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Small extracellular vesicles from hypoxia-preconditioned bone marrow mesenchymal stem cells attenuate spinal cord injury via miR-146a-5p-mediated regulation of macrophage polarization

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Neural Regeneration Research 2024年第10期19卷 2259-2269页

作者： zeyan liang Zhelun Yang Haishu Xie Jian Rao Xiongjie Xu Yike Lin Chunhua Wang Chunmei Chen Department of Neurosurgery Fujian Medical University Union HospitalFuzhouFujian ProvinceChina Fujian Neurosurgical Institute FuzhouFujian ProvinceChina

Spinal cord injury is a disabling condition with limited treatment *** studies have provided evidence suggesting that small extracellular vesicles(SEVs)secreted by bone marrow mesenchymal stem cells(MSCs)help mediate the beneficial effects conferred by MSC transplantation following spinal cord ***,hypoxia-preconditioned bone marrow mesenchymal stem cell-derived SEVs(HSEVs)exhibit increased therapeutic *** thus explored the role of HSEVs in macrophage immune regulation after spinal cord injury in rats and their significance in spinal cord *** or HSEVs were isolated from bone marrow MSC supernatants by density gradient *** administration to rats via tail vein injection after spinal cord injury reduced the lesion area and attenuated spinal cord *** regulate macrophage polarization towards the M2 phenotype in vivo and in *** RNA sequencing and bioinformatics analyses of SEVs and HSEVs revealed that mi R-146a-5p is a potent mediator of macrophage polarization that targets interleukin-1 receptor-associated kinase *** mi R-146a-5p expression in HSEVs partially attenuated macrophage *** data suggest that HSEVs attenuate spinal cord inflammation and injury in rats by transporting mi R-146a-5p,which alters macrophage *** study provides new insights into the application of HSEVs as a therapeutic tool for spinal cord injury.

关键词： bone marrow mesenchymal stem cells hypoxia preconditioning interleukin-1 receptor-associated kinase 1 macrophages mesenchymal stem cells small extracellular vesicles spinal cord injury

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Mesenchymal stem cell-derived extracellular vesicles therapy in traumatic central nervous system diseases:a systematic review and meta-analysis

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Neural Regeneration Research 2023年第11期18卷 2406-2412页

作者： Zhelun Yang zeyan liang Jian Rao Fabin Lin Yike Lin Xiongjie Xu Chunhua Wang Chunmei Chen Department of Neurosurgery Fujian Medical University Union HospitalFuzhouFujian ProvinceChina

Although there are challenges in treating traumatic central nervous system diseases,mesenchymal stem cell-de rived extracellular vesicles(MSC-EVs) have recently proven to be a promising non-cellular the *** comprehensively evaluated the efficacy of mesenchymal stem cell-de rived extracellular vesicles in traumatic central nervous system diseases in this meta-analysis based on preclinical *** meta-analysis was registered at PROSPERO(CRD42022327904,May 24,2022).To fully retrieve the most relevant articles,the following databases were thoro ughly searched:PubMed,Web of Science,The Cochrane Library,and Ovid-Embase(up to April 1,2022).The included studies were preclinical studies of mesenchymal stem cell-derived extracellular vesicles for traumatic central nervous system *** Systematic Review Centre for Laboratory Animal Experimentation(SYRCLE)’s risk of bias tool was used to examine the risk of publication bias in animal *** screening 2347studies,60 studies were included in this study.A meta-analysis was conducted for spinal co rd injury(n=52) and traumatic brain injury(n=8).The results indicated that mesenchymal stem cell-derived extracellular vesicles treatment prominently promoted motor function recovery in spinal co rd injury animals,including rat Basso,Beattie and Bresnahan locomotor rating scale scores(standardized mean difference [SMD]:2.36,95% confidence interval [CI]:1.96-2.76,P <0.01,I2=71%) and mouse Basso Mouse Scale scores(SMD=2.31,95% CI:1.57-3.04,P=0.01,I2=60%) compared with ***,mesenchymal stem cell-de rived extracellular vesicles treatment significantly promoted neurological recovery in traumatic brain injury animals,including the modified N eurological Severity Score(SMD=-4.48,95% CI:-6.12 to-2.84,P <0.01,I2=79%) and Foot Fault Test(SMD=-3.26,95% CI:-4.09 to-2.42,P=0.28,I2=21%) compared with *** analyses showed that characteristics may be related to the therapeutic effect of mesenchymal stem cel

