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Gapless Genome Assembly of zh8015 and Preliminary Multi-Omics Analysis to Investigate zh8015's Responses Against Brown Planthopper Infestation

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Rice science 2024年第3期31卷 317-327,I0042-I0045页

作者： LI Dian DUAN Wenjing LIU Qun’en wu Weixun zhAN Xiaodeng SUN Lianping zhANG Yingxin CHENG Shihua State Key Laboratory of Rice Biology and Breeding China National Rice Research InstituteHangzhou 310006China

Accurate genomic information is essential for advancing genetic breeding research in specific rice *** study presented a gapless genome assembly of the indica rice cultivar zhonghui 8015(zh8015)using Pac Bio HiFi,Hi-C,and ONT(Oxford Nanopore Technologies)ultra-long sequencing technologies,annotating 43037 gene ***,utilizing this genome along with transcriptomic and metabolomic techniques,we explored zh8015's response to brown planthopper(BPH)*** transcriptomic sampling indicated significant changes in gene expression levels around 48 h after BPH *** analysis revealed particularly significant alterations in genes related to reactive oxygen species scavenging and cell wall *** results demonstrated marked increases in levels of several monosaccharides,which are components of the cell wall and dramatic changes in flavonoid *** association analysis identified differentially expressed genes associated with key metabolites,shedding light on zh8015's response to BPH *** summary,this study constructed a reliable genome sequence resource for zh8015,and the preliminary multi-omics results will guide future insect-resistant breeding research.

关键词： brown planthopper gapless genome genome assembly multi-omics Nilaparvata lugens rice

General anesthetic agents induce neurotoxicity through astrocytes

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Neural Regeneration Research 2024年第6期19卷 1299-1307页

作者： Yanchang Yang Tiantian Liu Jun Li Dandan Yan Yuhan Hu Pin wu Fuquan Fang Patrick M.McQuillan Wenxin Hang Jianhang Leng zhiyong Hu Department of Anesthesiology The First Affiliated Hospital Zhejiang University School of Medicine Department of Anesthesiology Ningbo Women and Children's Hospital 3. Department of Anesthesiology Shulan (Hangzhou) Hospital Affiliated to Zhejiang Shuren University Shulan International Medical College 4. Cell Biology Department Yale University 5. Department of Anesthesiology Penn State Hershey Medical Centre Penn State College of Medicine 6. Department of Central Laboratory Affiliated Hangzhou First People's Hospital Zhejiang University School of Medicine

Neuroscientists have recognized the importance of astrocytes in regulating neurological function and their influence on the release of glial transmitters. Few studies, however, have focused on the effects of general anesthetic agents on neuroglia or astrocytes. Astrocytes can also be an important target of general anesthetic agents as they exert not only sedative, analgesic, and amnesic effects but also mediate general anesthetic-induced neurotoxicity and postoperative cognitive dysfunction. Here, we analyzed recent advances in understanding the mechanism of general anesthetic agents on astrocytes, and found that exposure to general anesthetic agents will destroy the morphology and proliferation of astrocytes, in addition to acting on the receptors on their surface, which not only affect Ca2+signaling, inhibit the release of brain-derived neurotrophic factor and lactate from astrocytes, but are even involved in the regulation of the pro-and anti-inflammatory processes of astrocytes. These would obviously affect the communication between astrocytes as well as between astrocytes and neighboring neurons, other neuroglia, and vascular cells. In this review, we summarize how general anesthetic agents act on neurons via astrocytes, and explore potential mechanisms of action of general anesthetic agents on the nervous system. We hope that this review will provide a new direction for mitigating the neurotoxicity of general anesthetic agents.

关键词： astrocytes brain-derived neurotrophic factor general anesthetic agents neuron neurotoxicity N-methyl-D-aspartate receptor perioperative neurocognition Toll-like receptor γ-aminobutyric acid receptor

Endoscopic dacryocystorhinostomy in acute dacryocystitis:a multicenter study in China

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International Journal of Ophthalmology(English edition) 2024年第9期17卷 1689-1695页

