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Chinese Neurosurgical Journal 2016年第3期2卷 -页

作者： Xiaofeng Wang Yuqiang Sun zeshi tan Anlong Ji Xu Sun Xinyu Li Ningwei Che Department of Neurosurgery Department of Neurosurgery The Second Affiliated Hospital of Dalian Medical University 467 Zhongshan RoadShahekou Dalian Liaoning 116023 People's Republic of China Department of General Surgery The Second Affiliated Hospital of Dalian Medical University Dalian Liaoning 116023 People's Republic of China

Background:Supratentorial primitive neuroectodermal tumors (sPNET) are rarely occurred in *** 39 cases have been reported in the past *** transformation from low grade to aggressive astrocytoma is well ***,such convert from a low-grade astrocytoma (LGA) into a sPNET between two completely different tumors is *** Presentation:This report discussed a 36-year-old male,who presented with the chief complaint of partial seizures and left limbs dysfunction and Magnetic resonance imaging (MRI) of whom revealed right frontal lesions which was operated to resect accompanied by the histological diagnosis of *** patient underwent operation 2.5 years ago because of seizures and was diagnosed with right frontal astrocytoma confirmed by ***,radiotherapy was not preformed on him after the primary *** now revealed high grade ***:It is exactly uncertain that reports revelant to transformation from low-grade astrocytoma to a new kind of tumor or neoplasm induced by radiotation have been *** case report is accompanied by a review of 39 cases of adult sPNET in the past decade,especially discussing about the transformation of low grade glioma into sPNET.

关键词： sPNET LGA Adult

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MicroRNAs as biomarkers in molecular diagnosis of refractory epilepsy

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Chinese Neurosurgical Journal 2016年第4期2卷 223-228页

作者： Xiaofeng Wang Hang Yin Alyson M.Rich7 Yuqiang Sun zeshi tan Xiaodong Luo Ningwei Che Department of Neurosurgery Dalian No.24 high school Dalian Liaoning 116044 People's Republic of China Department of Psychiatry Department of Neurosurgery The Second Affiliated Hospital of Dalian Medical University 467 Zhongshan RoadShahekou Dalian Liaoning 116044 People's Republic of China

MicroRNA (miRNA) is a type of endogenous non-coding RNA that can regulate cell proliferation,differentiation,invasion,apoptosis and several other biological activities by specially inducing gene silencing,and thereby is related to development and disease in life *** recent years,researchers have found that miRNAs are closely related with refractory *** can intervene in the modification of mRNAs,the synthesis of proteins and some the connectivity of signal pathways in pathogenesis of ***,some miRNAs in neurons are of great importance in neuronal ***,miRNA may play a very important role in the occurrence,development and episodes of refractory *** discoveries can provide a new direction for the research of pathogenesis,diagnostic methods and therapeutic approach of refractory *** research about miRNA and intractable epilepsy has progressed,more remains to be done before miRNA can be used in clinical diagnosis and treatment *** paper focuses on the research progress of molecular diagnosis about miRNA in intractable epilepsy.

关键词： MicroRNA Refractory epilepsy Biomarker Diagnosis

Frontal disconnectionfor drug-resistant epilepsy:outcome in a series of 8 patients

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Frontal disconnectionfor drug-resistant epilepsy:outcome in ...

The Security Analysis of Quantum SAGR04 Protocol in Collective-Rotation Noise Channel

第十六届中国医师协会神经外科医师年会

作者： Chen YAO FengJun ZHU Fengpeng WANG Yang SUN Chong LI Lin LI zeshi tan Xiaofan REN Yuanqing WANG Xiaobin ZHANG Xiaodong CAI Yi YAO 深圳市第二人民医院/深圳大学第一附属医院深圳市儿童医院厦门弘爱医院

Objective:It has been suggested that drug-resistant epilepsy(DRE) caused by lesions restricted to the frontal lobe can be treated successfully by a procedure termed frontal *** objective of the present paper was to evaluate the effectiveness of frontal disconnection surgery in seizurecontrol and related consequences in a consecutive patient series.

