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Fabrication of Anodic Aluminum Oxide Templates with Small Interpore distances

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Chinese Physics Letters 2010年第6期27卷 148-151页

作者： WANG Na zhang wen-di XU Ji-Peng MA Bin zhang Zong-Zhi JIN Qing-Yuan E. Bunte J. Hupkes H. P. Bochem Key Laboratory of Micro and Nano Photonic Structures (Ministry of Education) Laboratory of Advanced Materials and Department of Optical Science and Engineering Fudan University Shanghai 200433 IEFS-Photovoltaik Forschungszentrum Jfilich GmbH D-52425 Julich Germany Institut fur Bio-und Nanosysteme (IBN-PT) julich GmbH D52425 Julich Germany

The influence of the electropolishing and anodization voltage on surface morphology has been carefully studied for fabrication of ordered anodic aluminum oxide （AAO） templates. In accordance with that in the anodization experiment, the size of small patterns on the foil surface formed from the electropolishing treatment increases with voltage. Using a combined method of small-voltage eleetropolishing and anodization, we have fabricated well ordered templates with much smaller interpore distances compared with that under normal-voltage fabrication conditions. The Ni nanowire arrays with two small diameters are eleetrodeposited through the above templates, exhibiting different magnetic properties. This also helps us to clarify the inner structure of this kind of templates.

关键词： MICROFABRICATION ALUMINUM oxide POROUS materials ELECTROLYTIC polishing SURFACES (Technology) CHEMICAL templates NANOWIRES MAGNETIC properties

Toward Selective Synthesis of Protein Olympiadanes via Orthogonal Active Templates in One Step

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CCS Chemistry 2024年第4期6卷 1047-1059页

作者： Fan zhang Yajie Liu Xiao-di Da wen-Bin zhang Beijing National Laboratory for Molecular Sciences Key Laboratory of Polymer Chemistry and Physics of Ministry of EducationCenter for Soft Matter Science and EngineeringCollege of Chemistry and Molecular EngineeringPeking UniversityBeijing100871 Beijing Academy of Artificial Intelligence Beijing 100084

Unlike small molecules,the topological complexity of macromolecules remains largely unexplored due to the huge synthetic ***,we report the development of orthogonal active templates for concise and selective synthesis of protein[n]heterocatenanes toward protein *** active template(AT-Snoop)was first developed based on the isopeptide-bond-forming RrgA domain with comparable efficiency and excellent orthogonality to the previously reported active template(AT-Spy)based on the CnaB2 *** combination facilitated the selective synthesis of protein[n]catenanes from multiple components in one step and the resulting structures were verified by sodium dodecyl sulfate-polyacrylamide gel electrophoresis,size exclusion chromatography,liquid chromatography-mass spectrometry,and proteolytic digestion *** results offered a promising solution to tackling the daunting challenge of precision synthesis of protein olympiadane with five distinct ring *** only did the success provide new tools for proteintopology engin eering but alsospurred and fueled the future exploitation of topology-related functional benefits in protein science.

关键词： catenane topology active template SnoopTag SnoopCatcher SpyTag SpyCatcher

Study on the Relationship between AMPK/UCP2 Pathway and Mitochondrial Dysfunction in Granulosa Cells of Polycystic Ovay Syndrome

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Chinese Journal of Biomedical Engineering(English Edition) 2024年第1期33卷 1-8页

作者： zhang Ju-shun HE Bin-bin wen Shi-di Longyan First Affiliated Hospital of Fujian Medical University Longyan Fujian 364000China