作者： Bang-Xun Mao Yao-Hua Wang zhen-Kai Liu Ning-Yu An Hai-Li Jin Ming-Ling Wang Wen-Can wu Bo Yu Department of Ophthalmology Central Hospital of LishuiThe Fifth Affiliated Hospital of Wenzhou Medical UniversityLishui 323000Zhejiang ProvinceChina Department of Orbital Disease and Ophthalmic Tumor Affiliated Eye Hospital of Nanchang UniversityNanchang 330000Jiangxi ProvinceChina Department of Ophthalmology Renmin Hospital of ShiyanShiyan 442000Hubei ProvinceChina Eye Hospital of Ningxia Yinchuan 750000Ningxia Hui Autonomous RegionChina Eye Hospital of wuhu City Wuhu 241000Anhui ProvinceChina Department of Ophthalmology Baoan Central Hospital of ShenzhenShenzhen 518000Guangdong ProvinceChina Department of Orbital and Oculoplastic Surgery Eye Hospital of Wenzhou Medical UniversityWenzhou 325000Zhejiang ProvinceChina

AIM:To repor t the clinical profile,endoscopic dacryocystorhinostomy(En-DCR)management,and acute dacryocystitis(AD)outcomes in ***:Clinical data of 554 adult AD patients(554 eyes)who presented in 7 tertiary eye care centers for 10y from Jan 2010 to Mar 2020 were retrospectively *** profile,En-DCR management,and outcomes of all cases were *** anatomical and functional success were evaluated for 12mo ***:The analysis included 149 males and 368 females with a median age of 55.2y(range:18-84y).There were 459 eyes with a history of epiphora or purulent *** time between a symptom of lacrimal duct obstruction and acute onset was 1 to 540(66.1±58.2)***-nine eyes had a history of the previous acute ***-four eyes developed a cutaneous fistula,while 11 eyes had post septal cellulitis ***-DCR with an anatomical success of 91.7%and functional success of 90.1%.The success rate of the patients with a history of acute episodes and the preoperative fistula was lower than the overall success ***:En-DCR can be performed during an acute episode in AD with a success rate of over 90%.

关键词： acute dacryocystitis endoscopic dacryocystorhinostomy lacrimal sac

Spectroelectrochemical Studies on Poly-o-phenylenediamine 1. In-situ Resonance Raman Spectroscopy

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Chinese Chemical Letters 1997年第2期8卷 171-174页

作者： wu, LL Luo, J Lin, zh XIAMEN UNIV DEPT CHEMSTATE KEY LAB PHYS CHEM SOLID SURFACEXIAMEN 361005PEOPLES R CHINA

The structure of poly-o-phenylenediamine in the redox process has been studied using in-situ resonance Raman spectroscopy, in-situ UV-Vis subtractive reflectance spectroscopy and cyclic voltammetry. The results show that the structure of PoPD is dominated by a ladder polymer with phenazine rings, and at least three structures of PoPD are formed in the redox process. The three kinds of PoPD have different resonance enhancement effect, and the electronic structure of PoPD molecule is influenced obviously by protonation. The results also show that the most stable state of PoPD is its semi-oxidized state.

关键词： SCATTERING PHENAZINE

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基于差分卷积的弱光照车牌图像增强

武汉大学学报（信息科学版） 2024年第5期49卷 709-714页

作者：杨云飞汪家明吴疆程起敏王宇清华大学计算机科学与技术系北京100084 武汉大学测绘遥感信息工程国家重点实验室湖北武汉430079 中科控股集团科学技术有限公司北京100081 华中科技大学电子信息与通信学院湖北武汉430074

车牌识别作为现代化智能交通系统中重要的环节,对提升路网效率以及缓解城市交通压力等问题具有重要的社会意义,然而弱光照车牌图像识别仍然具有重大的挑战。构建了一个基于差分卷积神经网络的弱光照车牌图像增强网络,将车牌的纹理信息... 详细信息

车牌识别作为现代化智能交通系统中重要的环节,对提升路网效率以及缓解城市交通压力等问题具有重要的社会意义,然而弱光照车牌图像识别仍然具有重大的挑战。构建了一个基于差分卷积神经网络的弱光照车牌图像增强网络,将车牌的纹理信息解耦为水平垂直和对角线两个方向,对不同尺度空间的低照度图像进行纹理增强。为了避免增强结果局部过曝或低曝,该方法使用YCbCr颜色空间的损失函数来优化模型。图像增强实验结果表明,所提出的方法较传统的低照度图像增强方法相比,图像客观质量结果峰值信噪比提升了0.47 dB。同时,在仿真车牌和真实场景的车牌识别实验结果也证明了所提算法对于低照度图像感知质量提升的有效性。

