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NONMONOTONE LOCAL MINIMAX METHODS FOR FINDING MULTIPLE SADDLE POINTS

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Journal of Computational Mathematics 2024年第3期42卷 851-884页

作者： Wei liu Ziqing Xie Wenfan Yi South China Research Center for Applied Mathematics and Interdisciplinary Studies South China Normal UniversityGuangzhou 510631China Key Laboratory of Computing and Stochastic Mathematics(Ministry of Education) Hunan Normal UniversityChangshaHunan 410081China Hunan Provincial Key Laboratory of Intelligent Information Processing and Applied Mathematics School of MathematicsHunan UniversityChangshaHunan 410082China

In this paper,by designing a normalized nonmonotone search strategy with the BarzilaiBorwein-type step-size,a novel local minimax method(LMM),which is a globally convergent iterative method,is proposed and analyzed to find multiple(unstable)saddle points of nonconvex functionals in Hilbert *** to traditional LMMs with monotone search strategies,this approach,which does not require strict decrease of the objective functional value at each iterative step,is observed to converge faster with less ***,based on a normalized iterative scheme coupled with a local peak selection that pulls the iterative point back onto the solution submanifold,by generalizing the zhang-Hager(zh)search strategy in the optimization theory to the LMM framework,a kind of normalized zh-type nonmonotone step-size search strategy is introduced,and then a novel nonmonotone LMM is *** feasibility and global convergence results are rigorously carried out under the relaxation of the monotonicity for the functional at the iterative ***,in order to speed up the convergence of the nonmonotone LMM,a globally convergent Barzilai-Borwein-type LMM(GBBLMM)is presented by explicitly constructing the Barzilai-Borwein-type step-size as a trial step-size of the normalized zh-type nonmonotone step-size search strategy in each ***,the GBBLMM algorithm is implemented to find multiple unstable solutions of two classes of semilinear elliptic boundary value problems with variational structures:one is the semilinear elliptic equations with the homogeneous Dirichlet boundary condition and another is the linear elliptic equations with semilinear Neumann boundary *** numerical results indicate that our approach is very effective and speeds up the LMMs significantly.

关键词： Multiple saddle points Local minimax method Barzilai-Borwein gradient method Normalized nonmonotone search strategy Global convergence

Credit risk prediction for small and medium enterprises utilizing adjacent enterprise data and a relational graph attention network

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Journal of Management Science and Engineering 2024年第2期9卷 177-192页

作者： Jiaxing Wang Guoquan liu Xiaobo Xu Xinjie Xing International Business School Suzhou Xi'an Jiaotong-Liverpool UniversitySuzhou215028China Financial Technology Research Institute Fudan UniversityShanghai200433China Management School University of LiverpoolChatham StreetLiverpoolL697ZHUK

Credit risk prediction for small and medium enterprises(SMEs)has long posed a complex research *** approaches have primarily focused on enterprise-specific variables,but these models often prove inadequate when applied to SMEs with incomplete *** this innovative study,we push the theoretical boundaries by leveraging data from adjacent enterprises to address the issue of data *** strategy involves constructing an intricate network that interconnects enterprises based on shared managerial teams and business *** this network,we propose a novel relational graph attention network(RGAT)algorithm capable of capturing the inherent complexity in its topological *** doing so,our model enhances financial service providers'ability to predict credit risk even in the face of incomplete data from target *** experiments conducted using China's SMEs highlight the predictive proficiency and potential economic benefits of our proposed *** approach offers a comprehensive and nuanced perspective on credit risk while demonstrating the advantages of incorporating network-wide data in credit risk prediction.

