检索结果-南通市图书馆

CMKLR1 senses chemerin/resolvin E1 to control adipose thermogenesis and modulate metabolic homeostasis

Fundamental Research 2024年第3期4卷 575-588页

作者： zewei Zhao Siqi Liu Bingxiu Qian Lin Zhou Jianglin Shi Junxi Liu Lin Xu Zhonghan Yang Department of Biochemistry Molecular Cancer Research CenterSchool of MedicineSun Yat-sen UniversityShenzhenGuangdong 518107China Department of Biochemistry Zhongshan School of MedicineSun Yat-sen UniversityGuangzhouGuangdong 510080China School of Public Health Sun Yat-sen UniversityGuangzhouGuangdong 510080China

Induction of beige fat for thermogenesis is a potential therapy to improve homeostasis against obesity.β3-adrenoceptor(β3-AR),a type of G protein-coupled receptor(GPCR),is believed to mediate the thermogenesis of brown fat in mice.However,β3-AR has low expression in human adipose tissue,precluding its activation as a standalone clinical modality.This study aimed at identifying a potential GPCR target to induce beige fat.We found that chemerin chemokine-like receptor 1(CMKLR1),one of the novel GPCRs,mediated the development of beige fat via its two ligands,chemerin and resolvin E1(RvE1).The RvE1 levels were decreased in the obese mice,and RvE1 treatment led to a substantial improvement in obese features and augmented beige fat markers.Inversely,despite sharing the same receptor as RvE1,the chemerin levels were increased in obesogenic conditions,and chemerin treatment led to an augmented obese phenotype and a decline of beige fat markers.Moreover,RvE1 and chemerin induced or restrained the development of beige fat,respectively,via the mechanistic target of rapamycin complex 1(mTORC1)signaling pathway.We further showed that RvE1 and chemerin regulated mTORC1 signaling differentially by forming hydrogen bonds with different binding sites of CMKLR1.In conclusion,our study showed that RvE1 and chemerin affected metabolic homeostasis differentially,suggesting that selectively modulating CMKLR1 may be a potential therapeutic target for restoring metabolic homeostasis.

关键词： Obesity Insulin resistance Thermogenesis CMKLR1 Resolvin E1 Chemerin

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Steering surface reconstruction of hybrid metal oxides for efficient oxygen evolution reaction in water splitting and zinc-air batteries

引用

Journal of Energy Chemistry 2024年第5期92卷 383-393页

作者： Jie Zhu Junxue Chen Xida Li Kun Luo zewei Xiong Zhiyu Zhou Wenyun Zhu Zhihong Luo Jingbin Huang Yibing Li Key Lab of New Processing Technology for Nonferrous Metals and Materials Ministry of EducationSchool of Materials Science and EngineeringGuilin University of TechnologyGuilin 541000GuangxiChina The Key Laboratory of Rare Earth Functional Materials and Applications Zhoukou Normal UniversityZhoukou 466001HenanChina School of Chemistry and Chemical Engineering Beijing Institute of TechnologyBeijing 100081China School of Materials Science and Engineering Changzhou UniversityChangzhou 213164JiangsuChina Wuhan Sunmoon Battery Co. LtdWuhan 430090HubeiChina

Surface reconstruction yields real active species in electrochemical oxygen evolution reaction(OER)conditions;however,rationally regulating reconstruction in a targeted manner for constructing highly active OER electrocatalysts remains a formidable challenge.Here,an electrochemical activation strategy with selective etching was utilized to guide the reconstruction process of a hybrid cobalt-molybdenum oxide(CoMoO_(4)/Co_(3)O_(4)@CC)in a favorable direction to improve the OER performance.Both in-situ Raman and multiple ex-situ characterization tools demonstrate that controlled surface reconstruction can be easily achieved through Mo etching,with the formation of a dynamically stable amorphous-crystalline heterostructure.Theoretical calculations together with experimental results reveal that the synergistic effects between amorphous CoOOH and crystalline Co_(3)O_(4) are crucial in enhancing the catalytic performance.Consequently,the reconstructed CoMoO_(4)/Co_(3)O_(4)@CC exhibits a low overpotential of 250 mV to achieve a current density of 10 mA cm^(-2) in 1 M KOH,and more importantly it can be practiced in electrolytic water splitting and rechargeable zinc-air batteries devices,achieving ultra-long stability for over 500 and 1200 h,respectively.This work provides a promising route for the construction of high-performance electrocatalysts.