关键词： animals central nervous system diseases extracellular vesicles mesenchymal stromal cell meta-analysis spinal cord injury traumatic brain injury

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空间目标偶数重连续覆盖星座设计方法

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航空学报 2024年第14期45卷 284-298页

作者：肖广瀚胡泽岩刘军虎王亮毛青堂航天科工空间工程发展有限公司北京100854 中国航天科工二院研究生院北京100854

为满足对空间目标的多重连续覆盖需求,提出一种基于大角度探测范围的偶数重连续覆盖星座设计方法。首先,由大角度探测范围确定圆环形探测区域,并依此给出覆盖带设计方法。然后,基于覆盖带拼接的方式提出了空间目标偶数重连续覆盖星座设... 详细信息

为满足对空间目标的多重连续覆盖需求,提出一种基于大角度探测范围的偶数重连续覆盖星座设计方法。首先,由大角度探测范围确定圆环形探测区域,并依此给出覆盖带设计方法。然后,基于覆盖带拼接的方式提出了空间目标偶数重连续覆盖星座设计方法。所提出的星座设计方法具有两大优势:一是该方法对基于覆盖带拼接的星座设计方法引入了有约束条件的参数优化方法,能够用尽可能少的卫星快速设计出偶数重连续覆盖星座;二是传感器探测区域选为圆环形,可拓展所提星座设计方法的适用范围。当传感器指向天时,所设计星座可实现高、中、低轨空间目标偶数重连续覆盖。当传感器指向地时,所提星座设计方法适用于任意纬度地面目标偶数重连续覆盖问题。仿真结果表明,所提星座设计方法简单有效,可快速用较少的卫星实现空间或地面目标偶数重连续覆盖。

关键词：空间目标连续覆盖星座设计圆环形探测区域参数优化

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母亲的正面身教在家庭教育中的作用及引导策略

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当代家庭教育 2021年第35期 1-2页

作者：梁泽艳甘肃省武威市凉州区黄羊镇九年制学校

在中小学生的基础教育当中,家庭教育与学校相辅相成,形成孩子良好的品格。而在家庭教育中,母亲在其中所承载的重要作用日益凸显,而母亲的正面身教对中小学生良好学习习惯、生活习惯、正确三观形成有着重大推动作用。基于此,本文从以下... 详细信息

在中小学生的基础教育当中,家庭教育与学校相辅相成,形成孩子良好的品格。而在家庭教育中,母亲在其中所承载的重要作用日益凸显,而母亲的正面身教对中小学生良好学习习惯、生活习惯、正确三观形成有着重大推动作用。基于此,本文从以下三个方面浅谈母亲在家庭教育当中的重要作用以及教育策略。

关键词：母亲家庭教育正面身教中小学生

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生殖细胞特异基因-2敲低导致体内胶质瘤增殖抑制及其机制研究

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中华实验外科杂志 2020年第12期37卷 2247-2248页

作者：陈萍萍王殷庆梁泽燕杨冠雄王锐庄源东石松生陈春美福建医科大学附属协和医院神经外科福州350001

目的探讨生殖细胞特异基因-2(GSG2)基因在神经胶质瘤中的作用。方法通过慢病毒敲除GSG2的U87细胞系构建裸鼠成瘤模型。随后进行瘤体体积、重量测量和动物活体成像分析,并应用蛋白芯片技术探讨下游分子机制。采用非配对t检验或χ^2检验... 详细信息

目的探讨生殖细胞特异基因-2(GSG2)基因在神经胶质瘤中的作用。方法通过慢病毒敲除GSG2的U87细胞系构建裸鼠成瘤模型。随后进行瘤体体积、重量测量和动物活体成像分析,并应用蛋白芯片技术探讨下游分子机制。采用非配对t检验或χ^2检验来计算两组之间的差异。结果GSG2敲低后1个月裸鼠瘤体明显减小[敲低(KD)组:(109.42±209.94)mm3,对照(NC)组:(1070.00±410.28)mm3,P<0.05],凋亡相关蛋白Fas、Fas配体(FasL)、p27、p53、SMAC的表达水平显著上调(P<0.05),SMAC蛋白激活最为明显。结论GSG2在体内促进神经胶质瘤细胞凋亡,并降低胶质瘤增殖。

