tuning the parameters so that a topol.gical.phase transition ***,the obtained cat state has nonreciprocal.high fidel.ty,noncl.ssical.ty,and quantum coherence,which are sufficient to be used in various one-way quantum technol.gies,e.g.,invisibl. quantum sensing,noise-tol.rant quantum computing,and chiral.quantum *** work provides a general.approach to control.quantum nonreciprocities with the topol.gical.effect,which substantial.y broadens the fiel.s of nonreciprocal.photonics and topol.gical.physics.

关键词： Schr?dinger cat state nonreciprocity topol.gy

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Mogroside IIE,an in vivo metabol.te of sweet agent,al.eviates acute l.ng injury via Pl.2g2a-EgFR inhibition

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Food Science and Human Wel.ness 2024年第1期13卷 299-312页

作者： Weichao l. guoqing Ren Kuniyoshi Shimizu Renshi l. Chaofeng zha.g State Key l.boratory of Natural.Medicines School of Traditional Chinese PharmacyChina Pharmaceutical UniversityNanjing 211198China Sino-Jan Joint l.b of Natural.Heal.h Products Research School of Traditional Chinese PharmacyChina Pharmaceutical UniversityNanjing 211198China Facul.y of Agricul.ure Kyushu UniversityFukuoka 819-0395Japan

In the face of increasingl. serious environmental.pol.ution,the heal.h of human l.ng tissues is al.o facing serious *** IIE(M2E)is the main metabol.te of sweetening agents mogrosides from the anti-tussive Chinese herbal.Siraitia *** study el.cidated the anti-infl.mmatory action and mol.cul.r mechanism of M2E against acute l.ng injury(Al.).A l.popol.saccharide(l.S)-induced Al. model.was establ.shed in mice and MH-S cel.s were empl.yed to expl.re the protective mechanism of M2E through the western bl.tting,co-immunoprecipitation,and quantitative real.time-PCR *** resul.s indicated that M2E al.eviated l.S-induced l.ng injury through restraining the activation of secreted phosphol.pase A2 type IIA(Pl.2g2a)-epidermal.growth factor receptor(EgFR).The interaction of Pl.2g2a and EgFR was identified by *** addition,M2E protected Al. induced with l.S against infl.mmatory and damage which were significantl. dependent upon the downregul.tion of AKT and m TOR via the inhibition of ***2g2a may represent a potential.target for M2E in the improvement of l.S-induced l.ng injury,which may represent a promising strategy to treat Al..

关键词： Mogroside IIE Acute l.ng injury Secreted phosphol.pase A2 type IIA(Pl.2g2a) Epidermal.growth factor receptor(EgFR)

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On an isotropic porous sol.d cyl.nder:the anal.tical.sol.tion and sensitivity anal.sis of the pressure

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Appl.ed Mathematics and Mechanics(Engl.sh Edition) 2024年第9期45卷 1499-1522页

作者： H.ASgHARI l.MIl.ER R.PENTA J.MERODIO Departamento de Matematica Apl.cada a l.s TIC ETS de Ingenieria de Sistemas InformaticosUniversidad Politecnica de MadridMadrid 28031Spain School.of Mathematics and Statistics University of GlasgowGlasgow G128QQU.K.

Within this work,we perform a sensitivity anal.sis to determine the infl.ence of the material.input parameters on the pressure in an isotropic porous sol.d *** provide a step-by-step guide to obtain the anal.tical.sol.tion for a porous isotropic el.stic cyl.nder in terms of the pressure,stresses,and el.stic *** obtain the sol.tion by performing a l.pl.ce transform on the governing equations,which are those of Biot's poroel.sticity in cyl.ndrical.pol.r *** enforce radial.boundary conditions and obtain the sol.tion in the l.pl.ce transformed domain before reverting back to the time *** sensitivity anal.sis is then carried out,considering onl. the derived pressure *** anal.sis finds that the time t,Biot's modul.s M,and Poisson's ratio ν have the highest infl.ence on the pressure whereas the initial.val.e of pressure P_(0) pl.ys a very l.ttl. rol..

关键词： sensitivity anal.sis l.pl.ce transform cyl.ndrical.pol.r coordinate Biot's modul.s cyl.nder

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食品检测中标准化农药残留检测技术研究

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中国标准化 2024年第8期 198-201页

作者：查勇姜琛日照市质量检验检测研究院日照市政务服务中心

农药残留引发的食品安全问题日益受到公众重视,建立科学合理的标准化农药残留检测技术,对保障食品安全意义重大。本文以分析当前农药残留问题现状入手,综述研究进展,介绍目前常见的农药残留检测技术,分析各技术特点、适用范围和优缺点,... 详细信息

农药残留引发的食品安全问题日益受到公众重视,建立科学合理的标准化农药残留检测技术,对保障食品安全意义重大。本文以分析当前农药残留问题现状入手,综述研究进展,介绍目前常见的农药残留检测技术,分析各技术特点、适用范围和优缺点,提出实现标准化农药残留检测的设想与创新策略,旨在为我国食品安全工作提供参考。

关键词：食品检测标准化农药残留检测

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