关键词： Electrocatalyst Oxygen evolution reaction Surface reconstruction Selective etching Amorphous-crystalline heterostructures

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Matrix-Mediated Color-Tunable Ultralong Organic Room Temperature Phosphorescence of 7H-Benzo[c]carbazole Derivatives

引用

CCS Chemistry 2024年第3期6卷 798-811页

作者： Chen Qian Xue Zhang Zhimin Ma Xiaohua Fu zewei Li Huiwen Jin Mingxing Chen Hong Jiang Zhiyong Ma Beijing Advanced Innovation Center for Soft Matter Science and Engineering State Key Laboratory of Organic–Inorganic CompositesCollege of Chemical EngineeringBeijing University of Chemical TechnologyBeijing 100029 Beijing National Laboratory for Molecular Sciences College of Chemistry and Molecular EngineeringPeking UniversityBeijing 100871

Building on the recent systematic research on 1Hbenzo[f]indole(Bd),an important advancement in constructing ultralong organic room temperature(UORTP)materials with a universal strategy via a readily obtained unit(7H-Benzo[c]carbazole,BCz)is proposed in this work.Pure powders of BCz and its derivatives merely exhibit blue fluorescence at ambient condition.However,when BCz and its derivatives are dispersed into polymer or powder matrixes,strong photo-activated green UORTP can be observed from their doped systems at room temperature.Moreover,the UORTP color can be tuned between green and yellow depending on the matrix.The ultralong phosphorescence originates from the generation of charge-separated states via radicals.The matrixes play a key role in both stabilizing charge-separated states and controlling UORTP color.More interestingly,when using polymethyl methacrylate as matrix,the doped films achieve stronger photo-activated ultralong phosphorescence underwater than in air at room temperature.Comparedwith Bd,BCz achieves better performance not only in ultralong phosphorescence properties but also in practical applications.This work gains a deeper insight into the mechanism of UORTP and paves a new approach to applying organic phosphorescent materials to underwater coating and imaging.

关键词： 7H-Benzo[c]carbazole ultralong organic room temperature phosphorescence ion radical matrix-mediated color tunning underwater application

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Isolation and oral immunogenicity assessment of porcine epidemic diarrhea virus NH-TA2020 strain:One of the predominant strains circulating in China from 2017 to 2021

引用

Virologica Sinica 2022年第5期37卷 646-655页

作者： Xiaowen Li Yang Li Jiapei Huang Yali Yao Wenying Zhao Yunjing Zhang Jie Qing Jing Ren Zhong Yan zewei wang Xiaofang Hu Duli Kang Hongqiang Liu Zhichun Yan New Hope Liuhe Co. Ltd.Chengdu610041China National Research Center for Veterinary Medicine Luoyang471000China Shandong New Hope Liuhe Agriculture and Animal Husbandry Technology Co. Ltd.(NHLH Academy of Swine Research)Dezhou253034China Swine Health Data and Intelligent Monitoring Project Laboratory Dezhou UniversityDezhou253011China Pulike Biological Engineering Inc. Luoyang471000China