关键词：胶质瘤生殖细胞特异基因-2基因组蛋白H3相关蛋白激酶 p53

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遂宁地区早期子宫颈鳞状细胞癌87例临床特征分析

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临床医药实践 2017年第3期26卷 176-178页

作者：杨娜刘禄蒲泽宴魏容梁艳丽李凤崔丽娟罗启翅遂宁市中心医院四川遂宁629000

目的:探讨遂宁地区早期子宫颈鳞状细胞癌的临床病理特征。方法:收集2013年—2015年遂宁市中心医院子宫颈鳞状细胞癌根治术患者87例,分析其临床资料、病理病变特征,采用SPSS17.0统计软件进行数据分析。结果:87例早期宫颈癌中年龄<45岁者3... 详细信息

目的:探讨遂宁地区早期子宫颈鳞状细胞癌的临床病理特征。方法:收集2013年—2015年遂宁市中心医院子宫颈鳞状细胞癌根治术患者87例,分析其临床资料、病理病变特征,采用SPSS17.0统计软件进行数据分析。结果:87例早期宫颈癌中年龄<45岁者37例,占42.5%,年轻女性组中ⅠA1期25例,占67.6%;中年女性组,共43例,占49.4%,中年女性宫颈癌的临床分期相对更高,其预后比年轻女性组更差。结论:从临床分期及病理分型的研究结果看,在宫颈癌的临床诊断与治疗中,早期诊断、早期治疗至关重要,这就要求临床与病理相互结合,以期获得更佳的治疗效果。

关键词：早期宫颈癌鳞状细胞癌临床特征

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Prognostic value of a modified Immunoscore in patients with stage Ⅰ-Ⅲ resectable colon cancer

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Chinese Journal of Cancer Research 2021年第3期33卷 379-390页

作者： Ke Zhao Xiaomei Wu Zhenhui Li Yingyi Wang zeyan Xu Yajun Li Lin Wu Su Yao Yanqi Huang Changhong liang Zaiyi Liu Department of Radiology Guangdong Provincial People's HospitalGuangdong Academy of Medical SciencesGuangzhou 510080China School of Medicine South China University of TechnologyGuangzhou 510006China Department of Radiology the Sixth Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510655China Department of Radiology the Third Affiliated Hospital of Kunming Medical UniversityYunnan Cancer HospitalYunnan Cancer CenterKunming 650118China Department of Radiology Zhuhai People's HospitalZhuhai Hospital Affiliated with Jinan UniversityZhuhai 519000China Department of Pathology the Third Affiliated Hospital of Kunming Medical UniversityYunnan Cancer HospitalYunnan Cancer CenterKunming 650118China Department of Pathology Guangdong Provincial People's HospitalGuangdong Academy of Medical SciencesGuangzhou 510080China the Second School of Clinical Medicine Southern Medical UniversityGuangzhou 510080China

Objective: The Immunoscore method has proved fruitful for predicting prognosis in patients with colon ***, there is still room for improvement in this scoring method to achieve further advances in its clinical translation. This study aimed to develop and validate a modified Immunoscore(IS-mod) system for predicting overall survival(OS) in patients with stage Ⅰ-Ⅲ colon ***: The IS-mod was proposed by counting CD3+ and CD8+ immune cells in regions of the tumor core and its invasive margin by drawing two lines of interest. A discovery cohort(N=212) and validation cohort(N=103)from two centers were used to evaluate the prognostic value of the ***: In the discovery cohort, 5-year survival rates were 88.6% in the high IS-mod group and 60.7% in the low IS-mod group. Multivariate analysis confirmed that the IS-mod was an independent prognostic factor for OS[adjusted hazard ratio(HR)=0.36, 95% confidence interval(95% CI): 0.20-0.63]. With less annotation and computation cost, the IS-mod achieved performance comparable to that of the Immunoscore-like(IS-like) system(C-index, 0.676 vs. 0.661, P=0.231). The 2-category IS-mod using 47.5% as the threshold had a better prognostic value than that using a fixed threshold of 25%(C-index, 0.653 vs. 0.573, P=0.004). Similar results were confirmed in the validation ***: Our method simplifies the annotation and accelerates the calculation of Immunoscore method,thus making it easier for clinical implementation. The IS-mod achieved comparable prognostic performance when compared to the IS-like system in both cohorts. Besides, we further found that even with a small reference set(N≥120), the IS-mod still demonstrated a stable prognostic value. This finding may inspire other institutions to develop a local reference set of an IS-mod system for more accurate risk stratification of colon cancer.