关键词： Risk management SMEC redit risk Transactional data Graph neural network

A telomere-to-telomere genome assembly of zhonghuang 13,a widely-grown soybean variety from the original center of Glycine max

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The Crop Journal 2024年第1期12卷 142-153页

作者： Anqi zhang Tangchao Kong Baiquan Sun Shizheng Qiu Jiahe Guo Shuyong Ruan Yu Guo Jirui Guo zhishuai zhang Yue liu zheng Hu Tao Jiang Yadong liu Shuqi Cao Shi Sun Tingting Wu Huilong Hong Bingjun Jiang Maoxiang Yang Xiangyu Yao Yang Hu Bo liu Tianfu Han Yadong Wang Center for Bioinformatics School of Computer Science and TechnologyHarbin Institute of TechnologyHarbin 150001HeilongjiangChina Ministry of Agriculture Key Laboratory of Soybean Biology(Beijing) Institute of Crop SciencesChinese Academy of Agricultural SciencesBeijing 100081China National Key Facility for Crop Gene Resources and Genetic Improvement Institute of Crop SciencesChinese Academy of Agricultural SciencesBeijing 100081China

Soybean(Glycine max)stands as a globally significant agricultural crop,and the comprehensive assembly of its genome is of paramount importance for unraveling its biological characteristics and evolutionary ***,previous soybean genome assemblies have harbored gaps and incompleteness,which have constrained in-depth investigations into ***,we present Telomere-to-Telomere(T2T)assembly of the Chinese soybean cultivar zhonghuang 13(zh13)genome,termed zh13-T2T,utilizing PacBio Hifi and ONT ultralong *** employed a multi-assembler approach,integrating Hifiasm,NextDenovo,and Canu,to minimize biases and enhance assembly *** assembly spans 1,015,024,879 bp,effectively resolving all 393 gaps that previously plagued the reference *** annotation efforts identified 50,564 high-confidence protein-coding genes,707 of which are ***13-T2T revealed longer chromosomes,421 not-aligned regions(NARs),112 structure variations(SVs),and a substantial expansion of repetitive element compared to earlier ***,we identified 25.67 Mb of tandem repeats,an enrichment of 5S and 48S rDNAs,and characterized their genotypic *** summary,we deliver the first complete Chinese soybean cultivar T2T *** comprehensive annotation,along with precise centromere and telomere characterization,as well as insights into structural variations,further enhance our understanding of soybean genetics and evolution.

关键词： Soybean Telomere-to-Telomere assembly zhonghuang 13 Structure variations

Gapless Genome Assembly of zh8015 and Preliminary Multi-Omics Analysis to Investigate zh8015's Responses Against Brown Planthopper Infestation

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Rice science 2024年第3期31卷 317-327,I0042-I0045页

作者： LI Dian DUAN Wenjing liu Qun’en WU Weixun zhAN Xiaodeng SUN Lianping zhANG Yingxin CHENG Shihua State Key Laboratory of Rice Biology and Breeding China National Rice Research InstituteHangzhou 310006China

Accurate genomic information is essential for advancing genetic breeding research in specific rice *** study presented a gapless genome assembly of the indica rice cultivar zhonghui 8015(zh8015)using Pac Bio HiFi,Hi-C,and ONT(Oxford Nanopore Technologies)ultra-long sequencing technologies,annotating 43037 gene ***,utilizing this genome along with transcriptomic and metabolomic techniques,we explored zh8015's response to brown planthopper(BPH)*** transcriptomic sampling indicated significant changes in gene expression levels around 48 h after BPH *** analysis revealed particularly significant alterations in genes related to reactive oxygen species scavenging and cell wall *** results demonstrated marked increases in levels of several monosaccharides,which are components of the cell wall and dramatic changes in flavonoid *** association analysis identified differentially expressed genes associated with key metabolites,shedding light on zh8015's response to BPH *** summary,this study constructed a reliable genome sequence resource for zh8015,and the preliminary multi-omics results will guide future insect-resistant breeding research.

关键词： brown planthopper gapless genome genome assembly multi-omics Nilaparvata lugens rice

General anesthetic agents induce neurotoxicity through astrocytes

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Neural Regeneration Research 2024年第6期19卷 1299-1307页

作者： Yanchang Yang Tiantian liu Jun Li Dandan Yan Yuhan Hu Pin Wu Fuquan Fang Patrick M.McQuillan Wenxin Hang Jianhang Leng zhiyong Hu Department of Anesthesiology The First Affiliated Hospital Zhejiang University School of Medicine Department of Anesthesiology Ningbo Women and Children's Hospital 3. Department of Anesthesiology Shulan (Hangzhou) Hospital Affiliated to Zhejiang Shuren University Shulan International Medical College 4. Cell Biology Department Yale University 5. Department of Anesthesiology Penn State Hershey Medical Centre Penn State College of Medicine 6. Department of Central Laboratory Affiliated Hangzhou First People's Hospital Zhejiang University School of Medicine