Objective:To investigate the changes of the AMP-activated protein kinase(AMPK)/uncoupling protein 2(UCP2)(AMPK/UCP2)pathway in ovarian granulosa cells with PCOS and its relationship with mitochondrial ***:PCOS mouse models and normally fed mice,ovarian granulosa cells from the two mice were extracted,and the protein expression levels of AMPKα,p-AMPKαand UCP2 were detected by western *** ROS and ATP content of granulosa cells were determined by colorimetric and chemiluminescence immunoassays to assess mitochondrial *** correlation analysis was used to determine the correlation between AMPK/UCP2 pathway-related proteins,ROS and ***:P-AMPKα/GAPDH(0.12±0.09),AMPKα/GAPDH(0.35±0.40),P-AMPKα/AMPKα(0.56±0.33)and ATP(0.36±0.04)pmol/mg in PCOS model mice were lower than those in non-POCS groups,while UCP2/GAPDH(1.18±0.28)and ROS(48810.92±4498.08)were lower than those in non-POCS *** fluorescence intensity of DCF was higher than that of the non-POCS group(Pding to mitochondrial *** of AMPK/UCP2 pathway activity may be a potential therapeutic target to ameliorate PCOS-related mitochondrial dysfunction.

关键词： polycystic ovary syndrome AMP-activated protein kinase(AMPK) uncoupling protein 2(UCP2) mitochondrial dysfunction granule cells

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颈椎病的运动疗法及机制研究进展

中国疗养医学 2024年第7期33卷 71-76页

作者：邹首琴戴康乐刘钰祯李桂花汤雯雁张文娣陈朝晖安徽中医药大学安徽合肥230012

目的本文对颈椎病的运动疗法及机制进展进行综述,以期进一步为本病临床运动处方的制定和相关研究的开展提供参考。方法基于文献研究,以“颈椎病”“颈痛”“运动治疗”“运动控制”“悬吊”“传统功法”“八段锦”等为关键词,在中国知... 详细信息

目的本文对颈椎病的运动疗法及机制进展进行综述,以期进一步为本病临床运动处方的制定和相关研究的开展提供参考。方法基于文献研究,以“颈椎病”“颈痛”“运动治疗”“运动控制”“悬吊”“传统功法”“八段锦”等为关键词,在中国知网、万方知识服务平台、维普网数据库中检索中文文献;以“cervical spondylosis”“neck pain”“exercise therapy”“motor control training”“sling exercise training”“qigong”“Baduanjin”为关键词,在PubMed、Web of Science数据库中检索英文文献,检索时间范围2013年2月至2023年5月。结果在治疗颈椎病的运动疗法中,传统功法如八段锦、太极拳、五禽戏等运动强度小,简便易学,安全有效;现代运动疗法如运动控制、悬吊、牵伸训练等运动强度不等、坚持治疗疗效显著;运动疗法联合其他常规治疗或是运动疗法间的联合治疗效果更佳。运动疗法通过拉伸颈肌促进血液循环,激活脊髓上中枢镇痛通路,增加抗炎信号转导,降低肿瘤坏死因子-α(TNF-α)水平,发挥镇痛作用;增强肌力,改善僵硬和疲劳,恢复椎体力学平衡;增加神经与肌肉间的反馈,改善颈部本体感觉。结论运动疗法主要通过抗炎镇痛、改善颈椎感觉与运动功能来治疗颈椎病。运动疗法可有效改善颈椎病患者颈部疼痛和功能障碍,缓解患者焦虑不安等不良情绪,提高患者生活质量。

关键词：颈椎病运动疗法康复锻炼研究进展

Establishment and evaluation of a prognostic model for patients with unresectable gastric cancer liver metastases

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World Journal of Clinical Cases 2024年第13期12卷 2182-2193页

作者： Zheng-Yao Chang wen-Xing Gao Yue zhang wen Zhao di Wu Lin Chen Department of General Surgery The First Medical Center of Chinese PLA General HospitalBeijing 100853China Department of Endocrinology The First Medical Center of Chinese PLA General HospitalBeijing 100853China School of Medicine Nankai UniversityTianjin 300071China

