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Effect of perioperative autologous versus allogeneic blood transfusion on the immune system in gastric cancer patients

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2007年第8期8卷 560-565页

作者： CHEN Gang zhang feng-jiang GONG ming YAN Min Department of Anesthesiology the Second Affiliated Hospital School of Medicine Zhejiang University Hangzhou 310009 China

Background： Allogeneic blood transfusion-induced immunomodulation （TRIM） and its adverse effect on the prognosis of patients treated surgically for cancer remain complex and controversial. However, the potential risk associated with allogeneic blood transfusion has heightened interest in the use of autologous blood transfusion. In the present study, the serum concentrations of neopterin, interferon-gamma （IFN-γ）, T lymphocyte subsets （CD3^＋, CD4^＋, CD8^＋, CD4^＋/CD8^＋） and a possible association between these variables were investigated. The purpose was to further evaluate the effect of autologous versus allogeneic blood transfusion on immunological status in patients undergoing surgery for gastric cancer. Methods： Sixty ASA Ⅰ～Ⅱ（American Society of Anesthesiologists） patients undergoing elective radical resection for stomach cancer were randomly allocated to receive either allogeneic blood transfusion （n=30） or autologous blood transfusion （n=30）. Serum concentrations of the neopterin, IFN-γ and T lymphocyte subsets in the recipients were measured before induction of anesthesia, after operation, and on the 5th postoperative day. Results： Both two groups, serum neopterin, IFN-γ, percentages of T-cell subsets （CD3^＋, CD4^＋）, and CD4^＋/CD8^＋ ratio had significantly decreased after operation, but decreased more significantly in group H （receiving allogeneic blood transfusion） than those in group A （receiving autologous whole blood transfusion）（P〈0.05）. On the 5th postoperative day,serum neopterin, IFN-γ, CD3^＋, CD4^＋ T-cells, and CD4^＋/CD8^＋ ratio returned to the baseline values in group A. In contrast, the above remain decreasing in group H, where there were no significant relations between serum neopterin and IFN-γ. Conclusion：Perioperative surgical trauma and stress have an immunosuppressive impact on gastric cancer patients. Allogeneic blood transfusion exacerbates the impaired immune response. Autologous blood transfusion might be significantly beneficial for immun

关键词： Transfusion-induced immunomodulation (TRIM) Autologous blood transfusion Allogeneic blood transfusion Neopterin Interferon-gamma (IFN-γ) CD3^+ CD4^+ CD4^+/CD8^+ ratio

Microstructure,Properties and Heat Treatment Process of Powder Metallurgy Superalloy FGH95

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Journal of Iron and Steel Research International 2006年第5期13卷 65-68页

作者： GUO Wei-min WU Jian-tao zhang feng-ge ZHAO ming-han High Temperature Materials Research Institute Central Iron and Steel Research Institute Beijing 100081 China

Microstructure and properties of nickel based powder metallurgy （PM） superalloy were presented. Effects of nonmetallic inclusions and heat treatment on microstructure and properties were. discussed. Development tend... 详细信息

关键词： microstructure property PM superalloy heat treatment

Study on Site-specific Nutrient Management in Cotton Field

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Agricultural Sciences in China 2001年第1期 102-106页

作者： YANG Li-ping JIANG Cheng JIN Ji-yun zhang feng-ming Key Laboratory of Plant Nutrition Research of Ministry of Agriculture Soil and Fertilizer Institute of Chinese Academy of Agricultural Sciences Beijing 100081 Key Laboratory of Plant Nutrition Research of Ministry of Agriculture Soil and Fertilizer Institute of Chinese Academy of Agricultural Sciences Beijing 100081 Key Laboratory of Plant Nutrition Research of Ministry of Agriculture Soil and Fertilizer Institute of Chinese Academy of Agricultural Sciences Beijing 100081 Handan Agricultural Technology Extension Station Handan Hebei Province 056802

The study on the characteristics of spatial variability of soil nutrients and fertilizer recommendations in cotton field under certain conditions of agricultural management was conducted with GIS and systematic approach for soil nutrient constrains. The results showed that of the spatial variability of soil nutrient was greatly related to the management condition of previous crops. Grid sampling and variable rate application technology (VRAT) were the tools that would hopefully increase fertilizer efficiency. The fertilizers were applied where they were needed and at proper rate. Balance fertilization demonstration showed that fertilizer recommendations according to the available nutrient level in soil could decrease fertilizer cost with 657.4 yuan / ha and increase seed cotton yield by 19.8%. A net profit of the balanced fertilization was 5314.9 yuan / ha higher than that of local fertilization practice.

