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The compound(E)-2-(3,4-dihydroxystyryl)-3-hydroxy-4H-pyran-4-one alleviates neuroinflammation and cognitive impairment in a mouse model of Alzheimer's disease

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Neural Regeneration Research 2025年第11期20卷 3330-3344页

作者： Xueyan Liu Wei Wu Xuejuan Li Chengyan Wang Ke Chai Fanru Yuan Huijuan Zheng Yuxing Yao Chenlu Li Zu-Cheng Ye Daijun zha Department of Medicinal Chemistry School of PharmacyFujian Medical UniversityFuzhouFujian ProvinceChina Fujian Provincial Key Laboratory of Brain Aging and Neurodegenerative Diseases School of Basic Medical SciencesFujian Medical UniversityFuzhouFujian ProvinceChina Institute of Laboratory Animal Center Fujian Medical UniversityFuzhouFujian ProvinceChina Department of Neurosurgery Neurosurgery Research InstituteThe First Affiliated HospitalFujian Medical UniversityFuzhouFujian ProvinceChina Department of Hyperbaric Oxygen National Regional Medical CenterBinhai Campus of the First Affiliated HospitalFujian Medical UniversityFuzhouFujian ProvinceChina

Previous studies have shown that the compound(E)-2-(3,4-dihydroxystyryl)-3-hydroxy-4H-pyran-4-one(D30),a pyromeconic acid derivative,possesses antioxidant and anti-inflammatory properties,inhibits amyloid-β aggregation,and alleviates scopolamine-induced cognitive impairment,similar to the phase Ⅲ clinical drug *** this study,we established a mouse model of Alzheimer's disease via intracerebroventricular injection of fibrillar amyloid-β to investigate the effect of D30 on fibrillar amyloid-β-induced *** results showed that D30 alleviated fibrillar amyloid-β-induced cognitive impairment,promoted fibrillar amyloid-β clearance from the hippocampus and cortex,suppressed oxidative stress,and inhibited activation of microglia and astrocytes.D30 also reversed the fibrillar amyloid-β-induced loss of dendritic spines and synaptic protein ***,we demonstrated that exogenous fibrillar amyloid-βintroduced by intracerebroventricular injection greatly increased galectin-3 expression levels in the brain,and this increase was blocked by *** the role of D30 in clearing amyloid-β,inhibiting neuroinflammation,protecting synapses,and improving cognition,this study highlights the potential of galectin-3 as a promising treatment target for patients with Alzheimer's disease.

关键词： Alzheimer's disease amyloid-β astrocyte cognitive impairment D30 dendritic spines galectin-3 microglia neuroinflammation neuron

Production of anthocyanins in metabolically engineered microorganisms:Current status and perspectives

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Synthetic and Systems Biotechnology 2017年第4期2卷 259-266页

作者： Jian zha Mattheos A.g.Koffas Department of Chemical and Biological Engineering Center for Biotechnology and Interdisciplinary StudiesRensselaer Polytechnic InstituteTroyNYUSA Department of Biological Sciences Center for Biotechnology and Interdisciplinary StudiesRensselaer Polytechnic InstituteTroyNYUSA

Microbial production of plant-derived natural products by engineered microorganisms has achieved great success thanks to large extend to metabolic engineering and synthetic ***,the water-soluble colored pigments found in terrestrial plants that are responsible for the red,blue and purple coloration of many flowers and fruits,are extensively used in food and cosmetics industry;however,their current supply heavily relies on complex extraction from plant-based materials.A promising alternative is their sustainable production in metabolically engineered ***,we review the recent progress on anthocyanin biosynthesis in engineered bacteria,with a special focus on the systematic engineering modifications such as selection and engineering of biosynthetic enzymes,engineering of transportation,regulation of UDP-glucose supply,as well as process *** promising engineering strategies will facilitate successful microbial production of anthocyanins in industry in the near future.

关键词： Anthocyanin Enzyme engineering Metabolic engineering Microbial production

A Hybrid MCDM Approach Based on ANP and TOPSIS for Facility Layout Selection

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Transactions of Nanjing University of Aeronautics and Astronautics 2018年第6期35卷 1027-1037页

作者： zha Shanshan guo Yu Huang Shaohua Tang Pengzhou College of Mechanical and Electrical Engineering Nanjing University of Aeronautics and Astronautics

Facility layout selection is a multi-criteria decision making (MCDM) problem,since it has a strategic impact on the efficiency of manufacturing *** view of the interdependency among selection criteria,analytic network process (ANP) is proposed to analyze the structure of the facility layout selection problem and determine the weights for each criterion.A network structure is constructed that shows all elements and clusters and their *** priorities are also calculated which help decision maker evaluate the relative importance among criterion in the alternative selection ***,a hybrid MCDM approach that employs ANP and technique for order preference by similarity to an ideal solution (TOPSIS)method to rank the optimal facility layout ***,an application of a new aeronautic component assembly workshop facility layout selection is *** further illustrate the advantage of the proposed approach,the difference between ANP-TOPSIS and AHP-TOPSIS methods are compared and *** have demonstrated the effectiveness and feasibility of the proposed method.