关键词： Immunoscore colon cancer whole-slide image overall survival digital pathology

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Combining quantitative and qualitative magnetic resonance imaging features to differentiate anorectal malignant melanoma from low rectal cancer

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Precision Clinical Medicine 2021年第2期4卷 119-128页

作者： zeyan Xu Ke Zhao Lujun Han Pinxiong Li Zhenwei Shi Xiaomei Huang Chu Han Huihui Wang Minglei Chen Chen Liu Yanting liang Suyun Li Yanqi Huang Xin Chen Changhong liang Wuteng Cao Zaiyi Liu School of Medicine South China University of TechnologyGuangzhou 510006China Department of Radiology Guangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesGuangzhou 510080China State Key Laboratory of Oncology in South China Collaborative Innovation Center of Cancer MedicineGuangzhou 510060China Department of Radiology Sun Yat-Sen University Cancer CenterGuangzhou 510060China Department of Radiology the Affiliated Hospital of Southwest Medical UniversityLuzhou 646000China The Second School of Clinical Medicine Southern Medical UniversityGuangzhou 510080China Shantou University Medical College Shantou 515041China Guangdong Cardiovascular Institute Guangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesGuangzhou 510080China Department of Radiology Guangzhou First People’s Hospitalthe Second Affiliated Hospital of South China University of TechnologyGuangzhou 510180China Department of Radiology the Sixth Affiliated Hospital of Sun Yat-Sen UniversityGuangzhou 510655China

Background:Distinguishing anorectal malignant melanoma from low rectal cancer remains challenging because of the overlap of clinical symptoms and imaging *** aim to investigate whether combining quantitative and qualitative magnetic resonance imaging(MRI)features could differentiate anorectal malignant melanoma from low rectal ***:Thirty-seven anorectal malignant melanoma and 98 low rectal cancer patients who underwent preoperative rectal MRI from three hospitals were retrospectively *** patients were divided into the primary cohort(N=84)and validation cohort(N=51).Quantitative image analysiswas performed on T1-weighted(T1WI),T2-weighted(T2WI),and contrast-enhanced T1-weighted imaging(CE-T1WI).The subjective qualitative MRI findings were evaluated by two radiologists in *** analysis was performed using stepwise logistic *** discrimination performance was assessed by the area under the receiver operating characteristic curve(AUC)with a 95%confidence interval(CI).Results:The skewness derived from T2WI(T2WI-skewness)showed the best discrimination performance among the entire quantitative image features for differentiating anorectal malignant melanoma from low rectal cancer(primary cohort:AUC=0.852,95%CI 0.788–0.916;validation cohort:0.730,0.645–0.815).Multivariable analysis indicated that T2WI-skewness and the signal intensity of T1WI were independent factors,and incorporating both factors achieved good discrimination performance in two cohorts(primary cohort:AUC=0.913,95%CI 0.868–0.958;validation cohort:0.902,0.844–0.960).Conclusions:Incorporating T2WI-skewness and the signal intensity of T1WI achieved good performance for differentiating anorectal malignant melanoma from low rectal *** quantitative image analysis helps improve diagnostic accuracy.