关键词： Cotton field Site-specific nutrient management GIS Fertilizer recommendations Variable rate fertilization

Rho signaling inhibitor,Y-27632,inhibits invasiveness of metastastic hepatocellular carcinoma in a mouse model

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Chinese Medical Journal 2007年第24期120卷 2304-2307页

作者： XUE feng zhang Jian-jun QIU feng zhang ming CHEN Xiao-song LI Qi-gen HAN Long-zhi XI Zhi-feng XIA Qiang Organ Transplantation Center Renji Hospital Shanghai Jiao TongUniversity School of Medicine Shanghai 200127 China

Hepatocellular carcinoma(HCC)is among the mostcommon tumors *** extensiveexploration of novel therapies,the prognosis of HCCpatients with intrahepatic metastasis is still poor,and notreatment is effective against ***,... 详细信息

关键词： ROCK inhibitor hepatocellular carcinoma metastasis apoptosis invasiveness

Application of super gamma knife in the treatment of cancer of the tongue （a case report）

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中国口腔颌面外科杂志 2008年第B5期6卷 153-154页

作者： zhang feng Yao Hui ming Zhou feng Li Xiao Mi Super Gamma-Knife Center of Shanghai Armed Police Hospital.Shanghai 201103 China

Neuroprotective effect of Angiopep-2 peptide modified scutellarin-loaded PEGylated PAMAM dendrimer nanoparticles on ischemic stroke by modulating the Toll-like receptors-dependent MyD88/IKK/NF-κB signaling pathway

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中国药理学与毒理学杂志 2016年第10期30卷 1019-1020页

作者： LIU Xin LI Yu-tao LIU Wei zhang feng-ming CHEN Zeng-zhen ZENG Zhi-yong XU Meng-shu SUN Xiao-jun Department of Pharmaceutical Engineering School of Chemical and Environmental EngineeringHarbin University of Science And Technology

OBJECTIVE The greatest challenge in chemotherapy of ischemic stroke is the construction a suitable delivery system to overcome the poor physicochemical properties of drug and its low permeability across the blood brain barrier(BBB).METHODS In the present study,dendrimer,polyamidoamine(PAMAM),was synthesized as the nano-drug ***-2,which has been proved excellent ability to cross the BBB,was exploited as the targeting ligand to conjugate PAMAM via bifunctional polyethylene glycol(PEG).Then scutellarin(STA)was encapsulated into the functionalized nanoparticles(NPs)to formulate Angiopep-2 modified STA-loaded PEG-PAMAM *** stroke model was established to evaluate the treatment efficacy and protective mechanism of Angiopep-2-STA-PEG-PAMAM *** The pharmacokinetics and biodistribu-tion demonstrated that Angiopep-2-STA-PEG-PAMAM NPs exhibited significantly higher plasma concentration from 1 h to 10 h after intravenous administration and improve accumulation in brain(4.7-fold)compared with STA ***,prolonged elimination half-life(4.8-fold)and lower clearance(3.4-fold)were *** brain uptake study of 6-coumarin confirmed that Angiopep-2-PEG-PAMAM NPs possessed better brain targeting efficacy(3.2-fold)than PEG-PAMAM ***-2-STA-PEG-PAMAM NPs obviously ameliorated infarct volume,neurological deficit,histopathological severity and neuronal *** addition,Angiopep-2-STA-PEG-PAMAM NPs markedly inhibited the calcium content and the levels of IL-12p40,IL-13,IL-17 and ***,Angiopep-2-STA-PEG-PAMAM NPs significantly decreased the m RNA and protein expressions of HMGB1,TLR2,TLR4,TLR5,My D88,TRIF,TRAM,IRAK-4,TRAF6,IкBα,IKKβand NF-к*** The results suggested that Angiopep-2modified scutellarin-loaded PEG-PAMAM nanocarriers possessed remarkable neuroprotective effects on ischemic stroke through modulation of inflammatory cascades and HMGB1/TLRs/MyD 88-induced NF-κB activation pathways.