关键词： facility layout selection multi-criteria decision making(MCDM) analytic network process AHP TOPSIS

Microenvironment characterization for a novel biocompatible hybrid carbon-silicon material

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Science China Chemistry 2009年第8期52卷 1120-1127页

作者： SUI XiHua zha QingFang WU MingBo guo YanSheng State Key Laboratory of Heavy Oil China University of PetroleumDongying 257061China

The compatible carbon-silicon complex materials originated from precursor diglycerylsilane(DgS) and sugar-modified silane N-(3-triethoxysilylpropyl)gluconamide(gLS) have gained substantial popularity by demonstrating admirable properties to stabilize entrapped *** microenvironment inside these materials,especially the distribution of sugar moieties inside the matrix,which is likely the most critical factor determining compatibility of these materials,still remains *** deeply investigate the biocompatibility mechanism of these materials,we have adopted two different preparation routes for these materials by introducing gLS into the starting DgS sol stage,but things are different after the DgS gel is formed.A fluorescence probe rhodamine 6g is introduced herein in the DgS sol to monitor the distribution of gLS moieties,as well as the evolution of the microenvironment inside resulting *** in all,the findings demonstrated that the timing of gLS addition plays a critical role in controlling the evolution of the inner structure of materials,suggesting that this factor provides a promising route to tune the properties of the resulting materials.

关键词： biocompatibility carbon-silicon complex microenvironment characterization

CPg Control for Biped Hopping Robot in Unpredictable Environment

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Journal of Bionic Engineering 2012年第1期9卷 29-38页

作者： Tingting Wang Wei guo Mantian Li Fusheng zha Lining Sun State Key Laboratory of Robotics and System Harbin Institute of TechnologyHarbin 150080P.R.China

A CPg control mechanism is proposed for hopping motion control of biped robot in unpredictable environment. Based on analysis of robot motion and biological observation of animal＇s control mechanism, the motion control task is divided into two simple parts： motion sequence control and output force control. Inspired by a two-level CPg model, a two-level CPg control mechanism is constructed to coordinate the drivers of robot joint, while various feedback information are introduced into the control mechanism. Interneurons within the control mechanism are modeled to generate motion rhythm and pattern promptly for motion sequence control; motoneurons are modeled to control output forces of joint drivers in real time according to feedbacks. The control system can perceive changes caused by unknown perturbations and environment changes according to feedback information, and adapt to unpredictable environment by adjusting outputs of neurons. The control mechanism is applied to a biped hopping robot in unpredictable environment on simulation platform, and stable adaptive motions are obtained.

关键词： biped robot unpredictable environment hopping motion control bionic control CPg

晋西黄土区不同植被恢复阶段土壤生态化学计量特征

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水土保持研究 2025年第1期32卷 30-38+47页

作者：高连炜张红丽查同刚北京林业大学水土保持学院水利部水土保持监测中心

[目的]开展土壤生态化学计量特征随植被恢复进程的变化研究，探究植被恢复引起土壤养分变化规律及其作用机制，对认识植被恢复与土壤养分的关系，指导植被恢复实践具有重要意义。[方法]以晋西黄土区不同植被恢复阶段(撂荒地、草地、灌... 详细信息

[目的]开展土壤生态化学计量特征随植被恢复进程的变化研究，探究植被恢复引起土壤养分变化规律及其作用机制，对认识植被恢复与土壤养分的关系，指导植被恢复实践具有重要意义。[方法]以晋西黄土区不同植被恢复阶段(撂荒地、草地、灌木林、先锋阔叶林、针叶林)的5种林(草)地为研究对象，通过调查采样和室内分析，探究土壤生态化学计量特征随植被恢复的进程变化及其影响因素。[结果](1)随着植被的恢复，先锋阔叶林和针叶林阶段的SOC含量较上一阶段增加19.8%,土壤TN含量较上一阶段增加17.6%,而土壤TP含量较上一阶段减少12.4%;(2)随着植被恢复的发展，土壤C∶P和N∶P显著增加，C∶N的变化无明显规律，在先锋阔叶林和针叶林阶段的土壤C∶P较上一阶段增加26.6%;先锋阔叶林和针叶林阶段在0—40 cm土层的土壤N∶P较上一阶段增加40.2%,40—100 cm土层的土壤N∶P较上一阶段增加35.7%;土壤C∶N在不同植被恢复阶段间的变化未见明显规律，研究区土壤逐渐由C,N的限制转变为P的限制；(3)各植被恢复阶段土壤C∶P和N∶P主要与砂粒含量呈显著负相关，与孔隙度呈显著正相关，土壤C∶N与其他因子的相关性不明显。[结论]植被恢复有利于土壤C,N含量增加，改善土壤理化性质，在植被恢复过程应同时注重P元素的调控，以提高晋西黄土区植被生态恢复水平。