BACKGROUND Liver metastases(LM)is the primary factor contributing to unfavorable outcomes in patients diagnosed with gastric cancer(GC).The objective of this study is to analyze significant prognostic risk factors for patients with GCLM and develop a reliable nomogram model that can accurately predict individualized prognosis,thereby enhancing the ability to evaluate patient *** To analyze prognostic risk factors for GCLM and develop a reliable nomogram model to accurately predict individualized prognosis,thereby enhancing patient outcome *** Retrospective analysis was conducted on clinical data pertaining to GCLM(type III),admitted to the Department of General Surgery across multiple centers of the Chinese PLA General Hospital from January 2010 to January *** dataset was divided into a development cohort and validation cohort in a ratio of 2:*** the development cohort,we utilized univariate and multivariate Cox regression analyses to identify independent risk factors associated with overall survival in GCLM ***,we established a prediction model based on these findings and evaluated its performance using receiver operator characteristic curve analysis,calibration curves,and clinical decision curves.A nomogram was created to visually represent the prediction model,which was then externally validated using the validation *** A total of 372 patients were included in this study,comprising 248 individuals in the development cohort and 124 individuals in the validation *** on Cox analysis results,our final prediction model incorporated five independent risk factors including albumin levels,primary tumor size,presence of extrahepatic metastases,surgical treatment status,and chemotherapy *** 1-,3-,and 5-years Area Under the Curve values in the development cohort are 0.753,0.859,and 0.909,respectively;whereas in the validation cohort,they are observed to be 0.772,0.848,and ***,th

关键词： Gastric cancer Liver metastases Nomogram Prognostic model Survival analysis

Evaluation of the binding affinity and antioxidant activity of phlorizin to pepsin and trypsin

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Food Science and Human Wellness 2024年第1期13卷 392-400页

作者： Jing zhang Lan Tang Xia Hu Zhen Zeng wen Wu Fang Geng Hui Li di Wu Meat Processing Key Laboratory of Sichuan Province School of Food and Biological EngineeringChengdu UniversityChengdu 610106China School of Chemical Engineering Sichuan UniversityChengdu 610065China

Phlorizin(PHL)is a natural compound with strong antioxidant properties mainly found in *** this paper,the interaction mechanism of PHL with pepsin and trypsin was comparatively evaluated by computer simulation,fluorescence spectra,circular dichroism(CD),and Fourier transform infrared(FT-IR)spectra at a molecular *** spectra showed that PHL quenches the pepsin/trypsin by static *** parameters indicated that PHL binds to pepsin mainly through hydrogen bonds and van der Waals forces,and that of trypsin was electrostatic *** ground state complexes PHL and protease have a moderate affinity of 105 L/mol PHL binds more strongly to trypsin than to *** and FT-IR spectra results showed that pepsin/trypsin decreased theβ-sheet content and slightly changed its secondary structure upon *** experimental results are mutually verified with the predicted computer-aid simulation *** PHL and trypsin binding,the antioxidant capacity of PHL was ***,the antioxidant capacity of PHL was decreased after binding to *** work elucidates the binding of PHL binding mechanisms to pepsin/trypsin and provides useful information for the digestion of PHL to improve the application of PHL in food processing.

关键词： Interaction Phlorizin Pepsin Trypsin Antioxidation

A_(2)B_(7)-type La-Mg-Ni alloys prepared by Mg thermal diffusion for improved hydrogen storage performance

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Rare Metals 2024年第7期43卷 3260-3272页

作者： Yong-Xi zhang Guan-Jiu Wu Jing Gu Hong-Xing Kang Yuan Li di Zhou wen-Feng Wang Lu zhang Shu-Min Han Hebei Key Laboratory of Applied Chemistry School of Environmental and Chemical EngineeringYanshan UniversityQinhuangdao 066004China Department of Chemistry and Biochemistry San Diego State UniversitySan DiegoCA92182-1030USA State Key Laboratory of Metastable Materials Science and Technology Yanshan UniversityQinhuangdao 066004China