关键词： scutellarin cerebral ischemia Angiopep-2 modified PEG-PAMAM nanoparticles brain targeting HMGB1/TLR/MyD 88/IKK/NF-κB pathways neuroprotection

A NATIONAL SYSTEM OF INNOVATION TO BE BUILT FOR WELCOming THE ERA OF KNOWLEDGE ECONOMY

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Bulletin of the Chinese Academy of Sciences 1998年第3期12卷 173-179页

作者： (Chinese Academy of Sciences) He Chuanqi, Li Ning, zhang feng, Tian ming, Huo mingyuan

Editor’s note: Not long ago, CAS headquarters put forward a proposal entitled "A national innovation system (NIS) to be built up towards the era of knowledge economy (KE)" in a bid to plot a chart for China’s development in the next century. The suggestion was highly valued by the CPC Central Committee and here we publish an extracted translation of its full text.

关键词： Innovation A NATIONAL SYSTEM OF INNOVATION TO BE BUILT FOR WELCOming THE ERA OF KNOWLEDGE ECONOMY BE

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装备健康管理中的传感器优化配置问题研究

传感器与微系统 2008年第7期27卷 18-20页

作者：张亮张凤鸣空军工程大学工程学院陕西西安710038

传感器优化配置是装备健康管理(HM)的基础。考虑传感器失效对健康管理能力的影响,以传感器代价和漏检故障的危害程度最小为优化目标,以检测性能指标为约束条件,建立了传感器优化配置的模型;并针对传感器优化配置是一个多目标非线性整数... 详细信息

传感器优化配置是装备健康管理(HM)的基础。考虑传感器失效对健康管理能力的影响,以传感器代价和漏检故障的危害程度最小为优化目标,以检测性能指标为约束条件,建立了传感器优化配置的模型;并针对传感器优化配置是一个多目标非线性整数规划问题,提出了基于扩展微粒子群优化算法的模型求解方法。应用实例表明了模型和算法的有效性。

关键词：健康管理传感器优化配置故障检测微粒子群优化算法

刑事违法性判断必然受制于其他部门法吗?——破解“法秩序统一性原理”的迷思

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河北法学 2024年第3期42卷 129-151页

作者：张峰铭中共中央党校(国家行政学院)政治和法律教研部北京100091

刑事违法性判断在多大程度上受到其他部门法内容的制约,取决于应当如何正确理解刑事违法性判断的体系性要求。有学者认为应当同时考虑刑法内部体系和跨部门法外部体系,但这种看法忽视了两种体系存在不可通约性,没有中立的权衡点,必须重... 详细信息

刑事违法性判断在多大程度上受到其他部门法内容的制约,取决于应当如何正确理解刑事违法性判断的体系性要求。有学者认为应当同时考虑刑法内部体系和跨部门法外部体系,但这种看法忽视了两种体系存在不可通约性,没有中立的权衡点,必须重构为一个体系。所谓法秩序统一性原理的诸多版本都可以被视作对体系性要求的不同重构,要判断何者正确,必须回归刑事违法性判断本身的性质。刑事违法性判断蕴含三重宣称:原则融贯性宣称、道德正确性宣称与公共性宣称。其中,原则融贯性宣称是任何法律判断的内在宣称,因为法概念内在蕴含朝向法治的理想维度。道德正确性宣称与公共性宣称则是刑事违法性判断的特有宣称,前者指刑法主张刑事违法性的本质并非违反刑法,而是违反先于刑法存在的特定类型的道德规范;后者指刑法主张自身代表政治共同体的公共立场而非任何私人立场。上述三重宣称结合,意味着刑事违法性判断本质上是一种半制度化的公民道德体系判断,刑事不法即公民不法。这将导向一种独特的刑法内部体系立场:刑法并非后置法,刑事违法性判断并不直接受到其他部门法内容硬性约束,相反其他部门法要尊重刑法内部体系立场,但同时政治共同体的公民道德限定了刑法边界。

关键词：刑事违法性原则融贯性内部体系外部体系公民道德