关键词：植被恢复土壤养分生态化学计量特征

Preparation and Application of Silica-based Perfusion Packing of Size Exclusion Chromatography for Quantitation of Polyacrylamide in Enhanced Oil Recovery Systems

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Petroleum Science 2007年第2期4卷 82-90页

作者： Sui Xihua zha Qingfang Wu Mingbo guo Yansheng State Key Laboratory of Heavy Oil Processing China University of Petroleum （East China） Dongying Shandong 257061 China

The synthesis and characterization of a novel macroporous silica derived size exclusion chromatography （SEC） packing for quantitative analysis of high molecular weight （MW） polyacrylamide （PAM） are presented. Using this packing, a fast, sensitive and reproducible approach for quantitation of super high-MW PAM in demanding enhanced oil recovery （EOR） waters was developed and the effect of synthesis parameters on the properties of resultant materials was investigated. These parameters include salt addition, reaction temperature and duration, activation condition of functional groups on the silica surface, as well as the reaction cycles required for optimal silica modification. Moreover, SEC analysis conditions, such as mobile phase composition, flow rate, detection and sample preparation, were also explored and an optimal analysis protocol was developed. Under this optimized SEC analysis conditions, the synthesized macroporous materials proved satisfactory for quantification of PAM with average MW up to 22 million Daltons. An SEC analysis required less than few minutes with a detection limit of 1 ng, a linear response range of 0.1 to 75 mg/L with squared R value of 0.99 and reproducibility better than 9.2% RSD （relative standard deviation）. The analysis of PAM in highly saline oilfield production water containing interfering high MW polymeric surfactants indicated the recovery ranges from 92.5% to 110.1% for 1.0 mg/L PAM and 94.2% to 103.8% for 50 mg/L PAM solution. This study presented for the ftrst time that the reliable quantization of high MW PAM in highly demanding EOR waters can be achieved by SEC.

关键词： Macroporous silica size exclusion chromatography quantitation polyacrylamide

A Parallel Actuated Pantograph Leg for High-speed Locomotion

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Journal of Bionic Engineering 2017年第2期14卷 202-217页

作者： Wei guo Changrong Cai Mantian Li Fusheng zha Pengfei Wang Kenan Wang State Key Laboratory of Robotics and System Harbin Institute of Technology Harbin 150001 China

High-speed running is one of the most important topics in the field of legged robots which requires strict constraints on structural design and control. To solve the problems of high acceleration, high energy consumption, high pace frequency and ground impact during high-speed movement, this paper presents a parallel actuated pantograph leg with an approximately decoupled configuration. The articulated leg features in light weight, high load capacity, high mechanical efficiency and structural stability. The similarity features of force and position between the control point and the foot are analyzed. The key design parameters, K1 and K2, which concern the dynamic performances, are carefully optimized by comprehensive evaluation of the leg inertia and mass within the maximum foot trajectory, A control strategy that incorporates virtual Spring Loaded Inverted Pendulum （SLIP） model and active force is also proposed to test the design. The strategy can implement highly flexible impedance without mechanical springs, which substantially simplifies the design and satisfies the variable stiffness requirements during high-speed running. The rationality of the structure and the effectiveness of the control law are validated by simulation and experiments.

关键词： high-speed parallel actuated pantograph leg optimization virtual SLIP model active force

Optimization Algorithm of UWB Positioning for Aircraft Assembly Workshop

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Transactions of Nanjing University of Aeronautics and Astronautics 2018年第6期35卷 952-961页

作者： Huang Shaohua guo Yu Wu Qi zha Shanshan Song Likang College of Mechanical and Electrical Engineering Nanjing University of Aeronautics and AstronauticsNanjing 210016P.R.China Jiangxi Hongdu Aviation Industry group Co.Ltd. Nanchang 330001P.R.China

Due to the complexity of strong metal interference and multiple occlusions in aircraft assembly workshop,the random "drift"phenomenon often happens in the ultra wide band (UWB)based positioning *** solve this,a fusion positioning optimization algorithm is proposed based on median filtering,hidden Markov model (HMM)a nd Kalman ***,based on the three-dimensional (3D) median filtering,aqueue optimization method with weights is introduced to smooth the measurement data and eliminate the abnormal ***,taking Singer model as a reference,a single-dimension acceleration distribution model is *** order to further consider the spatial motion characteristics of objects in workshop,the distribution is extended from 1D to 3D,and discretized into the state quantity of ***,the data obtained by the two methods are fused by taking Kalman filter as an iterator,and then the optimized location solution is obtained based on dynamic ***,an experiment is conducted in an aircraft assembly *** show that 99.3% of dynamic positioning errors are less than 15 cm after using the proposed *** in the situation with large signal-fluctuation,there are 71.6% of positioning data whose errors are *** random "drift"is greatly decreased.

关键词： ultra wide band(UWB) aircraft assembly workshop hidden Markov model(HMM) median filtering Kalman filtering