Porcine epidemic diarrhea(PED)caused by porcine epidemic diarrhea virus(PEDV)is one of the most devastating diseases in the global pig industry due to its high mortality rate in piglets.Maternal vaccines can effectively enhance the gut-mammary gland-secretory IgA axis to boost lactogenic immunity and passive protection of nursing piglets against PEDV challenge.From 2017 to 2021,we collected 882 diarrhea samples from 303 farms in China to investigate the epidemiology of PEDV.The result showed that about 52.15%(158/303)of the farms were positive for PEDV with an overall detection rate of 63.95%(564/882)of the samples.The S1 fragments of S gene from 104 strains were sequenced for the phylogenetic analysis.A total of 71 PEDV strains(68.27%)sequenced in this study were clustered into the predominant G2c subgroup,while the newly-defined G2d strains(9.62%)were identified in three provinces of China.The NH-TA2020 strain of G2c subgroup was isolated and cultured,and its infection to piglets caused watery diarrhea within 24 h,indicating its strong pathogenicity.Oral administration of NH-TA2020 strain to pregnant gilts stimulated high levels of IgA antibody in colostrum.The piglets fed by the gilts above were challenged with NH-TA2020 strain or CH-HeB-RY-2020 strain from G2d subgroup,and the clinical symptoms and virus shedding were significantly reduced compared to the mock group.Our findings suggest that G2c subgroup is the predominant branch circulating in China from 2017 to 2021.Oral administration of NH-TA2020 enhances maternal IgA and lactogenic immune responses,which confer protection against the homologous and emerging G2d PEDV strains challenges in neonates.

关键词： Porcine epidemic diarrhea virus(PEDV) Molecular epidemiological investigation Virus isolation Lactogenic immune IgA

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

轴承内圆轴向超声高速磨削理论建模与试验研究

引用

表面技术 2024年第8期53卷 119-132页

作者：吴金津王旭袁巨龙苑泽伟王安静陈聪浙江工业大学机械工程学院超精密加工研究中心杭州310023 新昌浙江工业大学科学技术研究院浙江新昌312500 沈阳工业大学机械工程学院沈阳110000

目的以GCr15材料的6309型轴承内圆为研究对象,探究高转速超声磨削过程中超声辅助振动对磨粒运动轨迹、磨削后表面粗糙度、圆度以及微观形貌的影响规律。方法基于超声内圆磨削磨粒切削轨迹及超声振幅与砂轮转速对轨迹影响的理论仿真,构... 详细信息

目的以GCr15材料的6309型轴承内圆为研究对象,探究高转速超声磨削过程中超声辅助振动对磨粒运动轨迹、磨削后表面粗糙度、圆度以及微观形貌的影响规律。方法基于超声内圆磨削磨粒切削轨迹及超声振幅与砂轮转速对轨迹影响的理论仿真,构建磨削去除量与磨削表面粗糙度的理论模型,通过对轴承内圆进行超声磨削试验,研究高转速(16000~22000 r/min)下各工艺参数对内圆表面质量的影响并验证理论粗糙度评价模型。结果超声振幅的增大使磨粒与内圆接触轨迹变长,但随砂轮转速的提高,磨粒切削轨迹的密集程度也有所下降。振幅和砂轮转速的增大可使切削去除量增大、粗糙度降低,铬刚玉粒度100#陶瓷结合剂砂轮磨削GCr15轴承内圆后,其表面质量更有优势,单因素下表面质量变化趋势与理论分析结果相一致。结论在相同磨削参数下,1.5μm振幅超声磨削可使内圆圆度降至0.92μm,粗糙度降至130.5 nm,与传统磨削相比,粗糙度最高减小了41.5%,圆度最高减小了52.6%。在高转速下,各因素按砂轮对磨削后表面质量的影响由大到小的顺序依次为砂轮转速、超声振幅、进给速度,当磨粒线速度超过41.8 m/s、进给速度超过600 mm/min、振幅超过1.5μm时,表面质量呈下降趋势。

关键词：轴向超声内圆磨削高速去除量磨粒轨迹表面质量

来源：

维普期刊数据库博看期刊

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

中国参与亚洲区域组织的实践:发展历程、经验教训与未来展望

引用

太平洋学报 2024年第5期32卷 1-14页

作者：杨泽伟武汉大学湖北武汉430072

中国参与亚洲区域组织实践的发展历程,可以分为参与学习期、主动有为期和积极影响期三个阶段。中国参与亚洲区域组织实践的成就主要体现在倡导成立了上海合作组织和亚洲基础设施投资银行、开创了区域治理的新模式、推动了区域合作格局... 详细信息