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Chinese Journal of Electronics 2015年第4期24卷 689-693页

作者： LI Jian PAN zeshi ZHENG Jun SUN Fengqi YE Xinxin YUAN Kaiguo School of Computer Beijing University of Posts and Telecommunications Science and Technology on Communication Security Laboratory School of Computer Beijing institute of Technology

Noise exists in the actual communication environment. It is necessary and significant to analyze the security of SAGR04 protocol in the noise environment. An excellent model of collective rotation noise analysis is introduced and the discussing of the security of SAGR04 protocol is based on the method of information theory. The eavesdropping can be detected for the increment of the qubit error rate and eavesdropper can maximally get about50% of the keys. It can be concluded that the SAGR04 protocol, used as quantum key distribution, is secure.

关键词： SAGR04 Collective rotation noise Qubit error rate Average mutual information

Building a reference indicator model using co-kriging interpolation to determine the geographical origin of the flighted spongy moth complex in China

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Insect Science 2024年第5期31卷 1603-1616页

作者： zeshi Qin Yixia Cao Yan Wang Jun Ding Wuja Xia Juan Shi Sino-French Joint Laboratory for Invasive Forest Pests in Eurasia Beijing Forestry UniversityBeijingChina Beijing Key Laboratory for Forest Pest Control Beijing Forestry UniversityBeijingChina China Certification and Inspection Group Beijing Co. Ltd.BeijingChina Tibetan Autonomous Prefecture of Huangnan Forestry and Grassland Administration QinghaiChina

Using stable isotopes to detect and analyze the geographical origin of insects represents an important traceability technology,which requires a rich isotope *** this study,we representatively sampled the Chinese provinces where flighted spongy moth complex(FSMC)has been reported and,for the first time,used co-kriging interpolation to predict the distribution patterns of FSMC s13C values in the main distribution *** 2020 to 2022,we set up 60 traps in 12 provinces and cities in China and collected 795 ***,6 main climatic factors were obtained by multi-collinearity screening from 21 types of meteorological data collected at the sample plots,and a correlation analysis was carried out by combining longitude,latitude,and altitude data with the s13C val-ues of ***,we performed a co-kriging interpolation using the 2 climatic factors with the highest correlation(isothermality and altitude)and the s13C values of FSMC.A cross-validation was performed to systematically test 11 candidate models and select the best semi-variogram model(Exponential"),which was then used to build a co-kriging interpolation *** geographical distribution patterns of the FSMC s13C values ob-tained from the 2 interpolation models(i.e.,interpolated with isothermality and altitude,respectively)were almost the ***,the s13C values varied significantly at the regional scale,showing regular changes in spatial ***,the reference indi-cator map of the 813C values generated from stable isotopes can be used to greatly improve the efficiency of discrimination analyses on the geographical origin of FSMC.

关键词： C stable isotope environmental similarity flighted spongy moth complex(FSMC) geographical origin

New phenylbutenoids and terpene glycosides from Ginkgo biloba leaves

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Chinese Journal of Natural Medicines 2024年第2期22卷 161-170页

作者： SUN zeshi LIN Shan WU Zhi-Li DONG Hong-Yuan XU Xi-Ke LI Hui-Liang WANG Jinxin School of Pharmacy Second Military Medical UniversityShanghai 200433China State Key Laboratory of New Drug and Pharmaceutical Process Shanghai Institute of Pharmaceutical IndustryChina State Institute of Pharmaceutical IndustryShanghai 201203China

Our continued works on the chemical constituents of Ginkgo biloba(***)leaves has led to the isolation of two novel phenylbutenoids(1,2),along with five previously unidentified terpene glycosides(3−7).Among them,compounds 1 and 2 represent unique(Z)-phenylbutenoids,3−6 are megastigmane glycosides,and 7 is identified as a rare bilobanone glycoside(Fig.1).This study marks the first reported isolation of phenylbutenoid and bilobanone glycoside from *** chemical structures of these compounds were elucidated through extensive spectroscopic analysis,including HR-ESI-MS and various 1D and 2D NMR ***,the absolute configurations of these molecules were determined using Mosher’s method,ECD experiments,and Cu-KαX-ray crystallographic analyses.