A novel approach based on thermal diffusion was used to achieve controllable Mg content in A_(2)B_(7)-type La-Mg-Ni-based *** formation mechanism of the A_(2)B_(7)-type phase as a result of the thermal diffusion process and the effect of Mg content on hydrogen storage performance were investigated.X-ray diffraction(XRD)patterns and Rietveld refinement results showed that increased Mg transformed the LaNi_(5)phase in the La_(0.74)Sm_(0.03)Y_(0.23)Ni_(4.32)Al_(0.04)precursor alloy into a superlattice *** electron microscopy(SEM)images showed that Mg was evenly distributed in the alloy *** in the superlattice significantly inhibited the phase decomposition of the superlattice structure during the hydrogen absorption/desorption *** A_(2)B_(7)-type La_(0.57)Sm_(0.02)Y_(0.18)Mg_(0.23)Ni_(3.38)Al_(0.03)alloy composed of Gd_(2)Co_(7)and Ce_(2)Ni_(7)phases was successfully *** pressure-composition isotherm profiles showed that the alloy had a hydrogen storage capacity as high as 1.73 wt%,with good cycling *** 50 cycles of hydrogen absorption/desorption,the alloy retained a hydrogen storage capacity of 1.45 wt%,with a capacity retention rate of up to 84.28%.The Mg thermal diffusion process thus provides a new approach for the controlled preparation of La-Mg-Ni-based alloys.

关键词： La-Mg-Ni-based hydrogen storage alloy A_(2)B_(7)-type superlattice alloy Mg thermal diffusion process Phase transformation Hydrogen storage property

State of the art of lightweight aggregates used in lightweight refractories for working lining of high-temperature furnaces

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Journal of Iron and Steel Research International 2024年第6期31卷 1320-1343页

作者： Wei zhang wen-yong Dai Shenyang National Laboratory for Materials Science Institute of Metal ResearchChinese Academy of SciencesShenyang 110016LiaoningChina Research and Development Department AGC Plibrico(Dalian)Industries Inc.Dalian 116600LiaoningChina

Lightweight refractories for the working lining of high-temperature furnaces play an important role in the smelting of advanced steels and *** prepare lightweight refractories for the working lining of high-temperature furnaces,the synthesis of lightweight aggregates is the ***,the research on the synthesis of lightweight aggregates with high service temperature,low thermal conductivity,high strength,and good slag resistance has received widespread *** available literature on the synthesis of lightweight aggregates was summarized,including corundum,mullite,mullite-corundum,spinel,corundum-spinel,cordierite,cordierite-mullite,calcium hexaluminate,corundum-calcium hexaluminate,bauxite,magnesia,magnesia-based,and forsterite-based ***,the future development trend of lightweight aggregates was proposed.

关键词： Lightweight aggregate Lightweight refractory Working lining Apparent porosity Closed porosity Thermal conductivity Pore-forming approach

Porous nanofibrous dressing enables mesenchymal stem cell spheroid formation and delivery to promote diabetic wound healing

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Chinese Journal of Chemical Engineering 2024年第4期68卷 156-164页

作者： Kexin zhang wenmin zhang Heng An Zhe Huang Yanzhen wen Xiangyu Jiao Yongqiang wen College of Chemical Engineering and Technology Taiyuan University of Science and TechnologyTaiyuan 030024China Beijing Key Laboratory for Bioengineering and Sensing Technology Daxing Research InstituteSchool of Chemistry&Biological EngineeringUniversity of Science&Technology BeijingBeijing 100083China

Delayed and nonhealing of diabetic wounds imposes substantial economic burdens and physical pain on *** stem cells(MSCs)promote diabetic wound *** when MSCs aggregate into multicellular spheroids,their therapeutic effect is ***,traditional culture platforms are inadequate for the efficient preparation and delivery of MSC spheroids,resulting in inefficiencies and inconveniences in MSC spheroid *** this study,a three-dimensional porous nanofibrous dressing(NFD)is prepared using a combination of electrospinning and homogeneous *** thermal crosslinking,the NFD not only achieves satisfactory elasticity but also maintains notable *** the design of its structure and chemical composition,the NFD allows MSCs to spontaneously form MSC spheroids with controllable sizes,serving as MSC spheroid delivery systems for diabetic wound *** importantly,MSC spheroids cultured on the NFD exhibit improved secretion of vascular endothelial growth factor,basic fibroblast growth factor,and hepatocyte growth factor,thereby accelerating diabetic wound *** NFD provides a competitive strategy for MSC spheroid formation and delivery to promote diabetic wound healing.

关键词： Electrospinning Homogenization Biomedical engineering Nanomaterials Stem cell spheroids diabetic wound healing