中国参与亚洲区域组织实践的发展历程,可以分为参与学习期、主动有为期和积极影响期三个阶段。中国参与亚洲区域组织实践的成就主要体现在倡导成立了上海合作组织和亚洲基础设施投资银行、开创了区域治理的新模式、推动了区域合作格局的调整和促进区域合作,以及催生了新的国际机制等方面。中国参与亚洲区域组织实践的成功经验主要有:坚持开放的区域主义,坚持本国利益诉求与区域稳定发展相统一,谋求地区和平发展与参与全球治理有机结合。中国参与亚洲区域组织实践的教训主要包括:大国协调能力有待进一步加强、制度创设能力有限等。未来中国参与亚洲区域组织实践,应重点推动亚洲命运共同体的构建、进一步完善亚洲区域争端解决机制以及寻找多层次的亚洲区域治理方案等。

关键词：亚洲区域组织上海合作组织亚洲基础设施投资银行东盟亚洲命运共同体

来源：

维普期刊数据库

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

Expression and characterization of a novel GH128 laminarinase OUC-BsLam26 harboring both hydrolyzing and transferring activities

引用

Food Science and Human Wellness 2024年

作者： Yueyang Dong Yongyi Quan Hong Jiang Hamed I.Hamouda zewei Lu Yimiao Chen Chengqiang Li Xiangzhao Mao State Key Laboratory of Marine Food Processing and Safety Control College of Food Science and Engineering Ocean University of China Qingdao Key Laboratory of Food Biotechnology Sanya Ocean Research Institute Ocean University of China Processes Design and Development Department Egyptian Petroleum Research Institute Laboratory for Marine Drugs and Bioproducts of Qingdao National Laboratory for Marine Science and Technology Key Laboratory of Biological Processing of Aquatic Products China National Light Industry

Laminarin oligosaccharides (LOSs) with a specific degree of polymerization prepared through the laminarin degradation via laminarinase present more significant nutritional functions and application values. Human intestinal bacteria are promising potential producers of novel carbohydrate-active enzymes with unique properties. Here， a novel glycoside hydrolase family 128 (GH128) laminarinase OUC-BsLam26 from the intestinal bacterium Bacteroides sp. CBA7301 was heterologously expressed and characterized. The recombinant OUC-BsLam26 with a molecular mass of 49.86 kDa exhibits highest activity (6.60 U/mg) at 45 ℃ and pH 6.0， which shows noticeable temperature and pH stability. The purified OUC-BsLam26 could degrade laminarin via an endo-type mode with the generation of laminaripentaose， laminaritetraose， laminaritriose， and laminaribiose， among them， laminaritetraose is the principal product， which accounts for 45.25% of the total products， which is significantly different from the reported GH128 laminarinases. The minimum recognition substrate of OUC-BsLam26 is laminarihexaose. Furthermore， OUC-BsLam26 also could catalyze the transglycosylation process with the production of some novel glycosides. Altogether， the intestinal bacterium Bacteroides sp. CBA7301 contains laminarinase with unique product composition and OUC-BsLam26 is a hopeful bio-catalyst with the potential to produce laminaritetraose and some novel glycosides.

关键词：

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

新时代中国国际法学科体系的构造

引用

武汉大学学报（哲学社会科学版） 2024年第1期77卷 17-31页

作者：杨泽伟武汉大学国际法研究所湖北武汉430072

构造新时代中国国际法学科体系,既是为了进一步落实习近平有关学科建设的指示精神,也是为了改变国际法在整个法学体系中的地位与中国世界大国的地位不相称的状况,以及弥补我国涉外法治人才严重短缺的短板。中国国际法学科体系的构造,需... 详细信息