关键词：低照度增强差分卷积车牌识别

热处理工艺对Ti-5Ta-5V-8Cr-1Al合金耐沸腾硝酸腐蚀性能的影响

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稀有金属材料与工程 2024年第7期53卷 1992-1998页

作者：吴俊宇徐建平刘后龙李欢西安稀有金属材料研究院有限公司陕西西安710016

后处理工业所涉及的关键设备如溶解器、蒸发器等长期处于高浓度、高放射性的沸腾硝酸中,保证设备安全可靠运行是首要目标。本工作采用全浸腐蚀和电化学腐蚀实验手段研究了热处理工艺对Ti-5Ta-5V-8Cr-1Al(Ti5581)合金在6 mol/L沸腾硝酸... 详细信息

后处理工业所涉及的关键设备如溶解器、蒸发器等长期处于高浓度、高放射性的沸腾硝酸中,保证设备安全可靠运行是首要目标。本工作采用全浸腐蚀和电化学腐蚀实验手段研究了热处理工艺对Ti-5Ta-5V-8Cr-1Al(Ti5581)合金在6 mol/L沸腾硝酸溶液中的腐蚀行为的影响。结果表明,仅固溶和460℃时效时Ti5581合金具有较低的腐蚀速率,腐蚀240 h后腐蚀速率为0.022 mm/a。进一步采用金相显微镜(OM)、扫描电子显微镜(SEM)、透射电子显微镜(TEM)、X射线衍射(XRD)等方法分析了Ti5581合金腐蚀后表面钝化膜的结构和成分,表明腐蚀后表层钝化膜平滑且致密,表层钝化膜为Ti和Ta的混合氧化物。研究发现Ti5581合金表层钝化膜的形成与α相的数量和形态相关:与550℃高温时效相比,460℃低温时效时α相尺寸较小且Ta元素质量分数较高,腐蚀均匀性更好,易于形成致密钝化膜且钝化膜更稳定。

关键词： Ti-Ta-V-Cr-Al合金耐硝酸腐蚀热处理钝化膜 α相

A telomere-to-telomere genome assembly of zhonghuang 13,a widely-grown soybean variety from the original center of Glycine max

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The Crop Journal 2024年第1期12卷 142-153页

作者： Anqi zhang Tangchao Kong Baiquan Sun Shizheng Qiu Jiahe Guo Shuyong Ruan Yu Guo Jirui Guo zhishuai zhang Yue Liu zheng Hu Tao Jiang Yadong Liu Shuqi Cao Shi Sun Tingting wu Huilong Hong Bingjun Jiang Maoxiang Yang Xiangyu Yao Yang Hu Bo Liu Tianfu Han Yadong Wang Center for Bioinformatics School of Computer Science and TechnologyHarbin Institute of TechnologyHarbin 150001HeilongjiangChina Ministry of Agriculture Key Laboratory of Soybean Biology(Beijing) Institute of Crop SciencesChinese Academy of Agricultural SciencesBeijing 100081China National Key Facility for Crop Gene Resources and Genetic Improvement Institute of Crop SciencesChinese Academy of Agricultural SciencesBeijing 100081China

Soybean(Glycine max)stands as a globally significant agricultural crop,and the comprehensive assembly of its genome is of paramount importance for unraveling its biological characteristics and evolutionary ***,previous soybean genome assemblies have harbored gaps and incompleteness,which have constrained in-depth investigations into ***,we present Telomere-to-Telomere(T2T)assembly of the Chinese soybean cultivar zhonghuang 13(zh13)genome,termed zh13-T2T,utilizing PacBio Hifi and ONT ultralong *** employed a multi-assembler approach,integrating Hifiasm,NextDenovo,and Canu,to minimize biases and enhance assembly *** assembly spans 1,015,024,879 bp,effectively resolving all 393 gaps that previously plagued the reference *** annotation efforts identified 50,564 high-confidence protein-coding genes,707 of which are ***13-T2T revealed longer chromosomes,421 not-aligned regions(NARs),112 structure variations(SVs),and a substantial expansion of repetitive element compared to earlier ***,we identified 25.67 Mb of tandem repeats,an enrichment of 5S and 48S rDNAs,and characterized their genotypic *** summary,we deliver the first complete Chinese soybean cultivar T2T *** comprehensive annotation,along with precise centromere and telomere characterization,as well as insights into structural variations,further enhance our understanding of soybean genetics and evolution.

