Combining quantitative and qualitative magnetic resonance imaging features to differentiate anorectal malignant melanoma from low rectal cancer

作     者：Zeyan Xu Ke Zhao Lujun Han Pinxiong Li Zhenwei Shi Xiaomei Huang Chu Han Huihui Wang Minglei Chen Chen Liu Yanting Liang Suyun Li Yanqi Huang Xin Chen Changhong Liang Wuteng Cao Zaiyi Liu 

作者机构：School of MedicineSouth China University of TechnologyGuangzhou 510006China Department of RadiologyGuangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesGuangzhou 510080China State Key Laboratory of Oncology in South ChinaCollaborative Innovation Center of Cancer MedicineGuangzhou 510060China Department of RadiologySun Yat-Sen University Cancer CenterGuangzhou 510060China Department of Radiologythe Affiliated Hospital of Southwest Medical UniversityLuzhou 646000China The Second School of Clinical MedicineSouthern Medical UniversityGuangzhou 510080China Shantou University Medical CollegeShantou 515041China Guangdong Cardiovascular InstituteGuangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesGuangzhou 510080China Department of RadiologyGuangzhou First People’s Hospitalthe Second Affiliated Hospital of South China University of TechnologyGuangzhou 510180China Department of Radiologythe Sixth Affiliated Hospital of Sun Yat-Sen UniversityGuangzhou 510655China 

出 版 物：《Precision Clinical Medicine》 (精准临床医学（英文）)

年 卷 期：2021年第4卷第2期

页      面：119-128页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：This work was supported by the National Key Research and Development Program of China(Grant No.2017YFC1309100) the National Science Fund for Distinguished Young Scholars(Grant No.81925023) the National Natural Science Foundation of China(Grants No.81771912,82071892,and 82072090) the High-level Hospital Construction Project(Grant No.DFJH201805) 

主　　题：anorectal malignant melanoma low rectal cancer magnetic resonance imaging quantitative image analysis 

摘      要：Background:Distinguishing anorectal malignant melanoma from low rectal cancer remains challenging because of the overlap of clinical symptoms and imaging *** aim to investigate whether combining quantitative and qualitative magnetic resonance imaging(MRI)features could differentiate anorectal malignant melanoma from low rectal ***:Thirty-seven anorectal malignant melanoma and 98 low rectal cancer patients who underwent preoperative rectal MRI from three hospitals were retrospectively *** patients were divided into the primary cohort(N=84)and validation cohort(N=51).Quantitative image analysiswas performed on T1-weighted(T1WI),T2-weighted(T2WI),and contrast-enhanced T1-weighted imaging(CE-T1WI).The subjective qualitative MRI findings were evaluated by two radiologists in *** analysis was performed using stepwise logistic *** discrimination performance was assessed by the area under the receiver operating characteristic curve(AUC)with a 95%confidence interval(CI).Results:The skewness derived from T2WI(T2WI-skewness)showed the best discrimination performance among the entire quantitative image features for differentiating anorectal malignant melanoma from low rectal cancer(primary cohort:AUC=0.852,95%CI 0.788–0.916;validation cohort:0.730,0.645–0.815).Multivariable analysis indicated that T2WI-skewness and the signal intensity of T1WI were independent factors,and incorporating both factors achieved good discrimination performance in two cohorts(primary cohort:AUC=0.913,95%CI 0.868–0.958;validation cohort:0.902,0.844–0.960).Conclusions:Incorporating T2WI-skewness and the signal intensity of T1WI achieved good performance for differentiating anorectal malignant melanoma from low rectal *** quantitative image analysis helps improve diagnostic accuracy.