构造新时代中国国际法学科体系,既是为了进一步落实习近平有关学科建设的指示精神,也是为了改变国际法在整个法学体系中的地位与中国世界大国的地位不相称的状况,以及弥补我国涉外法治人才严重短缺的短板。中国国际法学科体系的构造,需要进一步厘清涉外法、涉外法治、对外关系法、国内法与国际法的关系,以及涉外法学、国际法与法学一级学科的关系。在中国国际法学科体系构造的过程中,最为重要的是构建国际法学一级学科专业。未来中国国际法学发展的任务主要包括:弘扬国际法治理念、为人类命运共同体的构建提供法治保障,传播中国国际法观、提升中国国际法理念的国际影响力,提高运用国际法的能力以及补齐涉外法治的短板等。涉外法治人才培养和推动国际法研究的理论创新,则成为今后中国国际法学者的应然使命。未来中国国际法学的发展方向涉及架设国际法与国内法沟通的桥梁、谨慎使用“涉外法学”名称,以及在国际法教育与研究中凸显中国的国际法理论与实践等。

关键词：国际法学涉外法治对外关系法国际法治中国特色哲学社会科学体系自主知识体系

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

磨粒振动对碳化硅CMP的微观结构演变和材料去除的影响

引用

金刚石与磨料磨具工程 2024年第1期44卷 109-122页

作者：唐爱玲苑泽伟唐美玲王颖沈阳工业大学机械工程学院沈阳110870

针对化学机械抛光中磨料易团聚、机械和化学作用不能充分发挥等问题,采用振动辅助的方法进行优化。通过分子动力学模拟,分析磨粒振动的频率、振幅及其压入深度、划切速度对工件表面微观原子迁移的演变规律,揭示振动对材料去除和表面改... 详细信息

针对化学机械抛光中磨料易团聚、机械和化学作用不能充分发挥等问题,采用振动辅助的方法进行优化。通过分子动力学模拟,分析磨粒振动的频率、振幅及其压入深度、划切速度对工件表面微观原子迁移的演变规律,揭示振动对材料去除和表面改善的促进机制;并通过振动辅助化学机械抛光工艺试验和表面成分分析,验证振动辅助的抛光效果和去除机制。结果表明:适当增大磨粒的振动频率、振动振幅及其压入深度、划切速度,可有效提高工件表面的原子势能和温度;磨粒振动有利于提高工件表面原子的混乱度,促进碳化硅参与氧化反应,形成氧化层并以机械方式去除;抛光试验和成分分析也证实振动可以提高材料去除率约50.5%,改善表面质量约25.4%。

关键词：碳化硅振动化学机械抛光分子动力学

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

非洲西海岸里奥-德雷盆地泥底辟平面地质结构特征研究

引用

浙江大学学报（理学版） 2024年第2期51卷 212-219,260页

作者：廖天奇姚泽伟浙江大学地球科学学院浙江省地学大数据与地球深部资源重点实验室浙江杭州310058 浙江工业大学土木工程学院浙江杭州310023

位于西非尼日尔三角洲盆地东缘的里奥-德雷盆地发育了大规模泥底辟,其活动时间和形成机理存在一定争议。基于对里奥-德雷盆地三维地震剖面的精细解释和平面成图,对其中中新世Nguti构造层顶面的泥底辟平面分布特征进行了重新厘定。结果表... 详细信息

位于西非尼日尔三角洲盆地东缘的里奥-德雷盆地发育了大规模泥底辟,其活动时间和形成机理存在一定争议。基于对里奥-德雷盆地三维地震剖面的精细解释和平面成图,对其中中新世Nguti构造层顶面的泥底辟平面分布特征进行了重新厘定。结果表明:(1)Nguti构造层顶面的泥底辟可分为北部隐伏区、中部刺穿区和南部刺穿区;(2)北部隐伏区的泥底辟形成于Nguti构造层沉积前,是受早期沉积作用控制的被动泥底辟;中部刺穿区的泥底辟形成于上新世S0构造层沉积前,是受重力构造作用控制的主动泥底辟;南部刺穿区的泥底辟形成于Nguti构造层沉积后,是受重力构造前缘逆冲断层控制的逆冲泥底辟;(3)泥底辟整体上为向南凸出的舌状体,分东、西两段,西段为北北西-北西走向,东段为北北东-北东走向。

关键词：泥底辟里奥-德雷盆地尼日尔三角洲大西洋

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：