Neuroscientists have recognized the importance of astrocytes in regulating neurological function and their influence on the release of glial transmitters. Few studies, however, have focused on the effects of general anesthetic agents on neuroglia or astrocytes. Astrocytes can also be an important target of general anesthetic agents as they exert not only sedative, analgesic, and amnesic effects but also mediate general anesthetic-induced neurotoxicity and postoperative cognitive dysfunction. Here, we analyzed recent advances in understanding the mechanism of general anesthetic agents on astrocytes, and found that exposure to general anesthetic agents will destroy the morphology and proliferation of astrocytes, in addition to acting on the receptors on their surface, which not only affect Ca2+signaling, inhibit the release of brain-derived neurotrophic factor and lactate from astrocytes, but are even involved in the regulation of the pro-and anti-inflammatory processes of astrocytes. These would obviously affect the communication between astrocytes as well as between astrocytes and neighboring neurons, other neuroglia, and vascular cells. In this review, we summarize how general anesthetic agents act on neurons via astrocytes, and explore potential mechanisms of action of general anesthetic agents on the nervous system. We hope that this review will provide a new direction for mitigating the neurotoxicity of general anesthetic agents.

关键词： astrocytes brain-derived neurotrophic factor general anesthetic agents neuron neurotoxicity N-methyl-D-aspartate receptor perioperative neurocognition Toll-like receptor γ-aminobutyric acid receptor

Semaphorin 7A impairs barrier function in cultured human corneal epithelial cells in a manner dependent on nuclear factor-kappa B

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International Journal of Ophthalmology(English edition) 2024年第3期17卷 444-453页

作者： Cheng-Cheng Yang Xiu-Xia Yang Xiao-Jing zhao Heng Wang Zi-Han Guo Kai Jin Yang liu Bin-Hui Li Department of Ophthalmology the Fifth Affiliated HospitalSun Yat-sen UniversityZhuhai 519000Guangdong ProvinceChina Department of Ophthalmology Hangzhou TCM Hospital Affiliated to Zhejiang Chinese Medical UniversityHangzhou 310006Zhejiang ProvinceChina Eye Institute of Xiamen University Fujian Provincial Key Laboratory of Ophthalmology and Visual ScienceSchool of MedicineXiamen UniversityXiamen 361005Fujian ProvinceChina

●AIM:To evaluate the role of semaphorin 7A(Sema7A)and its associated regulatory mechanisms in modulating the barrier function of cultured human corneal epithelial cells(HCEs).●METHODS:Barrier models of HCEs were treated with recombinant human Sema7A at concentrations of 0,125,250,or 500 ng/mL for 24,48,or 72h in *** electrical resistance(TEER)as well as Dextran-fluorescein isothiocyanate(FITC)permeability assays were conducted to assess barrier *** quantify tight junctions(TJs)such as occludin and zonula occludens-1(ZO-1)at the mRNA level,reverse transcriptionpolymerase chain reaction(RT-PCR)analysis was *** was used to examine the activity of the nuclear factor-kappa B(NF-κB)signaling pathway and the production of TJs *** analyses were employed to localize the ***-linked immunosorbent assay(ELISA)and RT-PCR were utilized to observe changes in interleukin(IL)-1β*** investigate the role of NF-κB signaling activation and IL^(-1)βin Sema7A’s anti-barrier mechanism,we employed 0.1μmol/L IκB kinase 2(IKK2)inhibitor IV or 500 ng/mL IL^(-1)receptor(IL-1R)antagonist.●RESULTS:Treatment with Sema7A resulted in decreased TEER and increased permeability of Dextran-FITC in HCEs through down-regulating mRNA and protein levels of TJs in a time-and dose-dependent manner,as well as altering the localization of ***,Sema7A stimulated the activation of inhibitor of kappa B alpha(IκBα)and expression of IL-1β.The anti-barrier function of Sema7A was significantly suppressed by treatment with IKK2 inhibitor IV or IL-1R antagonists.●CONCLUSION:Sema7A disrupts barrier function through its influence on NF-κB-mediated expression of TJ proteins,as well as the expression of IL-1β.These findings suggest that Sema7A could be a potential therapeutic target for the diseases in corneal epithelium.