关键词： anorectal malignant melanoma low rectal cancer magnetic resonance imaging quantitative image analysis

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Deep learning quantified mucus-tumor ratio predicting survival of patients with colorectal cancer using whole-slide images

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Precision Clinical Medicine 2021年第1期4卷 17-24页

作者： Ke Zhao Lin Wu Yanqi Huang Su Yao zeyan Xu Huan Lin Huihui Wang Yanting liang Yao Xu Xin Chen Minning Zhao Jiaming Peng Yuli Huang Changhong liang Zhenhui Li Yong Li Zaiyi Liu Department of Radiology Guangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesGuangzhou 510080China School of Medicine South China University of TechnologyGuangzhou 510006China Department of Pathology the Third Affiliated Hospital of Kunming Medical UniversityYunnan Cancer HospitalYunnan Cancer CenterKunming 650118China The Second School of Clinical Medicine Southern Medical UniversityGuangzhou 510080China Department of Pathology Guangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesGuangzhou 510080China Shantou University Medical College Shantou 515041China School of Bioengineering Chongqing UniversityChongqing 400044China Department of Radiology Guangzhou First People’s HospitalSchool of MedicineSouth China University of TechnologyGuangzhou 510180China School of Life Science and Technology Xidian UniversityXi’an 710071China Department of Radiology the Third Affiliated Hospital of Kunming Medical UniversityYunnan Cancer HospitalYunnan Cancer CenterKunming 650118China Department of General Surgery Guangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesGuangzhou 510080China

Background:In colorectal cancer(CRC),mucinous adenocarcinoma differs from other adenocarcinomas in gene-phenotype,morphology,and ***,mucinous components are present in a large number of adenocarcinomas,and the prognostic value of mucus proportion has not been *** intelligence provides a way to quantify mucus proportion on whole-slide images(WSIs)*** aimed to quantify mucus proportion by deep learning and further investigate its prognostic value in two CRC patient ***:Deep learning was used to segment WSIs stained with hematoxylin and ***-tumor ratio(MTR)was defined as the proportion of mucinous component in the tumor area.A training cohort(N=419)and a validation cohort(N=315)were used to evaluate the prognostic value of *** analysis was performed using the Cox proportional hazard ***:Patients were stratified tomucus-low andmucus-high groups,with 24.1%as the *** the training cohort,patients with mucus-high had unfavorable outcomes(hazard ratio for high *** 1.88,95%confidence interval 1.18–2.99,P=0.008),with 5-year overall survival rates of 54.8%and 73.7%in mucus-high and mucus-lowgroups,*** resultswere confirmed in the validation cohort(2.09,1.21–3.60,0.008;62.8%vs.79.8%).The prognostic value of MTR was maintained in multivariate analysis for both ***:The deep learning quantified MTR was an independent prognostic factor in *** the advantages of advanced efficiency and high consistency,our method is suitable for clinical application and promotes precision medicine development.

关键词： deep learning whole-slide images mucus-tumor ratio colorectal cancer digital pathology

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功能梯度材料动力学问题的POD模型降阶分析

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力学学报 2018年第4期50卷 787-797页

作者：郑保敬梁钰高效伟朱强华吴泽艳三峡大学水利与环境学院湖北宜昌443002 大连理工大学航空航天学院工业装备结构分析国家重点实验室大连116024

为了快速分析非均质材料结构在复杂载荷作用下的动态响应,提出一种模型降阶方法,只需计算结构在简单均质材料情况下的动力学问题,进而用其计算结果对非均质材料结构进行分析.首先,采用结构内部任意一点处的材料参数值作为整个结构的材... 详细信息

为了快速分析非均质材料结构在复杂载荷作用下的动态响应,提出一种模型降阶方法,只需计算结构在简单均质材料情况下的动力学问题,进而用其计算结果对非均质材料结构进行分析.首先,采用结构内部任意一点处的材料参数值作为整个结构的材料参数,利用有限元分析软件计算该均质材料结构在动态载荷作用下的位移场建立数据库,该数据库包含计算模型各个节点(自由度为N)在某时间段内L个时刻的位移;其次,对数据库中的信息按照时间离散的特定方式组集成瞬像矩阵,并利用特征正交分解方法对其进行分解,得到该模型的L个特征正交基底,选取其中能反应模型主要特征的H个(其中H

关键词：特征正交分解模型降阶动力响应功能梯度材料

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