关键词： Soybean Telomere-to-Telomere assembly zhonghuang 13 Structure variations

Sex-and age-specific associations between abdominal fat and non-alcoholic fatty liver disease:a prospective cohort study

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Journal of Molecular Cell Biology 2023年第11期15卷 33-42页

作者： Hongli Chen Yuexing Liu Dan Liu Yebei Liang zhĳun zhu Keqing Dong Huating Li Yuqian Bao Jiarui wu Xuhong Hou Weiping Jia Department of Endocrinology and Metabolism Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai Diabetes InstituteShanghai Key Laboratory of Diabetes MellitusShanghai Key Clinical Center for Metabolic DiseaseShanghai 200233China General Practitioner Teams in Community Health Service Center of Nicheng Pudong New Area DistrictShanghai 201306China CAS Key Laboratory of Systems Biology Shanghai Institute of Biochemistry and Cell BiologyCenter for Excellence in Molecular Cell ScienceChinese Academy of SciencesShanghai 200031China

Obesity is closely related to non-alcoholic fatty liver disease(NAFLD).Although sex differences in body fat distribution have been well demonstrated,little is known about the sex-specific associations between adipose tissue and the development of *** community-based cohort data,we evaluated the associations between magnetic resonance imaging quantified areas of abdominal adipose tissue,including visceral adipose tissue(VAT)and subcutaneous adipose tissue(SAT),and incident NAFLD in 2830 participants(1205 males and 1625 females)aged 55–70 *** a 4.6-year median follow-up,the cumulative incidence rates of NAFLD increased with areas of VAT and SAT both in males and in *** analyses showed that the abovementioned positive associations were stronger in males than in females,especially in participants under 60 years *** contrast,these sex differences disappeared in those over 60 years ***,the risk of developing NAFLD increased non-linearly with increasing fat area in a sex-specific ***,sex-specific potential mediators,such as insulin resistance,lipid metabolism,inflammation,and adipokines,may exist in the associations between adipose tissue and *** study showed that the associations between abdominal fat and the risk of NAFLD were stratified by sex and age,highlighting the potential need for sex-and age-specific management of NAFLD.

关键词： visceral adipose tissue subcutaneous adipose tissue sex difference NAFLD incidence prospective study

温度、盐度和密度对菲律宾蛤仔稚贝生长和存活的影响

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中国海洋大学学报（自然科学版） 2024年第1期54卷 58-66页

作者：吴磊涂康周丽青刘志鸿吴彪孙秀俊中国水产科学研究院黄海水产研究所山东青岛266071 青岛海洋科学与技术试点国家实验室海洋渔业科学与食物产出过程功能实验室山东青岛266237 江苏海洋大学海洋科学与水产学院江苏连云港222005 莆田市水产研究所福建莆田351100

为查明温度、盐度和密度对菲律宾蛤仔(Ruditapes philippinarum)稚贝生长和存活的影响,本研究通过响应面法构建了不同环境条件下蛤仔生长存活模型并进行分析。实验设计了3因素(温度、盐度、密度)和3水平(-1、0、1),以稚贝壳长为响应值,... 详细信息

为查明温度、盐度和密度对菲律宾蛤仔(Ruditapes philippinarum)稚贝生长和存活的影响,本研究通过响应面法构建了不同环境条件下蛤仔生长存活模型并进行分析。实验设计了3因素(温度、盐度、密度)和3水平(-1、0、1),以稚贝壳长为响应值,探究温度、盐度、密度三因素及其相互作用对蛤仔稚贝生长和存活的影响。研究表明,培育73 d后,温度、盐度、密度的二次效应对蛤仔稚贝的壳长生长影响极显著(P0.05)。壳长预测值Y对应自变量温度(T)、盐度(S)和密度(D)的二次多项回归方程:Y=-6.33105+0.2765 T+0.573 S+0.689 D-0.00566 T^(2)-0.0137 S^(2)-0.1159 D^(2)。本研究通过二次响应面回归方程构建了不同环境下蛤仔苗种的生长模型,得出稚贝最适生长环境为温度24.32℃、盐度21.13、密度2.88×10^(4)粒/m^(2),在此条件下蛤仔稚贝平均壳长可达到最大值(4.07 mm)。

关键词：菲律宾蛤仔温度盐度密度生长

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