关键词： Ginkgo biloba Phenylbutenoid Megastigmane glycoside Bilobanone glycoside

Single-Channel Compressive Sensing for DOA Estimation via Sensing Model Optimization

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International Journal of Communications, Network and System Sciences 2017年第5期10卷 191-201页

作者： Hongtao Li zeshi Yuan Nanjing University of Science and Technology Nanjing China

The performance of multi-channel Compressive Sensing (CS)-based Direction-of-Arrival (DOA) estimation algorithm degrades when the gains between Radio Frequency (RF) channels are inconsistent, and when target angle information mismatches with system sensing model. To solve these problems, a novel single-channel CS-based DOA estimation algorithm via sensing model optimization is proposed. Firstly, a DOA sparse sensing model using single-channel array considering the sensing model mismatch is established. Secondly, a new single-channel CS-based DOA estimation algorithm is presented. The basic idea behind the proposed algorithm is to iteratively solve two CS optimizations with respect to target angle information vector and sensing model quantization error vector, respectively. In addition, it avoids the loss of DOA estimation performance caused by the inconsistent gain between RF channels. Finally, simulation results are presented to verify the efficacy of the proposed algorithm.

关键词： Compressive Sensing Direction-of-Arrival Estimation Single-Channel Mismatching Error

In vitro expression and analysis of the 826 human G protein-coupled receptors

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Protein & Cell 2016年第5期7卷 325-337页

作者： Xuechen Lv Junlin Liu Qiaoyun Shi Qiwen tan Dong Wu John J. Skinner Angela L. Walker Lixia Zhao Xiangxiang Gu Na Chen Lu Xue Pei Si Lu Zhang zeshi Wang Vsevolod Katritch Zhijie Liu Raymond C. Stevens iHuman Institute ShanghaiTech University Shanghai 201210 China Department of Biological Sciences Bridge Institute University of Southern California Los Angeles CA 90089 USA

G protein-coupled receptors （GPCRs） are involved in all human physiological systems where they are responsible for transducing extracellular signals into cells. GPCRs signal in response to a diverse array of stimuli including light, hormones, and lipids, where these signals affect downstream cascades to impact both health and disease states. Yet, despite their importance as therapeutic tar- gets, detailed molecular structures of only 30 GPCRs have been determined to date. A key challenge to their structure determination is adequate protein expression. Here we report the quantification of protein expression in an insect cell expression system for all 826 human GPCRs using two different fusion constructs. Expression char- acteristics are analyzed in aggregate and among each of the five distinct subfamilies. These data can be used to identify trends related to GPCR expression between dif- ferent fusion constructs and between different GPCR families, and to prioritize lead candidates for future structure determination feasibility.

关键词： G protein-coupled receptors insect,protein expression surface expression analysis fusionconstruct

A three-layer model for the thermal structure in the Huanghai Sea

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Acta Oceanologica Sinica 1990年第2期9卷 159-172页

作者： Wan Bangjun, Guo Binghuo and Chen zeshi First Institute of Oceanography, State Oceanic Administration, P. O. Box 98, Qingdao, China

A one-dimentional three-layer model for the thermal structure in the Huanghai Sea is presented in this study, me model consists of the upper mixed layer caused by heating and wind mixing, the lower mixed layer driven by tidal mixing, and the thermocline with certain thickness. The entrainment velocities of the upper and lower layers are obtained respectively. The results show that the model is capable of describing the development and decline processes of the seasonal thermocline in the Huanghai Sea, simulating successfully the Huanghai Sea Cold Water Mass, the nearshore front and surface cold water off North Jiangsu and explaining reasonably their formation mechanisms as well as the strong thermocline off Qingdao. It is suggested that the tidal mixing plays key role in the formation of the nearshore front off North Jiangsu and the strong thermocline off Qingdao. The wind mixing and the tidal mixing make the lower layer water with high nutrients go up to the upper layer. This physical process may be significant for biological plant production.

关键词： A three-layer model for the thermal structure in the Huanghai Sea

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现代化理论与中国发展

开放导报 2014年第1期 64-66页

作者：李泽实谢菲尔德大学

现代化理论兴起于上世纪50年代。作为主流发展理论之一,早期的现代化理论机械地遵循着"传统/现代"的二分法原则,且僵化地坚持西化的发展思路,致使其逐渐难以跟上世界发展的潮流,并于上世纪70年代遭到了全面的理论批判。随后,现代化理论... 详细信息

现代化理论兴起于上世纪50年代。作为主流发展理论之一,早期的现代化理论机械地遵循着"传统/现代"的二分法原则,且僵化地坚持西化的发展思路,致使其逐渐难以跟上世界发展的潮流,并于上世纪70年代遭到了全面的理论批判。随后,现代化理论进行了一系列自我反思与修正,因而重获解释力并具有了良好的适应性。

关键词：现代化理论中国发展理论背景发展优势