关键词： human corneal epithelial barrier function transepithelial electrical resistance zonula occludens-1 occludin nuclear factor-kappa B

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秦汉时期的“中国观”

安徽史学 2024年第3期 5-12页

作者：刘洁云南大学西南联合研究生院云南昆明650091

“中国”一词在秦汉时期最普遍的用法是与“四夷”并称。以地理范围而论,“中国”或指“京师”,或指“十二州”,但主要指“中原”或者“北方”。语境的差异导致了“中国”含义的不确定性,但“中国”本质上是一种“优越性”,即当以“中... 详细信息

“中国”一词在秦汉时期最普遍的用法是与“四夷”并称。以地理范围而论,“中国”或指“京师”,或指“十二州”,但主要指“中原”或者“北方”。语境的差异导致了“中国”含义的不确定性,但“中国”本质上是一种“优越性”,即当以“中国”自居时,必然会产生“差序”。至汉代,“汉”作为“领有天下之号”的王朝之名,其统治的合法性不仅囊括了整个华夷,而且在超越了“汉国”的同时,也高居于“中国”之上。

关键词：中国四夷地理范围王朝汉国

从便捷服务到增值服务:政务服务体系重塑与治理变革

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中共天津市委党校学报 2024年第3期26卷 63-75页

作者：刘祺中共河南省委党校公共管理教研部河南郑州450003 广东数字政府研究院

依据法定职责的政务服务供给已难以满足企业发展的个性化、多样化需求,政府从“做减法”提供便捷服务,转为围绕企业全生命周期、产业全链条“做乘法”提供政策、人才、科技、金融等增值服务。政务服务增值化改革可以看作是治理结构、治... 详细信息

依据法定职责的政务服务供给已难以满足企业发展的个性化、多样化需求,政府从“做减法”提供便捷服务,转为围绕企业全生命周期、产业全链条“做乘法”提供政策、人才、科技、金融等增值服务。政务服务增值化改革可以看作是治理结构、治理过程和领导作用的有机结合与反复互动的非线性跨界治理过程,跨界领导者依托价值共创引领多元主体协作,整合涉企机构职能,重塑政务服务架构,综合集成服务场景,构建政务服务共同体。以政务服务增值化改革持续优化营商环境,需要聚焦涉企高频事项,做好部门核心业务梳理;智能精准推送服务,应用政务数据感知态势;延伸产业服务链条,打造共享服务生态环境;增值服务寓管于服,探索服管融合政务模式;健全标准规范体系,从服务创新到制度重塑。

关键词：增值服务营商环境跨界治理新质生产力

基于深度学习的水声信道联合多分支合并与均衡算法

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电子与信息学报 2024年第5期46卷 2004-2010页

作者：刘志勇金子皓杨洪娟刘彪唐新丰李博哈尔滨工业大学(威海)信息科学与工程学院威海264209 北京宇航系统工程研究所北京100076 山东省海洋电子信息与智能无人系统重点实验室威海264209 海洋无人系统跨域协同与综合保障工业和信息化部重点实验室威海264209

为了更好地解决水声信道中的衰落及严重码间干扰问题,该文提出一种基于深度学习的联合多分支合并与均衡算法。该算法借助深度学习网络的非线性拟合能力,联合实现了多分支合并和均衡。在算法实现中,合并与均衡并非相互独立,而是基于深度... 详细信息

为了更好地解决水声信道中的衰落及严重码间干扰问题,该文提出一种基于深度学习的联合多分支合并与均衡算法。该算法借助深度学习网络的非线性拟合能力,联合实现了多分支合并和均衡。在算法实现中,合并与均衡并非相互独立,而是基于深度学习网络的总输出计算出总误差,以总误差对网络参数实现联合调整,数据集则基于统计水声信道模型进行构建。仿真结果表明,相较于已有算法,所提算法能获得更快的收敛速度和更好的误码率性能,使得其能更好地适应水声信道。

关键词：水声通信深度学习水声信道联合多分支合并与均衡

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