Production of anthocyanins in metabolically engineered microorganisms:Current status and perspectives

作     者：Jian Zha Mattheos A.G.Koffas 

作者机构：Department of Chemical and Biological EngineeringCenter for Biotechnology and Interdisciplinary StudiesRensselaer Polytechnic InstituteTroyNYUSA Department of Biological SciencesCenter for Biotechnology and Interdisciplinary StudiesRensselaer Polytechnic InstituteTroyNYUSA 

出 版 物：《Synthetic and Systems Biotechnology》 (合成和系统生物技术（英文）)

年 卷 期：2017年第2卷第4期

页      面：259-266页

核心收录：

学科分类：0202[经济学-应用经济学] 02[经济学] 020205[经济学-产业经济学] 

基　　金：Funding for some of the work reviewed in this manuscript was provided by the National Science Foundation grant number IIP-1549767 

主　　题：Anthocyanin Enzyme engineering Metabolic engineering Microbial production 

摘      要：Microbial production of plant-derived natural products by engineered microorganisms has achieved great success thanks to large extend to metabolic engineering and synthetic ***,the water-soluble colored pigments found in terrestrial plants that are responsible for the red,blue and purple coloration of many flowers and fruits,are extensively used in food and cosmetics industry;however,their current supply heavily relies on complex extraction from plant-based materials.A promising alternative is their sustainable production in metabolically engineered ***,we review the recent progress on anthocyanin biosynthesis in engineered bacteria,with a special focus on the systematic engineering modifications such as selection and engineering of biosynthetic enzymes,engineering of transportation,regulation of UDP-glucose supply,as well as process *** promising engineering strategies will facilitate successful microbial production of anthocyanins in industry in the near future.